Amino acid dipepetide frequency for Streptomyces lydicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.737AlaAla: 23.737 ± 0.204	1.105AlaCys: 1.105 ± 0.022	8.409AlaAsp: 8.409 ± 0.075	8.848AlaGlu: 8.848 ± 0.095	3.571AlaPhe: 3.571 ± 0.039	14.477AlaGly: 14.477 ± 0.1	3.192AlaHis: 3.192 ± 0.045	3.128AlaIle: 3.128 ± 0.043	2.815AlaLys: 2.815 ± 0.052	15.608AlaLeu: 15.608 ± 0.13	2.494AlaMet: 2.494 ± 0.033	1.86AlaAsn: 1.86 ± 0.034	8.056AlaPro: 8.056 ± 0.093	3.739AlaGln: 3.739 ± 0.044	11.018AlaArg: 11.018 ± 0.097	5.415AlaSer: 5.415 ± 0.054	7.222AlaThr: 7.222 ± 0.066	12.754AlaVal: 12.754 ± 0.098	1.814AlaTrp: 1.814 ± 0.027	2.684AlaTyr: 2.684 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.193CysAla: 1.193 ± 0.025	0.102CysCys: 0.102 ± 0.008	0.469CysAsp: 0.469 ± 0.015	0.386CysGlu: 0.386 ± 0.013	0.24CysPhe: 0.24 ± 0.01	0.991CysGly: 0.991 ± 0.022	0.201CysHis: 0.201 ± 0.009	0.187CysIle: 0.187 ± 0.009	0.105CysLys: 0.105 ± 0.007	0.789CysLeu: 0.789 ± 0.018	0.124CysMet: 0.124 ± 0.007	0.134CysAsn: 0.134 ± 0.008	0.495CysPro: 0.495 ± 0.016	0.159CysGln: 0.159 ± 0.007	0.647CysArg: 0.647 ± 0.017	0.416CysSer: 0.416 ± 0.013	0.538CysThr: 0.538 ± 0.014	0.663CysVal: 0.663 ± 0.017	0.136CysTrp: 0.136 ± 0.007	0.166CysTyr: 0.166 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.049AspAla: 8.049 ± 0.073	0.417AspCys: 0.417 ± 0.015	3.388AspAsp: 3.388 ± 0.048	3.682AspGlu: 3.682 ± 0.048	1.598AspPhe: 1.598 ± 0.027	6.565AspGly: 6.565 ± 0.066	1.459AspHis: 1.459 ± 0.03	1.771AspIle: 1.771 ± 0.032	1.133AspLys: 1.133 ± 0.03	6.033AspLeu: 6.033 ± 0.052	0.765AspMet: 0.765 ± 0.017	0.923AspAsn: 0.923 ± 0.023	4.51AspPro: 4.51 ± 0.051	1.43AspGln: 1.43 ± 0.026	5.053AspArg: 5.053 ± 0.055	2.274AspSer: 2.274 ± 0.036	3.008AspThr: 3.008 ± 0.038	4.331AspVal: 4.331 ± 0.05	1.005AspTrp: 1.005 ± 0.021	1.058AspTyr: 1.058 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.214GluAla: 7.214 ± 0.086	0.36GluCys: 0.36 ± 0.013	2.682GluAsp: 2.682 ± 0.039	3.507GluGlu: 3.507 ± 0.054	1.375GluPhe: 1.375 ± 0.025	4.11GluGly: 4.11 ± 0.05	1.437GluHis: 1.437 ± 0.027	2.113GluIle: 2.113 ± 0.03	1.29GluLys: 1.29 ± 0.03	6.819GluLeu: 6.819 ± 0.067	0.875GluMet: 0.875 ± 0.02	0.927GluAsn: 0.927 ± 0.023	3.226GluPro: 3.226 ± 0.039	2.196GluGln: 2.196 ± 0.028	5.556GluArg: 5.556 ± 0.068	2.329GluSer: 2.329 ± 0.034	2.71GluThr: 2.71 ± 0.036	4.447GluVal: 4.447 ± 0.05	0.716GluTrp: 0.716 ± 0.017	0.982GluTyr: 0.982 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.761PheAla: 3.761 ± 0.045	0.272PheCys: 0.272 ± 0.011	1.902PheAsp: 1.902 ± 0.035	1.327PheGlu: 1.327 ± 0.025	0.894PhePhe: 0.894 ± 0.021	3.041PheGly: 3.041 ± 0.039	0.666PheHis: 0.666 ± 0.019	0.685PheIle: 0.685 ± 0.018	0.494PheLys: 0.494 ± 0.016	2.691PheLeu: 2.691 ± 0.039	0.383PheMet: 0.383 ± 0.013	0.55PheAsn: 0.55 ± 0.019	1.405PhePro: 1.405 ± 0.026	0.628PheGln: 0.628 ± 0.015	1.864PheArg: 1.864 ± 0.03	1.402PheSer: 1.402 ± 0.028	1.981PheThr: 1.981 ± 0.036	2.188PheVal: 2.188 ± 0.036	0.43PheTrp: 0.43 ± 0.016	0.552PheTyr: 0.552 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	12.13GlyAla: 12.13 ± 0.093	0.875GlyCys: 0.875 ± 0.019	5.057GlyAsp: 5.057 ± 0.048	5.021GlyGlu: 5.021 ± 0.057	2.873GlyPhe: 2.873 ± 0.046	9.382GlyGly: 9.382 ± 0.101	2.439GlyHis: 2.439 ± 0.038	3.364GlyIle: 3.364 ± 0.044	2.454GlyLys: 2.454 ± 0.05	9.625GlyLeu: 9.625 ± 0.077	2.048GlyMet: 2.048 ± 0.036	1.711GlyAsn: 1.711 ± 0.027	5.796GlyPro: 5.796 ± 0.06	2.633GlyGln: 2.633 ± 0.036	8.274GlyArg: 8.274 ± 0.071	5.323GlySer: 5.323 ± 0.057	6.386GlyThr: 6.386 ± 0.077	7.401GlyVal: 7.401 ± 0.068	1.684GlyTrp: 1.684 ± 0.029	2.288GlyTyr: 2.288 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.81HisAla: 2.81 ± 0.04	0.229HisCys: 0.229 ± 0.011	1.424HisAsp: 1.424 ± 0.025	1.199HisGlu: 1.199 ± 0.023	0.664HisPhe: 0.664 ± 0.017	2.655HisGly: 2.655 ± 0.04	0.778HisHis: 0.778 ± 0.02	0.658HisIle: 0.658 ± 0.018	0.391HisLys: 0.391 ± 0.014	2.568HisLeu: 2.568 ± 0.033	0.338HisMet: 0.338 ± 0.012	0.383HisAsn: 0.383 ± 0.014	1.975HisPro: 1.975 ± 0.031	0.668HisGln: 0.668 ± 0.019	2.319HisArg: 2.319 ± 0.033	1.013HisSer: 1.013 ± 0.02	1.433HisThr: 1.433 ± 0.028	1.589HisVal: 1.589 ± 0.024	0.387HisTrp: 0.387 ± 0.014	0.48HisTyr: 0.48 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.581IleAla: 4.581 ± 0.054	0.285IleCys: 0.285 ± 0.014	2.126IleAsp: 2.126 ± 0.037	1.956IleGlu: 1.956 ± 0.033	0.691IlePhe: 0.691 ± 0.018	3.551IleGly: 3.551 ± 0.049	0.599IleHis: 0.599 ± 0.017	0.843IleIle: 0.843 ± 0.021	0.715IleLys: 0.715 ± 0.02	2.186IleLeu: 2.186 ± 0.038	0.431IleMet: 0.431 ± 0.014	0.702IleAsn: 0.702 ± 0.016	1.675IlePro: 1.675 ± 0.033	0.684IleGln: 0.684 ± 0.02	2.104IleArg: 2.104 ± 0.032	1.56IleSer: 1.56 ± 0.024	2.043IleThr: 2.043 ± 0.032	2.563IleVal: 2.563 ± 0.038	0.352IleTrp: 0.352 ± 0.014	0.489IleTyr: 0.489 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.706LysAla: 2.706 ± 0.048	0.113LysCys: 0.113 ± 0.008	1.333LysAsp: 1.333 ± 0.034	1.159LysGlu: 1.159 ± 0.024	0.45LysPhe: 0.45 ± 0.016	1.806LysGly: 1.806 ± 0.038	0.433LysHis: 0.433 ± 0.013	0.846LysIle: 0.846 ± 0.022	0.867LysLys: 0.867 ± 0.035	1.985LysLeu: 1.985 ± 0.035	0.392LysMet: 0.392 ± 0.014	0.489LysAsn: 0.489 ± 0.017	1.308LysPro: 1.308 ± 0.03	0.699LysGln: 0.699 ± 0.02	1.386LysArg: 1.386 ± 0.028	1.067LysSer: 1.067 ± 0.027	1.177LysThr: 1.177 ± 0.03	1.772LysVal: 1.772 ± 0.038	0.259LysTrp: 0.259 ± 0.011	0.429LysTyr: 0.429 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.076LeuAla: 16.076 ± 0.126	0.917LeuCys: 0.917 ± 0.021	6.682LeuAsp: 6.682 ± 0.065	4.472LeuGlu: 4.472 ± 0.056	2.621LeuPhe: 2.621 ± 0.036	9.428LeuGly: 9.428 ± 0.072	2.458LeuHis: 2.458 ± 0.031	3.346LeuIle: 3.346 ± 0.049	1.927LeuLys: 1.927 ± 0.038	11.744LeuLeu: 11.744 ± 0.121	1.619LeuMet: 1.619 ± 0.029	1.634LeuAsn: 1.634 ± 0.027	6.826LeuPro: 6.826 ± 0.061	2.338LeuGln: 2.338 ± 0.036	9.067LeuArg: 9.067 ± 0.077	5.212LeuSer: 5.212 ± 0.053	7.165LeuThr: 7.165 ± 0.055	8.775LeuVal: 8.775 ± 0.078	1.299LeuTrp: 1.299 ± 0.029	1.812LeuTyr: 1.812 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.296MetAla: 2.296 ± 0.035	0.136MetCys: 0.136 ± 0.008	0.849MetAsp: 0.849 ± 0.019	0.735MetGlu: 0.735 ± 0.019	0.44MetPhe: 0.44 ± 0.015	1.305MetGly: 1.305 ± 0.025	0.348MetHis: 0.348 ± 0.012	0.624MetIle: 0.624 ± 0.019	0.39MetLys: 0.39 ± 0.013	1.694MetLeu: 1.694 ± 0.03	0.286MetMet: 0.286 ± 0.013	0.442MetAsn: 0.442 ± 0.014	1.112MetPro: 1.112 ± 0.023	0.434MetGln: 0.434 ± 0.015	1.406MetArg: 1.406 ± 0.026	1.276MetSer: 1.276 ± 0.022	1.504MetThr: 1.504 ± 0.027	1.255MetVal: 1.255 ± 0.023	0.202MetTrp: 0.202 ± 0.01	0.305MetTyr: 0.305 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.145AsnAla: 2.145 ± 0.03	0.171AsnCys: 0.171 ± 0.008	0.929AsnAsp: 0.929 ± 0.022	0.776AsnGlu: 0.776 ± 0.019	0.485AsnPhe: 0.485 ± 0.016	1.881AsnGly: 1.881 ± 0.032	0.382AsnHis: 0.382 ± 0.014	0.61AsnIle: 0.61 ± 0.018	0.417AsnLys: 0.417 ± 0.015	1.571AsnLeu: 1.571 ± 0.026	0.288AsnMet: 0.288 ± 0.011	0.413AsnAsn: 0.413 ± 0.014	1.264AsnPro: 1.264 ± 0.028	0.48AsnGln: 0.48 ± 0.016	1.206AsnArg: 1.206 ± 0.026	0.871AsnSer: 0.871 ± 0.023	1.049AsnThr: 1.049 ± 0.027	1.298AsnVal: 1.298 ± 0.025	0.29AsnTrp: 0.29 ± 0.012	0.408AsnTyr: 0.408 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.781ProAla: 9.781 ± 0.103	0.356ProCys: 0.356 ± 0.012	4.673ProAsp: 4.673 ± 0.056	4.253ProGlu: 4.253 ± 0.055	1.569ProPhe: 1.569 ± 0.029	7.116ProGly: 7.116 ± 0.069	1.535ProHis: 1.535 ± 0.029	1.146ProIle: 1.146 ± 0.026	1.119ProLys: 1.119 ± 0.027	5.632ProLeu: 5.632 ± 0.056	0.976ProMet: 0.976 ± 0.021	0.849ProAsn: 0.849 ± 0.022	3.766ProPro: 3.766 ± 0.058	1.937ProGln: 1.937 ± 0.048	4.22ProArg: 4.22 ± 0.051	3.072ProSer: 3.072 ± 0.04	3.205ProThr: 3.205 ± 0.047	5.486ProVal: 5.486 ± 0.058	0.909ProTrp: 0.909 ± 0.02	1.403ProTyr: 1.403 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.68GlnAla: 3.68 ± 0.044	0.177GlnCys: 0.177 ± 0.008	1.411GlnAsp: 1.411 ± 0.029	1.475GlnGlu: 1.475 ± 0.031	0.688GlnPhe: 0.688 ± 0.02	2.248GlnGly: 2.248 ± 0.033	0.687GlnHis: 0.687 ± 0.02	1.063GlnIle: 1.063 ± 0.022	0.588GlnLys: 0.588 ± 0.019	3.267GlnLeu: 3.267 ± 0.042	0.493GlnMet: 0.493 ± 0.015	0.462GlnAsn: 0.462 ± 0.017	1.764GlnPro: 1.764 ± 0.055	1.409GlnGln: 1.409 ± 0.077	2.407GlnArg: 2.407 ± 0.031	1.178GlnSer: 1.178 ± 0.026	1.241GlnThr: 1.241 ± 0.026	2.296GlnVal: 2.296 ± 0.037	0.449GlnTrp: 0.449 ± 0.013	0.538GlnTyr: 0.538 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.721ArgAla: 10.721 ± 0.101	0.641ArgCys: 0.641 ± 0.017	4.278ArgAsp: 4.278 ± 0.047	4.552ArgGlu: 4.552 ± 0.049	2.32ArgPhe: 2.32 ± 0.034	6.025ArgGly: 6.025 ± 0.065	2.255ArgHis: 2.255 ± 0.032	3.252ArgIle: 3.252 ± 0.037	1.661ArgLys: 1.661 ± 0.034	9.048ArgLeu: 9.048 ± 0.079	1.791ArgMet: 1.791 ± 0.03	1.372ArgAsn: 1.372 ± 0.026	5.428ArgPro: 5.428 ± 0.051	2.363ArgGln: 2.363 ± 0.033	8.078ArgArg: 8.078 ± 0.08	3.982ArgSer: 3.982 ± 0.043	5.709ArgThr: 5.709 ± 0.058	5.557ArgVal: 5.557 ± 0.049	1.374ArgTrp: 1.374 ± 0.028	1.858ArgTyr: 1.858 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.586SerAla: 6.586 ± 0.055	0.441SerCys: 0.441 ± 0.014	2.435SerAsp: 2.435 ± 0.04	2.156SerGlu: 2.156 ± 0.032	1.505SerPhe: 1.505 ± 0.028	5.73SerGly: 5.73 ± 0.069	1.033SerHis: 1.033 ± 0.022	1.245SerIle: 1.245 ± 0.026	0.96SerLys: 0.96 ± 0.023	4.633SerLeu: 4.633 ± 0.049	0.976SerMet: 0.976 ± 0.023	0.809SerAsn: 0.809 ± 0.019	3.032SerPro: 3.032 ± 0.038	1.184SerGln: 1.184 ± 0.024	3.546SerArg: 3.546 ± 0.043	2.588SerSer: 2.588 ± 0.042	2.717SerThr: 2.717 ± 0.038	4.03SerVal: 4.03 ± 0.049	0.91SerTrp: 0.91 ± 0.021	1.165SerTyr: 1.165 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	9.346ThrAla: 9.346 ± 0.077	0.426ThrCys: 0.426 ± 0.017	3.589ThrAsp: 3.589 ± 0.041	3.08ThrGlu: 3.08 ± 0.04	1.629ThrPhe: 1.629 ± 0.031	6.769ThrGly: 6.769 ± 0.065	1.211ThrHis: 1.211 ± 0.023	1.473ThrIle: 1.473 ± 0.031	1.073ThrLys: 1.073 ± 0.025	5.78ThrLeu: 5.78 ± 0.059	0.867ThrMet: 0.867 ± 0.019	0.934ThrAsn: 0.934 ± 0.02	4.193ThrPro: 4.193 ± 0.048	1.245ThrGln: 1.245 ± 0.033	3.771ThrArg: 3.771 ± 0.041	2.892ThrSer: 2.892 ± 0.039	3.735ThrThr: 3.735 ± 0.064	6.181ThrVal: 6.181 ± 0.076	0.862ThrTrp: 0.862 ± 0.018	1.245ThrTyr: 1.245 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.723ValAla: 10.723 ± 0.081	0.785ValCys: 0.785 ± 0.019	4.627ValAsp: 4.627 ± 0.048	4.413ValGlu: 4.413 ± 0.056	2.341ValPhe: 2.341 ± 0.035	6.384ValGly: 6.384 ± 0.063	2.06ValHis: 2.06 ± 0.027	2.819ValIle: 2.819 ± 0.043	1.588ValLys: 1.588 ± 0.032	9.796ValLeu: 9.796 ± 0.076	1.356ValMet: 1.356 ± 0.023	1.609ValAsn: 1.609 ± 0.029	5.362ValPro: 5.362 ± 0.049	2.076ValGln: 2.076 ± 0.031	7.157ValArg: 7.157 ± 0.065	4.063ValSer: 4.063 ± 0.045	5.421ValThr: 5.421 ± 0.084	7.659ValVal: 7.659 ± 0.08	1.096ValTrp: 1.096 ± 0.022	1.473ValTyr: 1.473 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.652TrpAla: 1.652 ± 0.026	0.162TrpCys: 0.162 ± 0.008	0.794TrpAsp: 0.794 ± 0.022	0.716TrpGlu: 0.716 ± 0.017	0.517TrpPhe: 0.517 ± 0.015	1.015TrpGly: 1.015 ± 0.023	0.403TrpHis: 0.403 ± 0.016	0.539TrpIle: 0.539 ± 0.018	0.345TrpLys: 0.345 ± 0.014	1.796TrpLeu: 1.796 ± 0.032	0.305TrpMet: 0.305 ± 0.013	0.36TrpAsn: 0.36 ± 0.015	0.765TrpPro: 0.765 ± 0.019	0.673TrpGln: 0.673 ± 0.019	1.318TrpArg: 1.318 ± 0.022	0.9TrpSer: 0.9 ± 0.019	0.955TrpThr: 0.955 ± 0.023	0.973TrpVal: 0.973 ± 0.023	0.345TrpTrp: 0.345 ± 0.012	0.338TrpTyr: 0.338 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.761TyrAla: 2.761 ± 0.036	0.174TyrCys: 0.174 ± 0.008	1.394TyrAsp: 1.394 ± 0.031	1.159TyrGlu: 1.159 ± 0.024	0.646TyrPhe: 0.646 ± 0.016	2.282TyrGly: 2.282 ± 0.035	0.386TyrHis: 0.386 ± 0.014	0.424TyrIle: 0.424 ± 0.014	0.343TyrLys: 0.343 ± 0.014	2.153TyrLeu: 2.153 ± 0.033	0.232TyrMet: 0.232 ± 0.009	0.368TyrAsn: 0.368 ± 0.012	1.042TyrPro: 1.042 ± 0.024	0.547TyrGln: 0.547 ± 0.018	1.87TyrArg: 1.87 ± 0.031	0.848TyrSer: 0.848 ± 0.02	1.1TyrThr: 1.1 ± 0.027	1.592TyrVal: 1.592 ± 0.025	0.35TyrTrp: 0.35 ± 0.013	0.426TyrTyr: 0.426 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6848 proteins (2258271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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