Amino acid dipepetide frequency for Lactococcus phage 38507

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.63AlaAla: 0.63 ± 0.24
0.315AlaCys: 0.315 ± 0.205
2.413AlaAsp: 2.413 ± 0.555
4.407AlaGlu: 4.407 ± 0.837
3.673AlaPhe: 3.673 ± 0.612
3.568AlaGly: 3.568 ± 0.811
0.944AlaHis: 0.944 ± 0.361
4.932AlaIle: 4.932 ± 1.096
7.24AlaLys: 7.24 ± 1.185
6.296AlaLeu: 6.296 ± 0.956
2.308AlaMet: 2.308 ± 0.514
4.197AlaAsn: 4.197 ± 0.837
0.839AlaPro: 0.839 ± 0.285
1.889AlaGln: 1.889 ± 0.406
1.889AlaArg: 1.889 ± 0.421
3.358AlaSer: 3.358 ± 0.626
2.308AlaThr: 2.308 ± 0.597
3.568AlaVal: 3.568 ± 0.689
1.679AlaTrp: 1.679 ± 0.517
1.994AlaTyr: 1.994 ± 0.502
0.0AlaXaa: 0.0 ± 0.0
Cys
0.42CysAla: 0.42 ± 0.238
0.21CysCys: 0.21 ± 0.162
0.315CysAsp: 0.315 ± 0.186
0.315CysGlu: 0.315 ± 0.21
0.315CysPhe: 0.315 ± 0.188
0.735CysGly: 0.735 ± 0.309
0.105CysHis: 0.105 ± 0.109
0.525CysIle: 0.525 ± 0.236
1.154CysLys: 1.154 ± 0.408
0.63CysLeu: 0.63 ± 0.354
0.105CysMet: 0.105 ± 0.104
0.63CysAsn: 0.63 ± 0.248
0.105CysPro: 0.105 ± 0.118
0.315CysGln: 0.315 ± 0.191
0.839CysArg: 0.839 ± 0.297
0.525CysSer: 0.525 ± 0.251
0.315CysThr: 0.315 ± 0.191
0.42CysVal: 0.42 ± 0.207
0.21CysTrp: 0.21 ± 0.143
0.42CysTyr: 0.42 ± 0.257
0.0CysXaa: 0.0 ± 0.0
Asp
1.679AspAla: 1.679 ± 0.528
0.21AspCys: 0.21 ± 0.139
3.253AspAsp: 3.253 ± 0.737
4.407AspGlu: 4.407 ± 0.854
3.987AspPhe: 3.987 ± 0.521
3.568AspGly: 3.568 ± 0.607
0.839AspHis: 0.839 ± 0.336
4.302AspIle: 4.302 ± 0.81
5.666AspLys: 5.666 ± 0.615
5.456AspLeu: 5.456 ± 0.701
1.259AspMet: 1.259 ± 0.404
3.778AspAsn: 3.778 ± 0.662
1.364AspPro: 1.364 ± 0.467
0.735AspGln: 0.735 ± 0.271
2.099AspArg: 2.099 ± 0.474
3.253AspSer: 3.253 ± 0.527
4.092AspThr: 4.092 ± 0.69
2.728AspVal: 2.728 ± 0.539
0.944AspTrp: 0.944 ± 0.297
3.043AspTyr: 3.043 ± 0.642
0.0AspXaa: 0.0 ± 0.0
Glu
3.253GluAla: 3.253 ± 0.542
0.63GluCys: 0.63 ± 0.282
2.833GluAsp: 2.833 ± 0.591
6.086GluGlu: 6.086 ± 1.273
4.302GluPhe: 4.302 ± 0.574
1.889GluGly: 1.889 ± 0.425
1.154GluHis: 1.154 ± 0.377
5.456GluIle: 5.456 ± 0.673
7.03GluLys: 7.03 ± 1.321
9.759GluLeu: 9.759 ± 1.312
2.938GluMet: 2.938 ± 0.484
6.086GluAsn: 6.086 ± 0.881
1.154GluPro: 1.154 ± 0.332
3.778GluGln: 3.778 ± 0.729
3.568GluArg: 3.568 ± 0.62
3.882GluSer: 3.882 ± 0.606
4.617GluThr: 4.617 ± 0.71
4.407GluVal: 4.407 ± 0.817
1.154GluTrp: 1.154 ± 0.305
3.358GluTyr: 3.358 ± 0.615
0.0GluXaa: 0.0 ± 0.0
Phe
3.148PheAla: 3.148 ± 0.62
0.525PheCys: 0.525 ± 0.221
3.253PheAsp: 3.253 ± 0.555
2.938PheGlu: 2.938 ± 0.683
1.889PhePhe: 1.889 ± 0.474
2.413PheGly: 2.413 ± 0.63
0.21PheHis: 0.21 ± 0.164
3.463PheIle: 3.463 ± 0.563
4.617PheLys: 4.617 ± 0.694
2.518PheLeu: 2.518 ± 0.469
1.364PheMet: 1.364 ± 0.325
4.092PheAsn: 4.092 ± 0.686
0.63PhePro: 0.63 ± 0.238
1.574PheGln: 1.574 ± 0.344
1.259PheArg: 1.259 ± 0.289
3.358PheSer: 3.358 ± 0.568
2.518PheThr: 2.518 ± 0.405
2.308PheVal: 2.308 ± 0.466
0.315PheTrp: 0.315 ± 0.19
2.623PheTyr: 2.623 ± 0.487
0.0PheXaa: 0.0 ± 0.0
Gly
2.938GlyAla: 2.938 ± 0.792
0.42GlyCys: 0.42 ± 0.21
2.833GlyAsp: 2.833 ± 0.578
4.617GlyGlu: 4.617 ± 0.705
1.889GlyPhe: 1.889 ± 0.465
4.827GlyGly: 4.827 ± 1.111
0.839GlyHis: 0.839 ± 0.255
3.778GlyIle: 3.778 ± 1.037
7.345GlyLys: 7.345 ± 1.348
6.191GlyLeu: 6.191 ± 0.897
1.364GlyMet: 1.364 ± 0.41
3.358GlyAsn: 3.358 ± 0.609
0.21GlyPro: 0.21 ± 0.159
1.889GlyGln: 1.889 ± 0.398
2.099GlyArg: 2.099 ± 0.428
3.778GlySer: 3.778 ± 0.917
3.778GlyThr: 3.778 ± 0.861
4.407GlyVal: 4.407 ± 0.863
1.049GlyTrp: 1.049 ± 0.31
3.148GlyTyr: 3.148 ± 0.617
0.0GlyXaa: 0.0 ± 0.0
His
1.049HisAla: 1.049 ± 0.31
0.42HisCys: 0.42 ± 0.208
0.839HisAsp: 0.839 ± 0.334
0.839HisGlu: 0.839 ± 0.327
0.42HisPhe: 0.42 ± 0.215
1.364HisGly: 1.364 ± 0.367
0.315HisHis: 0.315 ± 0.156
0.839HisIle: 0.839 ± 0.329
0.735HisLys: 0.735 ± 0.252
1.154HisLeu: 1.154 ± 0.374
0.315HisMet: 0.315 ± 0.217
1.259HisAsn: 1.259 ± 0.537
0.315HisPro: 0.315 ± 0.191
0.525HisGln: 0.525 ± 0.232
0.42HisArg: 0.42 ± 0.29
0.315HisSer: 0.315 ± 0.205
0.944HisThr: 0.944 ± 0.342
0.735HisVal: 0.735 ± 0.268
0.0HisTrp: 0.0 ± 0.0
0.839HisTyr: 0.839 ± 0.304
0.0HisXaa: 0.0 ± 0.0
Ile
3.882IleAla: 3.882 ± 0.701
0.21IleCys: 0.21 ± 0.153
4.617IleAsp: 4.617 ± 0.729
7.24IleGlu: 7.24 ± 0.919
2.728IlePhe: 2.728 ± 0.613
3.358IleGly: 3.358 ± 0.722
1.154IleHis: 1.154 ± 0.401
5.037IleIle: 5.037 ± 0.671
6.506IleLys: 6.506 ± 0.712
5.352IleLeu: 5.352 ± 0.932
1.679IleMet: 1.679 ± 0.418
5.142IleAsn: 5.142 ± 0.605
1.784IlePro: 1.784 ± 0.419
2.308IleGln: 2.308 ± 0.504
2.204IleArg: 2.204 ± 0.516
4.512IleSer: 4.512 ± 0.908
5.142IleThr: 5.142 ± 0.685
4.512IleVal: 4.512 ± 0.809
1.049IleTrp: 1.049 ± 0.336
2.833IleTyr: 2.833 ± 0.475
0.0IleXaa: 0.0 ± 0.0
Lys
8.814LysAla: 8.814 ± 1.412
1.259LysCys: 1.259 ± 0.504
5.037LysAsp: 5.037 ± 0.57
8.395LysGlu: 8.395 ± 1.298
2.728LysPhe: 2.728 ± 0.549
7.24LysGly: 7.24 ± 1.128
1.259LysHis: 1.259 ± 0.412
5.666LysIle: 5.666 ± 0.852
8.814LysLys: 8.814 ± 1.36
7.555LysLeu: 7.555 ± 0.876
3.043LysMet: 3.043 ± 0.572
4.827LysAsn: 4.827 ± 0.753
1.574LysPro: 1.574 ± 0.459
3.987LysGln: 3.987 ± 0.687
3.987LysArg: 3.987 ± 0.679
5.247LysSer: 5.247 ± 0.729
5.247LysThr: 5.247 ± 0.724
5.981LysVal: 5.981 ± 0.676
1.784LysTrp: 1.784 ± 0.414
4.302LysTyr: 4.302 ± 0.723
0.0LysXaa: 0.0 ± 0.0
Leu
5.456LeuAla: 5.456 ± 0.743
0.21LeuCys: 0.21 ± 0.171
4.722LeuAsp: 4.722 ± 0.741
5.771LeuGlu: 5.771 ± 0.831
4.197LeuPhe: 4.197 ± 0.693
3.778LeuGly: 3.778 ± 0.827
1.259LeuHis: 1.259 ± 0.385
7.66LeuIle: 7.66 ± 0.877
8.08LeuLys: 8.08 ± 1.024
5.247LeuLeu: 5.247 ± 0.903
1.574LeuMet: 1.574 ± 0.499
6.191LeuAsn: 6.191 ± 0.859
3.253LeuPro: 3.253 ± 0.548
3.463LeuGln: 3.463 ± 0.568
2.623LeuArg: 2.623 ± 0.549
6.296LeuSer: 6.296 ± 0.876
5.771LeuThr: 5.771 ± 0.74
4.512LeuVal: 4.512 ± 0.585
1.469LeuTrp: 1.469 ± 0.411
4.512LeuTyr: 4.512 ± 0.651
0.105LeuXaa: 0.105 ± 0.104
Met
2.833MetAla: 2.833 ± 0.482
0.105MetCys: 0.105 ± 0.132
1.469MetAsp: 1.469 ± 0.394
2.204MetGlu: 2.204 ± 0.564
0.42MetPhe: 0.42 ± 0.225
1.154MetGly: 1.154 ± 0.338
0.42MetHis: 0.42 ± 0.223
2.204MetIle: 2.204 ± 0.488
2.518MetLys: 2.518 ± 0.551
1.889MetLeu: 1.889 ± 0.576
0.525MetMet: 0.525 ± 0.243
2.099MetAsn: 2.099 ± 0.458
0.42MetPro: 0.42 ± 0.211
1.364MetGln: 1.364 ± 0.378
0.735MetArg: 0.735 ± 0.268
1.154MetSer: 1.154 ± 0.323
1.889MetThr: 1.889 ± 0.508
1.469MetVal: 1.469 ± 0.395
0.105MetTrp: 0.105 ± 0.091
1.364MetTyr: 1.364 ± 0.379
0.0MetXaa: 0.0 ± 0.0
Asn
3.778AsnAla: 3.778 ± 0.99
0.315AsnCys: 0.315 ± 0.187
4.092AsnAsp: 4.092 ± 0.682
4.722AsnGlu: 4.722 ± 0.727
2.623AsnPhe: 2.623 ± 0.529
6.506AsnGly: 6.506 ± 1.001
0.525AsnHis: 0.525 ± 0.22
4.407AsnIle: 4.407 ± 0.639
7.03AsnLys: 7.03 ± 1.008
5.561AsnLeu: 5.561 ± 0.758
1.889AsnMet: 1.889 ± 0.472
4.092AsnAsn: 4.092 ± 0.742
1.679AsnPro: 1.679 ± 0.458
2.518AsnGln: 2.518 ± 0.551
2.204AsnArg: 2.204 ± 0.384
3.882AsnSer: 3.882 ± 0.513
3.882AsnThr: 3.882 ± 0.569
3.673AsnVal: 3.673 ± 0.662
1.259AsnTrp: 1.259 ± 0.359
2.518AsnTyr: 2.518 ± 0.485
0.0AsnXaa: 0.0 ± 0.0
Pro
1.049ProAla: 1.049 ± 0.271
0.21ProCys: 0.21 ± 0.151
1.574ProAsp: 1.574 ± 0.458
1.889ProGlu: 1.889 ± 0.497
0.839ProPhe: 0.839 ± 0.308
0.105ProGly: 0.105 ± 0.11
0.21ProHis: 0.21 ± 0.15
1.889ProIle: 1.889 ± 0.562
1.469ProLys: 1.469 ± 0.426
2.099ProLeu: 2.099 ± 0.394
0.735ProMet: 0.735 ± 0.243
1.784ProAsn: 1.784 ± 0.606
0.63ProPro: 0.63 ± 0.285
0.315ProGln: 0.315 ± 0.186
0.735ProArg: 0.735 ± 0.334
0.839ProSer: 0.839 ± 0.325
1.889ProThr: 1.889 ± 0.427
0.839ProVal: 0.839 ± 0.3
0.315ProTrp: 0.315 ± 0.171
0.735ProTyr: 0.735 ± 0.301
0.0ProXaa: 0.0 ± 0.0
Gln
3.043GlnAla: 3.043 ± 0.74
0.315GlnCys: 0.315 ± 0.174
2.308GlnAsp: 2.308 ± 0.433
2.728GlnGlu: 2.728 ± 0.549
1.469GlnPhe: 1.469 ± 0.346
2.413GlnGly: 2.413 ± 0.495
0.525GlnHis: 0.525 ± 0.219
1.889GlnIle: 1.889 ± 0.39
3.463GlnLys: 3.463 ± 0.624
3.043GlnLeu: 3.043 ± 0.637
0.839GlnMet: 0.839 ± 0.241
2.308GlnAsn: 2.308 ± 0.431
0.63GlnPro: 0.63 ± 0.214
2.204GlnGln: 2.204 ± 0.539
1.469GlnArg: 1.469 ± 0.461
2.204GlnSer: 2.204 ± 0.497
2.204GlnThr: 2.204 ± 0.461
2.099GlnVal: 2.099 ± 0.585
0.525GlnTrp: 0.525 ± 0.217
0.944GlnTyr: 0.944 ± 0.342
0.0GlnXaa: 0.0 ± 0.0
Arg
2.204ArgAla: 2.204 ± 0.588
0.315ArgCys: 0.315 ± 0.175
1.784ArgAsp: 1.784 ± 0.349
3.148ArgGlu: 3.148 ± 0.532
1.049ArgPhe: 1.049 ± 0.317
2.308ArgGly: 2.308 ± 0.475
0.63ArgHis: 0.63 ± 0.218
2.413ArgIle: 2.413 ± 0.475
4.827ArgLys: 4.827 ± 1.026
3.568ArgLeu: 3.568 ± 0.542
0.735ArgMet: 0.735 ± 0.301
2.833ArgAsn: 2.833 ± 0.589
0.63ArgPro: 0.63 ± 0.25
1.259ArgGln: 1.259 ± 0.325
1.784ArgArg: 1.784 ± 0.39
1.469ArgSer: 1.469 ± 0.391
1.364ArgThr: 1.364 ± 0.337
1.994ArgVal: 1.994 ± 0.413
0.105ArgTrp: 0.105 ± 0.11
2.204ArgTyr: 2.204 ± 0.438
0.0ArgXaa: 0.0 ± 0.0
Ser
4.302SerAla: 4.302 ± 1.272
0.944SerCys: 0.944 ± 0.367
3.673SerAsp: 3.673 ± 0.632
3.358SerGlu: 3.358 ± 0.614
3.778SerPhe: 3.778 ± 0.671
4.302SerGly: 4.302 ± 0.934
0.63SerHis: 0.63 ± 0.225
4.302SerIle: 4.302 ± 0.588
6.191SerLys: 6.191 ± 0.729
4.827SerLeu: 4.827 ± 0.683
1.574SerMet: 1.574 ± 0.336
3.253SerAsn: 3.253 ± 0.488
1.049SerPro: 1.049 ± 0.352
2.204SerGln: 2.204 ± 0.481
2.204SerArg: 2.204 ± 0.391
5.247SerSer: 5.247 ± 1.088
3.148SerThr: 3.148 ± 0.703
3.673SerVal: 3.673 ± 0.6
0.63SerTrp: 0.63 ± 0.302
2.204SerTyr: 2.204 ± 0.501
0.0SerXaa: 0.0 ± 0.0
Thr
4.302ThrAla: 4.302 ± 0.687
0.42ThrCys: 0.42 ± 0.233
3.673ThrAsp: 3.673 ± 0.909
4.827ThrGlu: 4.827 ± 0.772
2.413ThrPhe: 2.413 ± 0.6
4.617ThrGly: 4.617 ± 0.634
0.525ThrHis: 0.525 ± 0.244
4.092ThrIle: 4.092 ± 0.722
4.092ThrLys: 4.092 ± 0.612
5.876ThrLeu: 5.876 ± 0.76
1.154ThrMet: 1.154 ± 0.334
4.302ThrAsn: 4.302 ± 0.734
1.679ThrPro: 1.679 ± 0.357
2.518ThrGln: 2.518 ± 0.474
1.889ThrArg: 1.889 ± 0.447
4.092ThrSer: 4.092 ± 0.602
3.568ThrThr: 3.568 ± 0.578
3.358ThrVal: 3.358 ± 0.668
0.735ThrTrp: 0.735 ± 0.302
2.204ThrTyr: 2.204 ± 0.555
0.0ThrXaa: 0.0 ± 0.0
Val
3.358ValAla: 3.358 ± 0.635
0.525ValCys: 0.525 ± 0.257
4.197ValAsp: 4.197 ± 0.726
4.302ValGlu: 4.302 ± 0.511
2.728ValPhe: 2.728 ± 0.496
2.833ValGly: 2.833 ± 0.499
0.839ValHis: 0.839 ± 0.334
3.882ValIle: 3.882 ± 0.528
6.191ValLys: 6.191 ± 0.697
3.358ValLeu: 3.358 ± 0.784
1.574ValMet: 1.574 ± 0.451
2.518ValAsn: 2.518 ± 0.504
1.259ValPro: 1.259 ± 0.389
1.259ValGln: 1.259 ± 0.35
2.623ValArg: 2.623 ± 0.562
4.407ValSer: 4.407 ± 0.684
4.512ValThr: 4.512 ± 0.775
3.463ValVal: 3.463 ± 0.703
0.315ValTrp: 0.315 ± 0.167
2.728ValTyr: 2.728 ± 0.534
0.0ValXaa: 0.0 ± 0.0
Trp
0.944TrpAla: 0.944 ± 0.298
0.315TrpCys: 0.315 ± 0.194
0.839TrpAsp: 0.839 ± 0.314
0.735TrpGlu: 0.735 ± 0.268
1.259TrpPhe: 1.259 ± 0.398
0.735TrpGly: 0.735 ± 0.297
0.21TrpHis: 0.21 ± 0.156
0.63TrpIle: 0.63 ± 0.206
0.63TrpLys: 0.63 ± 0.242
1.784TrpLeu: 1.784 ± 0.572
0.315TrpMet: 0.315 ± 0.178
1.259TrpAsn: 1.259 ± 0.348
0.0TrpPro: 0.0 ± 0.0
0.944TrpGln: 0.944 ± 0.286
0.525TrpArg: 0.525 ± 0.281
0.944TrpSer: 0.944 ± 0.275
0.63TrpThr: 0.63 ± 0.234
0.525TrpVal: 0.525 ± 0.296
0.0TrpTrp: 0.0 ± 0.0
1.154TrpTyr: 1.154 ± 0.322
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.364TyrAla: 1.364 ± 0.426
0.735TyrCys: 0.735 ± 0.366
2.833TyrAsp: 2.833 ± 0.725
4.407TyrGlu: 4.407 ± 0.703
2.308TyrPhe: 2.308 ± 0.53
3.043TyrGly: 3.043 ± 0.629
1.049TyrHis: 1.049 ± 0.285
3.882TyrIle: 3.882 ± 0.733
3.148TyrLys: 3.148 ± 0.641
3.987TyrLeu: 3.987 ± 0.792
0.944TyrMet: 0.944 ± 0.435
3.253TyrAsn: 3.253 ± 0.535
0.944TyrPro: 0.944 ± 0.311
1.574TyrGln: 1.574 ± 0.485
1.469TyrArg: 1.469 ± 0.432
2.728TyrSer: 2.728 ± 0.578
2.518TyrThr: 2.518 ± 0.608
2.204TyrVal: 2.204 ± 0.537
0.735TyrTrp: 0.735 ± 0.29
2.204TyrTyr: 2.204 ± 0.594
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.105XaaAsp: 0.105 ± 0.104
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (9531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski