Amino acid dipepetide frequency for Gordonia phage Schnabeltier

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.293AlaAla: 19.293 ± 1.56
0.787AlaCys: 0.787 ± 0.253
8.137AlaAsp: 8.137 ± 0.762
6.693AlaGlu: 6.693 ± 0.738
2.69AlaPhe: 2.69 ± 0.543
11.221AlaGly: 11.221 ± 1.152
2.034AlaHis: 2.034 ± 0.49
5.381AlaIle: 5.381 ± 0.688
3.412AlaLys: 3.412 ± 0.547
10.499AlaLeu: 10.499 ± 0.881
2.756AlaMet: 2.756 ± 0.468
2.953AlaAsn: 2.953 ± 0.5
7.218AlaPro: 7.218 ± 0.632
4.265AlaGln: 4.265 ± 0.764
9.187AlaArg: 9.187 ± 0.815
6.89AlaSer: 6.89 ± 0.785
8.793AlaThr: 8.793 ± 1.063
9.121AlaVal: 9.121 ± 1.098
2.231AlaTrp: 2.231 ± 0.387
2.231AlaTyr: 2.231 ± 0.304
0.0AlaXaa: 0.0 ± 0.0
Cys
0.787CysAla: 0.787 ± 0.268
0.066CysCys: 0.066 ± 0.065
0.853CysAsp: 0.853 ± 0.258
0.459CysGlu: 0.459 ± 0.188
0.066CysPhe: 0.066 ± 0.071
0.919CysGly: 0.919 ± 0.217
0.131CysHis: 0.131 ± 0.081
0.197CysIle: 0.197 ± 0.105
0.131CysLys: 0.131 ± 0.082
0.656CysLeu: 0.656 ± 0.239
0.066CysMet: 0.066 ± 0.071
0.394CysAsn: 0.394 ± 0.141
0.525CysPro: 0.525 ± 0.226
0.262CysGln: 0.262 ± 0.128
0.787CysArg: 0.787 ± 0.255
0.787CysSer: 0.787 ± 0.2
0.591CysThr: 0.591 ± 0.214
0.459CysVal: 0.459 ± 0.171
0.328CysTrp: 0.328 ± 0.139
0.197CysTyr: 0.197 ± 0.111
0.0CysXaa: 0.0 ± 0.0
Asp
7.743AspAla: 7.743 ± 0.72
0.853AspCys: 0.853 ± 0.276
4.922AspAsp: 4.922 ± 0.91
5.709AspGlu: 5.709 ± 0.625
2.362AspPhe: 2.362 ± 0.368
5.381AspGly: 5.381 ± 0.696
1.641AspHis: 1.641 ± 0.287
1.837AspIle: 1.837 ± 0.445
1.116AspLys: 1.116 ± 0.337
6.234AspLeu: 6.234 ± 0.659
0.787AspMet: 0.787 ± 0.189
1.181AspAsn: 1.181 ± 0.274
4.265AspPro: 4.265 ± 0.644
2.1AspGln: 2.1 ± 0.343
4.462AspArg: 4.462 ± 0.675
3.74AspSer: 3.74 ± 0.475
3.281AspThr: 3.281 ± 0.408
3.937AspVal: 3.937 ± 0.531
1.378AspTrp: 1.378 ± 0.269
1.312AspTyr: 1.312 ± 0.299
0.0AspXaa: 0.0 ± 0.0
Glu
6.168GluAla: 6.168 ± 0.646
0.459GluCys: 0.459 ± 0.176
3.675GluAsp: 3.675 ± 0.511
2.559GluGlu: 2.559 ± 0.413
1.706GluPhe: 1.706 ± 0.407
4.265GluGly: 4.265 ± 0.575
1.116GluHis: 1.116 ± 0.303
3.215GluIle: 3.215 ± 0.529
1.312GluLys: 1.312 ± 0.25
5.053GluLeu: 5.053 ± 0.607
1.116GluMet: 1.116 ± 0.301
1.772GluAsn: 1.772 ± 0.411
3.544GluPro: 3.544 ± 0.631
2.362GluGln: 2.362 ± 0.357
4.659GluArg: 4.659 ± 0.73
2.887GluSer: 2.887 ± 0.378
2.822GluThr: 2.822 ± 0.428
3.937GluVal: 3.937 ± 0.485
1.378GluTrp: 1.378 ± 0.347
2.1GluTyr: 2.1 ± 0.321
0.0GluXaa: 0.0 ± 0.0
Phe
3.281PheAla: 3.281 ± 0.51
0.066PheCys: 0.066 ± 0.08
1.837PheAsp: 1.837 ± 0.326
1.837PheGlu: 1.837 ± 0.359
0.787PhePhe: 0.787 ± 0.189
2.362PheGly: 2.362 ± 0.407
0.591PheHis: 0.591 ± 0.155
1.181PheIle: 1.181 ± 0.311
0.525PheLys: 0.525 ± 0.173
2.428PheLeu: 2.428 ± 0.522
0.525PheMet: 0.525 ± 0.192
0.459PheAsn: 0.459 ± 0.251
1.312PhePro: 1.312 ± 0.269
0.787PheGln: 0.787 ± 0.182
1.706PheArg: 1.706 ± 0.347
1.903PheSer: 1.903 ± 0.384
2.1PheThr: 2.1 ± 0.426
2.165PheVal: 2.165 ± 0.362
0.591PheTrp: 0.591 ± 0.18
0.656PheTyr: 0.656 ± 0.218
0.0PheXaa: 0.0 ± 0.0
Gly
8.137GlyAla: 8.137 ± 0.792
0.656GlyCys: 0.656 ± 0.25
4.922GlyAsp: 4.922 ± 0.706
4.528GlyGlu: 4.528 ± 0.41
3.019GlyPhe: 3.019 ± 0.427
8.071GlyGly: 8.071 ± 1.075
2.231GlyHis: 2.231 ± 0.354
3.74GlyIle: 3.74 ± 0.856
2.559GlyLys: 2.559 ± 0.392
7.481GlyLeu: 7.481 ± 0.822
2.1GlyMet: 2.1 ± 0.302
2.1GlyAsn: 2.1 ± 0.41
3.74GlyPro: 3.74 ± 0.456
3.806GlyGln: 3.806 ± 0.493
7.35GlyArg: 7.35 ± 0.726
4.659GlySer: 4.659 ± 0.511
5.315GlyThr: 5.315 ± 0.56
6.562GlyVal: 6.562 ± 0.566
1.772GlyTrp: 1.772 ± 0.259
2.1GlyTyr: 2.1 ± 0.323
0.0GlyXaa: 0.0 ± 0.0
His
2.297HisAla: 2.297 ± 0.365
0.328HisCys: 0.328 ± 0.168
1.181HisAsp: 1.181 ± 0.287
1.05HisGlu: 1.05 ± 0.235
0.591HisPhe: 0.591 ± 0.236
1.575HisGly: 1.575 ± 0.402
0.656HisHis: 0.656 ± 0.206
0.722HisIle: 0.722 ± 0.201
0.591HisLys: 0.591 ± 0.185
2.034HisLeu: 2.034 ± 0.393
0.394HisMet: 0.394 ± 0.136
0.591HisAsn: 0.591 ± 0.216
1.706HisPro: 1.706 ± 0.294
0.394HisGln: 0.394 ± 0.152
1.181HisArg: 1.181 ± 0.313
1.312HisSer: 1.312 ± 0.321
0.919HisThr: 0.919 ± 0.345
1.378HisVal: 1.378 ± 0.32
0.525HisTrp: 0.525 ± 0.18
0.525HisTyr: 0.525 ± 0.172
0.0HisXaa: 0.0 ± 0.0
Ile
6.496IleAla: 6.496 ± 0.622
0.328IleCys: 0.328 ± 0.15
2.822IleAsp: 2.822 ± 0.474
3.15IleGlu: 3.15 ± 0.502
0.984IlePhe: 0.984 ± 0.24
3.609IleGly: 3.609 ± 0.519
0.394IleHis: 0.394 ± 0.139
1.969IleIle: 1.969 ± 0.277
1.641IleLys: 1.641 ± 0.422
2.69IleLeu: 2.69 ± 0.431
0.394IleMet: 0.394 ± 0.153
1.181IleAsn: 1.181 ± 0.29
2.428IlePro: 2.428 ± 0.394
1.444IleGln: 1.444 ± 0.317
3.347IleArg: 3.347 ± 0.463
2.887IleSer: 2.887 ± 0.591
2.625IleThr: 2.625 ± 0.384
4.593IleVal: 4.593 ± 0.513
0.919IleTrp: 0.919 ± 0.215
0.722IleTyr: 0.722 ± 0.18
0.0IleXaa: 0.0 ± 0.0
