Amino acid dipepetide frequency for Aminomonas paucivorans DSM 12260

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.407AlaAla: 12.407 ± 0.204	1.491AlaCys: 1.491 ± 0.056	4.223AlaAsp: 4.223 ± 0.082	6.281AlaGlu: 6.281 ± 0.091	4.367AlaPhe: 4.367 ± 0.086	8.888AlaGly: 8.888 ± 0.132	1.703AlaHis: 1.703 ± 0.058	2.985AlaIle: 2.985 ± 0.075	2.844AlaLys: 2.844 ± 0.069	15.175AlaLeu: 15.175 ± 0.19	2.075AlaMet: 2.075 ± 0.055	1.686AlaAsn: 1.686 ± 0.05	4.93AlaPro: 4.93 ± 0.099	3.228AlaGln: 3.228 ± 0.074	8.295AlaArg: 8.295 ± 0.125	5.766AlaSer: 5.766 ± 0.098	3.96AlaThr: 3.96 ± 0.079	7.815AlaVal: 7.815 ± 0.124	1.477AlaTrp: 1.477 ± 0.051	2.187AlaTyr: 2.187 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.243CysAla: 1.243 ± 0.04	0.234CysCys: 0.234 ± 0.017	0.599CysAsp: 0.599 ± 0.03	0.532CysGlu: 0.532 ± 0.025	0.478CysPhe: 0.478 ± 0.029	1.547CysGly: 1.547 ± 0.059	0.262CysHis: 0.262 ± 0.017	0.435CysIle: 0.435 ± 0.023	0.252CysLys: 0.252 ± 0.017	1.537CysLeu: 1.537 ± 0.042	0.225CysMet: 0.225 ± 0.017	0.272CysAsn: 0.272 ± 0.018	1.048CysPro: 1.048 ± 0.043	0.266CysGln: 0.266 ± 0.019	1.235CysArg: 1.235 ± 0.039	0.719CysSer: 0.719 ± 0.031	0.619CysThr: 0.619 ± 0.032	0.883CysVal: 0.883 ± 0.039	0.176CysTrp: 0.176 ± 0.015	0.249CysTyr: 0.249 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.523AspAla: 4.523 ± 0.082	0.505AspCys: 0.505 ± 0.025	1.895AspAsp: 1.895 ± 0.046	3.045AspGlu: 3.045 ± 0.076	1.714AspPhe: 1.714 ± 0.05	4.333AspGly: 4.333 ± 0.091	1.072AspHis: 1.072 ± 0.035	1.554AspIle: 1.554 ± 0.052	1.163AspLys: 1.163 ± 0.046	8.063AspLeu: 8.063 ± 0.125	0.916AspMet: 0.916 ± 0.027	0.818AspAsn: 0.818 ± 0.037	4.301AspPro: 4.301 ± 0.075	1.558AspGln: 1.558 ± 0.048	5.334AspArg: 5.334 ± 0.087	1.861AspSer: 1.861 ± 0.055	1.826AspThr: 1.826 ± 0.052	3.744AspVal: 3.744 ± 0.078	0.74AspTrp: 0.74 ± 0.031	1.182AspTyr: 1.182 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	9.314GluAla: 9.314 ± 0.119	0.459GluCys: 0.459 ± 0.029	4.281GluAsp: 4.281 ± 0.075	7.592GluGlu: 7.592 ± 0.144	1.447GluPhe: 1.447 ± 0.048	8.036GluGly: 8.036 ± 0.125	1.201GluHis: 1.201 ± 0.042	3.05GluIle: 3.05 ± 0.071	2.58GluLys: 2.58 ± 0.074	6.316GluLeu: 6.316 ± 0.089	1.503GluMet: 1.503 ± 0.05	1.572GluAsn: 1.572 ± 0.043	2.875GluPro: 2.875 ± 0.065	2.049GluGln: 2.049 ± 0.057	6.106GluArg: 6.106 ± 0.096	2.825GluSer: 2.825 ± 0.074	3.755GluThr: 3.755 ± 0.072	5.628GluVal: 5.628 ± 0.088	0.657GluTrp: 0.657 ± 0.03	1.063GluTyr: 1.063 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.506PheAla: 3.506 ± 0.068	0.569PheCys: 0.569 ± 0.026	2.007PheAsp: 2.007 ± 0.054	1.929PheGlu: 1.929 ± 0.052	1.613PhePhe: 1.613 ± 0.052	3.247PheGly: 3.247 ± 0.067	0.768PheHis: 0.768 ± 0.029	0.876PheIle: 0.876 ± 0.037	0.755PheLys: 0.755 ± 0.033	5.249PheLeu: 5.249 ± 0.091	0.563PheMet: 0.563 ± 0.026	0.598PheAsn: 0.598 ± 0.027	2.336PhePro: 2.336 ± 0.063	1.136PheGln: 1.136 ± 0.039	3.332PheArg: 3.332 ± 0.052	2.159PheSer: 2.159 ± 0.056	1.511PheThr: 1.511 ± 0.044	2.67PheVal: 2.67 ± 0.06	0.617PheTrp: 0.617 ± 0.032	0.828PheTyr: 0.828 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.783GlyAla: 9.783 ± 0.139	1.448GlyCys: 1.448 ± 0.043	4.852GlyAsp: 4.852 ± 0.083	6.867GlyGlu: 6.867 ± 0.1	3.756GlyPhe: 3.756 ± 0.062	8.749GlyGly: 8.749 ± 0.165	1.683GlyHis: 1.683 ± 0.044	4.597GlyIle: 4.597 ± 0.099	3.862GlyLys: 3.862 ± 0.074	10.157GlyLeu: 10.157 ± 0.148	2.436GlyMet: 2.436 ± 0.052	2.151GlyAsn: 2.151 ± 0.065	3.54GlyPro: 3.54 ± 0.079	2.421GlyGln: 2.421 ± 0.06	7.313GlyArg: 7.313 ± 0.099	4.834GlySer: 4.834 ± 0.081	5.511GlyThr: 5.511 ± 0.092	8.377GlyVal: 8.377 ± 0.119	1.509GlyTrp: 1.509 ± 0.042	2.386GlyTyr: 2.386 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.567HisAla: 1.567 ± 0.043	0.263HisCys: 0.263 ± 0.019	0.818HisAsp: 0.818 ± 0.032	0.912HisGlu: 0.912 ± 0.036	0.691HisPhe: 0.691 ± 0.031	1.635HisGly: 1.635 ± 0.049	0.531HisHis: 0.531 ± 0.031	0.649HisIle: 0.649 ± 0.032	0.389HisLys: 0.389 ± 0.02	2.553HisLeu: 2.553 ± 0.061	0.349HisMet: 0.349 ± 0.021	0.369HisAsn: 0.369 ± 0.02	1.659HisPro: 1.659 ± 0.052	0.57HisGln: 0.57 ± 0.025	1.964HisArg: 1.964 ± 0.053	0.774HisSer: 0.774 ± 0.032	0.763HisThr: 0.763 ± 0.033	1.274HisVal: 1.274 ± 0.043	0.257HisTrp: 0.257 ± 0.02	0.424HisTyr: 0.424 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	3.337IleAla: 3.337 ± 0.075	0.463IleCys: 0.463 ± 0.025	1.544IleAsp: 1.544 ± 0.043	1.729IleGlu: 1.729 ± 0.059	0.997IlePhe: 0.997 ± 0.038	2.713IleGly: 2.713 ± 0.068	0.794IleHis: 0.794 ± 0.031	0.909IleIle: 0.909 ± 0.038	0.877IleLys: 0.877 ± 0.042	5.384IleLeu: 5.384 ± 0.083	0.578IleMet: 0.578 ± 0.032	0.706IleAsn: 0.706 ± 0.029	2.723IlePro: 2.723 ± 0.057	1.383IleGln: 1.383 ± 0.044	3.409IleArg: 3.409 ± 0.062	1.755IleSer: 1.755 ± 0.053	1.547IleThr: 1.547 ± 0.058	2.357IleVal: 2.357 ± 0.076	0.361IleTrp: 0.361 ± 0.022	0.708IleTyr: 0.708 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.4LysAla: 3.4 ± 0.08	0.208LysCys: 0.208 ± 0.02	1.894LysAsp: 1.894 ± 0.054	2.312LysGlu: 2.312 ± 0.057	0.593LysPhe: 0.593 ± 0.03	3.452LysGly: 3.452 ± 0.081	0.525LysHis: 0.525 ± 0.026	1.213LysIle: 1.213 ± 0.05	1.373LysLys: 1.373 ± 0.05	2.771LysLeu: 2.771 ± 0.068	0.656LysMet: 0.656 ± 0.028	0.803LysAsn: 0.803 ± 0.033	1.479LysPro: 1.479 ± 0.046	0.789LysGln: 0.789 ± 0.032	2.207LysArg: 2.207 ± 0.051	1.32LysSer: 1.32 ± 0.046	1.753LysThr: 1.753 ± 0.049	2.758LysVal: 2.758 ± 0.077	0.272LysTrp: 0.272 ± 0.018	0.508LysTyr: 0.508 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.81LeuAla: 13.81 ± 0.163	1.776LeuCys: 1.776 ± 0.054	6.336LeuAsp: 6.336 ± 0.09	9.778LeuGlu: 9.778 ± 0.126	4.52LeuPhe: 4.52 ± 0.085	12.405LeuGly: 12.405 ± 0.171	2.234LeuHis: 2.234 ± 0.058	3.185LeuIle: 3.185 ± 0.076	3.6LeuLys: 3.6 ± 0.076	14.939LeuLeu: 14.939 ± 0.25	2.026LeuMet: 2.026 ± 0.05	2.114LeuAsn: 2.114 ± 0.057	7.245LeuPro: 7.245 ± 0.1	3.362LeuGln: 3.362 ± 0.073	10.568LeuArg: 10.568 ± 0.156	7.25LeuSer: 7.25 ± 0.106	5.188LeuThr: 5.188 ± 0.089	9.968LeuVal: 9.968 ± 0.141	1.842LeuTrp: 1.842 ± 0.065	2.297LeuTyr: 2.297 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.239MetAla: 2.239 ± 0.054	0.125MetCys: 0.125 ± 0.013	1.261MetAsp: 1.261 ± 0.042	1.772MetGlu: 1.772 ± 0.045	0.404MetPhe: 0.404 ± 0.025	2.279MetGly: 2.279 ± 0.056	0.301MetHis: 0.301 ± 0.019	0.697MetIle: 0.697 ± 0.027	1.037MetLys: 1.037 ± 0.036	1.657MetLeu: 1.657 ± 0.049	0.428MetMet: 0.428 ± 0.021	0.639MetAsn: 0.639 ± 0.029	0.914MetPro: 0.914 ± 0.039	0.452MetGln: 0.452 ± 0.026	1.345MetArg: 1.345 ± 0.04	1.089MetSer: 1.089 ± 0.035	1.187MetThr: 1.187 ± 0.041	1.51MetVal: 1.51 ± 0.042	0.148MetTrp: 0.148 ± 0.016	0.268MetTyr: 0.268 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	1.899AsnAla: 1.899 ± 0.053	0.237AsnCys: 0.237 ± 0.018	0.907AsnAsp: 0.907 ± 0.037	0.897AsnGlu: 0.897 ± 0.038	0.571AsnPhe: 0.571 ± 0.031	1.626AsnGly: 1.626 ± 0.049	0.427AsnHis: 0.427 ± 0.022	0.739AsnIle: 0.739 ± 0.037	0.505AsnLys: 0.505 ± 0.027	3.05AsnLeu: 3.05 ± 0.068	0.406AsnMet: 0.406 ± 0.022	0.424AsnAsn: 0.424 ± 0.027	1.878AsnPro: 1.878 ± 0.052	0.622AsnGln: 0.622 ± 0.029	1.827AsnArg: 1.827 ± 0.056	0.779AsnSer: 0.779 ± 0.035	0.813AsnThr: 0.813 ± 0.036	1.597AsnVal: 1.597 ± 0.05	0.255AsnTrp: 0.255 ± 0.019	0.498AsnTyr: 0.498 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.579ProAla: 4.579 ± 0.08	0.719ProCys: 0.719 ± 0.03	2.967ProAsp: 2.967 ± 0.069	5.576ProGlu: 5.576 ± 0.1	2.387ProPhe: 2.387 ± 0.054	5.904ProGly: 5.904 ± 0.093	1.021ProHis: 1.021 ± 0.038	1.326ProIle: 1.326 ± 0.046	1.577ProLys: 1.577 ± 0.049	7.226ProLeu: 7.226 ± 0.115	1.012ProMet: 1.012 ± 0.034	0.992ProAsn: 0.992 ± 0.035	3.071ProPro: 3.071 ± 0.086	1.917ProGln: 1.917 ± 0.047	4.349ProArg: 4.349 ± 0.095	3.243ProSer: 3.243 ± 0.075	2.23ProThr: 2.23 ± 0.061	4.416ProVal: 4.416 ± 0.087	1.007ProTrp: 1.007 ± 0.034	1.231ProTyr: 1.231 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.214GlnAla: 3.214 ± 0.075	0.267GlnCys: 0.267 ± 0.018	1.671GlnAsp: 1.671 ± 0.05	2.718GlnGlu: 2.718 ± 0.06	0.742GlnPhe: 0.742 ± 0.034	3.453GlnGly: 3.453 ± 0.075	0.451GlnHis: 0.451 ± 0.025	1.35GlnIle: 1.35 ± 0.042	1.151GlnLys: 1.151 ± 0.04	2.107GlnLeu: 2.107 ± 0.052	0.688GlnMet: 0.688 ± 0.032	0.68GlnAsn: 0.68 ± 0.031	1.083GlnPro: 1.083 ± 0.04	0.784GlnGln: 0.784 ± 0.038	2.115GlnArg: 2.115 ± 0.062	1.221GlnSer: 1.221 ± 0.037	1.43GlnThr: 1.43 ± 0.05	2.771GlnVal: 2.771 ± 0.058	0.4GlnTrp: 0.4 ± 0.023	0.529GlnTyr: 0.529 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.714ArgAla: 6.714 ± 0.095	1.178ArgCys: 1.178 ± 0.045	4.495ArgAsp: 4.495 ± 0.085	7.49ArgGlu: 7.49 ± 0.112	3.612ArgPhe: 3.612 ± 0.065	7.401ArgGly: 7.401 ± 0.11	1.574ArgHis: 1.574 ± 0.045	4.08ArgIle: 4.08 ± 0.064	2.776ArgLys: 2.776 ± 0.065	9.389ArgLeu: 9.389 ± 0.127	2.118ArgMet: 2.118 ± 0.056	1.788ArgAsn: 1.788 ± 0.045	3.997ArgPro: 3.997 ± 0.077	2.274ArgGln: 2.274 ± 0.059	7.796ArgArg: 7.796 ± 0.127	4.255ArgSer: 4.255 ± 0.085	4.068ArgThr: 4.068 ± 0.08	6.706ArgVal: 6.706 ± 0.105	1.301ArgTrp: 1.301 ± 0.049	1.91ArgTyr: 1.91 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.313SerAla: 4.313 ± 0.076	0.812SerCys: 0.812 ± 0.032	2.013SerAsp: 2.013 ± 0.048	2.388SerGlu: 2.388 ± 0.064	2.412SerPhe: 2.412 ± 0.061	5.377SerGly: 5.377 ± 0.1	0.897SerHis: 0.897 ± 0.03	1.656SerIle: 1.656 ± 0.052	1.212SerLys: 1.212 ± 0.045	7.662SerLeu: 7.662 ± 0.108	1.154SerMet: 1.154 ± 0.039	0.854SerAsn: 0.854 ± 0.036	3.559SerPro: 3.559 ± 0.077	1.466SerGln: 1.466 ± 0.045	4.374SerArg: 4.374 ± 0.077	2.916SerSer: 2.916 ± 0.071	2.185SerThr: 2.185 ± 0.052	4.13SerVal: 4.13 ± 0.069	0.828SerTrp: 0.828 ± 0.034	1.087SerTyr: 1.087 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.404ThrAla: 4.404 ± 0.079	0.585ThrCys: 0.585 ± 0.03	2.114ThrAsp: 2.114 ± 0.06	2.762ThrGlu: 2.762 ± 0.064	1.747ThrPhe: 1.747 ± 0.048	4.855ThrGly: 4.855 ± 0.085	0.883ThrHis: 0.883 ± 0.038	1.456ThrIle: 1.456 ± 0.044	1.156ThrLys: 1.156 ± 0.042	6.66ThrLeu: 6.66 ± 0.096	0.678ThrMet: 0.678 ± 0.031	0.99ThrAsn: 0.99 ± 0.043	3.468ThrPro: 3.468 ± 0.072	1.177ThrGln: 1.177 ± 0.042	3.266ThrArg: 3.266 ± 0.054	2.313ThrSer: 2.313 ± 0.061	2.158ThrThr: 2.158 ± 0.062	3.86ThrVal: 3.86 ± 0.076	0.605ThrTrp: 0.605 ± 0.027	1.09ThrTyr: 1.09 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.433ValAla: 8.433 ± 0.132	1.071ValCys: 1.071 ± 0.042	4.316ValAsp: 4.316 ± 0.087	5.444ValGlu: 5.444 ± 0.106	2.97ValPhe: 2.97 ± 0.066	6.334ValGly: 6.334 ± 0.113	1.506ValHis: 1.506 ± 0.043	2.3ValIle: 2.3 ± 0.061	2.099ValLys: 2.099 ± 0.064	10.567ValLeu: 10.567 ± 0.136	1.301ValMet: 1.301 ± 0.044	1.635ValAsn: 1.635 ± 0.049	4.863ValPro: 4.863 ± 0.088	2.313ValGln: 2.313 ± 0.056	6.819ValArg: 6.819 ± 0.109	4.515ValSer: 4.515 ± 0.068	4.105ValThr: 4.105 ± 0.078	7.289ValVal: 7.289 ± 0.115	0.919ValTrp: 0.919 ± 0.036	1.693ValTyr: 1.693 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.177TrpAla: 1.177 ± 0.042	0.164TrpCys: 0.164 ± 0.014	0.714TrpAsp: 0.714 ± 0.036	0.94TrpGlu: 0.94 ± 0.037	0.5TrpPhe: 0.5 ± 0.027	1.679TrpGly: 1.679 ± 0.054	0.182TrpHis: 0.182 ± 0.014	0.671TrpIle: 0.671 ± 0.032	0.598TrpLys: 0.598 ± 0.029	1.382TrpLeu: 1.382 ± 0.049	0.325TrpMet: 0.325 ± 0.021	0.433TrpAsn: 0.433 ± 0.024	0.513TrpPro: 0.513 ± 0.029	0.354TrpGln: 0.354 ± 0.023	1.089TrpArg: 1.089 ± 0.046	0.747TrpSer: 0.747 ± 0.031	0.739TrpThr: 0.739 ± 0.036	1.206TrpVal: 1.206 ± 0.043	0.26TrpTrp: 0.26 ± 0.019	0.254TrpTyr: 0.254 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.924TyrAla: 1.924 ± 0.051	0.239TyrCys: 0.239 ± 0.017	1.237TyrAsp: 1.237 ± 0.042	1.343TyrGlu: 1.343 ± 0.042	0.747TyrPhe: 0.747 ± 0.031	2.319TyrGly: 2.319 ± 0.055	0.396TyrHis: 0.396 ± 0.023	0.545TyrIle: 0.545 ± 0.031	0.479TyrLys: 0.479 ± 0.026	2.601TyrLeu: 2.601 ± 0.06	0.313TyrMet: 0.313 ± 0.022	0.434TyrAsn: 0.434 ± 0.028	1.267TyrPro: 1.267 ± 0.04	0.706TyrGln: 0.706 ± 0.03	2.178TyrArg: 2.178 ± 0.06	0.956TyrSer: 0.956 ± 0.037	0.881TyrThr: 0.881 ± 0.032	1.533TyrVal: 1.533 ± 0.043	0.292TyrTrp: 0.292 ± 0.02	0.502TyrTyr: 0.502 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2391 proteins (794651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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