Amino acid dipepetide frequency for Actinoallomurus bryophytorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.492AlaAla: 19.492 ± 0.131	1.074AlaCys: 1.074 ± 0.023	7.937AlaAsp: 7.937 ± 0.067	8.198AlaGlu: 8.198 ± 0.073	3.648AlaPhe: 3.648 ± 0.037	13.672AlaGly: 13.672 ± 0.082	2.672AlaHis: 2.672 ± 0.035	4.679AlaIle: 4.679 ± 0.05	2.632AlaLys: 2.632 ± 0.039	13.471AlaLeu: 13.471 ± 0.09	2.697AlaMet: 2.697 ± 0.033	2.082AlaAsn: 2.082 ± 0.033	6.189AlaPro: 6.189 ± 0.068	3.383AlaGln: 3.383 ± 0.039	10.159AlaArg: 10.159 ± 0.082	5.997AlaSer: 5.997 ± 0.053	7.203AlaThr: 7.203 ± 0.061	11.236AlaVal: 11.236 ± 0.09	1.862AlaTrp: 1.862 ± 0.029	2.785AlaTyr: 2.785 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.977CysAla: 0.977 ± 0.02	0.103CysCys: 0.103 ± 0.006	0.51CysAsp: 0.51 ± 0.013	0.397CysGlu: 0.397 ± 0.011	0.215CysPhe: 0.215 ± 0.009	0.981CysGly: 0.981 ± 0.02	0.21CysHis: 0.21 ± 0.008	0.147CysIle: 0.147 ± 0.007	0.107CysLys: 0.107 ± 0.006	0.722CysLeu: 0.722 ± 0.017	0.132CysMet: 0.132 ± 0.007	0.14CysAsn: 0.14 ± 0.008	0.487CysPro: 0.487 ± 0.019	0.17CysGln: 0.17 ± 0.009	0.614CysArg: 0.614 ± 0.016	0.432CysSer: 0.432 ± 0.014	0.465CysThr: 0.465 ± 0.013	0.697CysVal: 0.697 ± 0.016	0.107CysTrp: 0.107 ± 0.006	0.158CysTyr: 0.158 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.214AspAla: 7.214 ± 0.061	0.378AspCys: 0.378 ± 0.014	3.804AspAsp: 3.804 ± 0.045	3.833AspGlu: 3.833 ± 0.047	1.597AspPhe: 1.597 ± 0.022	6.203AspGly: 6.203 ± 0.065	1.492AspHis: 1.492 ± 0.022	1.926AspIle: 1.926 ± 0.03	1.069AspLys: 1.069 ± 0.022	6.616AspLeu: 6.616 ± 0.054	0.86AspMet: 0.86 ± 0.019	0.924AspAsn: 0.924 ± 0.021	4.535AspPro: 4.535 ± 0.048	1.702AspGln: 1.702 ± 0.026	5.091AspArg: 5.091 ± 0.049	2.319AspSer: 2.319 ± 0.035	2.912AspThr: 2.912 ± 0.036	5.105AspVal: 5.105 ± 0.044	0.919AspTrp: 0.919 ± 0.02	1.27AspTyr: 1.27 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.805GluAla: 6.805 ± 0.066	0.349GluCys: 0.349 ± 0.012	2.836GluAsp: 2.836 ± 0.036	3.325GluGlu: 3.325 ± 0.046	1.468GluPhe: 1.468 ± 0.025	3.821GluGly: 3.821 ± 0.04	1.505GluHis: 1.505 ± 0.022	2.514GluIle: 2.514 ± 0.029	1.151GluLys: 1.151 ± 0.025	6.305GluLeu: 6.305 ± 0.067	1.021GluMet: 1.021 ± 0.02	0.983GluAsn: 0.983 ± 0.02	3.345GluPro: 3.345 ± 0.048	1.995GluGln: 1.995 ± 0.03	5.544GluArg: 5.544 ± 0.051	2.548GluSer: 2.548 ± 0.031	3.05GluThr: 3.05 ± 0.041	4.406GluVal: 4.406 ± 0.045	0.771GluTrp: 0.771 ± 0.018	1.054GluTyr: 1.054 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.827PheAla: 3.827 ± 0.039	0.263PheCys: 0.263 ± 0.01	2.022PheAsp: 2.022 ± 0.03	1.46PheGlu: 1.46 ± 0.023	0.883PhePhe: 0.883 ± 0.02	3.23PheGly: 3.23 ± 0.038	0.628PheHis: 0.628 ± 0.017	0.821PheIle: 0.821 ± 0.018	0.49PheLys: 0.49 ± 0.014	2.517PheLeu: 2.517 ± 0.038	0.417PheMet: 0.417 ± 0.012	0.617PheAsn: 0.617 ± 0.016	1.372PhePro: 1.372 ± 0.023	0.692PheGln: 0.692 ± 0.016	1.833PheArg: 1.833 ± 0.026	1.473PheSer: 1.473 ± 0.028	2.017PheThr: 2.017 ± 0.032	2.409PheVal: 2.409 ± 0.03	0.416PheTrp: 0.416 ± 0.012	0.607PheTyr: 0.607 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.468GlyAla: 10.468 ± 0.078	0.85GlyCys: 0.85 ± 0.022	5.506GlyAsp: 5.506 ± 0.043	5.105GlyGlu: 5.105 ± 0.052	2.942GlyPhe: 2.942 ± 0.039	9.236GlyGly: 9.236 ± 0.092	2.524GlyHis: 2.524 ± 0.029	3.679GlyIle: 3.679 ± 0.046	2.24GlyLys: 2.24 ± 0.034	9.805GlyLeu: 9.805 ± 0.072	2.131GlyMet: 2.131 ± 0.026	1.803GlyAsn: 1.803 ± 0.035	5.129GlyPro: 5.129 ± 0.056	2.684GlyGln: 2.684 ± 0.042	8.13GlyArg: 8.13 ± 0.064	5.278GlySer: 5.278 ± 0.049	6.027GlyThr: 6.027 ± 0.058	7.712GlyVal: 7.712 ± 0.057	1.729GlyTrp: 1.729 ± 0.027	2.368GlyTyr: 2.368 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.739HisAla: 2.739 ± 0.033	0.21HisCys: 0.21 ± 0.008	1.516HisAsp: 1.516 ± 0.024	1.221HisGlu: 1.221 ± 0.021	0.642HisPhe: 0.642 ± 0.017	2.395HisGly: 2.395 ± 0.028	0.698HisHis: 0.698 ± 0.019	0.699HisIle: 0.699 ± 0.017	0.345HisLys: 0.345 ± 0.011	2.448HisLeu: 2.448 ± 0.033	0.351HisMet: 0.351 ± 0.012	0.408HisAsn: 0.408 ± 0.014	1.717HisPro: 1.717 ± 0.03	0.627HisGln: 0.627 ± 0.016	2.039HisArg: 2.039 ± 0.029	1.01HisSer: 1.01 ± 0.016	1.23HisThr: 1.23 ± 0.024	1.859HisVal: 1.859 ± 0.027	0.387HisTrp: 0.387 ± 0.013	0.501HisTyr: 0.501 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.482IleAla: 5.482 ± 0.044	0.33IleCys: 0.33 ± 0.01	2.558IleAsp: 2.558 ± 0.032	2.333IleGlu: 2.333 ± 0.029	0.962IlePhe: 0.962 ± 0.019	3.969IleGly: 3.969 ± 0.045	0.705IleHis: 0.705 ± 0.016	1.274IleIle: 1.274 ± 0.028	0.814IleLys: 0.814 ± 0.02	2.954IleLeu: 2.954 ± 0.035	0.557IleMet: 0.557 ± 0.015	0.814IleAsn: 0.814 ± 0.016	1.947IlePro: 1.947 ± 0.027	0.876IleGln: 0.876 ± 0.02	2.657IleArg: 2.657 ± 0.032	2.012IleSer: 2.012 ± 0.027	2.494IleThr: 2.494 ± 0.034	3.378IleVal: 3.378 ± 0.04	0.454IleTrp: 0.454 ± 0.014	0.648IleTyr: 0.648 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.588LysAla: 2.588 ± 0.036	0.126LysCys: 0.126 ± 0.007	1.147LysAsp: 1.147 ± 0.022	0.961LysGlu: 0.961 ± 0.022	0.451LysPhe: 0.451 ± 0.014	1.563LysGly: 1.563 ± 0.027	0.421LysHis: 0.421 ± 0.01	0.99LysIle: 0.99 ± 0.022	0.707LysLys: 0.707 ± 0.022	1.776LysLeu: 1.776 ± 0.028	0.383LysMet: 0.383 ± 0.013	0.519LysAsn: 0.519 ± 0.016	1.242LysPro: 1.242 ± 0.023	0.6LysGln: 0.6 ± 0.017	1.378LysArg: 1.378 ± 0.023	1.119LysSer: 1.119 ± 0.023	1.297LysThr: 1.297 ± 0.024	1.898LysVal: 1.898 ± 0.031	0.258LysTrp: 0.258 ± 0.011	0.438LysTyr: 0.438 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.69LeuAla: 14.69 ± 0.106	0.77LeuCys: 0.77 ± 0.016	6.46LeuAsp: 6.46 ± 0.051	4.649LeuGlu: 4.649 ± 0.054	2.611LeuPhe: 2.611 ± 0.038	9.274LeuGly: 9.274 ± 0.061	2.126LeuHis: 2.126 ± 0.032	3.872LeuIle: 3.872 ± 0.043	1.84LeuLys: 1.84 ± 0.03	10.624LeuLeu: 10.624 ± 0.098	1.679LeuMet: 1.679 ± 0.024	1.795LeuAsn: 1.795 ± 0.032	6.203LeuPro: 6.203 ± 0.064	2.078LeuGln: 2.078 ± 0.033	8.871LeuArg: 8.871 ± 0.082	5.674LeuSer: 5.674 ± 0.051	6.905LeuThr: 6.905 ± 0.051	8.811LeuVal: 8.811 ± 0.071	1.277LeuTrp: 1.277 ± 0.024	1.843LeuTyr: 1.843 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.366MetAla: 2.366 ± 0.03	0.148MetCys: 0.148 ± 0.007	0.879MetAsp: 0.879 ± 0.02	0.752MetGlu: 0.752 ± 0.019	0.537MetPhe: 0.537 ± 0.016	1.349MetGly: 1.349 ± 0.025	0.377MetHis: 0.377 ± 0.012	0.82MetIle: 0.82 ± 0.017	0.436MetLys: 0.436 ± 0.012	1.868MetLeu: 1.868 ± 0.029	0.321MetMet: 0.321 ± 0.013	0.476MetAsn: 0.476 ± 0.013	1.251MetPro: 1.251 ± 0.023	0.404MetGln: 0.404 ± 0.012	1.651MetArg: 1.651 ± 0.023	1.384MetSer: 1.384 ± 0.025	1.638MetThr: 1.638 ± 0.025	1.397MetVal: 1.397 ± 0.021	0.229MetTrp: 0.229 ± 0.01	0.314MetTyr: 0.314 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.373AsnAla: 2.373 ± 0.032	0.17AsnCys: 0.17 ± 0.01	1.05AsnAsp: 1.05 ± 0.022	0.833AsnGlu: 0.833 ± 0.02	0.493AsnPhe: 0.493 ± 0.017	2.081AsnGly: 2.081 ± 0.038	0.406AsnHis: 0.406 ± 0.014	0.723AsnIle: 0.723 ± 0.018	0.369AsnLys: 0.369 ± 0.014	1.858AsnLeu: 1.858 ± 0.028	0.3AsnMet: 0.3 ± 0.011	0.454AsnAsn: 0.454 ± 0.016	1.371AsnPro: 1.371 ± 0.024	0.516AsnGln: 0.516 ± 0.017	1.295AsnArg: 1.295 ± 0.025	0.885AsnSer: 0.885 ± 0.021	1.165AsnThr: 1.165 ± 0.024	1.522AsnVal: 1.522 ± 0.027	0.293AsnTrp: 0.293 ± 0.011	0.432AsnTyr: 0.432 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.308ProAla: 8.308 ± 0.072	0.352ProCys: 0.352 ± 0.012	4.316ProAsp: 4.316 ± 0.044	3.898ProGlu: 3.898 ± 0.046	1.48ProPhe: 1.48 ± 0.024	6.744ProGly: 6.744 ± 0.06	1.322ProHis: 1.322 ± 0.026	1.825ProIle: 1.825 ± 0.027	1.201ProLys: 1.201 ± 0.025	5.042ProLeu: 5.042 ± 0.048	1.092ProMet: 1.092 ± 0.019	1.012ProAsn: 1.012 ± 0.02	4.116ProPro: 4.116 ± 0.072	1.632ProGln: 1.632 ± 0.032	4.016ProArg: 4.016 ± 0.049	3.458ProSer: 3.458 ± 0.05	2.921ProThr: 2.921 ± 0.044	5.129ProVal: 5.129 ± 0.048	0.909ProTrp: 0.909 ± 0.019	1.47ProTyr: 1.47 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.75GlnAla: 3.75 ± 0.044	0.167GlnCys: 0.167 ± 0.009	1.271GlnAsp: 1.271 ± 0.022	1.312GlnGlu: 1.312 ± 0.029	0.626GlnPhe: 0.626 ± 0.016	2.093GlnGly: 2.093 ± 0.031	0.604GlnHis: 0.604 ± 0.018	1.287GlnIle: 1.287 ± 0.026	0.545GlnLys: 0.545 ± 0.018	2.617GlnLeu: 2.617 ± 0.036	0.473GlnMet: 0.473 ± 0.012	0.536GlnAsn: 0.536 ± 0.014	1.539GlnPro: 1.539 ± 0.039	1.097GlnGln: 1.097 ± 0.036	2.323GlnArg: 2.323 ± 0.036	1.252GlnSer: 1.252 ± 0.024	1.462GlnThr: 1.462 ± 0.025	2.577GlnVal: 2.577 ± 0.031	0.459GlnTrp: 0.459 ± 0.013	0.534GlnTyr: 0.534 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.591ArgAla: 9.591 ± 0.085	0.591ArgCys: 0.591 ± 0.017	4.636ArgAsp: 4.636 ± 0.045	4.643ArgGlu: 4.643 ± 0.046	2.493ArgPhe: 2.493 ± 0.032	5.865ArgGly: 5.865 ± 0.048	2.242ArgHis: 2.242 ± 0.031	3.325ArgIle: 3.325 ± 0.034	1.447ArgLys: 1.447 ± 0.026	9.624ArgLeu: 9.624 ± 0.078	1.869ArgMet: 1.869 ± 0.025	1.334ArgAsn: 1.334 ± 0.025	5.296ArgPro: 5.296 ± 0.05	2.374ArgGln: 2.374 ± 0.033	8.456ArgArg: 8.456 ± 0.074	4.359ArgSer: 4.359 ± 0.048	5.147ArgThr: 5.147 ± 0.047	6.128ArgVal: 6.128 ± 0.048	1.389ArgTrp: 1.389 ± 0.025	1.866ArgTyr: 1.866 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.804SerAla: 6.804 ± 0.061	0.407SerCys: 0.407 ± 0.012	2.74SerAsp: 2.74 ± 0.03	2.453SerGlu: 2.453 ± 0.034	1.532SerPhe: 1.532 ± 0.026	6.28SerGly: 6.28 ± 0.062	1.099SerHis: 1.099 ± 0.02	1.721SerIle: 1.721 ± 0.025	1.011SerLys: 1.011 ± 0.024	4.879SerLeu: 4.879 ± 0.047	1.17SerMet: 1.17 ± 0.02	0.933SerAsn: 0.933 ± 0.022	3.349SerPro: 3.349 ± 0.036	1.276SerGln: 1.276 ± 0.023	3.985SerArg: 3.985 ± 0.045	3.098SerSer: 3.098 ± 0.048	3.039SerThr: 3.039 ± 0.04	4.281SerVal: 4.281 ± 0.046	0.936SerTrp: 0.936 ± 0.021	1.236SerTyr: 1.236 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.117ThrAla: 8.117 ± 0.057	0.478ThrCys: 0.478 ± 0.013	3.421ThrAsp: 3.421 ± 0.04	3.032ThrGlu: 3.032 ± 0.036	1.727ThrPhe: 1.727 ± 0.027	6.689ThrGly: 6.689 ± 0.061	1.243ThrHis: 1.243 ± 0.021	2.239ThrIle: 2.239 ± 0.032	1.184ThrLys: 1.184 ± 0.024	5.872ThrLeu: 5.872 ± 0.057	1.113ThrMet: 1.113 ± 0.02	1.115ThrAsn: 1.115 ± 0.025	4.021ThrPro: 4.021 ± 0.043	1.314ThrGln: 1.314 ± 0.024	4.21ThrArg: 4.21 ± 0.034	3.308ThrSer: 3.308 ± 0.041	3.883ThrThr: 3.883 ± 0.051	5.659ThrVal: 5.659 ± 0.058	0.947ThrTrp: 0.947 ± 0.021	1.361ThrTyr: 1.361 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	11.118ValAla: 11.118 ± 0.077	0.682ValCys: 0.682 ± 0.016	4.815ValAsp: 4.815 ± 0.053	4.516ValGlu: 4.516 ± 0.045	2.527ValPhe: 2.527 ± 0.033	6.535ValGly: 6.535 ± 0.054	1.916ValHis: 1.916 ± 0.029	3.554ValIle: 3.554 ± 0.04	1.578ValLys: 1.578 ± 0.026	9.089ValLeu: 9.089 ± 0.085	1.47ValMet: 1.47 ± 0.025	1.794ValAsn: 1.794 ± 0.029	5.143ValPro: 5.143 ± 0.043	1.924ValGln: 1.924 ± 0.028	7.178ValArg: 7.178 ± 0.06	4.593ValSer: 4.593 ± 0.042	5.871ValThr: 5.871 ± 0.054	7.875ValVal: 7.875 ± 0.061	1.079ValTrp: 1.079 ± 0.02	1.588ValTyr: 1.588 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.667TrpAla: 1.667 ± 0.026	0.144TrpCys: 0.144 ± 0.007	0.813TrpAsp: 0.813 ± 0.021	0.664TrpGlu: 0.664 ± 0.015	0.497TrpPhe: 0.497 ± 0.014	1.026TrpGly: 1.026 ± 0.02	0.421TrpHis: 0.421 ± 0.013	0.579TrpIle: 0.579 ± 0.015	0.319TrpLys: 0.319 ± 0.011	1.773TrpLeu: 1.773 ± 0.028	0.296TrpMet: 0.296 ± 0.009	0.429TrpAsn: 0.429 ± 0.014	0.869TrpPro: 0.869 ± 0.02	0.537TrpGln: 0.537 ± 0.015	1.415TrpArg: 1.415 ± 0.025	0.984TrpSer: 0.984 ± 0.023	1.019TrpThr: 1.019 ± 0.02	0.988TrpVal: 0.988 ± 0.019	0.349TrpTrp: 0.349 ± 0.011	0.341TrpTyr: 0.341 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.032	0.18TyrCys: 0.18 ± 0.008	1.534TyrAsp: 1.534 ± 0.031	1.209TyrGlu: 1.209 ± 0.022	0.667TyrPhe: 0.667 ± 0.017	2.338TyrGly: 2.338 ± 0.036	0.43TyrHis: 0.43 ± 0.013	0.541TyrIle: 0.541 ± 0.014	0.377TyrLys: 0.377 ± 0.013	2.191TyrLeu: 2.191 ± 0.031	0.265TyrMet: 0.265 ± 0.009	0.423TyrAsn: 0.423 ± 0.015	1.119TyrPro: 1.119 ± 0.022	0.645TyrGln: 0.645 ± 0.019	1.831TyrArg: 1.831 ± 0.025	1.046TyrSer: 1.046 ± 0.021	1.188TyrThr: 1.188 ± 0.026	1.781TyrVal: 1.781 ± 0.03	0.358TyrTrp: 0.358 ± 0.013	0.497TyrTyr: 0.497 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8518 proteins (2754208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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