Amino acid dipepetide frequency for Moraxella lincolnii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.495AlaAla: 4.495 ± 0.14
1.055AlaCys: 1.055 ± 0.045
5.66AlaAsp: 5.66 ± 0.111
3.69AlaGlu: 3.69 ± 0.09
3.091AlaPhe: 3.091 ± 0.079
5.893AlaGly: 5.893 ± 0.121
2.2AlaHis: 2.2 ± 0.064
6.057AlaIle: 6.057 ± 0.108
5.943AlaLys: 5.943 ± 0.108
8.896AlaLeu: 8.896 ± 0.146
2.909AlaMet: 2.909 ± 0.067
4.809AlaAsn: 4.809 ± 0.097
2.528AlaPro: 2.528 ± 0.077
4.591AlaGln: 4.591 ± 0.093
3.084AlaArg: 3.084 ± 0.075
5.251AlaSer: 5.251 ± 0.118
5.004AlaThr: 5.004 ± 0.096
5.904AlaVal: 5.904 ± 0.101
1.026AlaTrp: 1.026 ± 0.054
2.578AlaTyr: 2.578 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.627CysAla: 0.627 ± 0.033
0.119CysCys: 0.119 ± 0.015
0.601CysAsp: 0.601 ± 0.035
0.406CysGlu: 0.406 ± 0.026
0.357CysPhe: 0.357 ± 0.026
0.818CysGly: 0.818 ± 0.042
0.489CysHis: 0.489 ± 0.032
0.458CysIle: 0.458 ± 0.032
0.292CysLys: 0.292 ± 0.023
1.019CysLeu: 1.019 ± 0.042
0.209CysMet: 0.209 ± 0.016
0.297CysAsn: 0.297 ± 0.025
0.468CysPro: 0.468 ± 0.03
0.72CysGln: 0.72 ± 0.035
0.39CysArg: 0.39 ± 0.03
0.433CysSer: 0.433 ± 0.026
0.363CysThr: 0.363 ± 0.023
0.768CysVal: 0.768 ± 0.037
0.09CysTrp: 0.09 ± 0.013
0.287CysTyr: 0.287 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
5.6AspAla: 5.6 ± 0.1
0.577AspCys: 0.577 ± 0.034
4.971AspAsp: 4.971 ± 0.115
3.576AspGlu: 3.576 ± 0.096
2.245AspPhe: 2.245 ± 0.067
4.396AspGly: 4.396 ± 0.101
1.162AspHis: 1.162 ± 0.053
4.671AspIle: 4.671 ± 0.095
4.621AspLys: 4.621 ± 0.104
5.051AspLeu: 5.051 ± 0.106
1.82AspMet: 1.82 ± 0.067
3.657AspAsn: 3.657 ± 0.098
1.818AspPro: 1.818 ± 0.062
1.328AspGln: 1.328 ± 0.05
2.065AspArg: 2.065 ± 0.061
3.129AspSer: 3.129 ± 0.072
3.512AspThr: 3.512 ± 0.086
4.581AspVal: 4.581 ± 0.095
0.948AspTrp: 0.948 ± 0.046
2.086AspTyr: 2.086 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
3.531GluAla: 3.531 ± 0.094
0.387GluCys: 0.387 ± 0.025
2.124GluAsp: 2.124 ± 0.063
2.169GluGlu: 2.169 ± 0.089
1.894GluPhe: 1.894 ± 0.067
2.212GluGly: 2.212 ± 0.067
1.613GluHis: 1.613 ± 0.057
2.78GluIle: 2.78 ± 0.076
2.438GluLys: 2.438 ± 0.077
5.55GluLeu: 5.55 ± 0.105
1.373GluMet: 1.373 ± 0.05
2.003GluAsn: 2.003 ± 0.064
1.896GluPro: 1.896 ± 0.066
4.18GluGln: 4.18 ± 0.104
2.93GluArg: 2.93 ± 0.097
2.328GluSer: 2.328 ± 0.061
2.279GluThr: 2.279 ± 0.076
2.942GluVal: 2.942 ± 0.089
0.547GluTrp: 0.547 ± 0.035
1.381GluTyr: 1.381 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.797PheAla: 3.797 ± 0.089
0.421PheCys: 0.421 ± 0.025
2.966PheAsp: 2.966 ± 0.075
1.972PheGlu: 1.972 ± 0.054
1.571PhePhe: 1.571 ± 0.069
3.056PheGly: 3.056 ± 0.083
0.73PheHis: 0.73 ± 0.039
2.611PheIle: 2.611 ± 0.062
1.665PheLys: 1.665 ± 0.053
3.13PheLeu: 3.13 ± 0.093
1.071PheMet: 1.071 ± 0.044
1.929PheAsn: 1.929 ± 0.056
0.936PhePro: 0.936 ± 0.045
0.813PheGln: 0.813 ± 0.036
1.183PheArg: 1.183 ± 0.04
2.315PheSer: 2.315 ± 0.062
2.124PheThr: 2.124 ± 0.059
2.694PheVal: 2.694 ± 0.078
0.49PheTrp: 0.49 ± 0.033
1.38PheTyr: 1.38 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.377GlyAla: 4.377 ± 0.1
0.694GlyCys: 0.694 ± 0.042
3.522GlyAsp: 3.522 ± 0.078
3.554GlyGlu: 3.554 ± 0.096
3.092GlyPhe: 3.092 ± 0.076
4.7GlyGly: 4.7 ± 0.117
1.896GlyHis: 1.896 ± 0.063
4.949GlyIle: 4.949 ± 0.098
4.293GlyLys: 4.293 ± 0.106
6.769GlyLeu: 6.769 ± 0.112
2.271GlyMet: 2.271 ± 0.064
3.063GlyAsn: 3.063 ± 0.095
0.843GlyPro: 0.843 ± 0.046
3.277GlyGln: 3.277 ± 0.085
2.894GlyArg: 2.894 ± 0.077
3.699GlySer: 3.699 ± 0.081
3.174GlyThr: 3.174 ± 0.089
5.154GlyVal: 5.154 ± 0.109
0.832GlyTrp: 0.832 ± 0.044
2.355GlyTyr: 2.355 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
2.626HisAla: 2.626 ± 0.079
0.295HisCys: 0.295 ± 0.023
1.789HisAsp: 1.789 ± 0.057
1.145HisGlu: 1.145 ± 0.05
1.008HisPhe: 1.008 ± 0.047
2.022HisGly: 2.022 ± 0.071
1.499HisHis: 1.499 ± 0.065
2.001HisIle: 2.001 ± 0.06
1.393HisLys: 1.393 ± 0.047
2.88HisLeu: 2.88 ± 0.084
0.61HisMet: 0.61 ± 0.031
1.238HisAsn: 1.238 ± 0.046
1.209HisPro: 1.209 ± 0.051
2.003HisGln: 2.003 ± 0.069
1.26HisArg: 1.26 ± 0.047
1.545HisSer: 1.545 ± 0.051
1.67HisThr: 1.67 ± 0.069
1.677HisVal: 1.677 ± 0.057
0.371HisTrp: 0.371 ± 0.025
0.894HisTyr: 0.894 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.807IleAla: 5.807 ± 0.107
0.687IleCys: 0.687 ± 0.035
5.113IleAsp: 5.113 ± 0.116
3.935IleGlu: 3.935 ± 0.093
2.027IlePhe: 2.027 ± 0.064
4.481IleGly: 4.481 ± 0.105
1.747IleHis: 1.747 ± 0.06
4.351IleIle: 4.351 ± 0.1
4.025IleLys: 4.025 ± 0.087
5.358IleLeu: 5.358 ± 0.115
1.608IleMet: 1.608 ± 0.054
4.008IleAsn: 4.008 ± 0.092
2.295IlePro: 2.295 ± 0.063
2.486IleGln: 2.486 ± 0.066
2.72IleArg: 2.72 ± 0.075
4.265IleSer: 4.265 ± 0.084
4.187IleThr: 4.187 ± 0.097
3.407IleVal: 3.407 ± 0.078
0.653IleTrp: 0.653 ± 0.034
1.832IleTyr: 1.832 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.65LysAla: 4.65 ± 0.112
0.321LysCys: 0.321 ± 0.027
3.172LysAsp: 3.172 ± 0.086
2.502LysGlu: 2.502 ± 0.069
1.513LysPhe: 1.513 ± 0.052
3.153LysGly: 3.153 ± 0.092
1.659LysHis: 1.659 ± 0.055
3.182LysIle: 3.182 ± 0.077
3.277LysLys: 3.277 ± 0.09
5.513LysLeu: 5.513 ± 0.104
1.385LysMet: 1.385 ± 0.055
2.953LysAsn: 2.953 ± 0.085
2.716LysPro: 2.716 ± 0.069
4.22LysGln: 4.22 ± 0.103
2.72LysArg: 2.72 ± 0.063
3.424LysSer: 3.424 ± 0.084
3.731LysThr: 3.731 ± 0.085
3.398LysVal: 3.398 ± 0.081
0.547LysTrp: 0.547 ± 0.031
1.376LysTyr: 1.376 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
10.004LeuAla: 10.004 ± 0.179
0.905LeuCys: 0.905 ± 0.039
5.788LeuAsp: 5.788 ± 0.122
4.135LeuGlu: 4.135 ± 0.108
3.692LeuPhe: 3.692 ± 0.097
6.712LeuGly: 6.712 ± 0.122
2.198LeuHis: 2.198 ± 0.068
6.078LeuIle: 6.078 ± 0.113
5.265LeuLys: 5.265 ± 0.096
10.405LeuLeu: 10.405 ± 0.2
3.003LeuMet: 3.003 ± 0.087
4.83LeuAsn: 4.83 ± 0.098
5.468LeuPro: 5.468 ± 0.089
4.591LeuGln: 4.591 ± 0.115
3.743LeuArg: 3.743 ± 0.084
7.989LeuSer: 7.989 ± 0.131
6.876LeuThr: 6.876 ± 0.13
6.292LeuVal: 6.292 ± 0.122
1.157LeuTrp: 1.157 ± 0.054
2.661LeuTyr: 2.661 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.977MetAla: 2.977 ± 0.073
0.2MetCys: 0.2 ± 0.021
1.259MetAsp: 1.259 ± 0.053
0.78MetGlu: 0.78 ± 0.037
0.748MetPhe: 0.748 ± 0.041
2.267MetGly: 2.267 ± 0.062
0.483MetHis: 0.483 ± 0.03
1.499MetIle: 1.499 ± 0.055
1.131MetLys: 1.131 ± 0.051
2.97MetLeu: 2.97 ± 0.078
1.014MetMet: 1.014 ± 0.046
1.492MetAsn: 1.492 ± 0.061
1.604MetPro: 1.604 ± 0.057
1.597MetGln: 1.597 ± 0.054
1.188MetArg: 1.188 ± 0.044
1.932MetSer: 1.932 ± 0.062
2.348MetThr: 2.348 ± 0.063
2.131MetVal: 2.131 ± 0.064
0.224MetTrp: 0.224 ± 0.02
0.654MetTyr: 0.654 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
4.267AsnAla: 4.267 ± 0.098
0.414AsnCys: 0.414 ± 0.022
3.353AsnAsp: 3.353 ± 0.074
2.208AsnGlu: 2.208 ± 0.062
1.589AsnPhe: 1.589 ± 0.053
2.985AsnGly: 2.985 ± 0.104
2.012AsnHis: 2.012 ± 0.059
3.217AsnIle: 3.217 ± 0.093
2.849AsnLys: 2.849 ± 0.088
4.51AsnLeu: 4.51 ± 0.093
1.195AsnMet: 1.195 ± 0.046
2.818AsnAsn: 2.818 ± 0.104
2.676AsnPro: 2.676 ± 0.082
3.393AsnGln: 3.393 ± 0.086
2.227AsnArg: 2.227 ± 0.062
2.626AsnSer: 2.626 ± 0.081
3.189AsnThr: 3.189 ± 0.089
2.827AsnVal: 2.827 ± 0.069
0.573AsnTrp: 0.573 ± 0.029
1.238AsnTyr: 1.238 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.963ProAla: 2.963 ± 0.072
0.283ProCys: 0.283 ± 0.021
2.255ProAsp: 2.255 ± 0.063
2.024ProGlu: 2.024 ± 0.066
1.628ProPhe: 1.628 ± 0.055
1.131ProGly: 1.131 ± 0.049
1.017ProHis: 1.017 ± 0.044
3.072ProIle: 3.072 ± 0.078
2.877ProLys: 2.877 ± 0.064
3.887ProLeu: 3.887 ± 0.088
1.279ProMet: 1.279 ± 0.046
2.789ProAsn: 2.789 ± 0.06
1.435ProPro: 1.435 ± 0.057
1.749ProGln: 1.749 ± 0.068
1.11ProArg: 1.11 ± 0.047
2.777ProSer: 2.777 ± 0.073
2.932ProThr: 2.932 ± 0.078
2.631ProVal: 2.631 ± 0.074
0.416ProTrp: 0.416 ± 0.029
1.368ProTyr: 1.368 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
5.878GlnAla: 5.878 ± 0.114
0.337GlnCys: 0.337 ± 0.021
2.775GlnAsp: 2.775 ± 0.081
2.217GlnGlu: 2.217 ± 0.072
1.846GlnPhe: 1.846 ± 0.064
3.365GlnGly: 3.365 ± 0.09
1.801GlnHis: 1.801 ± 0.081
3.346GlnIle: 3.346 ± 0.084
2.709GlnLys: 2.709 ± 0.078
6.102GlnLeu: 6.102 ± 0.143
1.537GlnMet: 1.537 ± 0.062
2.353GlnAsn: 2.353 ± 0.079
2.305GlnPro: 2.305 ± 0.065
4.027GlnGln: 4.027 ± 0.168
2.587GlnArg: 2.587 ± 0.071
3.514GlnSer: 3.514 ± 0.086
3.7GlnThr: 3.7 ± 0.086
3.593GlnVal: 3.593 ± 0.082
0.616GlnTrp: 0.616 ± 0.039
1.464GlnTyr: 1.464 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
2.785ArgAla: 2.785 ± 0.074
0.368ArgCys: 0.368 ± 0.024
1.922ArgAsp: 1.922 ± 0.056
2.234ArgGlu: 2.234 ± 0.068
1.915ArgPhe: 1.915 ± 0.064
2.277ArgGly: 2.277 ± 0.069
1.652ArgHis: 1.652 ± 0.06
2.992ArgIle: 2.992 ± 0.067
1.784ArgLys: 1.784 ± 0.056
5.342ArgLeu: 5.342 ± 0.1
1.197ArgMet: 1.197 ± 0.043
1.478ArgAsn: 1.478 ± 0.048
1.68ArgPro: 1.68 ± 0.055
3.16ArgGln: 3.16 ± 0.088
2.098ArgArg: 2.098 ± 0.064
1.915ArgSer: 1.915 ± 0.063
2.003ArgThr: 2.003 ± 0.061
2.549ArgVal: 2.549 ± 0.067
0.57ArgTrp: 0.57 ± 0.034
1.754ArgTyr: 1.754 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.721SerAla: 4.721 ± 0.104
0.489SerCys: 0.489 ± 0.028
3.775SerAsp: 3.775 ± 0.087
2.923SerGlu: 2.923 ± 0.085
2.262SerPhe: 2.262 ± 0.065
4.047SerGly: 4.047 ± 0.092
2.024SerHis: 2.024 ± 0.064
3.78SerIle: 3.78 ± 0.095
3.205SerLys: 3.205 ± 0.087
6.182SerLeu: 6.182 ± 0.095
1.651SerMet: 1.651 ± 0.054
2.868SerAsn: 2.868 ± 0.082
2.39SerPro: 2.39 ± 0.069
3.756SerGln: 3.756 ± 0.09
2.604SerArg: 2.604 ± 0.058
3.688SerSer: 3.688 ± 0.092
3.431SerThr: 3.431 ± 0.09
4.282SerVal: 4.282 ± 0.094
0.672SerTrp: 0.672 ± 0.034
1.789SerTyr: 1.789 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.686ThrAla: 5.686 ± 0.121
0.504ThrCys: 0.504 ± 0.036
4.261ThrAsp: 4.261 ± 0.104
2.359ThrGlu: 2.359 ± 0.065
1.88ThrPhe: 1.88 ± 0.068
4.173ThrGly: 4.173 ± 0.097
1.975ThrHis: 1.975 ± 0.071
3.417ThrIle: 3.417 ± 0.082
2.752ThrLys: 2.752 ± 0.088
6.484ThrLeu: 6.484 ± 0.114
1.345ThrMet: 1.345 ± 0.048
2.88ThrAsn: 2.88 ± 0.087
3.163ThrPro: 3.163 ± 0.073
3.652ThrGln: 3.652 ± 0.104
1.963ThrArg: 1.963 ± 0.056
3.269ThrSer: 3.269 ± 0.098
3.809ThrThr: 3.809 ± 0.098
3.825ThrVal: 3.825 ± 0.086
0.584ThrTrp: 0.584 ± 0.032
1.456ThrTyr: 1.456 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
6.458ValAla: 6.458 ± 0.115
0.746ValCys: 0.746 ± 0.039
3.854ValAsp: 3.854 ± 0.093
2.833ValGlu: 2.833 ± 0.093
2.714ValPhe: 2.714 ± 0.081
4.783ValGly: 4.783 ± 0.1
1.433ValHis: 1.433 ± 0.054
4.624ValIle: 4.624 ± 0.107
3.502ValLys: 3.502 ± 0.09
6.653ValLeu: 6.653 ± 0.14
2.212ValMet: 2.212 ± 0.072
3.417ValAsn: 3.417 ± 0.078
2.481ValPro: 2.481 ± 0.064
2.654ValGln: 2.654 ± 0.066
2.704ValArg: 2.704 ± 0.079
4.562ValSer: 4.562 ± 0.085
3.44ValThr: 3.44 ± 0.088
5.063ValVal: 5.063 ± 0.109
0.704ValTrp: 0.704 ± 0.041
1.882ValTyr: 1.882 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.803TrpAla: 0.803 ± 0.039
0.112TrpCys: 0.112 ± 0.014
0.435TrpAsp: 0.435 ± 0.025
0.368TrpGlu: 0.368 ± 0.026
0.521TrpPhe: 0.521 ± 0.031
0.718TrpGly: 0.718 ± 0.04
0.445TrpHis: 0.445 ± 0.034
0.656TrpIle: 0.656 ± 0.038
0.287TrpLys: 0.287 ± 0.024
1.918TrpLeu: 1.918 ± 0.072
0.238TrpMet: 0.238 ± 0.02
0.288TrpAsn: 0.288 ± 0.022
0.169TrpPro: 0.169 ± 0.018
1.578TrpGln: 1.578 ± 0.06
0.592TrpArg: 0.592 ± 0.034
0.534TrpSer: 0.534 ± 0.031
0.464TrpThr: 0.464 ± 0.029
0.858TrpVal: 0.858 ± 0.044
0.173TrpTrp: 0.173 ± 0.018
0.418TrpTyr: 0.418 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.612TyrAla: 2.612 ± 0.067
0.295TyrCys: 0.295 ± 0.021
2.217TyrAsp: 2.217 ± 0.066
1.526TyrGlu: 1.526 ± 0.057
1.26TyrPhe: 1.26 ± 0.052
2.215TyrGly: 2.215 ± 0.067
1.1TyrHis: 1.1 ± 0.045
1.25TyrIle: 1.25 ± 0.051
1.107TyrLys: 1.107 ± 0.045
3.174TyrLeu: 3.174 ± 0.077
0.573TyrMet: 0.573 ± 0.031
0.998TyrAsn: 0.998 ± 0.04
1.542TyrPro: 1.542 ± 0.054
2.296TyrGln: 2.296 ± 0.063
1.613TyrArg: 1.613 ± 0.056
1.343TyrSer: 1.343 ± 0.048
1.202TyrThr: 1.202 ± 0.051
2.145TyrVal: 2.145 ± 0.067
0.383TyrTrp: 0.383 ± 0.024
1.007TyrTyr: 1.007 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1751 proteins (579145 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski