Amino acid dipepetide frequency for Jimgerdemannia flammicorona

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.324AlaAla: 7.324 ± 0.066	1.243AlaCys: 1.243 ± 0.024	3.942AlaAsp: 3.942 ± 0.032	4.641AlaGlu: 4.641 ± 0.045	2.812AlaPhe: 2.812 ± 0.028	4.869AlaGly: 4.869 ± 0.039	2.351AlaHis: 2.351 ± 0.047	4.107AlaIle: 4.107 ± 0.031	4.122AlaLys: 4.122 ± 0.039	6.877AlaLeu: 6.877 ± 0.054	1.771AlaMet: 1.771 ± 0.019	2.956AlaAsn: 2.956 ± 0.032	3.913AlaPro: 3.913 ± 0.039	2.766AlaGln: 2.766 ± 0.031	5.397AlaArg: 5.397 ± 0.046	6.178AlaSer: 6.178 ± 0.044	5.217AlaThr: 5.217 ± 0.043	5.128AlaVal: 5.128 ± 0.035	0.898AlaTrp: 0.898 ± 0.014	1.993AlaTyr: 1.993 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.984CysAla: 0.984 ± 0.016	0.403CysCys: 0.403 ± 0.012	0.744CysAsp: 0.744 ± 0.014	0.732CysGlu: 0.732 ± 0.015	0.644CysPhe: 0.644 ± 0.012	1.053CysGly: 1.053 ± 0.017	0.547CysHis: 0.547 ± 0.016	0.772CysIle: 0.772 ± 0.014	0.589CysLys: 0.589 ± 0.013	1.655CysLeu: 1.655 ± 0.028	0.311CysMet: 0.311 ± 0.008	0.522CysAsn: 0.522 ± 0.012	1.18CysPro: 1.18 ± 0.041	0.494CysGln: 0.494 ± 0.011	1.017CysArg: 1.017 ± 0.019	1.054CysSer: 1.054 ± 0.017	0.772CysThr: 0.772 ± 0.014	1.022CysVal: 1.022 ± 0.016	0.235CysTrp: 0.235 ± 0.007	0.43CysTyr: 0.43 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.241AspAla: 4.241 ± 0.032	0.665AspCys: 0.665 ± 0.013	4.486AspAsp: 4.486 ± 0.051	4.327AspGlu: 4.327 ± 0.041	2.096AspPhe: 2.096 ± 0.024	4.27AspGly: 4.27 ± 0.042	1.317AspHis: 1.317 ± 0.019	3.064AspIle: 3.064 ± 0.029	2.539AspLys: 2.539 ± 0.024	4.854AspLeu: 4.854 ± 0.036	1.359AspMet: 1.359 ± 0.018	2.145AspAsn: 2.145 ± 0.023	2.976AspPro: 2.976 ± 0.029	1.66AspGln: 1.66 ± 0.019	3.113AspArg: 3.113 ± 0.034	3.48AspSer: 3.48 ± 0.031	2.902AspThr: 2.902 ± 0.028	3.916AspVal: 3.916 ± 0.033	0.729AspTrp: 0.729 ± 0.013	1.516AspTyr: 1.516 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	4.539GluAla: 4.539 ± 0.043	0.724GluCys: 0.724 ± 0.014	3.98GluAsp: 3.98 ± 0.036	5.934GluGlu: 5.934 ± 0.074	2.123GluPhe: 2.123 ± 0.027	3.744GluGly: 3.744 ± 0.038	1.454GluHis: 1.454 ± 0.019	3.215GluIle: 3.215 ± 0.03	3.589GluLys: 3.589 ± 0.038	5.223GluLeu: 5.223 ± 0.043	1.522GluMet: 1.522 ± 0.019	2.411GluAsn: 2.411 ± 0.031	2.418GluPro: 2.418 ± 0.03	2.301GluGln: 2.301 ± 0.027	4.05GluArg: 4.05 ± 0.044	3.618GluSer: 3.618 ± 0.035	3.169GluThr: 3.169 ± 0.029	3.893GluVal: 3.893 ± 0.035	0.823GluTrp: 0.823 ± 0.013	1.71GluTyr: 1.71 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.141PheAla: 3.141 ± 0.036	0.795PheCys: 0.795 ± 0.021	2.327PheAsp: 2.327 ± 0.023	2.123PheGlu: 2.123 ± 0.024	1.647PhePhe: 1.647 ± 0.026	2.656PheGly: 2.656 ± 0.029	1.011PheHis: 1.011 ± 0.015	1.876PheIle: 1.876 ± 0.025	1.554PheLys: 1.554 ± 0.02	3.67PheLeu: 3.67 ± 0.035	0.785PheMet: 0.785 ± 0.013	1.465PheAsn: 1.465 ± 0.019	1.991PhePro: 1.991 ± 0.024	1.288PheGln: 1.288 ± 0.019	2.1PheArg: 2.1 ± 0.023	2.919PheSer: 2.919 ± 0.028	2.128PheThr: 2.128 ± 0.025	2.783PheVal: 2.783 ± 0.03	0.554PheTrp: 0.554 ± 0.01	1.141PheTyr: 1.141 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.563GlyAla: 4.563 ± 0.04	0.914GlyCys: 0.914 ± 0.015	3.548GlyAsp: 3.548 ± 0.032	3.837GlyGlu: 3.837 ± 0.039	2.442GlyPhe: 2.442 ± 0.025	5.598GlyGly: 5.598 ± 0.074	1.576GlyHis: 1.576 ± 0.02	3.171GlyIle: 3.171 ± 0.026	4.905GlyLys: 4.905 ± 0.086	5.034GlyLeu: 5.034 ± 0.041	1.6GlyMet: 1.6 ± 0.019	3.145GlyAsn: 3.145 ± 0.044	2.589GlyPro: 2.589 ± 0.03	2.592GlyGln: 2.592 ± 0.039	4.031GlyArg: 4.031 ± 0.036	4.666GlySer: 4.666 ± 0.043	3.544GlyThr: 3.544 ± 0.029	4.368GlyVal: 4.368 ± 0.039	0.976GlyTrp: 0.976 ± 0.015	1.842GlyTyr: 1.842 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.87HisAla: 1.87 ± 0.021	0.419HisCys: 0.419 ± 0.01	1.352HisAsp: 1.352 ± 0.016	1.253HisGlu: 1.253 ± 0.016	1.141HisPhe: 1.141 ± 0.018	1.797HisGly: 1.797 ± 0.023	1.207HisHis: 1.207 ± 0.026	1.497HisIle: 1.497 ± 0.021	1.023HisLys: 1.023 ± 0.015	2.962HisLeu: 2.962 ± 0.039	0.491HisMet: 0.491 ± 0.011	1.002HisAsn: 1.002 ± 0.016	1.914HisPro: 1.914 ± 0.025	1.074HisGln: 1.074 ± 0.017	1.845HisArg: 1.845 ± 0.023	1.917HisSer: 1.917 ± 0.022	1.531HisThr: 1.531 ± 0.019	1.866HisVal: 1.866 ± 0.025	0.297HisTrp: 0.297 ± 0.006	0.802HisTyr: 0.802 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.013IleAla: 4.013 ± 0.033	0.829IleCys: 0.829 ± 0.015	3.0IleAsp: 3.0 ± 0.033	2.938IleGlu: 2.938 ± 0.03	2.074IlePhe: 2.074 ± 0.028	3.074IleGly: 3.074 ± 0.03	1.333IleHis: 1.333 ± 0.017	2.7IleIle: 2.7 ± 0.03	2.383IleLys: 2.383 ± 0.024	5.369IleLeu: 5.369 ± 0.063	1.098IleMet: 1.098 ± 0.015	1.967IleAsn: 1.967 ± 0.024	3.116IlePro: 3.116 ± 0.027	1.783IleGln: 1.783 ± 0.023	2.905IleArg: 2.905 ± 0.027	3.835IleSer: 3.835 ± 0.031	3.083IleThr: 3.083 ± 0.029	3.663IleVal: 3.663 ± 0.028	0.68IleTrp: 0.68 ± 0.013	1.513IleTyr: 1.513 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.666LysAla: 3.666 ± 0.036	0.617LysCys: 0.617 ± 0.014	2.622LysAsp: 2.622 ± 0.024	3.493LysGlu: 3.493 ± 0.037	1.655LysPhe: 1.655 ± 0.023	2.7LysGly: 2.7 ± 0.029	1.183LysHis: 1.183 ± 0.017	2.65LysIle: 2.65 ± 0.025	3.503LysLys: 3.503 ± 0.042	4.079LysLeu: 4.079 ± 0.037	2.162LysMet: 2.162 ± 0.053	1.974LysAsn: 1.974 ± 0.022	2.44LysPro: 2.44 ± 0.027	1.846LysGln: 1.846 ± 0.022	3.455LysArg: 3.455 ± 0.032	3.2LysSer: 3.2 ± 0.03	3.562LysThr: 3.562 ± 0.05	3.115LysVal: 3.115 ± 0.031	0.671LysTrp: 0.671 ± 0.012	1.489LysTyr: 1.489 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.695LeuAla: 7.695 ± 0.07	1.465LeuCys: 1.465 ± 0.021	4.908LeuAsp: 4.908 ± 0.033	5.3LeuGlu: 5.3 ± 0.047	3.48LeuPhe: 3.48 ± 0.032	5.115LeuGly: 5.115 ± 0.04	2.461LeuHis: 2.461 ± 0.026	4.073LeuIle: 4.073 ± 0.034	4.342LeuLys: 4.342 ± 0.034	8.624LeuLeu: 8.624 ± 0.065	1.834LeuMet: 1.834 ± 0.019	3.406LeuAsn: 3.406 ± 0.03	6.618LeuPro: 6.618 ± 0.087	3.515LeuGln: 3.515 ± 0.034	5.83LeuArg: 5.83 ± 0.045	7.173LeuSer: 7.173 ± 0.043	5.305LeuThr: 5.305 ± 0.039	5.844LeuVal: 5.844 ± 0.04	1.053LeuTrp: 1.053 ± 0.016	2.418LeuTyr: 2.418 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.99MetAla: 1.99 ± 0.02	0.31MetCys: 0.31 ± 0.008	1.364MetAsp: 1.364 ± 0.019	1.467MetGlu: 1.467 ± 0.028	0.782MetPhe: 0.782 ± 0.016	2.675MetGly: 2.675 ± 0.064	0.524MetHis: 0.524 ± 0.011	1.044MetIle: 1.044 ± 0.017	1.054MetLys: 1.054 ± 0.016	2.021MetLeu: 2.021 ± 0.025	0.62MetMet: 0.62 ± 0.013	0.87MetAsn: 0.87 ± 0.015	1.217MetPro: 1.217 ± 0.02	0.824MetGln: 0.824 ± 0.014	1.297MetArg: 1.297 ± 0.016	1.92MetSer: 1.92 ± 0.021	1.453MetThr: 1.453 ± 0.018	1.442MetVal: 1.442 ± 0.021	0.259MetTrp: 0.259 ± 0.006	0.589MetTyr: 0.589 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.974AsnAla: 2.974 ± 0.028	0.529AsnCys: 0.529 ± 0.012	2.186AsnAsp: 2.186 ± 0.022	2.174AsnGlu: 2.174 ± 0.02	1.519AsnPhe: 1.519 ± 0.02	2.822AsnGly: 2.822 ± 0.032	0.991AsnHis: 0.991 ± 0.014	2.335AsnIle: 2.335 ± 0.027	1.71AsnLys: 1.71 ± 0.023	3.652AsnLeu: 3.652 ± 0.033	1.326AsnMet: 1.326 ± 0.03	1.772AsnAsn: 1.772 ± 0.025	2.51AsnPro: 2.51 ± 0.025	1.298AsnGln: 1.298 ± 0.018	2.11AsnArg: 2.11 ± 0.024	2.805AsnSer: 2.805 ± 0.028	2.645AsnThr: 2.645 ± 0.033	2.651AsnVal: 2.651 ± 0.023	0.483AsnTrp: 0.483 ± 0.01	1.139AsnTyr: 1.139 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.602ProAla: 4.602 ± 0.04	0.771ProCys: 0.771 ± 0.02	2.68ProAsp: 2.68 ± 0.029	2.981ProGlu: 2.981 ± 0.026	2.189ProPhe: 2.189 ± 0.022	2.884ProGly: 2.884 ± 0.031	1.607ProHis: 1.607 ± 0.023	3.211ProIle: 3.211 ± 0.05	2.436ProLys: 2.436 ± 0.028	4.795ProLeu: 4.795 ± 0.037	1.213ProMet: 1.213 ± 0.023	2.299ProAsn: 2.299 ± 0.027	5.283ProPro: 5.283 ± 0.073	2.127ProGln: 2.127 ± 0.028	3.263ProArg: 3.263 ± 0.037	6.133ProSer: 6.133 ± 0.051	4.463ProThr: 4.463 ± 0.041	3.912ProVal: 3.912 ± 0.047	0.55ProTrp: 0.55 ± 0.011	1.495ProTyr: 1.495 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	2.829GlnAla: 2.829 ± 0.031	0.486GlnCys: 0.486 ± 0.01	2.251GlnAsp: 2.251 ± 0.037	2.087GlnGlu: 2.087 ± 0.028	1.293GlnPhe: 1.293 ± 0.017	1.953GlnGly: 1.953 ± 0.025	1.382GlnHis: 1.382 ± 0.023	1.87GlnIle: 1.87 ± 0.023	1.768GlnLys: 1.768 ± 0.02	3.406GlnLeu: 3.406 ± 0.033	0.819GlnMet: 0.819 ± 0.014	1.647GlnAsn: 1.647 ± 0.022	2.174GlnPro: 2.174 ± 0.029	2.779GlnGln: 2.779 ± 0.103	2.419GlnArg: 2.419 ± 0.026	2.49GlnSer: 2.49 ± 0.023	2.111GlnThr: 2.111 ± 0.02	2.072GlnVal: 2.072 ± 0.021	0.456GlnTrp: 0.456 ± 0.01	1.197GlnTyr: 1.197 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.608ArgAla: 4.608 ± 0.044	0.945ArgCys: 0.945 ± 0.015	3.263ArgAsp: 3.263 ± 0.033	3.809ArgGlu: 3.809 ± 0.039	2.397ArgPhe: 2.397 ± 0.025	3.653ArgGly: 3.653 ± 0.036	1.854ArgHis: 1.854 ± 0.021	3.048ArgIle: 3.048 ± 0.028	3.448ArgLys: 3.448 ± 0.031	5.629ArgLeu: 5.629 ± 0.041	1.451ArgMet: 1.451 ± 0.019	2.423ArgAsn: 2.423 ± 0.023	3.356ArgPro: 3.356 ± 0.03	2.724ArgGln: 2.724 ± 0.033	5.378ArgArg: 5.378 ± 0.045	4.542ArgSer: 4.542 ± 0.041	3.436ArgThr: 3.436 ± 0.036	3.772ArgVal: 3.772 ± 0.028	1.211ArgTrp: 1.211 ± 0.025	1.691ArgTyr: 1.691 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	5.915SerAla: 5.915 ± 0.045	1.393SerCys: 1.393 ± 0.037	3.754SerAsp: 3.754 ± 0.034	3.66SerGlu: 3.66 ± 0.034	3.04SerPhe: 3.04 ± 0.029	4.594SerGly: 4.594 ± 0.037	2.025SerHis: 2.025 ± 0.02	3.916SerIle: 3.916 ± 0.035	3.413SerLys: 3.413 ± 0.028	6.846SerLeu: 6.846 ± 0.044	1.595SerMet: 1.595 ± 0.024	3.005SerAsn: 3.005 ± 0.032	5.317SerPro: 5.317 ± 0.051	2.593SerGln: 2.593 ± 0.029	4.526SerArg: 4.526 ± 0.039	8.262SerSer: 8.262 ± 0.075	5.6SerThr: 5.6 ± 0.05	4.642SerVal: 4.642 ± 0.034	0.889SerTrp: 0.889 ± 0.013	1.986SerTyr: 1.986 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.803ThrAla: 4.803 ± 0.043	0.846ThrCys: 0.846 ± 0.015	2.968ThrAsp: 2.968 ± 0.027	3.11ThrGlu: 3.11 ± 0.029	2.362ThrPhe: 2.362 ± 0.027	4.539ThrGly: 4.539 ± 0.056	1.632ThrHis: 1.632 ± 0.02	3.375ThrIle: 3.375 ± 0.032	2.762ThrLys: 2.762 ± 0.027	5.494ThrLeu: 5.494 ± 0.038	1.274ThrMet: 1.274 ± 0.017	2.401ThrAsn: 2.401 ± 0.027	4.356ThrPro: 4.356 ± 0.045	1.998ThrGln: 1.998 ± 0.022	3.347ThrArg: 3.347 ± 0.032	5.448ThrSer: 5.448 ± 0.044	4.974ThrThr: 4.974 ± 0.048	3.904ThrVal: 3.904 ± 0.034	0.912ThrTrp: 0.912 ± 0.017	1.594ThrTyr: 1.594 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.516ValAla: 5.516 ± 0.045	1.062ValCys: 1.062 ± 0.017	3.924ValAsp: 3.924 ± 0.034	4.358ValGlu: 4.358 ± 0.038	2.477ValPhe: 2.477 ± 0.027	4.301ValGly: 4.301 ± 0.037	1.626ValHis: 1.626 ± 0.02	3.241ValIle: 3.241 ± 0.026	3.078ValLys: 3.078 ± 0.028	6.382ValLeu: 6.382 ± 0.056	1.523ValMet: 1.523 ± 0.022	2.441ValAsn: 2.441 ± 0.026	3.521ValPro: 3.521 ± 0.03	2.227ValGln: 2.227 ± 0.025	3.953ValArg: 3.953 ± 0.035	4.549ValSer: 4.549 ± 0.034	3.878ValThr: 3.878 ± 0.031	5.197ValVal: 5.197 ± 0.045	0.851ValTrp: 0.851 ± 0.013	1.79ValTyr: 1.79 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.318TrpAla: 1.318 ± 0.027	0.225TrpCys: 0.225 ± 0.007	0.75TrpAsp: 0.75 ± 0.014	0.733TrpGlu: 0.733 ± 0.013	0.512TrpPhe: 0.512 ± 0.012	0.749TrpGly: 0.749 ± 0.013	0.324TrpHis: 0.324 ± 0.008	0.68TrpIle: 0.68 ± 0.011	0.678TrpLys: 0.678 ± 0.013	1.116TrpLeu: 1.116 ± 0.016	0.355TrpMet: 0.355 ± 0.009	0.569TrpAsn: 0.569 ± 0.011	0.505TrpPro: 0.505 ± 0.011	0.532TrpGln: 0.532 ± 0.011	0.934TrpArg: 0.934 ± 0.016	0.926TrpSer: 0.926 ± 0.015	0.768TrpThr: 0.768 ± 0.014	0.85TrpVal: 0.85 ± 0.015	0.235TrpTrp: 0.235 ± 0.007	0.378TrpTyr: 0.378 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.914TyrAla: 1.914 ± 0.021	0.521TyrCys: 0.521 ± 0.012	1.608TyrAsp: 1.608 ± 0.02	1.48TyrGlu: 1.48 ± 0.019	1.266TyrPhe: 1.266 ± 0.017	1.898TyrGly: 1.898 ± 0.025	0.856TyrHis: 0.856 ± 0.015	1.511TyrIle: 1.511 ± 0.022	1.187TyrLys: 1.187 ± 0.017	2.768TyrLeu: 2.768 ± 0.028	0.613TyrMet: 0.613 ± 0.011	1.211TyrAsn: 1.211 ± 0.02	1.502TyrPro: 1.502 ± 0.024	1.068TyrGln: 1.068 ± 0.015	1.668TyrArg: 1.668 ± 0.021	1.856TyrSer: 1.856 ± 0.021	1.557TyrThr: 1.557 ± 0.018	1.855TyrVal: 1.855 ± 0.022	0.376TyrTrp: 0.376 ± 0.01	0.996TyrTyr: 0.996 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13497 proteins (4714404 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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