Amino acid dipepetide frequency for Streptomyces triticagri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.504AlaAla: 21.504 ± 0.152	1.021AlaCys: 1.021 ± 0.021	8.594AlaAsp: 8.594 ± 0.073	9.25AlaGlu: 9.25 ± 0.09	3.405AlaPhe: 3.405 ± 0.047	13.58AlaGly: 13.58 ± 0.093	2.77AlaHis: 2.77 ± 0.035	3.446AlaIle: 3.446 ± 0.045	2.987AlaLys: 2.987 ± 0.052	14.187AlaLeu: 14.187 ± 0.093	2.521AlaMet: 2.521 ± 0.033	1.763AlaAsn: 1.763 ± 0.033	7.186AlaPro: 7.186 ± 0.07	3.727AlaGln: 3.727 ± 0.045	10.149AlaArg: 10.149 ± 0.103	5.783AlaSer: 5.783 ± 0.056	6.849AlaThr: 6.849 ± 0.065	12.356AlaVal: 12.356 ± 0.088	1.777AlaTrp: 1.777 ± 0.029	2.69AlaTyr: 2.69 ± 0.036	0.002AlaXaa: 0.002 ± 0.001
Cys	1.11CysAla: 1.11 ± 0.023	0.095CysCys: 0.095 ± 0.007	0.436CysAsp: 0.436 ± 0.014	0.403CysGlu: 0.403 ± 0.014	0.206CysPhe: 0.206 ± 0.009	0.98CysGly: 0.98 ± 0.025	0.195CysHis: 0.195 ± 0.011	0.192CysIle: 0.192 ± 0.011	0.12CysLys: 0.12 ± 0.008	0.726CysLeu: 0.726 ± 0.019	0.116CysMet: 0.116 ± 0.008	0.12CysAsn: 0.12 ± 0.008	0.463CysPro: 0.463 ± 0.016	0.143CysGln: 0.143 ± 0.007	0.592CysArg: 0.592 ± 0.019	0.436CysSer: 0.436 ± 0.013	0.523CysThr: 0.523 ± 0.015	0.596CysVal: 0.596 ± 0.018	0.136CysTrp: 0.136 ± 0.007	0.134CysTyr: 0.134 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.008AspAla: 8.008 ± 0.067	0.447AspCys: 0.447 ± 0.015	3.899AspAsp: 3.899 ± 0.05	4.181AspGlu: 4.181 ± 0.042	1.657AspPhe: 1.657 ± 0.027	6.889AspGly: 6.889 ± 0.076	1.389AspHis: 1.389 ± 0.03	1.916AspIle: 1.916 ± 0.033	1.355AspLys: 1.355 ± 0.031	6.107AspLeu: 6.107 ± 0.058	0.81AspMet: 0.81 ± 0.02	0.924AspAsn: 0.924 ± 0.022	4.78AspPro: 4.78 ± 0.055	1.516AspGln: 1.516 ± 0.028	5.258AspArg: 5.258 ± 0.056	2.85AspSer: 2.85 ± 0.032	3.314AspThr: 3.314 ± 0.046	4.614AspVal: 4.614 ± 0.042	1.085AspTrp: 1.085 ± 0.024	1.075AspTyr: 1.075 ± 0.025	0.001AspXaa: 0.001 ± 0.001
Glu	7.43GluAla: 7.43 ± 0.084	0.351GluCys: 0.351 ± 0.013	2.95GluAsp: 2.95 ± 0.043	3.501GluGlu: 3.501 ± 0.053	1.554GluPhe: 1.554 ± 0.027	4.483GluGly: 4.483 ± 0.05	1.552GluHis: 1.552 ± 0.031	2.237GluIle: 2.237 ± 0.034	1.483GluLys: 1.483 ± 0.038	7.205GluLeu: 7.205 ± 0.065	0.873GluMet: 0.873 ± 0.023	1.017GluAsn: 1.017 ± 0.021	3.602GluPro: 3.602 ± 0.05	2.494GluGln: 2.494 ± 0.038	5.641GluArg: 5.641 ± 0.061	2.822GluSer: 2.822 ± 0.034	2.837GluThr: 2.837 ± 0.039	4.63GluVal: 4.63 ± 0.06	0.7GluTrp: 0.7 ± 0.017	1.158GluTyr: 1.158 ± 0.021	0.001GluXaa: 0.001 ± 0.001
Phe	3.737PheAla: 3.737 ± 0.043	0.269PheCys: 0.269 ± 0.011	1.948PheAsp: 1.948 ± 0.032	1.49PheGlu: 1.49 ± 0.027	0.874PhePhe: 0.874 ± 0.023	3.074PheGly: 3.074 ± 0.039	0.6PheHis: 0.6 ± 0.018	0.732PheIle: 0.732 ± 0.02	0.545PheLys: 0.545 ± 0.017	2.592PheLeu: 2.592 ± 0.036	0.4PheMet: 0.4 ± 0.014	0.563PheAsn: 0.563 ± 0.018	1.318PhePro: 1.318 ± 0.027	0.636PheGln: 0.636 ± 0.02	1.848PheArg: 1.848 ± 0.03	1.417PheSer: 1.417 ± 0.027	1.987PheThr: 1.987 ± 0.034	2.225PheVal: 2.225 ± 0.032	0.418PheTrp: 0.418 ± 0.016	0.551PheTyr: 0.551 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.563GlyAla: 11.563 ± 0.086	0.85GlyCys: 0.85 ± 0.019	5.553GlyAsp: 5.553 ± 0.058	5.468GlyGlu: 5.468 ± 0.055	2.899GlyPhe: 2.899 ± 0.038	9.135GlyGly: 9.135 ± 0.098	2.331GlyHis: 2.331 ± 0.035	3.558GlyIle: 3.558 ± 0.047	2.601GlyLys: 2.601 ± 0.046	9.561GlyLeu: 9.561 ± 0.075	1.945GlyMet: 1.945 ± 0.032	1.669GlyAsn: 1.669 ± 0.03	5.372GlyPro: 5.372 ± 0.065	2.573GlyGln: 2.573 ± 0.038	8.13GlyArg: 8.13 ± 0.076	5.749GlySer: 5.749 ± 0.06	6.229GlyThr: 6.229 ± 0.062	7.404GlyVal: 7.404 ± 0.07	1.592GlyTrp: 1.592 ± 0.033	2.194GlyTyr: 2.194 ± 0.038	0.0GlyXaa: 0.0 ± 0.001
His	2.642HisAla: 2.642 ± 0.039	0.225HisCys: 0.225 ± 0.011	1.404HisAsp: 1.404 ± 0.025	1.235HisGlu: 1.235 ± 0.024	0.669HisPhe: 0.669 ± 0.017	2.442HisGly: 2.442 ± 0.037	0.66HisHis: 0.66 ± 0.024	0.717HisIle: 0.717 ± 0.02	0.355HisLys: 0.355 ± 0.014	2.353HisLeu: 2.353 ± 0.038	0.299HisMet: 0.299 ± 0.011	0.364HisAsn: 0.364 ± 0.015	1.83HisPro: 1.83 ± 0.03	0.629HisGln: 0.629 ± 0.018	2.185HisArg: 2.185 ± 0.033	1.023HisSer: 1.023 ± 0.025	1.402HisThr: 1.402 ± 0.027	1.589HisVal: 1.589 ± 0.027	0.384HisTrp: 0.384 ± 0.012	0.473HisTyr: 0.473 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.891IleAla: 4.891 ± 0.062	0.294IleCys: 0.294 ± 0.011	2.292IleAsp: 2.292 ± 0.033	2.061IleGlu: 2.061 ± 0.038	0.723IlePhe: 0.723 ± 0.022	3.735IleGly: 3.735 ± 0.045	0.646IleHis: 0.646 ± 0.017	0.824IleIle: 0.824 ± 0.021	0.778IleLys: 0.778 ± 0.021	2.426IleLeu: 2.426 ± 0.042	0.436IleMet: 0.436 ± 0.016	0.693IleAsn: 0.693 ± 0.018	1.734IlePro: 1.734 ± 0.035	0.69IleGln: 0.69 ± 0.02	2.202IleArg: 2.202 ± 0.036	1.685IleSer: 1.685 ± 0.029	2.148IleThr: 2.148 ± 0.035	2.748IleVal: 2.748 ± 0.045	0.383IleTrp: 0.383 ± 0.013	0.529IleTyr: 0.529 ± 0.017	0.001IleXaa: 0.001 ± 0.001
Lys	2.964LysAla: 2.964 ± 0.053	0.118LysCys: 0.118 ± 0.009	1.51LysAsp: 1.51 ± 0.033	1.236LysGlu: 1.236 ± 0.027	0.489LysPhe: 0.489 ± 0.017	1.933LysGly: 1.933 ± 0.034	0.464LysHis: 0.464 ± 0.016	0.804LysIle: 0.804 ± 0.022	1.009LysLys: 1.009 ± 0.037	2.056LysLeu: 2.056 ± 0.037	0.378LysMet: 0.378 ± 0.014	0.522LysAsn: 0.522 ± 0.02	1.419LysPro: 1.419 ± 0.033	0.761LysGln: 0.761 ± 0.02	1.458LysArg: 1.458 ± 0.031	1.276LysSer: 1.276 ± 0.031	1.228LysThr: 1.228 ± 0.029	1.874LysVal: 1.874 ± 0.037	0.272LysTrp: 0.272 ± 0.012	0.491LysTyr: 0.491 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.95LeuAla: 14.95 ± 0.105	0.821LeuCys: 0.821 ± 0.021	6.924LeuAsp: 6.924 ± 0.063	4.699LeuGlu: 4.699 ± 0.053	2.663LeuPhe: 2.663 ± 0.044	9.388LeuGly: 9.388 ± 0.08	2.347LeuHis: 2.347 ± 0.036	3.425LeuIle: 3.425 ± 0.047	1.978LeuLys: 1.978 ± 0.032	11.403LeuLeu: 11.403 ± 0.107	1.612LeuMet: 1.612 ± 0.03	1.591LeuAsn: 1.591 ± 0.023	6.345LeuPro: 6.345 ± 0.058	2.353LeuGln: 2.353 ± 0.035	8.36LeuArg: 8.36 ± 0.073	5.144LeuSer: 5.144 ± 0.049	6.812LeuThr: 6.812 ± 0.058	8.733LeuVal: 8.733 ± 0.076	1.264LeuTrp: 1.264 ± 0.026	1.796LeuTyr: 1.796 ± 0.028	0.001LeuXaa: 0.001 ± 0.001
Met	2.227MetAla: 2.227 ± 0.034	0.126MetCys: 0.126 ± 0.008	0.855MetAsp: 0.855 ± 0.022	0.705MetGlu: 0.705 ± 0.019	0.469MetPhe: 0.469 ± 0.016	1.345MetGly: 1.345 ± 0.025	0.364MetHis: 0.364 ± 0.016	0.645MetIle: 0.645 ± 0.018	0.421MetLys: 0.421 ± 0.014	1.672MetLeu: 1.672 ± 0.03	0.301MetMet: 0.301 ± 0.013	0.418MetAsn: 0.418 ± 0.012	1.11MetPro: 1.11 ± 0.024	0.492MetGln: 0.492 ± 0.015	1.376MetArg: 1.376 ± 0.025	1.317MetSer: 1.317 ± 0.024	1.5MetThr: 1.5 ± 0.027	1.259MetVal: 1.259 ± 0.029	0.205MetTrp: 0.205 ± 0.01	0.324MetTyr: 0.324 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.0AsnAla: 2.0 ± 0.031	0.164AsnCys: 0.164 ± 0.008	0.939AsnAsp: 0.939 ± 0.022	0.774AsnGlu: 0.774 ± 0.022	0.476AsnPhe: 0.476 ± 0.015	1.726AsnGly: 1.726 ± 0.032	0.373AsnHis: 0.373 ± 0.015	0.631AsnIle: 0.631 ± 0.018	0.406AsnLys: 0.406 ± 0.016	1.535AsnLeu: 1.535 ± 0.03	0.304AsnMet: 0.304 ± 0.013	0.386AsnAsn: 0.386 ± 0.015	1.297AsnPro: 1.297 ± 0.029	0.468AsnGln: 0.468 ± 0.013	1.193AsnArg: 1.193 ± 0.027	0.956AsnSer: 0.956 ± 0.02	1.038AsnThr: 1.038 ± 0.024	1.298AsnVal: 1.298 ± 0.026	0.276AsnTrp: 0.276 ± 0.012	0.381AsnTyr: 0.381 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.627ProAla: 8.627 ± 0.079	0.322ProCys: 0.322 ± 0.013	4.886ProAsp: 4.886 ± 0.065	4.557ProGlu: 4.557 ± 0.045	1.527ProPhe: 1.527 ± 0.023	6.651ProGly: 6.651 ± 0.069	1.44ProHis: 1.44 ± 0.031	1.256ProIle: 1.256 ± 0.024	1.26ProLys: 1.26 ± 0.03	5.216ProLeu: 5.216 ± 0.059	0.974ProMet: 0.974 ± 0.023	0.872ProAsn: 0.872 ± 0.023	3.554ProPro: 3.554 ± 0.056	1.76ProGln: 1.76 ± 0.032	3.926ProArg: 3.926 ± 0.049	3.221ProSer: 3.221 ± 0.041	3.137ProThr: 3.137 ± 0.044	5.414ProVal: 5.414 ± 0.052	0.87ProTrp: 0.87 ± 0.021	1.475ProTyr: 1.475 ± 0.027	0.002ProXaa: 0.002 ± 0.001
Gln	3.561GlnAla: 3.561 ± 0.045	0.165GlnCys: 0.165 ± 0.01	1.526GlnAsp: 1.526 ± 0.029	1.518GlnGlu: 1.518 ± 0.027	0.685GlnPhe: 0.685 ± 0.019	2.377GlnGly: 2.377 ± 0.032	0.701GlnHis: 0.701 ± 0.017	1.068GlnIle: 1.068 ± 0.027	0.596GlnLys: 0.596 ± 0.019	3.199GlnLeu: 3.199 ± 0.042	0.482GlnMet: 0.482 ± 0.016	0.484GlnAsn: 0.484 ± 0.017	1.653GlnPro: 1.653 ± 0.032	1.294GlnGln: 1.294 ± 0.033	2.364GlnArg: 2.364 ± 0.034	1.399GlnSer: 1.399 ± 0.026	1.235GlnThr: 1.235 ± 0.027	2.327GlnVal: 2.327 ± 0.036	0.441GlnTrp: 0.441 ± 0.014	0.589GlnTyr: 0.589 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.8ArgAla: 9.8 ± 0.098	0.578ArgCys: 0.578 ± 0.02	4.388ArgAsp: 4.388 ± 0.069	4.71ArgGlu: 4.71 ± 0.055	2.274ArgPhe: 2.274 ± 0.032	5.96ArgGly: 5.96 ± 0.063	2.119ArgHis: 2.119 ± 0.029	3.587ArgIle: 3.587 ± 0.046	1.679ArgLys: 1.679 ± 0.031	8.637ArgLeu: 8.637 ± 0.073	1.705ArgMet: 1.705 ± 0.03	1.281ArgAsn: 1.281 ± 0.023	4.975ArgPro: 4.975 ± 0.054	2.251ArgGln: 2.251 ± 0.032	7.898ArgArg: 7.898 ± 0.086	4.343ArgSer: 4.343 ± 0.046	5.663ArgThr: 5.663 ± 0.059	5.638ArgVal: 5.638 ± 0.059	1.306ArgTrp: 1.306 ± 0.027	1.691ArgTyr: 1.691 ± 0.033	0.002ArgXaa: 0.002 ± 0.001
Ser	6.839SerAla: 6.839 ± 0.059	0.397SerCys: 0.397 ± 0.014	2.859SerAsp: 2.859 ± 0.037	2.553SerGlu: 2.553 ± 0.034	1.536SerPhe: 1.536 ± 0.025	6.249SerGly: 6.249 ± 0.063	0.999SerHis: 0.999 ± 0.019	1.481SerIle: 1.481 ± 0.029	1.128SerLys: 1.128 ± 0.03	4.856SerLeu: 4.856 ± 0.048	1.111SerMet: 1.111 ± 0.025	0.818SerAsn: 0.818 ± 0.021	3.215SerPro: 3.215 ± 0.04	1.186SerGln: 1.186 ± 0.028	3.756SerArg: 3.756 ± 0.039	2.854SerSer: 2.854 ± 0.048	3.093SerThr: 3.093 ± 0.048	4.267SerVal: 4.267 ± 0.046	0.909SerTrp: 0.909 ± 0.021	1.231SerTyr: 1.231 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.746ThrAla: 8.746 ± 0.066	0.407ThrCys: 0.407 ± 0.013	3.767ThrAsp: 3.767 ± 0.049	3.539ThrGlu: 3.539 ± 0.043	1.606ThrPhe: 1.606 ± 0.028	6.64ThrGly: 6.64 ± 0.063	1.239ThrHis: 1.239 ± 0.029	1.619ThrIle: 1.619 ± 0.032	1.144ThrLys: 1.144 ± 0.026	5.667ThrLeu: 5.667 ± 0.053	0.936ThrMet: 0.936 ± 0.023	0.88ThrAsn: 0.88 ± 0.022	4.014ThrPro: 4.014 ± 0.047	1.251ThrGln: 1.251 ± 0.024	3.97ThrArg: 3.97 ± 0.043	3.076ThrSer: 3.076 ± 0.039	3.648ThrThr: 3.648 ± 0.054	5.952ThrVal: 5.952 ± 0.06	0.826ThrTrp: 0.826 ± 0.022	1.331ThrTyr: 1.331 ± 0.031	0.002ThrXaa: 0.002 ± 0.001
Val	10.572ValAla: 10.572 ± 0.077	0.75ValCys: 0.75 ± 0.016	5.002ValAsp: 5.002 ± 0.052	4.667ValGlu: 4.667 ± 0.054	2.331ValPhe: 2.331 ± 0.038	6.501ValGly: 6.501 ± 0.065	1.961ValHis: 1.961 ± 0.033	2.744ValIle: 2.744 ± 0.043	1.678ValLys: 1.678 ± 0.035	9.471ValLeu: 9.471 ± 0.087	1.389ValMet: 1.389 ± 0.025	1.546ValAsn: 1.546 ± 0.03	5.283ValPro: 5.283 ± 0.056	2.194ValGln: 2.194 ± 0.035	7.109ValArg: 7.109 ± 0.071	4.166ValSer: 4.166 ± 0.045	5.518ValThr: 5.518 ± 0.064	7.884ValVal: 7.884 ± 0.07	1.109ValTrp: 1.109 ± 0.026	1.497ValTyr: 1.497 ± 0.025	0.001ValXaa: 0.001 ± 0.001
Trp	1.575TrpAla: 1.575 ± 0.027	0.157TrpCys: 0.157 ± 0.01	0.831TrpAsp: 0.831 ± 0.021	0.665TrpGlu: 0.665 ± 0.02	0.524TrpPhe: 0.524 ± 0.015	1.035TrpGly: 1.035 ± 0.023	0.35TrpHis: 0.35 ± 0.014	0.554TrpIle: 0.554 ± 0.017	0.354TrpLys: 0.354 ± 0.016	1.712TrpLeu: 1.712 ± 0.034	0.299TrpMet: 0.299 ± 0.012	0.36TrpAsn: 0.36 ± 0.015	0.778TrpPro: 0.778 ± 0.019	0.666TrpGln: 0.666 ± 0.016	1.258TrpArg: 1.258 ± 0.028	0.901TrpSer: 0.901 ± 0.023	0.973TrpThr: 0.973 ± 0.023	0.927TrpVal: 0.927 ± 0.021	0.309TrpTrp: 0.309 ± 0.015	0.369TrpTyr: 0.369 ± 0.015	0.0TrpXaa: 0.0 ± 0.001
Tyr	2.802TyrAla: 2.802 ± 0.036	0.167TyrCys: 0.167 ± 0.009	1.511TyrAsp: 1.511 ± 0.03	1.308TyrGlu: 1.308 ± 0.027	0.657TyrPhe: 0.657 ± 0.017	2.25TyrGly: 2.25 ± 0.037	0.38TyrHis: 0.38 ± 0.014	0.481TyrIle: 0.481 ± 0.019	0.386TyrLys: 0.386 ± 0.015	2.027TyrLeu: 2.027 ± 0.034	0.24TyrMet: 0.24 ± 0.011	0.35TyrAsn: 0.35 ± 0.014	1.015TyrPro: 1.015 ± 0.023	0.58TyrGln: 0.58 ± 0.018	1.812TyrArg: 1.812 ± 0.029	0.92TyrSer: 0.92 ± 0.022	1.123TyrThr: 1.123 ± 0.024	1.637TyrVal: 1.637 ± 0.028	0.334TyrTrp: 0.334 ± 0.012	0.437TyrTyr: 0.437 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6490 proteins (2119865 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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