Amino acid dipepetide frequency for Pseudogymnoascus sp. 05NY08

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.207AlaAla: 10.207 ± 0.084	1.016AlaCys: 1.016 ± 0.017	4.388AlaAsp: 4.388 ± 0.038	5.491AlaGlu: 5.491 ± 0.044	3.173AlaPhe: 3.173 ± 0.026	6.325AlaGly: 6.325 ± 0.041	1.726AlaHis: 1.726 ± 0.016	4.496AlaIle: 4.496 ± 0.036	4.462AlaLys: 4.462 ± 0.041	7.867AlaLeu: 7.867 ± 0.054	1.996AlaMet: 1.996 ± 0.02	3.146AlaAsn: 3.146 ± 0.028	5.378AlaPro: 5.378 ± 0.053	3.42AlaGln: 3.42 ± 0.03	4.88AlaArg: 4.88 ± 0.038	7.219AlaSer: 7.219 ± 0.051	5.675AlaThr: 5.675 ± 0.039	5.633AlaVal: 5.633 ± 0.038	1.133AlaTrp: 1.133 ± 0.018	2.213AlaTyr: 2.213 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.941CysAla: 0.941 ± 0.015	0.241CysCys: 0.241 ± 0.009	0.619CysAsp: 0.619 ± 0.013	0.569CysGlu: 0.569 ± 0.012	0.522CysPhe: 0.522 ± 0.009	0.953CysGly: 0.953 ± 0.014	0.294CysHis: 0.294 ± 0.009	0.683CysIle: 0.683 ± 0.013	0.497CysLys: 0.497 ± 0.011	1.132CysLeu: 1.132 ± 0.016	0.266CysMet: 0.266 ± 0.007	0.407CysAsn: 0.407 ± 0.011	0.602CysPro: 0.602 ± 0.014	0.39CysGln: 0.39 ± 0.009	0.643CysArg: 0.643 ± 0.013	0.83CysSer: 0.83 ± 0.015	0.671CysThr: 0.671 ± 0.014	0.744CysVal: 0.744 ± 0.015	0.194CysTrp: 0.194 ± 0.006	0.344CysTyr: 0.344 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.927AspAla: 4.927 ± 0.04	0.584AspCys: 0.584 ± 0.012	4.14AspAsp: 4.14 ± 0.044	4.505AspGlu: 4.505 ± 0.043	2.208AspPhe: 2.208 ± 0.021	4.238AspGly: 4.238 ± 0.031	1.078AspHis: 1.078 ± 0.017	3.154AspIle: 3.154 ± 0.027	2.436AspLys: 2.436 ± 0.026	4.873AspLeu: 4.873 ± 0.036	1.257AspMet: 1.257 ± 0.017	1.929AspAsn: 1.929 ± 0.021	3.026AspPro: 3.026 ± 0.025	1.701AspGln: 1.701 ± 0.018	2.815AspArg: 2.815 ± 0.027	4.03AspSer: 4.03 ± 0.03	2.968AspThr: 2.968 ± 0.027	3.704AspVal: 3.704 ± 0.032	0.834AspTrp: 0.834 ± 0.013	1.588AspTyr: 1.588 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.793GluAla: 5.793 ± 0.052	0.59GluCys: 0.59 ± 0.012	4.224GluAsp: 4.224 ± 0.04	6.047GluGlu: 6.047 ± 0.068	1.97GluPhe: 1.97 ± 0.021	4.52GluGly: 4.52 ± 0.036	1.255GluHis: 1.255 ± 0.017	3.125GluIle: 3.125 ± 0.025	3.867GluLys: 3.867 ± 0.038	5.152GluLeu: 5.152 ± 0.042	1.576GluMet: 1.576 ± 0.021	2.246GluAsn: 2.246 ± 0.021	2.675GluPro: 2.675 ± 0.033	2.275GluGln: 2.275 ± 0.03	4.019GluArg: 4.019 ± 0.041	4.276GluSer: 4.276 ± 0.036	3.428GluThr: 3.428 ± 0.029	3.972GluVal: 3.972 ± 0.032	0.907GluTrp: 0.907 ± 0.014	1.686GluTyr: 1.686 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.133PheAla: 3.133 ± 0.031	0.533PheCys: 0.533 ± 0.011	2.213PheAsp: 2.213 ± 0.023	2.185PheGlu: 2.185 ± 0.021	1.561PhePhe: 1.561 ± 0.022	2.982PheGly: 2.982 ± 0.035	0.817PheHis: 0.817 ± 0.014	1.844PheIle: 1.844 ± 0.023	1.593PheLys: 1.593 ± 0.017	3.317PheLeu: 3.317 ± 0.03	0.822PheMet: 0.822 ± 0.013	1.448PheAsn: 1.448 ± 0.02	1.866PhePro: 1.866 ± 0.02	1.327PheGln: 1.327 ± 0.017	1.788PheArg: 1.788 ± 0.02	2.89PheSer: 2.89 ± 0.026	2.151PheThr: 2.151 ± 0.021	2.357PheVal: 2.357 ± 0.024	0.611PheTrp: 0.611 ± 0.012	1.098PheTyr: 1.098 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	6.014GlyAla: 6.014 ± 0.045	0.863GlyCys: 0.863 ± 0.016	3.878GlyAsp: 3.878 ± 0.031	4.322GlyGlu: 4.322 ± 0.036	2.917GlyPhe: 2.917 ± 0.027	7.379GlyGly: 7.379 ± 0.074	1.645GlyHis: 1.645 ± 0.022	3.656GlyIle: 3.656 ± 0.032	3.916GlyLys: 3.916 ± 0.025	6.149GlyLeu: 6.149 ± 0.044	1.801GlyMet: 1.801 ± 0.022	2.765GlyAsn: 2.765 ± 0.029	3.345GlyPro: 3.345 ± 0.033	2.612GlyGln: 2.612 ± 0.033	4.306GlyArg: 4.306 ± 0.037	5.867GlySer: 5.867 ± 0.046	4.138GlyThr: 4.138 ± 0.031	4.84GlyVal: 4.84 ± 0.035	1.244GlyTrp: 1.244 ± 0.019	2.2GlyTyr: 2.2 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.739HisAla: 1.739 ± 0.021	0.286HisCys: 0.286 ± 0.008	1.173HisAsp: 1.173 ± 0.016	1.205HisGlu: 1.205 ± 0.017	0.858HisPhe: 0.858 ± 0.013	1.63HisGly: 1.63 ± 0.017	0.708HisHis: 0.708 ± 0.015	1.182HisIle: 1.182 ± 0.016	0.921HisLys: 0.921 ± 0.015	2.071HisLeu: 2.071 ± 0.022	0.458HisMet: 0.458 ± 0.009	0.831HisAsn: 0.831 ± 0.017	1.529HisPro: 1.529 ± 0.019	0.874HisGln: 0.874 ± 0.014	1.321HisArg: 1.321 ± 0.019	1.629HisSer: 1.629 ± 0.02	1.233HisThr: 1.233 ± 0.017	1.325HisVal: 1.325 ± 0.018	0.309HisTrp: 0.309 ± 0.007	0.661HisTyr: 0.661 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.406IleAla: 4.406 ± 0.033	0.739IleCys: 0.739 ± 0.013	2.916IleAsp: 2.916 ± 0.026	2.968IleGlu: 2.968 ± 0.029	2.006IlePhe: 2.006 ± 0.027	3.346IleGly: 3.346 ± 0.031	1.127IleHis: 1.127 ± 0.014	2.681IleIle: 2.681 ± 0.025	2.318IleLys: 2.318 ± 0.022	4.555IleLeu: 4.555 ± 0.037	1.054IleMet: 1.054 ± 0.016	1.877IleAsn: 1.877 ± 0.021	3.049IlePro: 3.049 ± 0.027	1.853IleGln: 1.853 ± 0.021	2.652IleArg: 2.652 ± 0.024	3.977IleSer: 3.977 ± 0.029	3.043IleThr: 3.043 ± 0.026	3.224IleVal: 3.224 ± 0.03	0.702IleTrp: 0.702 ± 0.013	1.439IleTyr: 1.439 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.627LysAla: 4.627 ± 0.04	0.485LysCys: 0.485 ± 0.011	2.854LysAsp: 2.854 ± 0.024	3.64LysGlu: 3.64 ± 0.039	1.547LysPhe: 1.547 ± 0.019	3.38LysGly: 3.38 ± 0.031	1.071LysHis: 1.071 ± 0.016	2.408LysIle: 2.408 ± 0.024	3.527LysLys: 3.527 ± 0.051	4.239LysLeu: 4.239 ± 0.029	1.053LysMet: 1.053 ± 0.013	1.816LysAsn: 1.816 ± 0.023	2.751LysPro: 2.751 ± 0.027	1.742LysGln: 1.742 ± 0.02	3.334LysArg: 3.334 ± 0.033	3.67LysSer: 3.67 ± 0.03	2.931LysThr: 2.931 ± 0.026	3.017LysVal: 3.017 ± 0.028	0.699LysTrp: 0.699 ± 0.013	1.424LysTyr: 1.424 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.878LeuAla: 7.878 ± 0.043	1.1LeuCys: 1.1 ± 0.016	4.991LeuAsp: 4.991 ± 0.036	5.468LeuGlu: 5.468 ± 0.036	3.185LeuPhe: 3.185 ± 0.034	6.033LeuGly: 6.033 ± 0.039	2.072LeuHis: 2.072 ± 0.022	3.949LeuIle: 3.949 ± 0.038	4.33LeuLys: 4.33 ± 0.033	8.233LeuLeu: 8.233 ± 0.067	1.78LeuMet: 1.78 ± 0.023	3.074LeuAsn: 3.074 ± 0.023	5.396LeuPro: 5.396 ± 0.035	3.551LeuGln: 3.551 ± 0.03	5.317LeuArg: 5.317 ± 0.039	7.13LeuSer: 7.13 ± 0.047	4.833LeuThr: 4.833 ± 0.037	5.227LeuVal: 5.227 ± 0.043	1.153LeuTrp: 1.153 ± 0.017	2.286LeuTyr: 2.286 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.287MetAla: 2.287 ± 0.021	0.23MetCys: 0.23 ± 0.006	1.261MetAsp: 1.261 ± 0.014	1.39MetGlu: 1.39 ± 0.019	0.772MetPhe: 0.772 ± 0.013	1.687MetGly: 1.687 ± 0.023	0.472MetHis: 0.472 ± 0.01	0.976MetIle: 0.976 ± 0.015	1.081MetLys: 1.081 ± 0.013	1.813MetLeu: 1.813 ± 0.021	0.602MetMet: 0.602 ± 0.011	0.804MetAsn: 0.804 ± 0.013	1.234MetPro: 1.234 ± 0.018	0.824MetGln: 0.824 ± 0.014	1.258MetArg: 1.258 ± 0.018	1.88MetSer: 1.88 ± 0.02	1.239MetThr: 1.239 ± 0.017	1.367MetVal: 1.367 ± 0.016	0.258MetTrp: 0.258 ± 0.008	0.53MetTyr: 0.53 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.231AsnAla: 3.231 ± 0.028	0.442AsnCys: 0.442 ± 0.009	1.936AsnAsp: 1.936 ± 0.022	2.021AsnGlu: 2.021 ± 0.021	1.422AsnPhe: 1.422 ± 0.019	3.236AsnGly: 3.236 ± 0.027	0.798AsnHis: 0.798 ± 0.012	2.143AsnIle: 2.143 ± 0.022	1.581AsnLys: 1.581 ± 0.017	3.179AsnLeu: 3.179 ± 0.031	0.859AsnMet: 0.859 ± 0.014	1.564AsnAsn: 1.564 ± 0.032	2.458AsnPro: 2.458 ± 0.023	1.297AsnGln: 1.297 ± 0.018	1.874AsnArg: 1.874 ± 0.02	2.812AsnSer: 2.812 ± 0.028	2.262AsnThr: 2.262 ± 0.024	2.29AsnVal: 2.29 ± 0.022	0.55AsnTrp: 0.55 ± 0.012	1.089AsnTyr: 1.089 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.435ProAla: 5.435 ± 0.053	0.452ProCys: 0.452 ± 0.012	2.917ProAsp: 2.917 ± 0.027	3.645ProGlu: 3.645 ± 0.031	1.957ProPhe: 1.957 ± 0.022	3.93ProGly: 3.93 ± 0.035	1.247ProHis: 1.247 ± 0.016	2.618ProIle: 2.618 ± 0.022	2.787ProLys: 2.787 ± 0.03	4.715ProLeu: 4.715 ± 0.034	1.052ProMet: 1.052 ± 0.017	2.192ProAsn: 2.192 ± 0.025	5.274ProPro: 5.274 ± 0.068	2.422ProGln: 2.422 ± 0.034	3.291ProArg: 3.291 ± 0.03	5.812ProSer: 5.812 ± 0.051	4.317ProThr: 4.317 ± 0.035	3.533ProVal: 3.533 ± 0.033	0.695ProTrp: 0.695 ± 0.013	1.496ProTyr: 1.496 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.343GlnAla: 3.343 ± 0.034	0.413GlnCys: 0.413 ± 0.01	1.892GlnAsp: 1.892 ± 0.018	2.26GlnGlu: 2.26 ± 0.024	1.242GlnPhe: 1.242 ± 0.019	2.503GlnGly: 2.503 ± 0.033	0.925GlnHis: 0.925 ± 0.017	1.825GlnIle: 1.825 ± 0.019	1.925GlnLys: 1.925 ± 0.021	3.276GlnLeu: 3.276 ± 0.03	0.875GlnMet: 0.875 ± 0.014	1.524GlnAsn: 1.524 ± 0.02	2.365GlnPro: 2.365 ± 0.03	2.5GlnGln: 2.5 ± 0.065	2.423GlnArg: 2.423 ± 0.025	2.885GlnSer: 2.885 ± 0.032	2.202GlnThr: 2.202 ± 0.021	2.026GlnVal: 2.026 ± 0.02	0.544GlnTrp: 0.544 ± 0.011	1.16GlnTyr: 1.16 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.692ArgAla: 4.692 ± 0.035	0.633ArgCys: 0.633 ± 0.012	3.22ArgAsp: 3.22 ± 0.034	3.939ArgGlu: 3.939 ± 0.043	1.952ArgPhe: 1.952 ± 0.02	4.011ArgGly: 4.011 ± 0.038	1.382ArgHis: 1.382 ± 0.018	2.742ArgIle: 2.742 ± 0.023	3.351ArgLys: 3.351 ± 0.028	4.966ArgLeu: 4.966 ± 0.042	1.279ArgMet: 1.279 ± 0.017	2.155ArgAsn: 2.155 ± 0.023	3.221ArgPro: 3.221 ± 0.033	2.399ArgGln: 2.399 ± 0.024	4.805ArgArg: 4.805 ± 0.049	4.373ArgSer: 4.373 ± 0.042	3.152ArgThr: 3.152 ± 0.028	3.306ArgVal: 3.306 ± 0.029	0.84ArgTrp: 0.84 ± 0.014	1.551ArgTyr: 1.551 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.69SerAla: 6.69 ± 0.047	0.821SerCys: 0.821 ± 0.015	4.155SerAsp: 4.155 ± 0.036	4.091SerGlu: 4.091 ± 0.033	2.914SerPhe: 2.914 ± 0.028	5.739SerGly: 5.739 ± 0.047	1.792SerHis: 1.792 ± 0.021	4.086SerIle: 4.086 ± 0.028	3.814SerLys: 3.814 ± 0.033	6.98SerLeu: 6.98 ± 0.041	1.696SerMet: 1.696 ± 0.019	3.014SerAsn: 3.014 ± 0.031	5.504SerPro: 5.504 ± 0.054	3.093SerGln: 3.093 ± 0.029	4.611SerArg: 4.611 ± 0.041	8.199SerSer: 8.199 ± 0.075	5.617SerThr: 5.617 ± 0.043	4.487SerVal: 4.487 ± 0.035	1.06SerTrp: 1.06 ± 0.017	2.1SerTyr: 2.1 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.445ThrAla: 5.445 ± 0.034	0.74ThrCys: 0.74 ± 0.015	2.882ThrAsp: 2.882 ± 0.026	3.197ThrGlu: 3.197 ± 0.026	2.226ThrPhe: 2.226 ± 0.021	4.366ThrGly: 4.366 ± 0.031	1.277ThrHis: 1.277 ± 0.016	3.233ThrIle: 3.233 ± 0.027	2.775ThrLys: 2.775 ± 0.023	5.218ThrLeu: 5.218 ± 0.039	1.182ThrMet: 1.182 ± 0.016	2.209ThrAsn: 2.209 ± 0.021	4.592ThrPro: 4.592 ± 0.035	2.009ThrGln: 2.009 ± 0.02	2.974ThrArg: 2.974 ± 0.027	5.394ThrSer: 5.394 ± 0.042	4.698ThrThr: 4.698 ± 0.042	3.696ThrVal: 3.696 ± 0.03	0.841ThrTrp: 0.841 ± 0.015	1.657ThrTyr: 1.657 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.679ValAla: 5.679 ± 0.041	0.782ValCys: 0.782 ± 0.013	3.777ValAsp: 3.777 ± 0.031	4.24ValGlu: 4.24 ± 0.037	2.395ValPhe: 2.395 ± 0.025	4.428ValGly: 4.428 ± 0.033	1.266ValHis: 1.266 ± 0.017	2.974ValIle: 2.974 ± 0.026	3.084ValLys: 3.084 ± 0.024	5.453ValLeu: 5.453 ± 0.039	1.37ValMet: 1.37 ± 0.018	2.234ValAsn: 2.234 ± 0.025	3.488ValPro: 3.488 ± 0.027	2.233ValGln: 2.233 ± 0.022	3.294ValArg: 3.294 ± 0.026	4.478ValSer: 4.478 ± 0.033	3.508ValThr: 3.508 ± 0.031	4.66ValVal: 4.66 ± 0.04	0.861ValTrp: 0.861 ± 0.016	1.711ValTyr: 1.711 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.163TrpAla: 1.163 ± 0.017	0.182TrpCys: 0.182 ± 0.007	0.881TrpAsp: 0.881 ± 0.014	0.868TrpGlu: 0.868 ± 0.013	0.52TrpPhe: 0.52 ± 0.01	1.003TrpGly: 1.003 ± 0.017	0.318TrpHis: 0.318 ± 0.007	0.712TrpIle: 0.712 ± 0.013	0.778TrpLys: 0.778 ± 0.012	1.239TrpLeu: 1.239 ± 0.016	0.379TrpMet: 0.379 ± 0.009	0.607TrpAsn: 0.607 ± 0.012	0.566TrpPro: 0.566 ± 0.011	0.506TrpGln: 0.506 ± 0.01	0.894TrpArg: 0.894 ± 0.013	1.025TrpSer: 1.025 ± 0.016	0.876TrpThr: 0.876 ± 0.015	0.92TrpVal: 0.92 ± 0.013	0.267TrpTrp: 0.267 ± 0.009	0.406TrpTyr: 0.406 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.213TyrAla: 2.213 ± 0.021	0.409TyrCys: 0.409 ± 0.01	1.678TyrAsp: 1.678 ± 0.023	1.552TyrGlu: 1.552 ± 0.019	1.188TyrPhe: 1.188 ± 0.018	2.167TyrGly: 2.167 ± 0.024	0.672TyrHis: 0.672 ± 0.012	1.445TyrIle: 1.445 ± 0.017	1.169TyrLys: 1.169 ± 0.014	2.561TyrLeu: 2.561 ± 0.025	0.607TyrMet: 0.607 ± 0.01	1.201TyrAsn: 1.201 ± 0.017	1.467TyrPro: 1.467 ± 0.016	1.08TyrGln: 1.08 ± 0.016	1.468TyrArg: 1.468 ± 0.019	2.091TyrSer: 2.091 ± 0.025	1.669TyrThr: 1.669 ± 0.02	1.59TyrVal: 1.59 ± 0.019	0.411TyrTrp: 0.411 ± 0.01	0.935TyrTyr: 0.935 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10300 proteins (5075312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---