Amino acid dipepetide frequency for Rubinisphaera italica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.532AlaAla: 7.532 ± 0.088	0.993AlaCys: 0.993 ± 0.026	4.768AlaAsp: 4.768 ± 0.061	6.153AlaGlu: 6.153 ± 0.068	3.018AlaPhe: 3.018 ± 0.05	6.38AlaGly: 6.38 ± 0.119	1.458AlaHis: 1.458 ± 0.029	5.384AlaIle: 5.384 ± 0.053	3.519AlaLys: 3.519 ± 0.058	7.0AlaLeu: 7.0 ± 0.075	2.132AlaMet: 2.132 ± 0.035	3.071AlaAsn: 3.071 ± 0.05	3.069AlaPro: 3.069 ± 0.048	3.044AlaGln: 3.044 ± 0.043	4.203AlaArg: 4.203 ± 0.052	5.088AlaSer: 5.088 ± 0.064	4.518AlaThr: 4.518 ± 0.084	5.45AlaVal: 5.45 ± 0.059	1.131AlaTrp: 1.131 ± 0.029	2.047AlaTyr: 2.047 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.722CysAla: 0.722 ± 0.018	0.298CysCys: 0.298 ± 0.018	0.714CysAsp: 0.714 ± 0.022	0.827CysGlu: 0.827 ± 0.026	0.496CysPhe: 0.496 ± 0.017	1.033CysGly: 1.033 ± 0.027	0.533CysHis: 0.533 ± 0.021	0.561CysIle: 0.561 ± 0.018	0.419CysLys: 0.419 ± 0.015	1.3CysLeu: 1.3 ± 0.028	0.245CysMet: 0.245 ± 0.012	0.391CysAsn: 0.391 ± 0.014	0.625CysPro: 0.625 ± 0.022	0.531CysGln: 0.531 ± 0.02	0.74CysArg: 0.74 ± 0.02	0.799CysSer: 0.799 ± 0.021	0.572CysThr: 0.572 ± 0.02	0.762CysVal: 0.762 ± 0.02	0.206CysTrp: 0.206 ± 0.01	0.399CysTyr: 0.399 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.388AspAla: 4.388 ± 0.056	0.64AspCys: 0.64 ± 0.023	3.482AspAsp: 3.482 ± 0.061	4.097AspGlu: 4.097 ± 0.045	2.471AspPhe: 2.471 ± 0.037	4.262AspGly: 4.262 ± 0.057	1.567AspHis: 1.567 ± 0.032	2.794AspIle: 2.794 ± 0.049	2.101AspLys: 2.101 ± 0.035	5.97AspLeu: 5.97 ± 0.064	1.056AspMet: 1.056 ± 0.024	1.869AspAsn: 1.869 ± 0.037	3.188AspPro: 3.188 ± 0.049	2.904AspGln: 2.904 ± 0.037	3.575AspArg: 3.575 ± 0.047	3.603AspSer: 3.603 ± 0.05	2.308AspThr: 2.308 ± 0.046	3.851AspVal: 3.851 ± 0.065	1.05AspTrp: 1.05 ± 0.027	1.894AspTyr: 1.894 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.354GluAla: 5.354 ± 0.066	0.615GluCys: 0.615 ± 0.021	3.226GluAsp: 3.226 ± 0.046	4.745GluGlu: 4.745 ± 0.057	2.978GluPhe: 2.978 ± 0.038	3.757GluGly: 3.757 ± 0.044	1.436GluHis: 1.436 ± 0.032	4.566GluIle: 4.566 ± 0.059	3.787GluLys: 3.787 ± 0.063	7.417GluLeu: 7.417 ± 0.073	1.911GluMet: 1.911 ± 0.035	3.041GluAsn: 3.041 ± 0.049	2.727GluPro: 2.727 ± 0.043	3.569GluGln: 3.569 ± 0.053	3.744GluArg: 3.744 ± 0.044	4.659GluSer: 4.659 ± 0.049	4.146GluThr: 4.146 ± 0.056	4.266GluVal: 4.266 ± 0.054	0.949GluTrp: 0.949 ± 0.023	1.85GluTyr: 1.85 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.412PheAla: 3.412 ± 0.049	0.596PheCys: 0.596 ± 0.02	2.742PheAsp: 2.742 ± 0.045	2.638PheGlu: 2.638 ± 0.043	1.506PhePhe: 1.506 ± 0.032	3.119PheGly: 3.119 ± 0.046	0.928PheHis: 0.928 ± 0.022	1.93PheIle: 1.93 ± 0.036	1.299PheLys: 1.299 ± 0.027	3.964PheLeu: 3.964 ± 0.058	0.791PheMet: 0.791 ± 0.023	1.517PheAsn: 1.517 ± 0.034	1.848PhePro: 1.848 ± 0.032	1.762PheGln: 1.762 ± 0.033	2.41PheArg: 2.41 ± 0.039	2.754PheSer: 2.754 ± 0.042	2.087PheThr: 2.087 ± 0.033	2.807PheVal: 2.807 ± 0.035	0.612PheTrp: 0.612 ± 0.02	1.067PheTyr: 1.067 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	4.549GlyAla: 4.549 ± 0.095	1.023GlyCys: 1.023 ± 0.028	3.878GlyAsp: 3.878 ± 0.072	4.533GlyGlu: 4.533 ± 0.046	3.041GlyPhe: 3.041 ± 0.043	5.373GlyGly: 5.373 ± 0.108	1.634GlyHis: 1.634 ± 0.039	4.399GlyIle: 4.399 ± 0.06	3.742GlyLys: 3.742 ± 0.057	6.646GlyLeu: 6.646 ± 0.068	1.896GlyMet: 1.896 ± 0.037	2.871GlyAsn: 2.871 ± 0.056	2.652GlyPro: 2.652 ± 0.044	3.033GlyGln: 3.033 ± 0.042	3.946GlyArg: 3.946 ± 0.056	4.573GlySer: 4.573 ± 0.08	4.263GlyThr: 4.263 ± 0.076	4.496GlyVal: 4.496 ± 0.06	1.229GlyTrp: 1.229 ± 0.029	2.278GlyTyr: 2.278 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	1.806HisAla: 1.806 ± 0.034	0.354HisCys: 0.354 ± 0.013	1.235HisAsp: 1.235 ± 0.029	1.42HisGlu: 1.42 ± 0.027	1.022HisPhe: 1.022 ± 0.028	1.679HisGly: 1.679 ± 0.032	0.732HisHis: 0.732 ± 0.021	1.041HisIle: 1.041 ± 0.024	0.813HisLys: 0.813 ± 0.018	2.3HisLeu: 2.3 ± 0.045	0.434HisMet: 0.434 ± 0.017	0.857HisAsn: 0.857 ± 0.023	1.466HisPro: 1.466 ± 0.03	1.099HisGln: 1.099 ± 0.029	1.428HisArg: 1.428 ± 0.03	1.466HisSer: 1.466 ± 0.03	1.005HisThr: 1.005 ± 0.021	1.412HisVal: 1.412 ± 0.031	0.473HisTrp: 0.473 ± 0.017	0.762HisTyr: 0.762 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.539IleAla: 5.539 ± 0.063	0.826IleCys: 0.826 ± 0.022	4.19IleAsp: 4.19 ± 0.061	4.505IleGlu: 4.505 ± 0.057	1.983IlePhe: 1.983 ± 0.036	4.213IleGly: 4.213 ± 0.057	1.344IleHis: 1.344 ± 0.029	2.934IleIle: 2.934 ± 0.042	2.086IleLys: 2.086 ± 0.036	5.45IleLeu: 5.45 ± 0.067	0.958IleMet: 0.958 ± 0.02	2.141IleAsn: 2.141 ± 0.045	3.266IlePro: 3.266 ± 0.05	2.387IleGln: 2.387 ± 0.034	3.538IleArg: 3.538 ± 0.049	4.342IleSer: 4.342 ± 0.061	3.181IleThr: 3.181 ± 0.067	4.301IleVal: 4.301 ± 0.056	0.726IleTrp: 0.726 ± 0.018	1.486IleTyr: 1.486 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.46LysAla: 3.46 ± 0.057	0.376LysCys: 0.376 ± 0.016	2.17LysAsp: 2.17 ± 0.038	2.736LysGlu: 2.736 ± 0.051	1.582LysPhe: 1.582 ± 0.03	2.331LysGly: 2.331 ± 0.046	1.016LysHis: 1.016 ± 0.025	2.758LysIle: 2.758 ± 0.043	2.524LysLys: 2.524 ± 0.055	4.667LysLeu: 4.667 ± 0.057	1.207LysMet: 1.207 ± 0.028	1.89LysAsn: 1.89 ± 0.034	2.616LysPro: 2.616 ± 0.057	2.307LysGln: 2.307 ± 0.04	2.568LysArg: 2.568 ± 0.044	3.405LysSer: 3.405 ± 0.045	2.931LysThr: 2.931 ± 0.041	2.654LysVal: 2.654 ± 0.041	0.666LysTrp: 0.666 ± 0.018	1.35LysTyr: 1.35 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	8.459LeuAla: 8.459 ± 0.075	1.268LeuCys: 1.268 ± 0.029	5.527LeuAsp: 5.527 ± 0.053	6.459LeuGlu: 6.459 ± 0.071	3.865LeuPhe: 3.865 ± 0.053	6.378LeuGly: 6.378 ± 0.054	2.04LeuHis: 2.04 ± 0.037	6.285LeuIle: 6.285 ± 0.069	5.236LeuLys: 5.236 ± 0.067	9.944LeuLeu: 9.944 ± 0.099	2.343LeuMet: 2.343 ± 0.04	4.069LeuAsn: 4.069 ± 0.054	5.152LeuPro: 5.152 ± 0.065	4.304LeuGln: 4.304 ± 0.055	5.126LeuArg: 5.126 ± 0.056	6.858LeuSer: 6.858 ± 0.067	5.926LeuThr: 5.926 ± 0.068	6.007LeuVal: 6.007 ± 0.066	1.246LeuTrp: 1.246 ± 0.028	2.308LeuTyr: 2.308 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	1.932MetAla: 1.932 ± 0.031	0.228MetCys: 0.228 ± 0.01	0.992MetAsp: 0.992 ± 0.02	1.218MetGlu: 1.218 ± 0.025	0.817MetPhe: 0.817 ± 0.023	1.418MetGly: 1.418 ± 0.031	0.509MetHis: 0.509 ± 0.019	1.539MetIle: 1.539 ± 0.03	1.309MetLys: 1.309 ± 0.03	2.386MetLeu: 2.386 ± 0.04	0.64MetMet: 0.64 ± 0.022	1.114MetAsn: 1.114 ± 0.023	1.267MetPro: 1.267 ± 0.028	1.089MetGln: 1.089 ± 0.027	1.261MetArg: 1.261 ± 0.026	1.786MetSer: 1.786 ± 0.037	1.665MetThr: 1.665 ± 0.034	1.325MetVal: 1.325 ± 0.025	0.245MetTrp: 0.245 ± 0.01	0.485MetTyr: 0.485 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.972AsnAla: 2.972 ± 0.051	0.552AsnCys: 0.552 ± 0.02	2.227AsnAsp: 2.227 ± 0.035	2.494AsnGlu: 2.494 ± 0.039	1.472AsnPhe: 1.472 ± 0.032	3.034AsnGly: 3.034 ± 0.069	0.984AsnHis: 0.984 ± 0.026	1.952AsnIle: 1.952 ± 0.036	1.35AsnLys: 1.35 ± 0.026	3.738AsnLeu: 3.738 ± 0.052	0.788AsnMet: 0.788 ± 0.021	1.617AsnAsn: 1.617 ± 0.046	2.476AsnPro: 2.476 ± 0.04	1.9AsnGln: 1.9 ± 0.036	2.546AsnArg: 2.546 ± 0.044	3.071AsnSer: 3.071 ± 0.055	1.99AsnThr: 1.99 ± 0.04	2.514AsnVal: 2.514 ± 0.057	0.711AsnTrp: 0.711 ± 0.019	1.255AsnTyr: 1.255 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.187ProAla: 4.187 ± 0.058	0.362ProCys: 0.362 ± 0.013	3.184ProAsp: 3.184 ± 0.046	4.644ProGlu: 4.644 ± 0.057	1.915ProPhe: 1.915 ± 0.037	3.573ProGly: 3.573 ± 0.054	1.183ProHis: 1.183 ± 0.027	2.788ProIle: 2.788 ± 0.038	2.203ProLys: 2.203 ± 0.05	4.328ProLeu: 4.328 ± 0.054	0.996ProMet: 0.996 ± 0.024	2.037ProAsn: 2.037 ± 0.037	2.248ProPro: 2.248 ± 0.05	2.154ProGln: 2.154 ± 0.04	2.158ProArg: 2.158 ± 0.035	2.873ProSer: 2.873 ± 0.047	2.684ProThr: 2.684 ± 0.043	3.649ProVal: 3.649 ± 0.053	0.63ProTrp: 0.63 ± 0.019	1.31ProTyr: 1.31 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.867GlnAla: 3.867 ± 0.058	0.415GlnCys: 0.415 ± 0.015	1.984GlnAsp: 1.984 ± 0.034	2.792GlnGlu: 2.792 ± 0.045	1.946GlnPhe: 1.946 ± 0.035	2.567GlnGly: 2.567 ± 0.04	0.96GlnHis: 0.96 ± 0.022	2.941GlnIle: 2.941 ± 0.043	2.402GlnLys: 2.402 ± 0.044	4.877GlnLeu: 4.877 ± 0.059	1.092GlnMet: 1.092 ± 0.026	1.84GlnAsn: 1.84 ± 0.038	2.283GlnPro: 2.283 ± 0.038	2.639GlnGln: 2.639 ± 0.052	2.497GlnArg: 2.497 ± 0.043	3.144GlnSer: 3.144 ± 0.044	2.618GlnThr: 2.618 ± 0.043	2.8GlnVal: 2.8 ± 0.042	0.604GlnTrp: 0.604 ± 0.019	1.173GlnTyr: 1.173 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.629ArgAla: 3.629 ± 0.048	0.657ArgCys: 0.657 ± 0.02	3.286ArgAsp: 3.286 ± 0.043	3.975ArgGlu: 3.975 ± 0.054	2.629ArgPhe: 2.629 ± 0.04	3.386ArgGly: 3.386 ± 0.047	1.28ArgHis: 1.28 ± 0.033	3.739ArgIle: 3.739 ± 0.05	2.865ArgLys: 2.865 ± 0.044	5.877ArgLeu: 5.877 ± 0.066	1.533ArgMet: 1.533 ± 0.029	2.369ArgAsn: 2.369 ± 0.038	2.431ArgPro: 2.431 ± 0.04	2.64ArgGln: 2.64 ± 0.046	3.528ArgArg: 3.528 ± 0.055	3.569ArgSer: 3.569 ± 0.045	2.885ArgThr: 2.885 ± 0.041	3.557ArgVal: 3.557 ± 0.05	0.912ArgTrp: 0.912 ± 0.026	1.831ArgTyr: 1.831 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.048SerAla: 5.048 ± 0.069	0.832SerCys: 0.832 ± 0.025	3.772SerAsp: 3.772 ± 0.045	4.702SerGlu: 4.702 ± 0.055	2.499SerPhe: 2.499 ± 0.038	5.486SerGly: 5.486 ± 0.077	1.55SerHis: 1.55 ± 0.032	3.904SerIle: 3.904 ± 0.056	2.873SerLys: 2.873 ± 0.047	6.857SerLeu: 6.857 ± 0.068	1.554SerMet: 1.554 ± 0.031	2.653SerAsn: 2.653 ± 0.045	3.468SerPro: 3.468 ± 0.053	3.216SerGln: 3.216 ± 0.048	3.98SerArg: 3.98 ± 0.051	4.97SerSer: 4.97 ± 0.076	3.806SerThr: 3.806 ± 0.059	4.305SerVal: 4.305 ± 0.063	1.011SerTrp: 1.011 ± 0.026	1.741SerTyr: 1.741 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.746ThrAla: 4.746 ± 0.073	0.662ThrCys: 0.662 ± 0.024	3.147ThrAsp: 3.147 ± 0.051	3.514ThrGlu: 3.514 ± 0.045	2.233ThrPhe: 2.233 ± 0.046	4.603ThrGly: 4.603 ± 0.079	1.163ThrHis: 1.163 ± 0.025	3.685ThrIle: 3.685 ± 0.071	2.16ThrLys: 2.16 ± 0.04	5.528ThrLeu: 5.528 ± 0.072	1.167ThrMet: 1.167 ± 0.026	2.045ThrAsn: 2.045 ± 0.053	3.245ThrPro: 3.245 ± 0.049	2.135ThrGln: 2.135 ± 0.028	2.821ThrArg: 2.821 ± 0.045	3.874ThrSer: 3.874 ± 0.059	3.287ThrThr: 3.287 ± 0.074	3.789ThrVal: 3.789 ± 0.066	0.791ThrTrp: 0.791 ± 0.022	1.442ThrTyr: 1.442 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.374ValAla: 5.374 ± 0.061	0.871ValCys: 0.871 ± 0.024	3.987ValAsp: 3.987 ± 0.057	4.514ValGlu: 4.514 ± 0.054	2.491ValPhe: 2.491 ± 0.042	4.286ValGly: 4.286 ± 0.059	1.376ValHis: 1.376 ± 0.028	4.168ValIle: 4.168 ± 0.056	2.786ValLys: 2.786 ± 0.045	6.119ValLeu: 6.119 ± 0.065	1.533ValMet: 1.533 ± 0.028	2.576ValAsn: 2.576 ± 0.053	3.085ValPro: 3.085 ± 0.049	2.509ValGln: 2.509 ± 0.032	3.634ValArg: 3.634 ± 0.043	4.53ValSer: 4.53 ± 0.063	4.095ValThr: 4.095 ± 0.08	4.75ValVal: 4.75 ± 0.066	0.852ValTrp: 0.852 ± 0.022	1.691ValTyr: 1.691 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.91TrpAla: 0.91 ± 0.026	0.182TrpCys: 0.182 ± 0.01	0.79TrpAsp: 0.79 ± 0.024	0.857TrpGlu: 0.857 ± 0.022	0.573TrpPhe: 0.573 ± 0.018	0.949TrpGly: 0.949 ± 0.02	0.394TrpHis: 0.394 ± 0.015	0.94TrpIle: 0.94 ± 0.026	0.888TrpLys: 0.888 ± 0.024	1.544TrpLeu: 1.544 ± 0.033	0.47TrpMet: 0.47 ± 0.016	0.701TrpAsn: 0.701 ± 0.021	0.661TrpPro: 0.661 ± 0.02	0.778TrpGln: 0.778 ± 0.021	0.789TrpArg: 0.789 ± 0.021	1.049TrpSer: 1.049 ± 0.025	0.845TrpThr: 0.845 ± 0.023	0.793TrpVal: 0.793 ± 0.024	0.252TrpTrp: 0.252 ± 0.013	0.405TrpTyr: 0.405 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.074TyrAla: 2.074 ± 0.04	0.424TyrCys: 0.424 ± 0.015	1.769TyrAsp: 1.769 ± 0.033	1.918TyrGlu: 1.918 ± 0.036	1.252TyrPhe: 1.252 ± 0.025	2.229TyrGly: 2.229 ± 0.042	0.716TyrHis: 0.716 ± 0.019	1.088TyrIle: 1.088 ± 0.027	0.852TyrLys: 0.852 ± 0.027	2.889TyrLeu: 2.889 ± 0.042	0.478TyrMet: 0.478 ± 0.015	0.975TyrAsn: 0.975 ± 0.027	1.331TyrPro: 1.331 ± 0.031	1.438TyrGln: 1.438 ± 0.033	2.088TyrArg: 2.088 ± 0.035	1.812TyrSer: 1.812 ± 0.036	1.225TyrThr: 1.225 ± 0.034	1.739TyrVal: 1.739 ± 0.031	0.476TyrTrp: 0.476 ± 0.018	0.975TyrTyr: 0.975 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5229 proteins (1885334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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