Amino acid dipepetide frequency for Strongylus vulgaris (Blood worm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.488AlaAla: 6.488 ± 0.054	1.282AlaCys: 1.282 ± 0.021	3.596AlaAsp: 3.596 ± 0.032	4.82AlaGlu: 4.82 ± 0.045	2.869AlaPhe: 2.869 ± 0.029	3.993AlaGly: 3.993 ± 0.043	1.638AlaHis: 1.638 ± 0.02	4.058AlaIle: 4.058 ± 0.033	4.095AlaLys: 4.095 ± 0.042	6.602AlaLeu: 6.602 ± 0.05	1.934AlaMet: 1.934 ± 0.023	2.779AlaAsn: 2.779 ± 0.03	3.6AlaPro: 3.6 ± 0.041	2.729AlaGln: 2.729 ± 0.029	3.88AlaArg: 3.88 ± 0.033	5.143AlaSer: 5.143 ± 0.042	3.96AlaThr: 3.96 ± 0.035	5.257AlaVal: 5.257 ± 0.046	0.677AlaTrp: 0.677 ± 0.013	1.907AlaTyr: 1.907 ± 0.023	0.02AlaXaa: 0.02 ± 0.002
Cys	1.413CysAla: 1.413 ± 0.023	0.584CysCys: 0.584 ± 0.018	1.161CysAsp: 1.161 ± 0.02	1.256CysGlu: 1.256 ± 0.022	0.947CysPhe: 0.947 ± 0.016	1.392CysGly: 1.392 ± 0.019	0.495CysHis: 0.495 ± 0.012	1.197CysIle: 1.197 ± 0.019	0.996CysLys: 0.996 ± 0.017	1.859CysLeu: 1.859 ± 0.024	0.524CysMet: 0.524 ± 0.011	0.825CysAsn: 0.825 ± 0.014	1.211CysPro: 1.211 ± 0.021	0.766CysGln: 0.766 ± 0.018	1.259CysArg: 1.259 ± 0.02	1.743CysSer: 1.743 ± 0.02	1.055CysThr: 1.055 ± 0.018	1.339CysVal: 1.339 ± 0.021	0.227CysTrp: 0.227 ± 0.008	0.634CysTyr: 0.634 ± 0.013	0.005CysXaa: 0.005 ± 0.001
Asp	3.659AspAla: 3.659 ± 0.031	1.03AspCys: 1.03 ± 0.018	3.614AspAsp: 3.614 ± 0.034	4.37AspGlu: 4.37 ± 0.036	2.312AspPhe: 2.312 ± 0.025	3.446AspGly: 3.446 ± 0.036	1.152AspHis: 1.152 ± 0.019	2.964AspIle: 2.964 ± 0.028	2.667AspLys: 2.667 ± 0.03	4.634AspLeu: 4.634 ± 0.034	1.362AspMet: 1.362 ± 0.018	1.903AspAsn: 1.903 ± 0.024	2.473AspPro: 2.473 ± 0.028	1.766AspGln: 1.766 ± 0.026	2.919AspArg: 2.919 ± 0.03	3.764AspSer: 3.764 ± 0.034	2.458AspThr: 2.458 ± 0.027	3.91AspVal: 3.91 ± 0.031	0.666AspTrp: 0.666 ± 0.015	1.829AspTyr: 1.829 ± 0.022	0.008AspXaa: 0.008 ± 0.001
Glu	4.555GluAla: 4.555 ± 0.035	1.2GluCys: 1.2 ± 0.02	3.838GluAsp: 3.838 ± 0.04	6.453GluGlu: 6.453 ± 0.081	2.335GluPhe: 2.335 ± 0.026	3.352GluGly: 3.352 ± 0.036	1.516GluHis: 1.516 ± 0.019	3.534GluIle: 3.534 ± 0.032	5.187GluLys: 5.187 ± 0.05	5.689GluLeu: 5.689 ± 0.047	1.922GluMet: 1.922 ± 0.023	3.077GluAsn: 3.077 ± 0.034	2.574GluPro: 2.574 ± 0.031	2.838GluGln: 2.838 ± 0.035	4.267GluArg: 4.267 ± 0.045	4.057GluSer: 4.057 ± 0.034	3.298GluThr: 3.298 ± 0.033	4.162GluVal: 4.162 ± 0.036	0.786GluTrp: 0.786 ± 0.016	1.773GluTyr: 1.773 ± 0.021	0.012GluXaa: 0.012 ± 0.002
Phe	3.054PheAla: 3.054 ± 0.029	1.064PheCys: 1.064 ± 0.018	2.398PheAsp: 2.398 ± 0.027	2.496PheGlu: 2.496 ± 0.028	2.239PhePhe: 2.239 ± 0.026	2.701PheGly: 2.701 ± 0.032	1.053PheHis: 1.053 ± 0.016	2.442PheIle: 2.442 ± 0.028	1.901PheLys: 1.901 ± 0.025	4.109PheLeu: 4.109 ± 0.038	1.139PheMet: 1.139 ± 0.019	1.601PheAsn: 1.601 ± 0.018	1.903PhePro: 1.903 ± 0.022	1.453PheGln: 1.453 ± 0.021	2.303PheArg: 2.303 ± 0.023	3.425PheSer: 3.425 ± 0.035	2.263PheThr: 2.263 ± 0.029	3.045PheVal: 3.045 ± 0.035	0.532PheTrp: 0.532 ± 0.012	1.52PheTyr: 1.52 ± 0.019	0.011PheXaa: 0.011 ± 0.002
Gly	3.908GlyAla: 3.908 ± 0.039	1.184GlyCys: 1.184 ± 0.02	3.047GlyAsp: 3.047 ± 0.033	3.68GlyGlu: 3.68 ± 0.037	2.52GlyPhe: 2.52 ± 0.029	4.533GlyGly: 4.533 ± 0.081	1.357GlyHis: 1.357 ± 0.021	3.187GlyIle: 3.187 ± 0.031	3.445GlyLys: 3.445 ± 0.035	4.545GlyLeu: 4.545 ± 0.036	1.662GlyMet: 1.662 ± 0.026	2.414GlyAsn: 2.414 ± 0.028	2.725GlyPro: 2.725 ± 0.051	2.105GlyGln: 2.105 ± 0.03	3.475GlyArg: 3.475 ± 0.033	4.388GlySer: 4.388 ± 0.036	3.259GlyThr: 3.259 ± 0.034	3.834GlyVal: 3.834 ± 0.037	0.71GlyTrp: 0.71 ± 0.016	2.009GlyTyr: 2.009 ± 0.023	0.017GlyXaa: 0.017 ± 0.002
His	1.477HisAla: 1.477 ± 0.019	0.561HisCys: 0.561 ± 0.014	1.159HisAsp: 1.159 ± 0.016	1.343HisGlu: 1.343 ± 0.02	1.157HisPhe: 1.157 ± 0.018	1.382HisGly: 1.382 ± 0.021	0.738HisHis: 0.738 ± 0.016	1.372HisIle: 1.372 ± 0.017	1.111HisLys: 1.111 ± 0.019	2.389HisLeu: 2.389 ± 0.028	0.677HisMet: 0.677 ± 0.015	0.895HisAsn: 0.895 ± 0.014	1.324HisPro: 1.324 ± 0.021	0.887HisGln: 0.887 ± 0.016	1.478HisArg: 1.478 ± 0.019	1.807HisSer: 1.807 ± 0.025	1.163HisThr: 1.163 ± 0.017	1.549HisVal: 1.549 ± 0.02	0.301HisTrp: 0.301 ± 0.01	0.865HisTyr: 0.865 ± 0.015	0.005HisXaa: 0.005 ± 0.001
Ile	4.251IleAla: 4.251 ± 0.04	1.32IleCys: 1.32 ± 0.017	3.128IleAsp: 3.128 ± 0.028	3.45IleGlu: 3.45 ± 0.03	2.522IlePhe: 2.522 ± 0.026	3.246IleGly: 3.246 ± 0.032	1.316IleHis: 1.316 ± 0.021	3.079IleIle: 3.079 ± 0.03	2.654IleLys: 2.654 ± 0.028	5.027IleLeu: 5.027 ± 0.038	1.382IleMet: 1.382 ± 0.021	2.134IleAsn: 2.134 ± 0.024	2.906IlePro: 2.906 ± 0.03	1.982IleGln: 1.982 ± 0.023	3.285IleArg: 3.285 ± 0.032	4.327IleSer: 4.327 ± 0.034	3.16IleThr: 3.16 ± 0.031	3.89IleVal: 3.89 ± 0.035	0.631IleTrp: 0.631 ± 0.016	1.803IleTyr: 1.803 ± 0.023	0.014IleXaa: 0.014 ± 0.002
Lys	3.846LysAla: 3.846 ± 0.036	1.095LysCys: 1.095 ± 0.017	2.977LysAsp: 2.977 ± 0.029	4.627LysGlu: 4.627 ± 0.054	2.094LysPhe: 2.094 ± 0.025	2.817LysGly: 2.817 ± 0.031	1.281LysHis: 1.281 ± 0.019	3.11LysIle: 3.11 ± 0.032	4.731LysLys: 4.731 ± 0.055	4.953LysLeu: 4.953 ± 0.044	1.755LysMet: 1.755 ± 0.023	2.485LysAsn: 2.485 ± 0.028	2.573LysPro: 2.573 ± 0.035	2.205LysGln: 2.205 ± 0.027	3.655LysArg: 3.655 ± 0.038	3.799LysSer: 3.799 ± 0.038	3.083LysThr: 3.083 ± 0.03	3.676LysVal: 3.676 ± 0.027	0.677LysTrp: 0.677 ± 0.013	1.775LysTyr: 1.775 ± 0.021	0.011LysXaa: 0.011 ± 0.002
Leu	6.607LeuAla: 6.607 ± 0.043	1.965LeuCys: 1.965 ± 0.026	4.617LeuAsp: 4.617 ± 0.037	5.601LeuGlu: 5.601 ± 0.044	4.122LeuPhe: 4.122 ± 0.038	4.54LeuGly: 4.54 ± 0.033	2.347LeuHis: 2.347 ± 0.026	4.95LeuIle: 4.95 ± 0.038	5.164LeuLys: 5.164 ± 0.036	9.29LeuLeu: 9.29 ± 0.066	2.463LeuMet: 2.463 ± 0.023	3.739LeuAsn: 3.739 ± 0.031	4.853LeuPro: 4.853 ± 0.043	3.727LeuGln: 3.727 ± 0.033	5.744LeuArg: 5.744 ± 0.042	7.234LeuSer: 7.234 ± 0.052	4.817LeuThr: 4.817 ± 0.039	5.648LeuVal: 5.648 ± 0.044	0.986LeuTrp: 0.986 ± 0.017	2.622LeuTyr: 2.622 ± 0.03	0.023LeuXaa: 0.023 ± 0.003
Met	2.0MetAla: 2.0 ± 0.024	0.544MetCys: 0.544 ± 0.013	1.53MetAsp: 1.53 ± 0.021	1.845MetGlu: 1.845 ± 0.022	1.163MetPhe: 1.163 ± 0.018	1.484MetGly: 1.484 ± 0.023	0.627MetHis: 0.627 ± 0.012	1.453MetIle: 1.453 ± 0.022	1.632MetLys: 1.632 ± 0.024	2.542MetLeu: 2.542 ± 0.034	0.804MetMet: 0.804 ± 0.018	1.192MetAsn: 1.192 ± 0.021	1.31MetPro: 1.31 ± 0.019	1.093MetGln: 1.093 ± 0.016	1.708MetArg: 1.708 ± 0.022	2.09MetSer: 2.09 ± 0.025	1.505MetThr: 1.505 ± 0.02	1.684MetVal: 1.684 ± 0.022	0.308MetTrp: 0.308 ± 0.009	0.753MetTyr: 0.753 ± 0.016	0.004MetXaa: 0.004 ± 0.001
Asn	2.922AsnAla: 2.922 ± 0.03	0.868AsnCys: 0.868 ± 0.017	2.165AsnAsp: 2.165 ± 0.023	2.717AsnGlu: 2.717 ± 0.028	1.822AsnPhe: 1.822 ± 0.022	2.854AsnGly: 2.854 ± 0.03	0.883AsnHis: 0.883 ± 0.016	2.451AsnIle: 2.451 ± 0.026	2.075AsnLys: 2.075 ± 0.024	3.602AsnLeu: 3.602 ± 0.031	1.066AsnMet: 1.066 ± 0.016	1.761AsnAsn: 1.761 ± 0.026	2.073AsnPro: 2.073 ± 0.022	1.392AsnGln: 1.392 ± 0.021	2.251AsnArg: 2.251 ± 0.029	2.975AsnSer: 2.975 ± 0.03	2.1AsnThr: 2.1 ± 0.027	2.958AsnVal: 2.958 ± 0.031	0.447AsnTrp: 0.447 ± 0.012	1.402AsnTyr: 1.402 ± 0.019	0.009AsnXaa: 0.009 ± 0.002
Pro	3.562ProAla: 3.562 ± 0.04	0.851ProCys: 0.851 ± 0.016	2.412ProAsp: 2.412 ± 0.025	3.109ProGlu: 3.109 ± 0.035	1.981ProPhe: 1.981 ± 0.024	3.325ProGly: 3.325 ± 0.069	1.158ProHis: 1.158 ± 0.018	2.666ProIle: 2.666 ± 0.031	2.648ProLys: 2.648 ± 0.037	4.351ProLeu: 4.351 ± 0.041	1.183ProMet: 1.183 ± 0.017	2.015ProAsn: 2.015 ± 0.024	4.443ProPro: 4.443 ± 0.076	2.061ProGln: 2.061 ± 0.03	2.658ProArg: 2.658 ± 0.031	4.527ProSer: 4.527 ± 0.041	3.087ProThr: 3.087 ± 0.03	3.338ProVal: 3.338 ± 0.036	0.499ProTrp: 0.499 ± 0.013	1.497ProTyr: 1.497 ± 0.021	0.016ProXaa: 0.016 ± 0.002
Gln	2.506GlnAla: 2.506 ± 0.027	0.871GlnCys: 0.871 ± 0.016	1.453GlnAsp: 1.453 ± 0.019	2.279GlnGlu: 2.279 ± 0.027	1.56GlnPhe: 1.56 ± 0.02	1.803GlnGly: 1.803 ± 0.027	0.97GlnHis: 0.97 ± 0.016	2.159GlnIle: 2.159 ± 0.025	2.381GlnLys: 2.381 ± 0.028	4.045GlnLeu: 4.045 ± 0.037	1.245GlnMet: 1.245 ± 0.02	1.595GlnAsn: 1.595 ± 0.023	2.071GlnPro: 2.071 ± 0.03	2.293GlnGln: 2.293 ± 0.048	2.456GlnArg: 2.456 ± 0.03	2.591GlnSer: 2.591 ± 0.032	1.955GlnThr: 1.955 ± 0.022	2.438GlnVal: 2.438 ± 0.024	0.502GlnTrp: 0.502 ± 0.011	1.212GlnTyr: 1.212 ± 0.021	0.007GlnXaa: 0.007 ± 0.001
Arg	3.719ArgAla: 3.719 ± 0.036	1.222ArgCys: 1.222 ± 0.019	2.981ArgAsp: 2.981 ± 0.032	3.833ArgGlu: 3.833 ± 0.04	2.49ArgPhe: 2.49 ± 0.031	3.105ArgGly: 3.105 ± 0.036	1.464ArgHis: 1.464 ± 0.022	3.39ArgIle: 3.39 ± 0.029	3.94ArgLys: 3.94 ± 0.04	5.571ArgLeu: 5.571 ± 0.04	1.769ArgMet: 1.769 ± 0.025	2.637ArgAsn: 2.637 ± 0.03	2.791ArgPro: 2.791 ± 0.031	2.399ArgGln: 2.399 ± 0.025	4.704ArgArg: 4.704 ± 0.048	4.312ArgSer: 4.312 ± 0.039	3.152ArgThr: 3.152 ± 0.029	3.513ArgVal: 3.513 ± 0.036	0.718ArgTrp: 0.718 ± 0.016	1.838ArgTyr: 1.838 ± 0.023	0.012ArgXaa: 0.012 ± 0.002
Ser	5.513SerAla: 5.513 ± 0.042	1.596SerCys: 1.596 ± 0.021	4.023SerAsp: 4.023 ± 0.035	4.496SerGlu: 4.496 ± 0.041	3.349SerPhe: 3.349 ± 0.031	4.492SerGly: 4.492 ± 0.03	1.743SerHis: 1.743 ± 0.025	4.113SerIle: 4.113 ± 0.034	3.931SerLys: 3.931 ± 0.033	6.956SerLeu: 6.956 ± 0.054	1.954SerMet: 1.954 ± 0.02	3.008SerAsn: 3.008 ± 0.029	4.042SerPro: 4.042 ± 0.045	2.761SerGln: 2.761 ± 0.028	4.319SerArg: 4.319 ± 0.036	7.584SerSer: 7.584 ± 0.076	4.809SerThr: 4.809 ± 0.042	4.852SerVal: 4.852 ± 0.041	0.841SerTrp: 0.841 ± 0.014	2.258SerTyr: 2.258 ± 0.028	0.019SerXaa: 0.019 ± 0.002
Thr	4.232ThrAla: 4.232 ± 0.038	1.136ThrCys: 1.136 ± 0.02	2.641ThrAsp: 2.641 ± 0.026	3.178ThrGlu: 3.178 ± 0.03	2.309ThrPhe: 2.309 ± 0.022	3.09ThrGly: 3.09 ± 0.028	1.175ThrHis: 1.175 ± 0.017	3.201ThrIle: 3.201 ± 0.034	2.838ThrLys: 2.838 ± 0.029	4.895ThrLeu: 4.895 ± 0.036	1.432ThrMet: 1.432 ± 0.022	2.151ThrAsn: 2.151 ± 0.024	3.212ThrPro: 3.212 ± 0.035	1.851ThrGln: 1.851 ± 0.029	2.742ThrArg: 2.742 ± 0.028	4.686ThrSer: 4.686 ± 0.038	3.941ThrThr: 3.941 ± 0.057	4.118ThrVal: 4.118 ± 0.035	0.597ThrTrp: 0.597 ± 0.015	1.613ThrTyr: 1.613 ± 0.022	0.014ThrXaa: 0.014 ± 0.002
Val	4.858ValAla: 4.858 ± 0.041	1.534ValCys: 1.534 ± 0.023	3.846ValAsp: 3.846 ± 0.04	4.384ValGlu: 4.384 ± 0.039	2.866ValPhe: 2.866 ± 0.029	3.777ValGly: 3.777 ± 0.039	1.628ValHis: 1.628 ± 0.021	3.789ValIle: 3.789 ± 0.036	3.518ValLys: 3.518 ± 0.036	6.048ValLeu: 6.048 ± 0.047	1.744ValMet: 1.744 ± 0.021	2.703ValAsn: 2.703 ± 0.028	3.388ValPro: 3.388 ± 0.034	2.472ValGln: 2.472 ± 0.023	3.795ValArg: 3.795 ± 0.035	5.094ValSer: 5.094 ± 0.038	3.704ValThr: 3.704 ± 0.035	5.206ValVal: 5.206 ± 0.075	0.7ValTrp: 0.7 ± 0.012	1.969ValTyr: 1.969 ± 0.021	0.02ValXaa: 0.02 ± 0.003
Trp	0.706TrpAla: 0.706 ± 0.013	0.216TrpCys: 0.216 ± 0.008	0.569TrpAsp: 0.569 ± 0.014	0.622TrpGlu: 0.622 ± 0.013	0.488TrpPhe: 0.488 ± 0.011	0.557TrpGly: 0.557 ± 0.014	0.26TrpHis: 0.26 ± 0.008	0.732TrpIle: 0.732 ± 0.015	0.757TrpLys: 0.757 ± 0.014	1.124TrpLeu: 1.124 ± 0.017	0.406TrpMet: 0.406 ± 0.011	0.571TrpAsn: 0.571 ± 0.014	0.463TrpPro: 0.463 ± 0.011	0.456TrpGln: 0.456 ± 0.012	0.766TrpArg: 0.766 ± 0.014	0.843TrpSer: 0.843 ± 0.016	0.676TrpThr: 0.676 ± 0.014	0.631TrpVal: 0.631 ± 0.013	0.192TrpTrp: 0.192 ± 0.007	0.353TrpTyr: 0.353 ± 0.009	0.004TrpXaa: 0.004 ± 0.001
Tyr	2.038TyrAla: 2.038 ± 0.025	0.759TyrCys: 0.759 ± 0.016	1.741TyrAsp: 1.741 ± 0.02	1.853TyrGlu: 1.853 ± 0.022	1.492TyrPhe: 1.492 ± 0.022	2.103TyrGly: 2.103 ± 0.028	0.83TyrHis: 0.83 ± 0.015	1.648TyrIle: 1.648 ± 0.023	1.542TyrLys: 1.542 ± 0.021	2.801TyrLeu: 2.801 ± 0.028	0.84TyrMet: 0.84 ± 0.015	1.297TyrAsn: 1.297 ± 0.021	1.436TyrPro: 1.436 ± 0.02	1.146TyrGln: 1.146 ± 0.02	1.884TyrArg: 1.884 ± 0.023	2.25TyrSer: 2.25 ± 0.026	1.595TyrThr: 1.595 ± 0.02	1.983TyrVal: 1.983 ± 0.023	0.393TyrTrp: 0.393 ± 0.011	1.174TyrTyr: 1.174 ± 0.021	0.007TyrXaa: 0.007 ± 0.001
Xaa	0.014XaaAla: 0.014 ± 0.002	0.005XaaCys: 0.005 ± 0.001	0.01XaaAsp: 0.01 ± 0.002	0.011XaaGlu: 0.011 ± 0.002	0.013XaaPhe: 0.013 ± 0.001	0.013XaaGly: 0.013 ± 0.002	0.008XaaHis: 0.008 ± 0.002	0.01XaaIle: 0.01 ± 0.002	0.012XaaLys: 0.012 ± 0.002	0.026XaaLeu: 0.026 ± 0.003	0.009XaaMet: 0.009 ± 0.002	0.014XaaAsn: 0.014 ± 0.002	0.012XaaPro: 0.012 ± 0.002	0.01XaaGln: 0.01 ± 0.002	0.015XaaArg: 0.015 ± 0.002	0.021XaaSer: 0.021 ± 0.003	0.014XaaThr: 0.014 ± 0.002	0.012XaaVal: 0.012 ± 0.002	0.003XaaTrp: 0.003 ± 0.001	0.005XaaTyr: 0.005 ± 0.001	1.771XaaXaa: 1.771 ± 0.127

Statistics based on 20844 proteins (3866246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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