Lys
3.15LysAla: 3.15 ± 0.409
0.459LysCys: 0.459 ± 0.161
2.362LysAsp: 2.362 ± 0.438
0.787LysGlu: 0.787 ± 0.227
0.722LysPhe: 0.722 ± 0.265
2.428LysGly: 2.428 ± 0.384
0.459LysHis: 0.459 ± 0.195
1.772LysIle: 1.772 ± 0.45
1.575LysLys: 1.575 ± 0.389
2.231LysLeu: 2.231 ± 0.401
0.656LysMet: 0.656 ± 0.225
0.591LysAsn: 0.591 ± 0.182
1.444LysPro: 1.444 ± 0.306
0.656LysGln: 0.656 ± 0.265
2.428LysArg: 2.428 ± 0.397
1.641LysSer: 1.641 ± 0.361
2.494LysThr: 2.494 ± 0.395
2.165LysVal: 2.165 ± 0.345
0.984LysTrp: 0.984 ± 0.281
0.459LysTyr: 0.459 ± 0.155
0.0LysXaa: 0.0 ± 0.0
Leu
11.484LeuAla: 11.484 ± 0.733
0.722LeuCys: 0.722 ± 0.212
4.397LeuAsp: 4.397 ± 0.644
4.462LeuGlu: 4.462 ± 0.812
2.428LeuPhe: 2.428 ± 0.5
5.84LeuGly: 5.84 ± 0.585
1.837LeuHis: 1.837 ± 0.422
3.74LeuIle: 3.74 ± 0.634
2.034LeuLys: 2.034 ± 0.312
6.234LeuLeu: 6.234 ± 0.811
1.837LeuMet: 1.837 ± 0.359
2.034LeuAsn: 2.034 ± 0.35
5.381LeuPro: 5.381 ± 0.654
2.69LeuGln: 2.69 ± 0.347
5.972LeuArg: 5.972 ± 0.679
5.25LeuSer: 5.25 ± 0.539
4.856LeuThr: 4.856 ± 0.56
5.972LeuVal: 5.972 ± 0.658
1.181LeuTrp: 1.181 ± 0.257
1.575LeuTyr: 1.575 ± 0.294
0.0LeuXaa: 0.0 ± 0.0
Met
3.084MetAla: 3.084 ± 0.633
0.197MetCys: 0.197 ± 0.103
1.181MetAsp: 1.181 ± 0.3
0.328MetGlu: 0.328 ± 0.134
0.459MetPhe: 0.459 ± 0.172
1.378MetGly: 1.378 ± 0.352
0.656MetHis: 0.656 ± 0.223
1.641MetIle: 1.641 ± 0.326
0.591MetLys: 0.591 ± 0.182
1.837MetLeu: 1.837 ± 0.359
0.591MetMet: 0.591 ± 0.175
0.787MetAsn: 0.787 ± 0.279
1.378MetPro: 1.378 ± 0.291
0.722MetGln: 0.722 ± 0.23
1.837MetArg: 1.837 ± 0.364
1.837MetSer: 1.837 ± 0.422
1.641MetThr: 1.641 ± 0.345
1.181MetVal: 1.181 ± 0.287
0.591MetTrp: 0.591 ± 0.224
0.197MetTyr: 0.197 ± 0.123
0.0MetXaa: 0.0 ± 0.0
Asn
3.347AsnAla: 3.347 ± 0.627
0.131AsnCys: 0.131 ± 0.09
1.837AsnAsp: 1.837 ± 0.245
1.575AsnGlu: 1.575 ± 0.354
0.591AsnPhe: 0.591 ± 0.235
2.953AsnGly: 2.953 ± 0.576
0.722AsnHis: 0.722 ± 0.214
0.919AsnIle: 0.919 ± 0.291
0.591AsnLys: 0.591 ± 0.214
2.165AsnLeu: 2.165 ± 0.372
0.459AsnMet: 0.459 ± 0.154
0.853AsnAsn: 0.853 ± 0.218
2.428AsnPro: 2.428 ± 0.408
1.247AsnGln: 1.247 ± 0.33
1.969AsnArg: 1.969 ± 0.404
1.181AsnSer: 1.181 ± 0.273
1.05AsnThr: 1.05 ± 0.235
2.1AsnVal: 2.1 ± 0.425
0.787AsnTrp: 0.787 ± 0.205
0.591AsnTyr: 0.591 ± 0.217
0.0AsnXaa: 0.0 ± 0.0
Pro
9.646ProAla: 9.646 ± 1.045
0.328ProCys: 0.328 ± 0.13
4.528ProAsp: 4.528 ± 0.595
3.544ProGlu: 3.544 ± 0.514
1.575ProPhe: 1.575 ± 0.342
4.856ProGly: 4.856 ± 0.688
1.05ProHis: 1.05 ± 0.337
2.494ProIle: 2.494 ± 0.382
2.034ProLys: 2.034 ± 0.357
3.478ProLeu: 3.478 ± 0.503
1.575ProMet: 1.575 ± 0.316
1.575ProAsn: 1.575 ± 0.372
5.118ProPro: 5.118 ± 0.883
2.165ProGln: 2.165 ± 0.361
3.412ProArg: 3.412 ± 0.57
3.74ProSer: 3.74 ± 0.529
4.134ProThr: 4.134 ± 0.693
4.725ProVal: 4.725 ± 0.644
1.837ProTrp: 1.837 ± 0.478
0.591ProTyr: 0.591 ± 0.168
0.0ProXaa: 0.0 ± 0.0
Gln
3.084GlnAla: 3.084 ± 0.844
0.525GlnCys: 0.525 ± 0.154
1.509GlnAsp: 1.509 ± 0.331
1.378GlnGlu: 1.378 ± 0.277
0.787GlnPhe: 0.787 ± 0.182
2.559GlnGly: 2.559 ± 0.395
0.722GlnHis: 0.722 ± 0.283
1.837GlnIle: 1.837 ± 0.449
1.247GlnLys: 1.247 ± 0.342
3.675GlnLeu: 3.675 ± 0.486
1.181GlnMet: 1.181 ± 0.295
1.116GlnAsn: 1.116 ± 0.194
1.837GlnPro: 1.837 ± 0.448
1.772GlnGln: 1.772 ± 0.385
3.084GlnArg: 3.084 ± 0.56
1.903GlnSer: 1.903 ± 0.356
1.903GlnThr: 1.903 ± 0.394
2.559GlnVal: 2.559 ± 0.404
0.787GlnTrp: 0.787 ± 0.222
0.656GlnTyr: 0.656 ± 0.193
0.0GlnXaa: 0.0 ± 0.0
Arg
7.809ArgAla: 7.809 ± 0.784
0.656ArgCys: 0.656 ± 0.216
4.987ArgAsp: 4.987 ± 0.672
3.937ArgGlu: 3.937 ± 0.682
1.706ArgPhe: 1.706 ± 0.255
6.168ArgGly: 6.168 ± 0.714
1.444ArgHis: 1.444 ± 0.388
3.478ArgIle: 3.478 ± 0.479
3.478ArgLys: 3.478 ± 0.489
5.118ArgLeu: 5.118 ± 0.462
3.019ArgMet: 3.019 ± 0.512
2.559ArgAsn: 2.559 ± 0.389
4.462ArgPro: 4.462 ± 0.745
3.084ArgGln: 3.084 ± 0.546
8.203ArgArg: 8.203 ± 1.148
3.609ArgSer: 3.609 ± 0.576
4.856ArgThr: 4.856 ± 0.555
4.79ArgVal: 4.79 ± 0.545
0.919ArgTrp: 0.919 ± 0.218
1.706ArgTyr: 1.706 ± 0.447
0.0ArgXaa: 0.0 ± 0.0
Ser
7.021SerAla: 7.021 ± 0.625
0.328SerCys: 0.328 ± 0.149
3.412SerAsp: 3.412 ± 0.381
3.347SerGlu: 3.347 ± 0.469
1.378SerPhe: 1.378 ± 0.384
7.284SerGly: 7.284 ± 0.852
1.116SerHis: 1.116 ± 0.201
2.953SerIle: 2.953 ± 0.353
1.575SerLys: 1.575 ± 0.33
4.397SerLeu: 4.397 ± 0.568
1.378SerMet: 1.378 ± 0.498
1.969SerAsn: 1.969 ± 0.287
3.806SerPro: 3.806 ± 0.521
1.247SerGln: 1.247 ± 0.334
3.281SerArg: 3.281 ± 0.555
3.215SerSer: 3.215 ± 0.527
3.478SerThr: 3.478 ± 0.438
4.593SerVal: 4.593 ± 0.679
0.919SerTrp: 0.919 ± 0.206
1.116SerTyr: 1.116 ± 0.239
0.0SerXaa: 0.0 ± 0.0
Thr
7.546ThrAla: 7.546 ± 0.834
0.722ThrCys: 0.722 ± 0.226
4.2ThrAsp: 4.2 ± 0.532
3.806ThrGlu: 3.806 ± 0.64
1.772ThrPhe: 1.772 ± 0.349
5.118ThrGly: 5.118 ± 0.539
0.853ThrHis: 0.853 ± 0.265
2.625ThrIle: 2.625 ± 0.498
0.919ThrLys: 0.919 ± 0.33
5.118ThrLeu: 5.118 ± 0.447
0.722ThrMet: 0.722 ± 0.252
1.837ThrAsn: 1.837 ± 0.29
5.118ThrPro: 5.118 ± 0.523
2.165ThrGln: 2.165 ± 0.381
3.872ThrArg: 3.872 ± 0.41
4.528ThrSer: 4.528 ± 0.633
4.659ThrThr: 4.659 ± 0.614
5.447ThrVal: 5.447 ± 0.608
1.575ThrTrp: 1.575 ± 0.376
0.984ThrTyr: 0.984 ± 0.255
0.0ThrXaa: 0.0 ± 0.0
Val
10.696ValAla: 10.696 ± 1.241
0.459ValCys: 0.459 ± 0.188
5.118ValAsp: 5.118 ± 0.661
4.462ValGlu: 4.462 ± 0.651
2.034ValPhe: 2.034 ± 0.374
5.906ValGly: 5.906 ± 0.519
0.984ValHis: 0.984 ± 0.253
3.412ValIle: 3.412 ± 0.566
2.494ValLys: 2.494 ± 0.491
4.79ValLeu: 4.79 ± 0.611
1.444ValMet: 1.444 ± 0.352
1.903ValAsn: 1.903 ± 0.345
4.79ValPro: 4.79 ± 0.642
1.837ValGln: 1.837 ± 0.4
5.972ValArg: 5.972 ± 0.636
4.134ValSer: 4.134 ± 0.568
5.25ValThr: 5.25 ± 0.531
5.775ValVal: 5.775 ± 0.66
1.509ValTrp: 1.509 ± 0.301
1.378ValTyr: 1.378 ± 0.294
0.0ValXaa: 0.0 ± 0.0
Trp
2.297TrpAla: 2.297 ± 0.349
0.328TrpCys: 0.328 ± 0.117
1.247TrpAsp: 1.247 ± 0.265
1.05TrpGlu: 1.05 ± 0.279
0.853TrpPhe: 0.853 ± 0.177
1.116TrpGly: 1.116 ± 0.248
0.787TrpHis: 0.787 ± 0.276
0.984TrpIle: 0.984 ± 0.269
0.853TrpLys: 0.853 ± 0.209
2.297TrpLeu: 2.297 ± 0.402
0.722TrpMet: 0.722 ± 0.193
1.116TrpAsn: 1.116 ± 0.315
1.05TrpPro: 1.05 ± 0.249
0.591TrpGln: 0.591 ± 0.207
1.575TrpArg: 1.575 ± 0.351
0.919TrpSer: 0.919 ± 0.238
1.509TrpThr: 1.509 ± 0.281
1.378TrpVal: 1.378 ± 0.352
0.722TrpTrp: 0.722 ± 0.244
0.131TrpTyr: 0.131 ± 0.097
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.428TyrAla: 2.428 ± 0.282
0.262TyrCys: 0.262 ± 0.139
1.116TyrAsp: 1.116 ± 0.265
1.444TyrGlu: 1.444 ± 0.426
0.591TyrPhe: 0.591 ± 0.198
1.837TyrGly: 1.837 ± 0.335
0.525TyrHis: 0.525 ± 0.151
0.591TyrIle: 0.591 ± 0.194
0.787TyrLys: 0.787 ± 0.24
1.509TyrLeu: 1.509 ± 0.332
0.328TyrMet: 0.328 ± 0.143
0.525TyrAsn: 0.525 ± 0.153
0.853TyrPro: 0.853 ± 0.24
0.525TyrGln: 0.525 ± 0.173
1.706TyrArg: 1.706 ± 0.359
0.787TyrSer: 0.787 ± 0.228
1.312TyrThr: 1.312 ± 0.289
1.509TyrVal: 1.509 ± 0.321
0.591TyrTrp: 0.591 ± 0.22
0.656TyrTyr: 0.656 ± 0.196
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (15240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski