Amino acid dipepetide frequency for Paramecium bursaria Chlorella virus FR483 (PBCV-FR483)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.006AlaAla: 5.006 ± 0.262
1.013AlaCys: 1.013 ± 0.093
3.271AlaAsp: 3.271 ± 0.194
2.682AlaGlu: 2.682 ± 0.144
3.066AlaPhe: 3.066 ± 0.151
4.946AlaGly: 4.946 ± 0.588
1.45AlaHis: 1.45 ± 0.11
4.317AlaIle: 4.317 ± 0.17
3.873AlaLys: 3.873 ± 0.258
5.721AlaLeu: 5.721 ± 0.285
2.046AlaMet: 2.046 ± 0.137
3.602AlaAsn: 3.602 ± 0.397
4.317AlaPro: 4.317 ± 0.445
1.88AlaGln: 1.88 ± 0.111
3.516AlaArg: 3.516 ± 0.179
5.701AlaSer: 5.701 ± 0.28
3.754AlaThr: 3.754 ± 0.202
3.946AlaVal: 3.946 ± 0.158
0.788AlaTrp: 0.788 ± 0.083
2.072AlaTyr: 2.072 ± 0.155
0.0AlaXaa: 0.0 ± 0.0
Cys
1.132CysAla: 1.132 ± 0.094
0.622CysCys: 0.622 ± 0.08
0.788CysAsp: 0.788 ± 0.077
0.589CysGlu: 0.589 ± 0.072
1.139CysPhe: 1.139 ± 0.101
1.331CysGly: 1.331 ± 0.114
0.662CysHis: 0.662 ± 0.078
1.41CysIle: 1.41 ± 0.111
1.006CysLys: 1.006 ± 0.106
1.927CysLeu: 1.927 ± 0.138
0.583CysMet: 0.583 ± 0.064
0.755CysAsn: 0.755 ± 0.071
1.218CysPro: 1.218 ± 0.121
0.689CysGln: 0.689 ± 0.071
1.192CysArg: 1.192 ± 0.1
1.735CysSer: 1.735 ± 0.12
1.0CysThr: 1.0 ± 0.082
1.318CysVal: 1.318 ± 0.115
0.384CysTrp: 0.384 ± 0.053
0.463CysTyr: 0.463 ± 0.053
0.0CysXaa: 0.0 ± 0.0
Asp
3.291AspAla: 3.291 ± 0.144
0.669AspCys: 0.669 ± 0.07
2.98AspAsp: 2.98 ± 0.225
2.45AspGlu: 2.45 ± 0.162
2.225AspPhe: 2.225 ± 0.152
3.231AspGly: 3.231 ± 0.215
0.761AspHis: 0.761 ± 0.08
4.092AspIle: 4.092 ± 0.196
2.41AspLys: 2.41 ± 0.149
3.489AspLeu: 3.489 ± 0.217
1.318AspMet: 1.318 ± 0.094
2.351AspAsn: 2.351 ± 0.141
2.086AspPro: 2.086 ± 0.142
0.808AspGln: 0.808 ± 0.068
1.933AspArg: 1.933 ± 0.119
2.668AspSer: 2.668 ± 0.155
3.317AspThr: 3.317 ± 0.163
3.873AspVal: 3.873 ± 0.181
0.556AspTrp: 0.556 ± 0.055
1.404AspTyr: 1.404 ± 0.111
0.0AspXaa: 0.0 ± 0.0
Glu
2.589GluAla: 2.589 ± 0.155
0.881GluCys: 0.881 ± 0.089
2.576GluAsp: 2.576 ± 0.178
2.847GluGlu: 2.847 ± 0.229
2.053GluPhe: 2.053 ± 0.151
1.847GluGly: 1.847 ± 0.124
1.106GluHis: 1.106 ± 0.111
3.019GluIle: 3.019 ± 0.165
3.225GluLys: 3.225 ± 0.2
3.575GluLeu: 3.575 ± 0.2
1.351GluMet: 1.351 ± 0.094
2.384GluAsn: 2.384 ± 0.145
1.801GluPro: 1.801 ± 0.154
1.278GluGln: 1.278 ± 0.098
2.245GluArg: 2.245 ± 0.136
2.655GluSer: 2.655 ± 0.142
3.172GluThr: 3.172 ± 0.173
2.642GluVal: 2.642 ± 0.172
0.53GluTrp: 0.53 ± 0.072
1.914GluTyr: 1.914 ± 0.155
0.0GluXaa: 0.0 ± 0.0
Phe
3.582PheAla: 3.582 ± 0.189
1.112PheCys: 1.112 ± 0.083
2.132PheAsp: 2.132 ± 0.134
2.218PheGlu: 2.218 ± 0.141
2.814PhePhe: 2.814 ± 0.169
3.317PheGly: 3.317 ± 0.308
1.066PheHis: 1.066 ± 0.084
2.735PheIle: 2.735 ± 0.15
2.159PheLys: 2.159 ± 0.12
5.297PheLeu: 5.297 ± 0.274
1.192PheMet: 1.192 ± 0.119
1.801PheAsn: 1.801 ± 0.122
3.119PhePro: 3.119 ± 0.211
1.51PheGln: 1.51 ± 0.11
1.814PheArg: 1.814 ± 0.133
4.218PheSer: 4.218 ± 0.198
3.112PheThr: 3.112 ± 0.16
3.622PheVal: 3.622 ± 0.161
0.755PheTrp: 0.755 ± 0.085
1.364PheTyr: 1.364 ± 0.091
0.0PheXaa: 0.0 ± 0.0
Gly
4.747GlyAla: 4.747 ± 0.529
1.04GlyCys: 1.04 ± 0.114
2.993GlyAsp: 2.993 ± 0.21
2.205GlyGlu: 2.205 ± 0.132
3.304GlyPhe: 3.304 ± 0.308
4.655GlyGly: 4.655 ± 0.351
1.152GlyHis: 1.152 ± 0.103
4.019GlyIle: 4.019 ± 0.187
4.357GlyLys: 4.357 ± 0.268
4.754GlyLeu: 4.754 ± 0.247
1.794GlyMet: 1.794 ± 0.153
5.502GlyAsn: 5.502 ± 0.939
1.967GlyPro: 1.967 ± 0.181
1.993GlyGln: 1.993 ± 0.189
3.251GlyArg: 3.251 ± 0.232
5.324GlySer: 5.324 ± 0.371
3.993GlyThr: 3.993 ± 0.283
4.834GlyVal: 4.834 ± 0.342
0.722GlyTrp: 0.722 ± 0.067
1.973GlyTyr: 1.973 ± 0.125
0.0GlyXaa: 0.0 ± 0.0
His
1.172HisAla: 1.172 ± 0.093
0.569HisCys: 0.569 ± 0.062
0.927HisAsp: 0.927 ± 0.091
1.006HisGlu: 1.006 ± 0.106
1.086HisPhe: 1.086 ± 0.092
1.51HisGly: 1.51 ± 0.144
0.934HisHis: 0.934 ± 0.101
1.675HisIle: 1.675 ± 0.134
1.278HisLys: 1.278 ± 0.095
2.079HisLeu: 2.079 ± 0.138
0.649HisMet: 0.649 ± 0.07
0.715HisAsn: 0.715 ± 0.073
1.066HisPro: 1.066 ± 0.101
0.834HisGln: 0.834 ± 0.083
1.397HisArg: 1.397 ± 0.118
1.609HisSer: 1.609 ± 0.113
1.304HisThr: 1.304 ± 0.108
1.424HisVal: 1.424 ± 0.116
0.358HisTrp: 0.358 ± 0.053
0.49HisTyr: 0.49 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
4.436IleAla: 4.436 ± 0.215
1.589IleCys: 1.589 ± 0.117
3.165IleAsp: 3.165 ± 0.164
2.503IleGlu: 2.503 ± 0.164
3.205IlePhe: 3.205 ± 0.178
4.39IleGly: 4.39 ± 0.425
1.291IleHis: 1.291 ± 0.108
4.291IleIle: 4.291 ± 0.271
3.337IleLys: 3.337 ± 0.158
5.502IleLeu: 5.502 ± 0.211
1.788IleMet: 1.788 ± 0.169
2.754IleAsn: 2.754 ± 0.153
3.523IlePro: 3.523 ± 0.203
1.867IleGln: 1.867 ± 0.116
3.072IleArg: 3.072 ± 0.13
5.688IleSer: 5.688 ± 0.219
4.257IleThr: 4.257 ± 0.182
4.82IleVal: 4.82 ± 0.206
0.669IleTrp: 0.669 ± 0.067
2.059IleTyr: 2.059 ± 0.132
0.0IleXaa: 0.0 ± 0.0
Lys
3.251LysAla: 3.251 ± 0.217
1.119LysCys: 1.119 ± 0.101
2.715LysAsp: 2.715 ± 0.184
3.258LysGlu: 3.258 ± 0.215
2.49LysPhe: 2.49 ± 0.147
2.549LysGly: 2.549 ± 0.171
1.417LysHis: 1.417 ± 0.098
3.648LysIle: 3.648 ± 0.19
5.575LysLys: 5.575 ± 0.368
4.774LysLeu: 4.774 ± 0.232
2.245LysMet: 2.245 ± 0.14
3.774LysAsn: 3.774 ± 0.206
3.516LysPro: 3.516 ± 0.375
1.914LysGln: 1.914 ± 0.16
2.768LysArg: 2.768 ± 0.164
4.397LysSer: 4.397 ± 0.276
4.032LysThr: 4.032 ± 0.228
3.417LysVal: 3.417 ± 0.238
0.563LysTrp: 0.563 ± 0.067
2.682LysTyr: 2.682 ± 0.177
0.0LysXaa: 0.0 ± 0.0
Leu
5.919LeuAla: 5.919 ± 0.273
1.94LeuCys: 1.94 ± 0.134
3.893LeuAsp: 3.893 ± 0.153
4.277LeuGlu: 4.277 ± 0.208
4.317LeuPhe: 4.317 ± 0.206
5.827LeuGly: 5.827 ± 0.315
2.185LeuHis: 2.185 ± 0.173
4.529LeuIle: 4.529 ± 0.196
4.483LeuLys: 4.483 ± 0.214
8.402LeuLeu: 8.402 ± 0.341
2.483LeuMet: 2.483 ± 0.147
3.635LeuAsn: 3.635 ± 0.205
5.35LeuPro: 5.35 ± 0.362
2.768LeuGln: 2.768 ± 0.15
4.92LeuArg: 4.92 ± 0.228
7.072LeuSer: 7.072 ± 0.262
5.026LeuThr: 5.026 ± 0.238
6.105LeuVal: 6.105 ± 0.276
1.185LeuTrp: 1.185 ± 0.1
2.615LeuTyr: 2.615 ± 0.117
0.0LeuXaa: 0.0 ± 0.0
Met
1.894MetAla: 1.894 ± 0.11
0.596MetCys: 0.596 ± 0.062
1.132MetAsp: 1.132 ± 0.095
1.132MetGlu: 1.132 ± 0.097
1.775MetPhe: 1.775 ± 0.126
1.675MetGly: 1.675 ± 0.21
0.516MetHis: 0.516 ± 0.055
1.635MetIle: 1.635 ± 0.119
1.761MetLys: 1.761 ± 0.122
3.291MetLeu: 3.291 ± 0.279
1.165MetMet: 1.165 ± 0.136
1.45MetAsn: 1.45 ± 0.097
1.582MetPro: 1.582 ± 0.122
0.795MetGln: 0.795 ± 0.084
1.808MetArg: 1.808 ± 0.156
3.019MetSer: 3.019 ± 0.162
2.152MetThr: 2.152 ± 0.157
1.688MetVal: 1.688 ± 0.11
0.411MetTrp: 0.411 ± 0.068
1.238MetTyr: 1.238 ± 0.1
0.0MetXaa: 0.0 ± 0.0
Asn
3.417AsnAla: 3.417 ± 0.205
1.0AsnCys: 1.0 ± 0.098
2.119AsnAsp: 2.119 ± 0.134
1.675AsnGlu: 1.675 ± 0.114
2.377AsnPhe: 2.377 ± 0.15
3.463AsnGly: 3.463 ± 0.247
1.013AsnHis: 1.013 ± 0.078
4.502AsnIle: 4.502 ± 0.412
2.695AsnLys: 2.695 ± 0.15
3.966AsnLeu: 3.966 ± 0.192
1.371AsnMet: 1.371 ± 0.101
2.721AsnAsn: 2.721 ± 0.244
1.907AsnPro: 1.907 ± 0.135
1.304AsnGln: 1.304 ± 0.104
2.079AsnArg: 2.079 ± 0.186
3.476AsnSer: 3.476 ± 0.216
3.993AsnThr: 3.993 ± 0.472
5.873AsnVal: 5.873 ± 0.885
0.463AsnTrp: 0.463 ± 0.07
1.331AsnTyr: 1.331 ± 0.134
0.0AsnXaa: 0.0 ± 0.0
Pro
4.655ProAla: 4.655 ± 0.413
0.828ProCys: 0.828 ± 0.074
2.106ProAsp: 2.106 ± 0.135
2.814ProGlu: 2.814 ± 0.187
1.761ProPhe: 1.761 ± 0.123
3.456ProGly: 3.456 ± 0.255
1.132ProHis: 1.132 ± 0.121
2.463ProIle: 2.463 ± 0.172
3.595ProLys: 3.595 ± 0.368
3.979ProLeu: 3.979 ± 0.225
2.231ProMet: 2.231 ± 0.2
1.953ProAsn: 1.953 ± 0.111
2.788ProPro: 2.788 ± 0.244
1.351ProGln: 1.351 ± 0.104
3.052ProArg: 3.052 ± 0.204
4.403ProSer: 4.403 ± 0.266
3.496ProThr: 3.496 ± 0.282
4.145ProVal: 4.145 ± 0.299
0.609ProTrp: 0.609 ± 0.064
1.192ProTyr: 1.192 ± 0.105
0.0ProXaa: 0.0 ± 0.0
Gln
1.569GlnAla: 1.569 ± 0.116
0.589GlnCys: 0.589 ± 0.07
1.0GlnAsp: 1.0 ± 0.073
1.404GlnGlu: 1.404 ± 0.094
1.132GlnPhe: 1.132 ± 0.087
1.496GlnGly: 1.496 ± 0.117
0.795GlnHis: 0.795 ± 0.083
1.702GlnIle: 1.702 ± 0.106
2.152GlnLys: 2.152 ± 0.188
2.701GlnLeu: 2.701 ± 0.135
1.053GlnMet: 1.053 ± 0.088
1.688GlnAsn: 1.688 ± 0.116
1.172GlnPro: 1.172 ± 0.101
1.331GlnGln: 1.331 ± 0.141
1.947GlnArg: 1.947 ± 0.122
1.94GlnSer: 1.94 ± 0.106
2.0GlnThr: 2.0 ± 0.137
1.887GlnVal: 1.887 ± 0.135
0.411GlnTrp: 0.411 ± 0.047
1.033GlnTyr: 1.033 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
3.172ArgAla: 3.172 ± 0.195
1.126ArgCys: 1.126 ± 0.111
2.258ArgAsp: 2.258 ± 0.146
2.165ArgGlu: 2.165 ± 0.133
1.947ArgPhe: 1.947 ± 0.118
3.331ArgGly: 3.331 ± 0.217
1.463ArgHis: 1.463 ± 0.148
3.112ArgIle: 3.112 ± 0.158
3.443ArgLys: 3.443 ± 0.243
4.251ArgLeu: 4.251 ± 0.203
1.973ArgMet: 1.973 ± 0.154
2.596ArgAsn: 2.596 ± 0.154
2.874ArgPro: 2.874 ± 0.256
1.629ArgGln: 1.629 ± 0.114
3.595ArgArg: 3.595 ± 0.217
4.065ArgSer: 4.065 ± 0.197
3.284ArgThr: 3.284 ± 0.209
3.628ArgVal: 3.628 ± 0.153
0.695ArgTrp: 0.695 ± 0.084
1.516ArgTyr: 1.516 ± 0.093
0.0ArgXaa: 0.0 ± 0.0
Ser
5.529SerAla: 5.529 ± 0.314
1.788SerCys: 1.788 ± 0.117
2.973SerAsp: 2.973 ± 0.151
2.993SerGlu: 2.993 ± 0.153
4.357SerPhe: 4.357 ± 0.181
5.78SerGly: 5.78 ± 0.375
1.49SerHis: 1.49 ± 0.122
5.244SerIle: 5.244 ± 0.219
4.284SerLys: 4.284 ± 0.24
6.919SerLeu: 6.919 ± 0.265
2.523SerMet: 2.523 ± 0.154
3.933SerAsn: 3.933 ± 0.314
4.297SerPro: 4.297 ± 0.285
2.092SerGln: 2.092 ± 0.157
4.913SerArg: 4.913 ± 0.234
8.608SerSer: 8.608 ± 0.437
5.708SerThr: 5.708 ± 0.253
5.191SerVal: 5.191 ± 0.203
1.298SerTrp: 1.298 ± 0.104
2.337SerTyr: 2.337 ± 0.16
0.0SerXaa: 0.0 ± 0.0
Thr
3.82ThrAla: 3.82 ± 0.248
1.265ThrCys: 1.265 ± 0.106
2.49ThrAsp: 2.49 ± 0.134
2.37ThrGlu: 2.37 ± 0.143
3.715ThrPhe: 3.715 ± 0.265
4.827ThrGly: 4.827 ± 0.382
1.218ThrHis: 1.218 ± 0.097
4.125ThrIle: 4.125 ± 0.193
3.834ThrLys: 3.834 ± 0.199
6.032ThrLeu: 6.032 ± 0.336
1.768ThrMet: 1.768 ± 0.12
3.052ThrAsn: 3.052 ± 0.22
4.244ThrPro: 4.244 ± 0.342
1.788ThrGln: 1.788 ± 0.127
3.278ThrArg: 3.278 ± 0.147
6.078ThrSer: 6.078 ± 0.258
4.317ThrThr: 4.317 ± 0.248
4.099ThrVal: 4.099 ± 0.202
0.841ThrTrp: 0.841 ± 0.065
2.053ThrTyr: 2.053 ± 0.12
0.0ThrXaa: 0.0 ± 0.0
Val
4.542ValAla: 4.542 ± 0.201
1.351ValCys: 1.351 ± 0.127
3.827ValAsp: 3.827 ± 0.162
2.986ValGlu: 2.986 ± 0.154
3.741ValPhe: 3.741 ± 0.169
4.502ValGly: 4.502 ± 0.452
1.424ValHis: 1.424 ± 0.112
4.668ValIle: 4.668 ± 0.184
3.94ValLys: 3.94 ± 0.22
6.621ValLeu: 6.621 ± 0.233
2.039ValMet: 2.039 ± 0.115
3.443ValAsn: 3.443 ± 0.206
3.635ValPro: 3.635 ± 0.271
1.841ValGln: 1.841 ± 0.133
3.178ValArg: 3.178 ± 0.166
6.297ValSer: 6.297 ± 0.306
4.264ValThr: 4.264 ± 0.35
5.277ValVal: 5.277 ± 0.222
0.768ValTrp: 0.768 ± 0.086
2.351ValTyr: 2.351 ± 0.137
0.0ValXaa: 0.0 ± 0.0
Trp
0.735TrpAla: 0.735 ± 0.08
0.338TrpCys: 0.338 ± 0.055
0.51TrpAsp: 0.51 ± 0.058
0.583TrpGlu: 0.583 ± 0.078
0.735TrpPhe: 0.735 ± 0.086
0.662TrpGly: 0.662 ± 0.066
0.344TrpHis: 0.344 ± 0.046
0.656TrpIle: 0.656 ± 0.066
0.967TrpLys: 0.967 ± 0.092
0.94TrpLeu: 0.94 ± 0.082
0.351TrpMet: 0.351 ± 0.055
0.788TrpAsn: 0.788 ± 0.085
0.404TrpPro: 0.404 ± 0.056
0.49TrpGln: 0.49 ± 0.054
0.748TrpArg: 0.748 ± 0.084
1.145TrpSer: 1.145 ± 0.095
0.788TrpThr: 0.788 ± 0.075
0.662TrpVal: 0.662 ± 0.065
0.212TrpTrp: 0.212 ± 0.044
0.411TrpTyr: 0.411 ± 0.056
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.509TyrAla: 2.509 ± 0.171
0.51TyrCys: 0.51 ± 0.056
2.059TyrAsp: 2.059 ± 0.144
1.53TyrGlu: 1.53 ± 0.102
1.702TyrPhe: 1.702 ± 0.126
1.781TyrGly: 1.781 ± 0.121
0.662TyrHis: 0.662 ± 0.061
2.364TyrIle: 2.364 ± 0.111
1.728TyrLys: 1.728 ± 0.143
2.708TyrLeu: 2.708 ± 0.14
0.788TyrMet: 0.788 ± 0.075
1.847TyrAsn: 1.847 ± 0.128
1.145TyrPro: 1.145 ± 0.104
0.841TyrGln: 0.841 ± 0.073
1.417TyrArg: 1.417 ± 0.104
2.159TyrSer: 2.159 ± 0.129
2.245TyrThr: 2.245 ± 0.131
2.245TyrVal: 2.245 ± 0.138
0.258TyrTrp: 0.258 ± 0.041
0.927TyrTyr: 0.927 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 848 proteins (151029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski