Amino acid dipepetide frequency for Desulfonema ishimotonii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.643AlaAla: 8.643 ± 0.111	1.26AlaCys: 1.26 ± 0.035	6.069AlaAsp: 6.069 ± 0.088	6.555AlaGlu: 6.555 ± 0.08	3.857AlaPhe: 3.857 ± 0.047	7.888AlaGly: 7.888 ± 0.093	1.683AlaHis: 1.683 ± 0.037	5.156AlaIle: 5.156 ± 0.06	3.192AlaLys: 3.192 ± 0.053	8.928AlaLeu: 8.928 ± 0.094	2.252AlaMet: 2.252 ± 0.044	2.158AlaAsn: 2.158 ± 0.035	3.222AlaPro: 3.222 ± 0.055	2.246AlaGln: 2.246 ± 0.04	5.643AlaArg: 5.643 ± 0.07	4.528AlaSer: 4.528 ± 0.06	3.707AlaThr: 3.707 ± 0.071	6.647AlaVal: 6.647 ± 0.081	1.014AlaTrp: 1.014 ± 0.027	2.435AlaTyr: 2.435 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.987CysAla: 0.987 ± 0.024	0.224CysCys: 0.224 ± 0.014	0.758CysAsp: 0.758 ± 0.026	0.742CysGlu: 0.742 ± 0.024	0.567CysPhe: 0.567 ± 0.019	1.355CysGly: 1.355 ± 0.036	0.411CysHis: 0.411 ± 0.02	0.703CysIle: 0.703 ± 0.021	0.492CysLys: 0.492 ± 0.018	1.205CysLeu: 1.205 ± 0.026	0.314CysMet: 0.314 ± 0.014	0.417CysAsn: 0.417 ± 0.018	0.788CysPro: 0.788 ± 0.024	0.382CysGln: 0.382 ± 0.014	0.976CysArg: 0.976 ± 0.025	0.671CysSer: 0.671 ± 0.019	0.6CysThr: 0.6 ± 0.022	0.8CysVal: 0.8 ± 0.024	0.14CysTrp: 0.14 ± 0.01	0.399CysTyr: 0.399 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.494AspAla: 5.494 ± 0.084	0.67AspCys: 0.67 ± 0.028	3.466AspAsp: 3.466 ± 0.101	3.894AspGlu: 3.894 ± 0.064	2.754AspPhe: 2.754 ± 0.043	4.876AspGly: 4.876 ± 0.131	1.149AspHis: 1.149 ± 0.026	4.308AspIle: 4.308 ± 0.053	2.376AspLys: 2.376 ± 0.039	5.554AspLeu: 5.554 ± 0.092	1.631AspMet: 1.631 ± 0.03	1.814AspAsn: 1.814 ± 0.043	3.033AspPro: 3.033 ± 0.056	1.573AspGln: 1.573 ± 0.027	4.137AspArg: 4.137 ± 0.055	2.736AspSer: 2.736 ± 0.061	3.179AspThr: 3.179 ± 0.062	3.616AspVal: 3.616 ± 0.047	0.701AspTrp: 0.701 ± 0.021	1.958AspTyr: 1.958 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.128GluAla: 6.128 ± 0.074	0.553GluCys: 0.553 ± 0.021	3.475GluAsp: 3.475 ± 0.059	4.244GluGlu: 4.244 ± 0.06	2.307GluPhe: 2.307 ± 0.037	3.853GluGly: 3.853 ± 0.056	1.08GluHis: 1.08 ± 0.027	5.285GluIle: 5.285 ± 0.07	5.719GluLys: 5.719 ± 0.075	5.31GluLeu: 5.31 ± 0.074	2.302GluMet: 2.302 ± 0.041	3.329GluAsn: 3.329 ± 0.046	2.26GluPro: 2.26 ± 0.043	2.326GluGln: 2.326 ± 0.04	3.776GluArg: 3.776 ± 0.058	3.444GluSer: 3.444 ± 0.048	4.273GluThr: 4.273 ± 0.057	3.628GluVal: 3.628 ± 0.051	0.725GluTrp: 0.725 ± 0.024	2.024GluTyr: 2.024 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.16PheAla: 3.16 ± 0.054	0.661PheCys: 0.661 ± 0.022	2.666PheAsp: 2.666 ± 0.042	2.689PheGlu: 2.689 ± 0.047	2.355PhePhe: 2.355 ± 0.044	3.379PheGly: 3.379 ± 0.051	0.963PheHis: 0.963 ± 0.024	2.688PheIle: 2.688 ± 0.041	1.728PheLys: 1.728 ± 0.035	3.969PheLeu: 3.969 ± 0.066	1.127PheMet: 1.127 ± 0.021	1.461PheAsn: 1.461 ± 0.029	1.863PhePro: 1.863 ± 0.033	1.379PheGln: 1.379 ± 0.029	3.058PheArg: 3.058 ± 0.045	3.378PheSer: 3.378 ± 0.044	2.34PheThr: 2.34 ± 0.038	2.542PheVal: 2.542 ± 0.04	0.521PheTrp: 0.521 ± 0.018	1.539PheTyr: 1.539 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.949GlyAla: 5.949 ± 0.072	1.158GlyCys: 1.158 ± 0.029	4.535GlyAsp: 4.535 ± 0.1	4.987GlyGlu: 4.987 ± 0.059	3.454GlyPhe: 3.454 ± 0.044	5.948GlyGly: 5.948 ± 0.093	1.713GlyHis: 1.713 ± 0.032	5.724GlyIle: 5.724 ± 0.063	4.737GlyLys: 4.737 ± 0.061	7.219GlyLeu: 7.219 ± 0.079	2.361GlyMet: 2.361 ± 0.04	2.921GlyAsn: 2.921 ± 0.053	2.538GlyPro: 2.538 ± 0.042	2.617GlyGln: 2.617 ± 0.048	4.659GlyArg: 4.659 ± 0.068	3.973GlySer: 3.973 ± 0.065	4.57GlyThr: 4.57 ± 0.095	5.254GlyVal: 5.254 ± 0.069	1.003GlyTrp: 1.003 ± 0.024	2.778GlyTyr: 2.778 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.439HisAla: 1.439 ± 0.03	0.287HisCys: 0.287 ± 0.014	0.989HisAsp: 0.989 ± 0.027	1.087HisGlu: 1.087 ± 0.024	0.991HisPhe: 0.991 ± 0.025	1.387HisGly: 1.387 ± 0.033	0.529HisHis: 0.529 ± 0.02	1.512HisIle: 1.512 ± 0.026	0.835HisLys: 0.835 ± 0.023	2.093HisLeu: 2.093 ± 0.037	0.562HisMet: 0.562 ± 0.018	0.648HisAsn: 0.648 ± 0.019	1.291HisPro: 1.291 ± 0.027	0.626HisGln: 0.626 ± 0.019	1.428HisArg: 1.428 ± 0.03	1.025HisSer: 1.025 ± 0.023	1.053HisThr: 1.053 ± 0.024	1.2HisVal: 1.2 ± 0.026	0.237HisTrp: 0.237 ± 0.012	0.714HisTyr: 0.714 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.449IleAla: 5.449 ± 0.052	0.988IleCys: 0.988 ± 0.026	3.364IleAsp: 3.364 ± 0.055	3.89IleGlu: 3.89 ± 0.051	2.969IlePhe: 2.969 ± 0.05	5.018IleGly: 5.018 ± 0.05	1.362IleHis: 1.362 ± 0.031	4.058IleIle: 4.058 ± 0.069	2.328IleLys: 2.328 ± 0.039	6.188IleLeu: 6.188 ± 0.072	1.36IleMet: 1.36 ± 0.03	2.136IleAsn: 2.136 ± 0.037	3.447IlePro: 3.447 ± 0.047	1.797IleGln: 1.797 ± 0.033	6.1IleArg: 6.1 ± 0.078	4.981IleSer: 4.981 ± 0.065	3.822IleThr: 3.822 ± 0.054	3.907IleVal: 3.907 ± 0.056	0.738IleTrp: 0.738 ± 0.022	1.82IleTyr: 1.82 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.446LysAla: 4.446 ± 0.068	0.499LysCys: 0.499 ± 0.02	2.568LysAsp: 2.568 ± 0.043	3.215LysGlu: 3.215 ± 0.049	1.649LysPhe: 1.649 ± 0.034	3.527LysGly: 3.527 ± 0.048	0.898LysHis: 0.898 ± 0.022	3.879LysIle: 3.879 ± 0.06	4.556LysLys: 4.556 ± 0.089	3.924LysLeu: 3.924 ± 0.057	1.526LysMet: 1.526 ± 0.034	2.457LysAsn: 2.457 ± 0.042	2.093LysPro: 2.093 ± 0.038	1.69LysGln: 1.69 ± 0.032	2.917LysArg: 2.917 ± 0.051	2.884LysSer: 2.884 ± 0.053	3.216LysThr: 3.216 ± 0.045	2.846LysVal: 2.846 ± 0.05	0.597LysTrp: 0.597 ± 0.02	1.742LysTyr: 1.742 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	8.191LeuAla: 8.191 ± 0.098	1.326LeuCys: 1.326 ± 0.028	4.8LeuAsp: 4.8 ± 0.078	5.784LeuGlu: 5.784 ± 0.076	4.2LeuPhe: 4.2 ± 0.065	6.386LeuGly: 6.386 ± 0.075	1.6LeuHis: 1.6 ± 0.032	6.144LeuIle: 6.144 ± 0.067	5.496LeuLys: 5.496 ± 0.066	8.612LeuLeu: 8.612 ± 0.107	2.609LeuMet: 2.609 ± 0.043	3.572LeuAsn: 3.572 ± 0.052	4.703LeuPro: 4.703 ± 0.064	2.278LeuGln: 2.278 ± 0.039	6.319LeuArg: 6.319 ± 0.075	6.955LeuSer: 6.955 ± 0.08	5.522LeuThr: 5.522 ± 0.069	5.29LeuVal: 5.29 ± 0.061	1.052LeuTrp: 1.052 ± 0.033	2.518LeuTyr: 2.518 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.932MetAla: 2.932 ± 0.045	0.263MetCys: 0.263 ± 0.012	1.35MetAsp: 1.35 ± 0.028	1.583MetGlu: 1.583 ± 0.031	0.852MetPhe: 0.852 ± 0.025	2.182MetGly: 2.182 ± 0.041	0.347MetHis: 0.347 ± 0.015	1.788MetIle: 1.788 ± 0.035	1.818MetLys: 1.818 ± 0.031	2.336MetLeu: 2.336 ± 0.037	0.743MetMet: 0.743 ± 0.022	1.09MetAsn: 1.09 ± 0.025	1.346MetPro: 1.346 ± 0.03	0.699MetGln: 0.699 ± 0.02	1.461MetArg: 1.461 ± 0.028	1.528MetSer: 1.528 ± 0.033	1.77MetThr: 1.77 ± 0.031	1.793MetVal: 1.793 ± 0.031	0.21MetTrp: 0.21 ± 0.011	0.517MetTyr: 0.517 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.087AsnAla: 3.087 ± 0.043	0.456AsnCys: 0.456 ± 0.019	1.714AsnAsp: 1.714 ± 0.039	1.73AsnGlu: 1.73 ± 0.038	1.464AsnPhe: 1.464 ± 0.031	2.747AsnGly: 2.747 ± 0.055	0.703AsnHis: 0.703 ± 0.017	2.699AsnIle: 2.699 ± 0.044	1.348AsnLys: 1.348 ± 0.032	3.461AsnLeu: 3.461 ± 0.051	0.907AsnMet: 0.907 ± 0.023	1.196AsnAsn: 1.196 ± 0.03	2.142AsnPro: 2.142 ± 0.044	1.032AsnGln: 1.032 ± 0.027	2.664AsnArg: 2.664 ± 0.048	1.834AsnSer: 1.834 ± 0.039	1.857AsnThr: 1.857 ± 0.037	2.162AsnVal: 2.162 ± 0.036	0.444AsnTrp: 0.444 ± 0.022	1.085AsnTyr: 1.085 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.071ProAla: 4.071 ± 0.068	0.568ProCys: 0.568 ± 0.017	4.312ProAsp: 4.312 ± 0.07	4.658ProGlu: 4.658 ± 0.059	2.109ProPhe: 2.109 ± 0.036	4.158ProGly: 4.158 ± 0.057	0.917ProHis: 0.917 ± 0.026	1.928ProIle: 1.928 ± 0.037	1.708ProLys: 1.708 ± 0.037	3.931ProLeu: 3.931 ± 0.054	0.984ProMet: 0.984 ± 0.026	1.139ProAsn: 1.139 ± 0.026	2.359ProPro: 2.359 ± 0.043	1.068ProGln: 1.068 ± 0.026	2.292ProArg: 2.292 ± 0.043	2.182ProSer: 2.182 ± 0.04	1.734ProThr: 1.734 ± 0.036	4.362ProVal: 4.362 ± 0.053	0.573ProTrp: 0.573 ± 0.019	1.242ProTyr: 1.242 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.953GlnAla: 2.953 ± 0.051	0.331GlnCys: 0.331 ± 0.016	1.396GlnAsp: 1.396 ± 0.034	1.847GlnGlu: 1.847 ± 0.038	1.089GlnPhe: 1.089 ± 0.028	2.106GlnGly: 2.106 ± 0.044	0.565GlnHis: 0.565 ± 0.018	2.192GlnIle: 2.192 ± 0.038	2.041GlnLys: 2.041 ± 0.039	2.493GlnLeu: 2.493 ± 0.043	0.972GlnMet: 0.972 ± 0.027	1.213GlnAsn: 1.213 ± 0.028	1.174GlnPro: 1.174 ± 0.025	1.069GlnGln: 1.069 ± 0.031	1.679GlnArg: 1.679 ± 0.036	1.502GlnSer: 1.502 ± 0.032	1.736GlnThr: 1.736 ± 0.032	2.175GlnVal: 2.175 ± 0.038	0.406GlnTrp: 0.406 ± 0.017	0.946GlnTyr: 0.946 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.927ArgAla: 4.927 ± 0.07	0.754ArgCys: 0.754 ± 0.022	3.54ArgAsp: 3.54 ± 0.052	4.991ArgGlu: 4.991 ± 0.073	3.252ArgPhe: 3.252 ± 0.046	3.779ArgGly: 3.779 ± 0.056	1.58ArgHis: 1.58 ± 0.031	4.868ArgIle: 4.868 ± 0.053	4.315ArgLys: 4.315 ± 0.066	6.775ArgLeu: 6.775 ± 0.087	1.869ArgMet: 1.869 ± 0.032	2.568ArgAsn: 2.568 ± 0.042	2.825ArgPro: 2.825 ± 0.047	2.755ArgGln: 2.755 ± 0.053	4.318ArgArg: 4.318 ± 0.067	3.357ArgSer: 3.357 ± 0.045	3.185ArgThr: 3.185 ± 0.043	4.004ArgVal: 4.004 ± 0.052	0.773ArgTrp: 0.773 ± 0.023	2.132ArgTyr: 2.132 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.403SerAla: 5.403 ± 0.076	0.673SerCys: 0.673 ± 0.02	4.075SerAsp: 4.075 ± 0.064	4.179SerGlu: 4.179 ± 0.055	2.356SerPhe: 2.356 ± 0.035	6.247SerGly: 6.247 ± 0.074	1.17SerHis: 1.17 ± 0.025	2.669SerIle: 2.669 ± 0.041	2.064SerLys: 2.064 ± 0.036	5.384SerLeu: 5.384 ± 0.07	1.254SerMet: 1.254 ± 0.032	1.378SerAsn: 1.378 ± 0.03	3.087SerPro: 3.087 ± 0.048	1.707SerGln: 1.707 ± 0.036	3.605SerArg: 3.605 ± 0.049	2.875SerSer: 2.875 ± 0.055	2.208SerThr: 2.208 ± 0.045	4.772SerVal: 4.772 ± 0.067	0.647SerTrp: 0.647 ± 0.018	1.579SerTyr: 1.579 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.025ThrAla: 5.025 ± 0.079	0.704ThrCys: 0.704 ± 0.02	3.941ThrAsp: 3.941 ± 0.086	3.522ThrGlu: 3.522 ± 0.052	2.214ThrPhe: 2.214 ± 0.047	5.579ThrGly: 5.579 ± 0.072	1.065ThrHis: 1.065 ± 0.026	2.987ThrIle: 2.987 ± 0.053	1.532ThrLys: 1.532 ± 0.034	5.637ThrLeu: 5.637 ± 0.071	0.976ThrMet: 0.976 ± 0.025	1.268ThrAsn: 1.268 ± 0.032	3.045ThrPro: 3.045 ± 0.051	1.329ThrGln: 1.329 ± 0.029	3.087ThrArg: 3.087 ± 0.045	2.466ThrSer: 2.466 ± 0.043	2.433ThrThr: 2.433 ± 0.06	4.435ThrVal: 4.435 ± 0.073	0.633ThrTrp: 0.633 ± 0.02	1.515ThrTyr: 1.515 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	5.565ValAla: 5.565 ± 0.072	0.981ValCys: 0.981 ± 0.025	3.088ValAsp: 3.088 ± 0.052	3.743ValGlu: 3.743 ± 0.045	3.042ValPhe: 3.042 ± 0.047	4.428ValGly: 4.428 ± 0.054	1.175ValHis: 1.175 ± 0.03	4.747ValIle: 4.747 ± 0.052	2.804ValLys: 2.804 ± 0.042	6.296ValLeu: 6.296 ± 0.066	1.888ValMet: 1.888 ± 0.039	2.344ValAsn: 2.344 ± 0.039	3.11ValPro: 3.11 ± 0.041	1.705ValGln: 1.705 ± 0.035	5.486ValArg: 5.486 ± 0.063	4.823ValSer: 4.823 ± 0.069	4.002ValThr: 4.002 ± 0.08	4.591ValVal: 4.591 ± 0.065	0.741ValTrp: 0.741 ± 0.027	1.895ValTyr: 1.895 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.874TrpAla: 0.874 ± 0.023	0.141TrpCys: 0.141 ± 0.009	0.662TrpAsp: 0.662 ± 0.019	0.776TrpGlu: 0.776 ± 0.023	0.536TrpPhe: 0.536 ± 0.02	0.92TrpGly: 0.92 ± 0.026	0.307TrpHis: 0.307 ± 0.015	0.674TrpIle: 0.674 ± 0.021	0.662TrpLys: 0.662 ± 0.019	1.225TrpLeu: 1.225 ± 0.029	0.297TrpMet: 0.297 ± 0.013	0.526TrpAsn: 0.526 ± 0.021	0.463TrpPro: 0.463 ± 0.016	0.578TrpGln: 0.578 ± 0.021	0.691TrpArg: 0.691 ± 0.022	0.542TrpSer: 0.542 ± 0.018	0.574TrpThr: 0.574 ± 0.021	0.684TrpVal: 0.684 ± 0.018	0.163TrpTrp: 0.163 ± 0.011	0.389TrpTyr: 0.389 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.36TyrAla: 2.36 ± 0.039	0.435TyrCys: 0.435 ± 0.017	2.15TyrAsp: 2.15 ± 0.052	1.926TyrGlu: 1.926 ± 0.037	1.449TyrPhe: 1.449 ± 0.032	2.337TyrGly: 2.337 ± 0.044	0.716TyrHis: 0.716 ± 0.021	1.713TyrIle: 1.713 ± 0.036	1.372TyrLys: 1.372 ± 0.036	2.818TyrLeu: 2.818 ± 0.044	0.677TyrMet: 0.677 ± 0.019	1.097TyrAsn: 1.097 ± 0.027	1.505TyrPro: 1.505 ± 0.031	1.027TyrGln: 1.027 ± 0.027	2.274TyrArg: 2.274 ± 0.038	1.646TyrSer: 1.646 ± 0.034	1.609TyrThr: 1.609 ± 0.031	1.747TyrVal: 1.747 ± 0.039	0.366TyrTrp: 0.366 ± 0.017	1.157TyrTyr: 1.157 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5012 proteins (1708607 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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