Amino acid dipepetide frequency for Prevotella sp. P3-120

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.894AlaAla: 5.894 ± 0.122
1.132AlaCys: 1.132 ± 0.038
4.997AlaAsp: 4.997 ± 0.077
4.876AlaGlu: 4.876 ± 0.076
3.191AlaPhe: 3.191 ± 0.067
4.816AlaGly: 4.816 ± 0.074
1.562AlaHis: 1.562 ± 0.039
5.166AlaIle: 5.166 ± 0.086
4.508AlaLys: 4.508 ± 0.083
6.83AlaLeu: 6.83 ± 0.098
2.347AlaMet: 2.347 ± 0.046
3.267AlaAsn: 3.267 ± 0.061
2.225AlaPro: 2.225 ± 0.054
3.093AlaGln: 3.093 ± 0.065
3.271AlaArg: 3.271 ± 0.067
4.203AlaSer: 4.203 ± 0.073
4.303AlaThr: 4.303 ± 0.078
5.106AlaVal: 5.106 ± 0.088
0.941AlaTrp: 0.941 ± 0.037
2.879AlaTyr: 2.879 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.904CysAla: 0.904 ± 0.035
0.242CysCys: 0.242 ± 0.017
0.842CysAsp: 0.842 ± 0.033
0.796CysGlu: 0.796 ± 0.035
0.573CysPhe: 0.573 ± 0.024
1.265CysGly: 1.265 ± 0.048
0.426CysHis: 0.426 ± 0.022
0.93CysIle: 0.93 ± 0.036
0.747CysLys: 0.747 ± 0.033
1.164CysLeu: 1.164 ± 0.039
0.386CysMet: 0.386 ± 0.019
0.681CysAsn: 0.681 ± 0.029
0.585CysPro: 0.585 ± 0.028
0.553CysGln: 0.553 ± 0.031
0.772CysArg: 0.772 ± 0.033
0.88CysSer: 0.88 ± 0.034
0.719CysThr: 0.719 ± 0.026
0.919CysVal: 0.919 ± 0.035
0.174CysTrp: 0.174 ± 0.014
0.625CysTyr: 0.625 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.468AspAla: 4.468 ± 0.066
0.842AspCys: 0.842 ± 0.033
3.476AspAsp: 3.476 ± 0.073
4.308AspGlu: 4.308 ± 0.068
3.084AspPhe: 3.084 ± 0.066
4.37AspGly: 4.37 ± 0.088
1.274AspHis: 1.274 ± 0.045
4.301AspIle: 4.301 ± 0.066
3.752AspLys: 3.752 ± 0.072
4.35AspLeu: 4.35 ± 0.071
1.734AspMet: 1.734 ± 0.04
3.038AspAsn: 3.038 ± 0.05
1.827AspPro: 1.827 ± 0.049
1.647AspGln: 1.647 ± 0.043
2.965AspArg: 2.965 ± 0.056
3.302AspSer: 3.302 ± 0.06
2.93AspThr: 2.93 ± 0.064
3.969AspVal: 3.969 ± 0.065
0.818AspTrp: 0.818 ± 0.029
3.054AspTyr: 3.054 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.953GluAla: 4.953 ± 0.089
0.713GluCys: 0.713 ± 0.033
3.266GluAsp: 3.266 ± 0.063
4.481GluGlu: 4.481 ± 0.095
2.206GluPhe: 2.206 ± 0.056
3.958GluGly: 3.958 ± 0.066
1.448GluHis: 1.448 ± 0.035
4.001GluIle: 4.001 ± 0.071
4.392GluLys: 4.392 ± 0.075
5.381GluLeu: 5.381 ± 0.092
2.16GluMet: 2.16 ± 0.048
3.016GluAsn: 3.016 ± 0.059
1.715GluPro: 1.715 ± 0.046
3.014GluGln: 3.014 ± 0.062
3.46GluArg: 3.46 ± 0.067
2.929GluSer: 2.929 ± 0.058
3.197GluThr: 3.197 ± 0.065
4.079GluVal: 4.079 ± 0.075
0.89GluTrp: 0.89 ± 0.033
2.603GluTyr: 2.603 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.078PheAla: 3.078 ± 0.065
0.767PheCys: 0.767 ± 0.031
2.895PheAsp: 2.895 ± 0.059
2.27PheGlu: 2.27 ± 0.043
2.021PhePhe: 2.021 ± 0.053
3.141PheGly: 3.141 ± 0.066
0.958PheHis: 0.958 ± 0.035
2.682PheIle: 2.682 ± 0.059
2.168PheLys: 2.168 ± 0.055
3.452PheLeu: 3.452 ± 0.07
1.141PheMet: 1.141 ± 0.04
2.072PheAsn: 2.072 ± 0.047
1.531PhePro: 1.531 ± 0.039
1.271PheGln: 1.271 ± 0.035
2.122PheArg: 2.122 ± 0.047
2.931PheSer: 2.931 ± 0.061
2.58PheThr: 2.58 ± 0.047
2.978PheVal: 2.978 ± 0.053
0.533PheTrp: 0.533 ± 0.027
1.731PheTyr: 1.731 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.487GlyAla: 4.487 ± 0.078
1.141GlyCys: 1.141 ± 0.044
3.622GlyAsp: 3.622 ± 0.07
3.87GlyGlu: 3.87 ± 0.071
3.012GlyPhe: 3.012 ± 0.055
4.701GlyGly: 4.701 ± 0.092
1.596GlyHis: 1.596 ± 0.037
5.033GlyIle: 5.033 ± 0.074
4.846GlyLys: 4.846 ± 0.079
5.571GlyLeu: 5.571 ± 0.084
2.178GlyMet: 2.178 ± 0.055
3.355GlyAsn: 3.355 ± 0.063
1.359GlyPro: 1.359 ± 0.044
2.349GlyGln: 2.349 ± 0.052
3.3GlyArg: 3.3 ± 0.063
3.739GlySer: 3.739 ± 0.066
3.965GlyThr: 3.965 ± 0.074
4.794GlyVal: 4.794 ± 0.078
1.057GlyTrp: 1.057 ± 0.036
2.999GlyTyr: 2.999 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.436HisAla: 1.436 ± 0.038
0.377HisCys: 0.377 ± 0.022
1.299HisAsp: 1.299 ± 0.039
1.228HisGlu: 1.228 ± 0.036
1.132HisPhe: 1.132 ± 0.037
1.524HisGly: 1.524 ± 0.041
0.807HisHis: 0.807 ± 0.041
1.682HisIle: 1.682 ± 0.046
1.094HisLys: 1.094 ± 0.035
2.139HisLeu: 2.139 ± 0.049
0.451HisMet: 0.451 ± 0.02
1.055HisAsn: 1.055 ± 0.035
1.259HisPro: 1.259 ± 0.041
0.935HisGln: 0.935 ± 0.035
1.178HisArg: 1.178 ± 0.04
1.181HisSer: 1.181 ± 0.039
1.243HisThr: 1.243 ± 0.035
1.411HisVal: 1.411 ± 0.04
0.321HisTrp: 0.321 ± 0.023
1.087HisTyr: 1.087 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.302IleAla: 5.302 ± 0.082
1.081IleCys: 1.081 ± 0.037
4.798IleAsp: 4.798 ± 0.077
4.252IleGlu: 4.252 ± 0.087
2.492IlePhe: 2.492 ± 0.054
4.707IleGly: 4.707 ± 0.071
1.413IleHis: 1.413 ± 0.04
4.579IleIle: 4.579 ± 0.088
3.796IleLys: 3.796 ± 0.068
5.447IleLeu: 5.447 ± 0.089
1.632IleMet: 1.632 ± 0.051
3.326IleAsn: 3.326 ± 0.069
2.839IlePro: 2.839 ± 0.057
2.105IleGln: 2.105 ± 0.051
3.266IleArg: 3.266 ± 0.06
4.071IleSer: 4.071 ± 0.067
3.762IleThr: 3.762 ± 0.072
4.592IleVal: 4.592 ± 0.066
0.698IleTrp: 0.698 ± 0.028
2.569IleTyr: 2.569 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.149LysAla: 5.149 ± 0.083
0.582LysCys: 0.582 ± 0.025
3.816LysAsp: 3.816 ± 0.075
4.576LysGlu: 4.576 ± 0.083
1.863LysPhe: 1.863 ± 0.046
4.231LysGly: 4.231 ± 0.065
1.275LysHis: 1.275 ± 0.034
3.627LysIle: 3.627 ± 0.066
4.564LysLys: 4.564 ± 0.102
4.733LysLeu: 4.733 ± 0.072
2.221LysMet: 2.221 ± 0.041
3.138LysAsn: 3.138 ± 0.063
2.205LysPro: 2.205 ± 0.058
2.771LysGln: 2.771 ± 0.057
3.293LysArg: 3.293 ± 0.063
3.236LysSer: 3.236 ± 0.061
3.708LysThr: 3.708 ± 0.056
4.082LysVal: 4.082 ± 0.065
0.763LysTrp: 0.763 ± 0.033
2.691LysTyr: 2.691 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
6.693LeuAla: 6.693 ± 0.102
1.491LeuCys: 1.491 ± 0.048
4.806LeuAsp: 4.806 ± 0.083
4.389LeuGlu: 4.389 ± 0.071
3.836LeuPhe: 3.836 ± 0.071
5.411LeuGly: 5.411 ± 0.09
2.112LeuHis: 2.112 ± 0.051
4.936LeuIle: 4.936 ± 0.078
5.443LeuLys: 5.443 ± 0.076
8.445LeuLeu: 8.445 ± 0.115
2.845LeuMet: 2.845 ± 0.051
4.04LeuAsn: 4.04 ± 0.071
3.844LeuPro: 3.844 ± 0.059
3.616LeuGln: 3.616 ± 0.073
4.703LeuArg: 4.703 ± 0.08
5.889LeuSer: 5.889 ± 0.089
5.463LeuThr: 5.463 ± 0.073
5.311LeuVal: 5.311 ± 0.085
1.101LeuTrp: 1.101 ± 0.035
3.392LeuTyr: 3.392 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.717MetAla: 2.717 ± 0.054
0.271MetCys: 0.271 ± 0.018
1.599MetAsp: 1.599 ± 0.039
1.874MetGlu: 1.874 ± 0.046
1.064MetPhe: 1.064 ± 0.037
1.994MetGly: 1.994 ± 0.056
0.576MetHis: 0.576 ± 0.025
1.742MetIle: 1.742 ± 0.041
2.496MetLys: 2.496 ± 0.053
2.783MetLeu: 2.783 ± 0.052
1.161MetMet: 1.161 ± 0.035
1.598MetAsn: 1.598 ± 0.035
1.3MetPro: 1.3 ± 0.03
1.33MetGln: 1.33 ± 0.037
1.56MetArg: 1.56 ± 0.046
1.629MetSer: 1.629 ± 0.041
1.936MetThr: 1.936 ± 0.046
1.96MetVal: 1.96 ± 0.044
0.238MetTrp: 0.238 ± 0.018
0.743MetTyr: 0.743 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.533AsnAla: 3.533 ± 0.069
0.566AsnCys: 0.566 ± 0.03
2.905AsnAsp: 2.905 ± 0.052
2.828AsnGlu: 2.828 ± 0.055
1.856AsnPhe: 1.856 ± 0.045
3.796AsnGly: 3.796 ± 0.078
1.132AsnHis: 1.132 ± 0.034
3.715AsnIle: 3.715 ± 0.075
2.96AsnLys: 2.96 ± 0.062
3.853AsnLeu: 3.853 ± 0.072
1.347AsnMet: 1.347 ± 0.033
2.689AsnAsn: 2.689 ± 0.066
2.354AsnPro: 2.354 ± 0.049
1.629AsnGln: 1.629 ± 0.046
2.343AsnArg: 2.343 ± 0.059
2.571AsnSer: 2.571 ± 0.057
2.773AsnThr: 2.773 ± 0.051
3.101AsnVal: 3.101 ± 0.058
0.638AsnTrp: 0.638 ± 0.026
2.143AsnTyr: 2.143 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.639ProAla: 2.639 ± 0.061
0.426ProCys: 0.426 ± 0.021
2.486ProAsp: 2.486 ± 0.055
2.839ProGlu: 2.839 ± 0.056
1.695ProPhe: 1.695 ± 0.035
2.117ProGly: 2.117 ± 0.053
0.84ProHis: 0.84 ± 0.03
2.351ProIle: 2.351 ± 0.053
2.085ProLys: 2.085 ± 0.052
3.207ProLeu: 3.207 ± 0.061
1.06ProMet: 1.06 ± 0.034
1.673ProAsn: 1.673 ± 0.04
0.727ProPro: 0.727 ± 0.028
1.628ProGln: 1.628 ± 0.04
1.38ProArg: 1.38 ± 0.04
2.182ProSer: 2.182 ± 0.052
2.214ProThr: 2.214 ± 0.056
2.681ProVal: 2.681 ± 0.056
0.504ProTrp: 0.504 ± 0.026
1.648ProTyr: 1.648 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.761GlnAla: 2.761 ± 0.065
0.452GlnCys: 0.452 ± 0.021
1.694GlnAsp: 1.694 ± 0.045
2.399GlnGlu: 2.399 ± 0.052
1.518GlnPhe: 1.518 ± 0.042
2.207GlnGly: 2.207 ± 0.052
0.977GlnHis: 0.977 ± 0.032
2.438GlnIle: 2.438 ± 0.056
2.457GlnLys: 2.457 ± 0.057
4.181GlnLeu: 4.181 ± 0.073
1.445GlnMet: 1.445 ± 0.045
1.734GlnAsn: 1.734 ± 0.05
1.511GlnPro: 1.511 ± 0.046
2.491GlnGln: 2.491 ± 0.064
2.299GlnArg: 2.299 ± 0.058
1.992GlnSer: 1.992 ± 0.044
2.255GlnThr: 2.255 ± 0.051
2.282GlnVal: 2.282 ± 0.055
0.669GlnTrp: 0.669 ± 0.028
1.714GlnTyr: 1.714 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
2.802ArgAla: 2.802 ± 0.064
0.65ArgCys: 0.65 ± 0.026
2.639ArgAsp: 2.639 ± 0.057
3.097ArgGlu: 3.097 ± 0.061
2.3ArgPhe: 2.3 ± 0.054
2.64ArgGly: 2.64 ± 0.059
1.354ArgHis: 1.354 ± 0.047
3.635ArgIle: 3.635 ± 0.07
3.377ArgLys: 3.377 ± 0.059
4.933ArgLeu: 4.933 ± 0.091
1.766ArgMet: 1.766 ± 0.045
2.582ArgAsn: 2.582 ± 0.059
1.752ArgPro: 1.752 ± 0.048
2.681ArgGln: 2.681 ± 0.06
2.822ArgArg: 2.822 ± 0.069
2.478ArgSer: 2.478 ± 0.054
2.539ArgThr: 2.539 ± 0.052
2.773ArgVal: 2.773 ± 0.06
0.778ArgTrp: 0.778 ± 0.029
2.358ArgTyr: 2.358 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.136SerAla: 4.136 ± 0.067
0.82SerCys: 0.82 ± 0.033
3.45SerAsp: 3.45 ± 0.068
3.279SerGlu: 3.279 ± 0.061
2.696SerPhe: 2.696 ± 0.059
3.881SerGly: 3.881 ± 0.073
1.365SerHis: 1.365 ± 0.038
3.987SerIle: 3.987 ± 0.069
3.325SerLys: 3.325 ± 0.063
5.331SerLeu: 5.331 ± 0.08
1.599SerMet: 1.599 ± 0.038
2.643SerAsn: 2.643 ± 0.056
2.117SerPro: 2.117 ± 0.05
2.209SerGln: 2.209 ± 0.047
2.634SerArg: 2.634 ± 0.057
3.348SerSer: 3.348 ± 0.071
2.981SerThr: 2.981 ± 0.06
4.006SerVal: 4.006 ± 0.086
0.819SerTrp: 0.819 ± 0.034
2.389SerTyr: 2.389 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.509ThrAla: 4.509 ± 0.072
0.693ThrCys: 0.693 ± 0.026
3.7ThrAsp: 3.7 ± 0.065
3.218ThrGlu: 3.218 ± 0.067
2.484ThrPhe: 2.484 ± 0.047
4.011ThrGly: 4.011 ± 0.071
1.191ThrHis: 1.191 ± 0.036
4.321ThrIle: 4.321 ± 0.074
2.949ThrLys: 2.949 ± 0.055
5.511ThrLeu: 5.511 ± 0.075
1.584ThrMet: 1.584 ± 0.043
2.446ThrAsn: 2.446 ± 0.055
2.7ThrPro: 2.7 ± 0.06
1.919ThrGln: 1.919 ± 0.047
2.312ThrArg: 2.312 ± 0.051
3.131ThrSer: 3.131 ± 0.072
3.538ThrThr: 3.538 ± 0.075
3.977ThrVal: 3.977 ± 0.075
0.663ThrTrp: 0.663 ± 0.031
2.257ThrTyr: 2.257 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
5.337ValAla: 5.337 ± 0.087
1.118ValCys: 1.118 ± 0.037
3.796ValAsp: 3.796 ± 0.066
4.243ValGlu: 4.243 ± 0.071
2.765ValPhe: 2.765 ± 0.061
4.368ValGly: 4.368 ± 0.079
1.104ValHis: 1.104 ± 0.038
4.14ValIle: 4.14 ± 0.073
4.364ValLys: 4.364 ± 0.076
5.654ValLeu: 5.654 ± 0.08
1.954ValMet: 1.954 ± 0.045
3.23ValAsn: 3.23 ± 0.059
2.492ValPro: 2.492 ± 0.052
1.874ValGln: 1.874 ± 0.049
3.243ValArg: 3.243 ± 0.062
4.255ValSer: 4.255 ± 0.065
3.952ValThr: 3.952 ± 0.087
5.035ValVal: 5.035 ± 0.083
0.817ValTrp: 0.817 ± 0.031
2.524ValTyr: 2.524 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.865TrpAla: 0.865 ± 0.032
0.182TrpCys: 0.182 ± 0.015
0.684TrpAsp: 0.684 ± 0.028
0.643TrpGlu: 0.643 ± 0.026
0.605TrpPhe: 0.605 ± 0.025
0.922TrpGly: 0.922 ± 0.032
0.345TrpHis: 0.345 ± 0.024
0.802TrpIle: 0.802 ± 0.032
0.82TrpLys: 0.82 ± 0.03
1.322TrpLeu: 1.322 ± 0.044
0.502TrpMet: 0.502 ± 0.023
0.806TrpAsn: 0.806 ± 0.034
0.301TrpPro: 0.301 ± 0.018
0.71TrpGln: 0.71 ± 0.029
0.733TrpArg: 0.733 ± 0.029
0.737TrpSer: 0.737 ± 0.033
0.765TrpThr: 0.765 ± 0.035
0.688TrpVal: 0.688 ± 0.032
0.219TrpTrp: 0.219 ± 0.015
0.553TrpTyr: 0.553 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.945TyrAla: 2.945 ± 0.052
0.637TyrCys: 0.637 ± 0.026
2.738TyrAsp: 2.738 ± 0.053
2.396TyrGlu: 2.396 ± 0.05
1.931TyrPhe: 1.931 ± 0.046
2.915TyrGly: 2.915 ± 0.064
1.083TyrHis: 1.083 ± 0.037
2.658TyrIle: 2.658 ± 0.058
2.382TyrLys: 2.382 ± 0.052
3.477TyrLeu: 3.477 ± 0.063
1.058TyrMet: 1.058 ± 0.034
2.341TyrAsn: 2.341 ± 0.055
1.742TyrPro: 1.742 ± 0.043
1.648TyrGln: 1.648 ± 0.043
2.3TyrArg: 2.3 ± 0.055
2.332TyrSer: 2.332 ± 0.062
2.292TyrThr: 2.292 ± 0.054
2.52TyrVal: 2.52 ± 0.049
0.563TyrTrp: 0.563 ± 0.027
2.008TyrTyr: 2.008 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2554 proteins (919724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski