Amino acid dipepetide frequency for Corynebacterium sp. KPL1855

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.435AlaAla: 15.435 ± 0.224
0.899AlaCys: 0.899 ± 0.036
7.036AlaAsp: 7.036 ± 0.123
8.118AlaGlu: 8.118 ± 0.138
3.553AlaPhe: 3.553 ± 0.08
9.794AlaGly: 9.794 ± 0.146
2.453AlaHis: 2.453 ± 0.056
5.433AlaIle: 5.433 ± 0.101
3.863AlaLys: 3.863 ± 0.083
11.203AlaLeu: 11.203 ± 0.174
2.721AlaMet: 2.721 ± 0.061
2.906AlaAsn: 2.906 ± 0.072
5.046AlaPro: 5.046 ± 0.119
4.629AlaGln: 4.629 ± 0.092
6.589AlaArg: 6.589 ± 0.12
5.819AlaSer: 5.819 ± 0.104
6.688AlaThr: 6.688 ± 0.101
8.75AlaVal: 8.75 ± 0.136
1.465AlaTrp: 1.465 ± 0.054
2.275AlaTyr: 2.275 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.84CysAla: 0.84 ± 0.034
0.083CysCys: 0.083 ± 0.01
0.41CysAsp: 0.41 ± 0.024
0.382CysGlu: 0.382 ± 0.025
0.238CysPhe: 0.238 ± 0.02
0.793CysGly: 0.793 ± 0.041
0.178CysHis: 0.178 ± 0.017
0.342CysIle: 0.342 ± 0.027
0.156CysLys: 0.156 ± 0.014
0.597CysLeu: 0.597 ± 0.034
0.139CysMet: 0.139 ± 0.014
0.214CysAsn: 0.214 ± 0.018
0.432CysPro: 0.432 ± 0.028
0.233CysGln: 0.233 ± 0.019
0.349CysArg: 0.349 ± 0.025
0.535CysSer: 0.535 ± 0.029
0.436CysThr: 0.436 ± 0.022
0.504CysVal: 0.504 ± 0.031
0.074CysTrp: 0.074 ± 0.011
0.151CysTyr: 0.151 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.036AspAla: 7.036 ± 0.119
0.375AspCys: 0.375 ± 0.028
3.947AspAsp: 3.947 ± 0.096
4.363AspGlu: 4.363 ± 0.093
2.394AspPhe: 2.394 ± 0.059
4.894AspGly: 4.894 ± 0.093
1.24AspHis: 1.24 ± 0.048
3.624AspIle: 3.624 ± 0.079
2.664AspLys: 2.664 ± 0.082
5.518AspLeu: 5.518 ± 0.095
1.378AspMet: 1.378 ± 0.044
2.068AspAsn: 2.068 ± 0.054
3.465AspPro: 3.465 ± 0.07
1.731AspGln: 1.731 ± 0.049
3.271AspArg: 3.271 ± 0.067
3.701AspSer: 3.701 ± 0.077
3.346AspThr: 3.346 ± 0.068
4.443AspVal: 4.443 ± 0.089
0.799AspTrp: 0.799 ± 0.036
1.739AspTyr: 1.739 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
6.722GluAla: 6.722 ± 0.125
0.389GluCys: 0.389 ± 0.024
4.206GluAsp: 4.206 ± 0.094
5.372GluGlu: 5.372 ± 0.108
2.153GluPhe: 2.153 ± 0.064
4.775GluGly: 4.775 ± 0.086
1.622GluHis: 1.622 ± 0.058
3.264GluIle: 3.264 ± 0.061
3.056GluLys: 3.056 ± 0.075
7.024GluLeu: 7.024 ± 0.123
1.356GluMet: 1.356 ± 0.042
2.046GluAsn: 2.046 ± 0.051
2.915GluPro: 2.915 ± 0.076
2.546GluGln: 2.546 ± 0.071
4.025GluArg: 4.025 ± 0.085
3.604GluSer: 3.604 ± 0.067
3.244GluThr: 3.244 ± 0.076
5.015GluVal: 5.015 ± 0.086
0.914GluTrp: 0.914 ± 0.039
1.403GluTyr: 1.403 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.818PheAla: 3.818 ± 0.075
0.263PheCys: 0.263 ± 0.018
2.29PheAsp: 2.29 ± 0.062
1.871PheGlu: 1.871 ± 0.053
1.315PhePhe: 1.315 ± 0.054
3.389PheGly: 3.389 ± 0.077
0.772PheHis: 0.772 ± 0.033
2.004PheIle: 2.004 ± 0.059
0.919PheLys: 0.919 ± 0.035
3.114PheLeu: 3.114 ± 0.084
0.708PheMet: 0.708 ± 0.035
1.104PheAsn: 1.104 ± 0.04
1.465PhePro: 1.465 ± 0.046
0.96PheGln: 0.96 ± 0.04
1.739PheArg: 1.739 ± 0.047
2.261PheSer: 2.261 ± 0.056
2.044PheThr: 2.044 ± 0.061
2.379PheVal: 2.379 ± 0.063
0.519PheTrp: 0.519 ± 0.03
0.864PheTyr: 0.864 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.56GlyAla: 8.56 ± 0.116
0.678GlyCys: 0.678 ± 0.03
4.667GlyAsp: 4.667 ± 0.094
5.296GlyGlu: 5.296 ± 0.097
3.108GlyPhe: 3.108 ± 0.075
6.676GlyGly: 6.676 ± 0.128
1.89GlyHis: 1.89 ± 0.05
4.868GlyIle: 4.868 ± 0.095
3.474GlyLys: 3.474 ± 0.068
8.025GlyLeu: 8.025 ± 0.119
2.31GlyMet: 2.31 ± 0.069
2.367GlyAsn: 2.367 ± 0.069
3.249GlyPro: 3.249 ± 0.07
2.733GlyGln: 2.733 ± 0.068
4.565GlyArg: 4.565 ± 0.089
5.019GlySer: 5.019 ± 0.093
5.344GlyThr: 5.344 ± 0.096
6.439GlyVal: 6.439 ± 0.108
1.351GlyTrp: 1.351 ± 0.049
2.204GlyTyr: 2.204 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.208HisAla: 2.208 ± 0.056
0.183HisCys: 0.183 ± 0.02
1.321HisAsp: 1.321 ± 0.046
1.281HisGlu: 1.281 ± 0.041
0.696HisPhe: 0.696 ± 0.034
1.942HisGly: 1.942 ± 0.049
0.651HisHis: 0.651 ± 0.034
1.1HisIle: 1.1 ± 0.032
0.657HisLys: 0.657 ± 0.032
2.067HisLeu: 2.067 ± 0.06
0.471HisMet: 0.471 ± 0.026
0.661HisAsn: 0.661 ± 0.033
1.446HisPro: 1.446 ± 0.042
0.681HisGln: 0.681 ± 0.028
1.433HisArg: 1.433 ± 0.042
1.36HisSer: 1.36 ± 0.045
1.338HisThr: 1.338 ± 0.044
1.524HisVal: 1.524 ± 0.045
0.293HisTrp: 0.293 ± 0.02
0.588HisTyr: 0.588 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.738IleAla: 6.738 ± 0.122
0.463IleCys: 0.463 ± 0.029
3.639IleAsp: 3.639 ± 0.074
3.144IleGlu: 3.144 ± 0.074
1.854IlePhe: 1.854 ± 0.057
4.621IleGly: 4.621 ± 0.088
1.011IleHis: 1.011 ± 0.037
3.074IleIle: 3.074 ± 0.082
1.649IleLys: 1.649 ± 0.049
4.196IleLeu: 4.196 ± 0.084
1.088IleMet: 1.088 ± 0.047
1.64IleAsn: 1.64 ± 0.05
2.726IlePro: 2.726 ± 0.067
1.339IleGln: 1.339 ± 0.041
2.611IleArg: 2.611 ± 0.059
3.381IleSer: 3.381 ± 0.074
3.338IleThr: 3.338 ± 0.08
4.265IleVal: 4.265 ± 0.081
0.521IleTrp: 0.521 ± 0.028
1.129IleTyr: 1.129 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
3.861LysAla: 3.861 ± 0.082
0.153LysCys: 0.153 ± 0.016
2.463LysAsp: 2.463 ± 0.073
2.479LysGlu: 2.479 ± 0.074
1.043LysPhe: 1.043 ± 0.044
2.486LysGly: 2.486 ± 0.064
0.729LysHis: 0.729 ± 0.035
1.711LysIle: 1.711 ± 0.052
2.189LysLys: 2.189 ± 0.085
3.254LysLeu: 3.254 ± 0.073
0.817LysMet: 0.817 ± 0.033
1.332LysAsn: 1.332 ± 0.043
1.779LysPro: 1.779 ± 0.064
1.467LysGln: 1.467 ± 0.051
2.431LysArg: 2.431 ± 0.058
2.061LysSer: 2.061 ± 0.062
1.886LysThr: 1.886 ± 0.059
2.715LysVal: 2.715 ± 0.066
0.496LysTrp: 0.496 ± 0.029
0.833LysTyr: 0.833 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
11.411LeuAla: 11.411 ± 0.16
0.688LeuCys: 0.688 ± 0.035
5.943LeuAsp: 5.943 ± 0.103
5.388LeuGlu: 5.388 ± 0.103
2.939LeuPhe: 2.939 ± 0.081
8.181LeuGly: 8.181 ± 0.12
1.976LeuHis: 1.976 ± 0.055
5.114LeuIle: 5.114 ± 0.105
2.922LeuLys: 2.922 ± 0.078
8.46LeuLeu: 8.46 ± 0.153
1.994LeuMet: 1.994 ± 0.051
2.708LeuAsn: 2.708 ± 0.063
5.024LeuPro: 5.024 ± 0.08
2.838LeuGln: 2.838 ± 0.057
6.103LeuArg: 6.103 ± 0.102
6.119LeuSer: 6.119 ± 0.095
5.6LeuThr: 5.6 ± 0.092
7.272LeuVal: 7.272 ± 0.11
1.203LeuTrp: 1.203 ± 0.044
1.826LeuTyr: 1.826 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.64MetAla: 2.64 ± 0.067
0.185MetCys: 0.185 ± 0.015
1.294MetAsp: 1.294 ± 0.045
1.168MetGlu: 1.168 ± 0.042
0.722MetPhe: 0.722 ± 0.03
1.781MetGly: 1.781 ± 0.056
0.49MetHis: 0.49 ± 0.026
1.058MetIle: 1.058 ± 0.044
0.757MetLys: 0.757 ± 0.033
2.128MetLeu: 2.128 ± 0.055
0.514MetMet: 0.514 ± 0.029
0.719MetAsn: 0.719 ± 0.031
1.225MetPro: 1.225 ± 0.04
0.746MetGln: 0.746 ± 0.036
1.383MetArg: 1.383 ± 0.047
1.803MetSer: 1.803 ± 0.053
1.613MetThr: 1.613 ± 0.049
1.843MetVal: 1.843 ± 0.053
0.299MetTrp: 0.299 ± 0.019
0.411MetTyr: 0.411 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.125AsnAla: 3.125 ± 0.07
0.189AsnCys: 0.189 ± 0.015
1.71AsnAsp: 1.71 ± 0.049
1.763AsnGlu: 1.763 ± 0.051
1.033AsnPhe: 1.033 ± 0.044
2.471AsnGly: 2.471 ± 0.053
0.675AsnHis: 0.675 ± 0.026
1.525AsnIle: 1.525 ± 0.047
1.119AsnLys: 1.119 ± 0.04
2.661AsnLeu: 2.661 ± 0.061
0.66AsnMet: 0.66 ± 0.03
1.074AsnAsn: 1.074 ± 0.04
2.014AsnPro: 2.014 ± 0.057
1.1AsnGln: 1.1 ± 0.042
1.765AsnArg: 1.765 ± 0.057
1.961AsnSer: 1.961 ± 0.061
1.572AsnThr: 1.572 ± 0.046
2.043AsnVal: 2.043 ± 0.05
0.426AsnTrp: 0.426 ± 0.026
0.893AsnTyr: 0.893 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
5.468ProAla: 5.468 ± 0.112
0.258ProCys: 0.258 ± 0.021
3.321ProAsp: 3.321 ± 0.08
4.428ProGlu: 4.428 ± 0.1
1.588ProPhe: 1.588 ± 0.042
4.193ProGly: 4.193 ± 0.089
1.156ProHis: 1.156 ± 0.041
2.165ProIle: 2.165 ± 0.06
1.729ProLys: 1.729 ± 0.06
4.199ProLeu: 4.199 ± 0.083
0.963ProMet: 0.963 ± 0.04
1.458ProAsn: 1.458 ± 0.046
1.771ProPro: 1.771 ± 0.058
2.057ProGln: 2.057 ± 0.053
2.74ProArg: 2.74 ± 0.072
2.925ProSer: 2.925 ± 0.072
3.033ProThr: 3.033 ± 0.066
3.971ProVal: 3.971 ± 0.074
0.729ProTrp: 0.729 ± 0.036
1.042ProTyr: 1.042 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.19GlnAla: 4.19 ± 0.083
0.151GlnCys: 0.151 ± 0.016
1.911GlnAsp: 1.911 ± 0.051
2.332GlnGlu: 2.332 ± 0.056
1.019GlnPhe: 1.019 ± 0.038
2.357GlnGly: 2.357 ± 0.065
0.79GlnHis: 0.79 ± 0.034
1.556GlnIle: 1.556 ± 0.049
1.186GlnLys: 1.186 ± 0.044
3.747GlnLeu: 3.747 ± 0.082
0.835GlnMet: 0.835 ± 0.033
0.939GlnAsn: 0.939 ± 0.044
1.835GlnPro: 1.835 ± 0.06
1.671GlnGln: 1.671 ± 0.069
2.651GlnArg: 2.651 ± 0.064
1.86GlnSer: 1.86 ± 0.058
1.514GlnThr: 1.514 ± 0.045
2.613GlnVal: 2.613 ± 0.066
0.579GlnTrp: 0.579 ± 0.03
0.708GlnTyr: 0.708 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
6.251ArgAla: 6.251 ± 0.113
0.353ArgCys: 0.353 ± 0.022
3.519ArgAsp: 3.519 ± 0.078
4.257ArgGlu: 4.257 ± 0.077
2.032ArgPhe: 2.032 ± 0.055
4.549ArgGly: 4.549 ± 0.091
1.307ArgHis: 1.307 ± 0.043
3.153ArgIle: 3.153 ± 0.066
2.303ArgLys: 2.303 ± 0.063
5.461ArgLeu: 5.461 ± 0.093
1.524ArgMet: 1.524 ± 0.047
1.794ArgAsn: 1.794 ± 0.051
2.813ArgPro: 2.813 ± 0.063
2.122ArgGln: 2.122 ± 0.06
4.722ArgArg: 4.722 ± 0.11
3.243ArgSer: 3.243 ± 0.072
3.613ArgThr: 3.613 ± 0.074
4.294ArgVal: 4.294 ± 0.084
0.933ArgTrp: 0.933 ± 0.035
1.517ArgTyr: 1.517 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.978SerAla: 6.978 ± 0.1
0.336SerCys: 0.336 ± 0.023
3.303SerAsp: 3.303 ± 0.073
3.507SerGlu: 3.507 ± 0.077
2.131SerPhe: 2.131 ± 0.055
5.596SerGly: 5.596 ± 0.091
1.306SerHis: 1.306 ± 0.048
3.024SerIle: 3.024 ± 0.066
1.95SerLys: 1.95 ± 0.059
5.589SerLeu: 5.589 ± 0.099
1.481SerMet: 1.481 ± 0.046
1.628SerAsn: 1.628 ± 0.05
3.042SerPro: 3.042 ± 0.075
2.186SerGln: 2.186 ± 0.06
3.554SerArg: 3.554 ± 0.074
4.061SerSer: 4.061 ± 0.088
4.153SerThr: 4.153 ± 0.093
4.397SerVal: 4.397 ± 0.083
0.889SerTrp: 0.889 ± 0.038
1.396SerTyr: 1.396 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
6.875ThrAla: 6.875 ± 0.111
0.461ThrCys: 0.461 ± 0.025
3.408ThrAsp: 3.408 ± 0.066
3.394ThrGlu: 3.394 ± 0.072
1.96ThrPhe: 1.96 ± 0.06
5.211ThrGly: 5.211 ± 0.092
1.236ThrHis: 1.236 ± 0.042
3.158ThrIle: 3.158 ± 0.066
1.997ThrLys: 1.997 ± 0.064
5.268ThrLeu: 5.268 ± 0.088
1.342ThrMet: 1.342 ± 0.042
1.743ThrAsn: 1.743 ± 0.051
3.478ThrPro: 3.478 ± 0.076
1.896ThrGln: 1.896 ± 0.056
3.138ThrArg: 3.138 ± 0.067
3.499ThrSer: 3.499 ± 0.077
3.889ThrThr: 3.889 ± 0.089
5.168ThrVal: 5.168 ± 0.08
0.875ThrTrp: 0.875 ± 0.035
1.411ThrTyr: 1.411 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
8.785ValAla: 8.785 ± 0.127
0.649ValCys: 0.649 ± 0.034
5.353ValAsp: 5.353 ± 0.098
5.049ValGlu: 5.049 ± 0.094
2.51ValPhe: 2.51 ± 0.069
6.1ValGly: 6.1 ± 0.102
1.608ValHis: 1.608 ± 0.045
4.461ValIle: 4.461 ± 0.086
2.426ValLys: 2.426 ± 0.069
7.304ValLeu: 7.304 ± 0.1
1.644ValMet: 1.644 ± 0.046
2.268ValAsn: 2.268 ± 0.062
3.647ValPro: 3.647 ± 0.069
2.14ValGln: 2.14 ± 0.057
4.29ValArg: 4.29 ± 0.088
4.807ValSer: 4.807 ± 0.077
4.674ValThr: 4.674 ± 0.095
6.542ValVal: 6.542 ± 0.106
1.022ValTrp: 1.022 ± 0.037
1.621ValTyr: 1.621 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
1.444TrpAla: 1.444 ± 0.047
0.122TrpCys: 0.122 ± 0.015
0.764TrpAsp: 0.764 ± 0.036
0.765TrpGlu: 0.765 ± 0.034
0.551TrpPhe: 0.551 ± 0.03
0.968TrpGly: 0.968 ± 0.038
0.307TrpHis: 0.307 ± 0.019
0.772TrpIle: 0.772 ± 0.036
0.485TrpLys: 0.485 ± 0.029
1.511TrpLeu: 1.511 ± 0.056
0.39TrpMet: 0.39 ± 0.025
0.451TrpAsn: 0.451 ± 0.023
0.658TrpPro: 0.658 ± 0.03
0.579TrpGln: 0.579 ± 0.032
0.91TrpArg: 0.91 ± 0.037
0.899TrpSer: 0.899 ± 0.033
0.774TrpThr: 0.774 ± 0.037
1.099TrpVal: 1.099 ± 0.042
0.349TrpTrp: 0.349 ± 0.026
0.289TrpTyr: 0.289 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.288TyrAla: 2.288 ± 0.063
0.208TyrCys: 0.208 ± 0.018
1.492TyrAsp: 1.492 ± 0.054
1.294TyrGlu: 1.294 ± 0.046
0.961TyrPhe: 0.961 ± 0.038
2.047TyrGly: 2.047 ± 0.053
0.5TyrHis: 0.5 ± 0.032
1.019TyrIle: 1.019 ± 0.037
0.685TyrLys: 0.685 ± 0.034
2.383TyrLeu: 2.383 ± 0.062
0.446TyrMet: 0.446 ± 0.025
0.658TyrAsn: 0.658 ± 0.033
1.164TyrPro: 1.164 ± 0.044
0.792TyrGln: 0.792 ± 0.027
1.492TyrArg: 1.492 ± 0.05
1.586TyrSer: 1.586 ± 0.041
1.31TyrThr: 1.31 ± 0.042
1.624TyrVal: 1.624 ± 0.05
0.351TyrTrp: 0.351 ± 0.024
0.597TyrTyr: 0.597 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2285 proteins (719998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski