Amino acid dipepetide frequency for Thiomonas sp. X19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.592AlaAla: 19.592 ± 0.167	1.473AlaCys: 1.473 ± 0.036	6.308AlaAsp: 6.308 ± 0.076	6.401AlaGlu: 6.401 ± 0.081	3.958AlaPhe: 3.958 ± 0.061	10.614AlaGly: 10.614 ± 0.104	3.144AlaHis: 3.144 ± 0.058	5.229AlaIle: 5.229 ± 0.069	3.58AlaLys: 3.58 ± 0.06	15.785AlaLeu: 15.785 ± 0.149	3.815AlaMet: 3.815 ± 0.049	2.825AlaAsn: 2.825 ± 0.061	6.54AlaPro: 6.54 ± 0.083	7.322AlaGln: 7.322 ± 0.103	9.293AlaArg: 9.293 ± 0.09	7.248AlaSer: 7.248 ± 0.081	6.041AlaThr: 6.041 ± 0.074	9.022AlaVal: 9.022 ± 0.084	2.208AlaTrp: 2.208 ± 0.047	2.534AlaTyr: 2.534 ± 0.044	0.003AlaXaa: 0.003 ± 0.001
Cys	1.323CysAla: 1.323 ± 0.029	0.167CysCys: 0.167 ± 0.013	0.548CysAsp: 0.548 ± 0.018	0.484CysGlu: 0.484 ± 0.02	0.292CysPhe: 0.292 ± 0.016	1.069CysGly: 1.069 ± 0.029	0.334CysHis: 0.334 ± 0.02	0.416CysIle: 0.416 ± 0.018	0.28CysLys: 0.28 ± 0.016	0.88CysLeu: 0.88 ± 0.028	0.23CysMet: 0.23 ± 0.012	0.257CysAsn: 0.257 ± 0.014	0.617CysPro: 0.617 ± 0.025	0.293CysGln: 0.293 ± 0.014	0.706CysArg: 0.706 ± 0.028	0.589CysSer: 0.589 ± 0.021	0.492CysThr: 0.492 ± 0.02	0.703CysVal: 0.703 ± 0.027	0.166CysTrp: 0.166 ± 0.018	0.181CysTyr: 0.181 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.615AspAla: 7.615 ± 0.093	0.502AspCys: 0.502 ± 0.019	2.645AspAsp: 2.645 ± 0.053	2.587AspGlu: 2.587 ± 0.05	1.905AspPhe: 1.905 ± 0.041	4.093AspGly: 4.093 ± 0.064	1.18AspHis: 1.18 ± 0.03	2.307AspIle: 2.307 ± 0.044	1.621AspLys: 1.621 ± 0.041	5.417AspLeu: 5.417 ± 0.074	1.199AspMet: 1.199 ± 0.034	1.135AspAsn: 1.135 ± 0.029	3.066AspPro: 3.066 ± 0.052	1.583AspGln: 1.583 ± 0.037	3.021AspArg: 3.021 ± 0.054	2.202AspSer: 2.202 ± 0.045	2.307AspThr: 2.307 ± 0.037	3.591AspVal: 3.591 ± 0.056	0.978AspTrp: 0.978 ± 0.029	1.254AspTyr: 1.254 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.27GluAla: 6.27 ± 0.084	0.37GluCys: 0.37 ± 0.018	1.931GluAsp: 1.931 ± 0.037	1.77GluGlu: 1.77 ± 0.039	1.611GluPhe: 1.611 ± 0.038	3.249GluGly: 3.249 ± 0.058	1.518GluHis: 1.518 ± 0.032	2.334GluIle: 2.334 ± 0.041	1.402GluLys: 1.402 ± 0.036	5.469GluLeu: 5.469 ± 0.076	1.056GluMet: 1.056 ± 0.03	1.093GluAsn: 1.093 ± 0.033	2.531GluPro: 2.531 ± 0.044	2.829GluGln: 2.829 ± 0.054	4.302GluArg: 4.302 ± 0.068	2.285GluSer: 2.285 ± 0.038	2.271GluThr: 2.271 ± 0.039	3.385GluVal: 3.385 ± 0.059	0.606GluTrp: 0.606 ± 0.019	0.805GluTyr: 0.805 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.18PheAla: 4.18 ± 0.074	0.355PheCys: 0.355 ± 0.016	2.256PheAsp: 2.256 ± 0.04	1.851PheGlu: 1.851 ± 0.037	1.263PhePhe: 1.263 ± 0.053	3.19PheGly: 3.19 ± 0.059	0.784PheHis: 0.784 ± 0.024	1.591PheIle: 1.591 ± 0.039	1.069PheLys: 1.069 ± 0.032	2.967PheLeu: 2.967 ± 0.053	0.768PheMet: 0.768 ± 0.026	1.021PheAsn: 1.021 ± 0.03	1.46PhePro: 1.46 ± 0.038	1.069PheGln: 1.069 ± 0.028	1.805PheArg: 1.805 ± 0.036	1.971PheSer: 1.971 ± 0.036	1.777PheThr: 1.777 ± 0.039	2.495PheVal: 2.495 ± 0.047	0.528PheTrp: 0.528 ± 0.021	0.833PheTyr: 0.833 ± 0.027	0.001PheXaa: 0.001 ± 0.001
Gly	9.168GlyAla: 9.168 ± 0.114	0.972GlyCys: 0.972 ± 0.037	3.599GlyAsp: 3.599 ± 0.05	3.864GlyGlu: 3.864 ± 0.059	3.132GlyPhe: 3.132 ± 0.06	6.764GlyGly: 6.764 ± 0.106	2.214GlyHis: 2.214 ± 0.043	3.833GlyIle: 3.833 ± 0.062	3.088GlyLys: 3.088 ± 0.06	9.312GlyLeu: 9.312 ± 0.102	2.53GlyMet: 2.53 ± 0.045	2.056GlyAsn: 2.056 ± 0.046	3.24GlyPro: 3.24 ± 0.052	3.701GlyGln: 3.701 ± 0.058	5.611GlyArg: 5.611 ± 0.067	4.65GlySer: 4.65 ± 0.081	3.943GlyThr: 3.943 ± 0.066	6.419GlyVal: 6.419 ± 0.084	1.506GlyTrp: 1.506 ± 0.035	2.19GlyTyr: 2.19 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	3.654HisAla: 3.654 ± 0.06	0.313HisCys: 0.313 ± 0.016	1.413HisAsp: 1.413 ± 0.039	1.153HisGlu: 1.153 ± 0.03	0.908HisPhe: 0.908 ± 0.023	2.382HisGly: 2.382 ± 0.042	0.788HisHis: 0.788 ± 0.028	1.066HisIle: 1.066 ± 0.028	0.666HisLys: 0.666 ± 0.025	2.631HisLeu: 2.631 ± 0.045	0.565HisMet: 0.565 ± 0.022	0.538HisAsn: 0.538 ± 0.02	1.751HisPro: 1.751 ± 0.041	0.923HisGln: 0.923 ± 0.029	1.813HisArg: 1.813 ± 0.044	1.105HisSer: 1.105 ± 0.036	1.151HisThr: 1.151 ± 0.03	1.761HisVal: 1.761 ± 0.037	0.497HisTrp: 0.497 ± 0.019	0.589HisTyr: 0.589 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.039IleAla: 6.039 ± 0.068	0.43IleCys: 0.43 ± 0.022	2.938IleAsp: 2.938 ± 0.051	2.741IleGlu: 2.741 ± 0.049	1.14IlePhe: 1.14 ± 0.03	3.937IleGly: 3.937 ± 0.066	1.036IleHis: 1.036 ± 0.027	1.608IleIle: 1.608 ± 0.04	1.351IleLys: 1.351 ± 0.03	3.55IleLeu: 3.55 ± 0.061	0.733IleMet: 0.733 ± 0.023	1.328IleAsn: 1.328 ± 0.027	2.175IlePro: 2.175 ± 0.043	1.469IleGln: 1.469 ± 0.037	2.64IleArg: 2.64 ± 0.051	2.325IleSer: 2.325 ± 0.052	2.349IleThr: 2.349 ± 0.048	3.262IleVal: 3.262 ± 0.063	0.525IleTrp: 0.525 ± 0.023	0.953IleTyr: 0.953 ± 0.028	0.001IleXaa: 0.001 ± 0.001
Lys	3.738LysAla: 3.738 ± 0.065	0.168LysCys: 0.168 ± 0.011	1.401LysAsp: 1.401 ± 0.039	1.12LysGlu: 1.12 ± 0.03	0.769LysPhe: 0.769 ± 0.027	2.029LysGly: 2.029 ± 0.045	0.697LysHis: 0.697 ± 0.024	1.29LysIle: 1.29 ± 0.034	1.114LysLys: 1.114 ± 0.039	3.505LysLeu: 3.505 ± 0.057	0.697LysMet: 0.697 ± 0.027	0.842LysAsn: 0.842 ± 0.028	2.351LysPro: 2.351 ± 0.051	1.241LysGln: 1.241 ± 0.035	2.294LysArg: 2.294 ± 0.046	1.756LysSer: 1.756 ± 0.035	2.027LysThr: 2.027 ± 0.042	2.072LysVal: 2.072 ± 0.036	0.316LysTrp: 0.316 ± 0.016	0.561LysTyr: 0.561 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.439LeuAla: 15.439 ± 0.135	0.989LeuCys: 0.989 ± 0.028	6.185LeuAsp: 6.185 ± 0.09	4.894LeuGlu: 4.894 ± 0.072	3.453LeuPhe: 3.453 ± 0.058	9.255LeuGly: 9.255 ± 0.103	2.903LeuHis: 2.903 ± 0.055	4.105LeuIle: 4.105 ± 0.066	3.198LeuLys: 3.198 ± 0.052	12.254LeuLeu: 12.254 ± 0.166	2.392LeuMet: 2.392 ± 0.047	2.502LeuAsn: 2.502 ± 0.047	6.403LeuPro: 6.403 ± 0.07	5.325LeuGln: 5.325 ± 0.082	8.717LeuArg: 8.717 ± 0.106	6.205LeuSer: 6.205 ± 0.085	5.143LeuThr: 5.143 ± 0.069	7.33LeuVal: 7.33 ± 0.097	1.497LeuTrp: 1.497 ± 0.044	2.019LeuTyr: 2.019 ± 0.042	0.003LeuXaa: 0.003 ± 0.002
Met	3.053MetAla: 3.053 ± 0.051	0.175MetCys: 0.175 ± 0.012	1.165MetAsp: 1.165 ± 0.035	0.962MetGlu: 0.962 ± 0.025	0.712MetPhe: 0.712 ± 0.022	1.791MetGly: 1.791 ± 0.038	0.636MetHis: 0.636 ± 0.021	0.896MetIle: 0.896 ± 0.027	0.844MetLys: 0.844 ± 0.022	2.824MetLeu: 2.824 ± 0.05	0.557MetMet: 0.557 ± 0.024	0.892MetAsn: 0.892 ± 0.027	1.707MetPro: 1.707 ± 0.038	1.439MetGln: 1.439 ± 0.036	2.054MetArg: 2.054 ± 0.04	1.559MetSer: 1.559 ± 0.035	1.449MetThr: 1.449 ± 0.028	1.588MetVal: 1.588 ± 0.038	0.214MetTrp: 0.214 ± 0.013	0.304MetTyr: 0.304 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.294AsnAla: 3.294 ± 0.055	0.239AsnCys: 0.239 ± 0.015	1.137AsnAsp: 1.137 ± 0.036	0.9AsnGlu: 0.9 ± 0.027	0.842AsnPhe: 0.842 ± 0.027	2.045AsnGly: 2.045 ± 0.05	0.61AsnHis: 0.61 ± 0.022	1.087AsnIle: 1.087 ± 0.031	0.746AsnLys: 0.746 ± 0.027	2.711AsnLeu: 2.711 ± 0.049	0.514AsnMet: 0.514 ± 0.021	0.686AsnAsn: 0.686 ± 0.033	2.043AsnPro: 2.043 ± 0.043	0.996AsnGln: 0.996 ± 0.031	1.592AsnArg: 1.592 ± 0.037	1.21AsnSer: 1.21 ± 0.038	1.467AsnThr: 1.467 ± 0.037	1.669AsnVal: 1.669 ± 0.035	0.444AsnTrp: 0.444 ± 0.017	0.58AsnTyr: 0.58 ± 0.021	0.001AsnXaa: 0.001 ± 0.001
Pro	7.601ProAla: 7.601 ± 0.091	0.523ProCys: 0.523 ± 0.023	3.14ProAsp: 3.14 ± 0.051	3.136ProGlu: 3.136 ± 0.06	1.701ProPhe: 1.701 ± 0.037	5.1ProGly: 5.1 ± 0.076	1.32ProHis: 1.32 ± 0.038	2.069ProIle: 2.069 ± 0.041	1.613ProLys: 1.613 ± 0.042	5.445ProLeu: 5.445 ± 0.074	1.495ProMet: 1.495 ± 0.037	1.346ProAsn: 1.346 ± 0.033	3.167ProPro: 3.167 ± 0.068	2.848ProGln: 2.848 ± 0.046	3.39ProArg: 3.39 ± 0.056	3.235ProSer: 3.235 ± 0.062	2.845ProThr: 2.845 ± 0.05	3.981ProVal: 3.981 ± 0.061	0.928ProTrp: 0.928 ± 0.03	1.133ProTyr: 1.133 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	7.439GlnAla: 7.439 ± 0.092	0.377GlnCys: 0.377 ± 0.016	1.924GlnAsp: 1.924 ± 0.041	1.742GlnGlu: 1.742 ± 0.043	1.362GlnPhe: 1.362 ± 0.032	3.73GlnGly: 3.73 ± 0.058	1.26GlnHis: 1.26 ± 0.036	1.974GlnIle: 1.974 ± 0.04	1.027GlnLys: 1.027 ± 0.031	4.363GlnLeu: 4.363 ± 0.064	0.979GlnMet: 0.979 ± 0.028	1.02GlnAsn: 1.02 ± 0.027	2.85GlnPro: 2.85 ± 0.053	2.6GlnGln: 2.6 ± 0.059	3.958GlnArg: 3.958 ± 0.068	2.483GlnSer: 2.483 ± 0.042	2.532GlnThr: 2.532 ± 0.045	3.199GlnVal: 3.199 ± 0.05	0.745GlnTrp: 0.745 ± 0.025	0.835GlnTyr: 0.835 ± 0.027	0.001GlnXaa: 0.001 ± 0.001
Arg	8.275ArgAla: 8.275 ± 0.087	0.754ArgCys: 0.754 ± 0.025	3.586ArgAsp: 3.586 ± 0.062	4.039ArgGlu: 4.039 ± 0.059	2.665ArgPhe: 2.665 ± 0.045	4.82ArgGly: 4.82 ± 0.063	2.189ArgHis: 2.189 ± 0.042	3.6ArgIle: 3.6 ± 0.057	2.339ArgLys: 2.339 ± 0.048	8.443ArgLeu: 8.443 ± 0.099	2.02ArgMet: 2.02 ± 0.035	1.794ArgAsn: 1.794 ± 0.038	3.618ArgPro: 3.618 ± 0.055	3.53ArgGln: 3.53 ± 0.053	5.699ArgArg: 5.699 ± 0.075	3.684ArgSer: 3.684 ± 0.052	3.173ArgThr: 3.173 ± 0.06	4.915ArgVal: 4.915 ± 0.06	1.245ArgTrp: 1.245 ± 0.032	1.749ArgTyr: 1.749 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	6.757SerAla: 6.757 ± 0.073	0.553SerCys: 0.553 ± 0.022	2.372SerAsp: 2.372 ± 0.043	2.247SerGlu: 2.247 ± 0.046	1.871SerPhe: 1.871 ± 0.041	5.237SerGly: 5.237 ± 0.091	1.295SerHis: 1.295 ± 0.026	2.456SerIle: 2.456 ± 0.049	1.62SerLys: 1.62 ± 0.034	5.865SerLeu: 5.865 ± 0.071	1.465SerMet: 1.465 ± 0.034	1.415SerAsn: 1.415 ± 0.029	3.184SerPro: 3.184 ± 0.054	2.115SerGln: 2.115 ± 0.045	3.745SerArg: 3.745 ± 0.065	3.252SerSer: 3.252 ± 0.067	3.2SerThr: 3.2 ± 0.053	3.642SerVal: 3.642 ± 0.061	0.783SerTrp: 0.783 ± 0.024	1.177SerTyr: 1.177 ± 0.034	0.002SerXaa: 0.002 ± 0.001
Thr	6.227ThrAla: 6.227 ± 0.078	0.468ThrCys: 0.468 ± 0.02	2.301ThrAsp: 2.301 ± 0.044	2.178ThrGlu: 2.178 ± 0.044	1.509ThrPhe: 1.509 ± 0.038	4.312ThrGly: 4.312 ± 0.067	1.222ThrHis: 1.222 ± 0.028	2.059ThrIle: 2.059 ± 0.043	1.26ThrLys: 1.26 ± 0.033	6.13ThrLeu: 6.13 ± 0.078	1.072ThrMet: 1.072 ± 0.031	1.182ThrAsn: 1.182 ± 0.036	3.7ThrPro: 3.7 ± 0.057	2.285ThrGln: 2.285 ± 0.047	3.437ThrArg: 3.437 ± 0.053	2.75ThrSer: 2.75 ± 0.052	2.817ThrThr: 2.817 ± 0.054	3.661ThrVal: 3.661 ± 0.046	0.74ThrTrp: 0.74 ± 0.027	1.018ThrTyr: 1.018 ± 0.032	0.001ThrXaa: 0.001 ± 0.001
Val	8.721ValAla: 8.721 ± 0.091	0.784ValCys: 0.784 ± 0.028	3.742ValAsp: 3.742 ± 0.045	3.647ValGlu: 3.647 ± 0.06	2.69ValPhe: 2.69 ± 0.056	5.214ValGly: 5.214 ± 0.078	1.671ValHis: 1.671 ± 0.04	3.116ValIle: 3.116 ± 0.057	2.067ValLys: 2.067 ± 0.044	8.256ValLeu: 8.256 ± 0.097	1.865ValMet: 1.865 ± 0.039	1.874ValAsn: 1.874 ± 0.041	3.693ValPro: 3.693 ± 0.057	3.224ValGln: 3.224 ± 0.058	5.063ValArg: 5.063 ± 0.072	3.802ValSer: 3.802 ± 0.055	3.299ValThr: 3.299 ± 0.053	5.714ValVal: 5.714 ± 0.077	1.071ValTrp: 1.071 ± 0.031	1.437ValTyr: 1.437 ± 0.039	0.001ValXaa: 0.001 ± 0.001
Trp	1.677TrpAla: 1.677 ± 0.041	0.175TrpCys: 0.175 ± 0.012	0.616TrpAsp: 0.616 ± 0.02	0.546TrpGlu: 0.546 ± 0.022	0.561TrpPhe: 0.561 ± 0.022	1.05TrpGly: 1.05 ± 0.037	0.409TrpHis: 0.409 ± 0.018	0.696TrpIle: 0.696 ± 0.024	0.489TrpLys: 0.489 ± 0.019	2.251TrpLeu: 2.251 ± 0.052	0.486TrpMet: 0.486 ± 0.021	0.448TrpAsn: 0.448 ± 0.02	0.815TrpPro: 0.815 ± 0.028	0.789TrpGln: 0.789 ± 0.026	1.426TrpArg: 1.426 ± 0.035	0.831TrpSer: 0.831 ± 0.027	0.774TrpThr: 0.774 ± 0.025	1.064TrpVal: 1.064 ± 0.027	0.281TrpTrp: 0.281 ± 0.016	0.264TrpTyr: 0.264 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.87TyrAla: 2.87 ± 0.046	0.241TyrCys: 0.241 ± 0.015	1.0TyrAsp: 1.0 ± 0.027	0.826TyrGlu: 0.826 ± 0.025	0.89TyrPhe: 0.89 ± 0.028	1.911TyrGly: 1.911 ± 0.043	0.457TyrHis: 0.457 ± 0.019	0.798TyrIle: 0.798 ± 0.023	0.61TyrLys: 0.61 ± 0.024	2.154TyrLeu: 2.154 ± 0.037	0.382TyrMet: 0.382 ± 0.018	0.562TyrAsn: 0.562 ± 0.023	1.104TyrPro: 1.104 ± 0.03	0.823TyrGln: 0.823 ± 0.028	1.567TyrArg: 1.567 ± 0.041	1.11TyrSer: 1.11 ± 0.03	1.269TyrThr: 1.269 ± 0.034	1.479TyrVal: 1.479 ± 0.03	0.367TyrTrp: 0.367 ± 0.019	0.509TyrTyr: 0.509 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4745 proteins (1333605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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