Amino acid dipepetide frequency for Usitatibacter palustris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.709AlaAla: 16.709 ± 0.172	1.275AlaCys: 1.275 ± 0.036	5.746AlaAsp: 5.746 ± 0.079	6.377AlaGlu: 6.377 ± 0.101	4.695AlaPhe: 4.695 ± 0.064	10.539AlaGly: 10.539 ± 0.143	2.346AlaHis: 2.346 ± 0.051	6.461AlaIle: 6.461 ± 0.075	5.41AlaLys: 5.41 ± 0.084	13.261AlaLeu: 13.261 ± 0.142	3.356AlaMet: 3.356 ± 0.058	3.486AlaAsn: 3.486 ± 0.07	6.091AlaPro: 6.091 ± 0.089	4.177AlaGln: 4.177 ± 0.068	8.745AlaArg: 8.745 ± 0.12	6.817AlaSer: 6.817 ± 0.088	7.008AlaThr: 7.008 ± 0.106	8.727AlaVal: 8.727 ± 0.096	1.835AlaTrp: 1.835 ± 0.044	2.63AlaTyr: 2.63 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.167CysAla: 1.167 ± 0.036	0.122CysCys: 0.122 ± 0.011	0.515CysAsp: 0.515 ± 0.02	0.54CysGlu: 0.54 ± 0.021	0.309CysPhe: 0.309 ± 0.016	1.001CysGly: 1.001 ± 0.036	0.309CysHis: 0.309 ± 0.024	0.38CysIle: 0.38 ± 0.018	0.254CysLys: 0.254 ± 0.014	0.719CysLeu: 0.719 ± 0.025	0.184CysMet: 0.184 ± 0.013	0.241CysAsn: 0.241 ± 0.014	0.474CysPro: 0.474 ± 0.025	0.211CysGln: 0.211 ± 0.013	0.565CysArg: 0.565 ± 0.02	0.508CysSer: 0.508 ± 0.021	0.533CysThr: 0.533 ± 0.029	0.685CysVal: 0.685 ± 0.022	0.128CysTrp: 0.128 ± 0.013	0.213CysTyr: 0.213 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.63AspAla: 6.63 ± 0.083	0.433AspCys: 0.433 ± 0.02	2.627AspAsp: 2.627 ± 0.046	3.148AspGlu: 3.148 ± 0.054	2.178AspPhe: 2.178 ± 0.043	4.428AspGly: 4.428 ± 0.071	1.02AspHis: 1.02 ± 0.031	2.371AspIle: 2.371 ± 0.046	2.015AspLys: 2.015 ± 0.048	5.081AspLeu: 5.081 ± 0.072	1.088AspMet: 1.088 ± 0.032	1.222AspAsn: 1.222 ± 0.037	3.36AspPro: 3.36 ± 0.06	1.326AspGln: 1.326 ± 0.03	3.807AspArg: 3.807 ± 0.072	2.252AspSer: 2.252 ± 0.052	2.351AspThr: 2.351 ± 0.051	4.146AspVal: 4.146 ± 0.06	0.838AspTrp: 0.838 ± 0.03	1.411AspTyr: 1.411 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.06GluAla: 7.06 ± 0.109	0.408GluCys: 0.408 ± 0.018	2.356GluAsp: 2.356 ± 0.05	2.931GluGlu: 2.931 ± 0.058	2.006GluPhe: 2.006 ± 0.042	4.375GluGly: 4.375 ± 0.068	1.231GluHis: 1.231 ± 0.033	3.079GluIle: 3.079 ± 0.06	2.756GluLys: 2.756 ± 0.061	5.352GluLeu: 5.352 ± 0.084	1.421GluMet: 1.421 ± 0.038	1.493GluAsn: 1.493 ± 0.035	2.555GluPro: 2.555 ± 0.057	1.951GluGln: 1.951 ± 0.044	4.88GluArg: 4.88 ± 0.084	2.951GluSer: 2.951 ± 0.053	2.832GluThr: 2.832 ± 0.054	4.358GluVal: 4.358 ± 0.074	0.796GluTrp: 0.796 ± 0.025	1.247GluTyr: 1.247 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.997PheAla: 4.997 ± 0.065	0.369PheCys: 0.369 ± 0.018	2.417PheAsp: 2.417 ± 0.046	2.253PheGlu: 2.253 ± 0.045	1.502PhePhe: 1.502 ± 0.042	3.512PheGly: 3.512 ± 0.061	0.843PheHis: 0.843 ± 0.028	1.677PheIle: 1.677 ± 0.041	1.268PheLys: 1.268 ± 0.035	3.4PheLeu: 3.4 ± 0.066	0.776PheMet: 0.776 ± 0.024	1.14PheAsn: 1.14 ± 0.035	1.784PhePro: 1.784 ± 0.039	0.976PheGln: 0.976 ± 0.029	2.254PheArg: 2.254 ± 0.039	2.178PheSer: 2.178 ± 0.043	2.392PheThr: 2.392 ± 0.075	3.096PheVal: 3.096 ± 0.054	0.53PheTrp: 0.53 ± 0.024	0.959PheTyr: 0.959 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.334GlyAla: 9.334 ± 0.111	0.906GlyCys: 0.906 ± 0.026	4.186GlyAsp: 4.186 ± 0.059	4.642GlyGlu: 4.642 ± 0.072	3.539GlyPhe: 3.539 ± 0.059	7.18GlyGly: 7.18 ± 0.137	1.837GlyHis: 1.837 ± 0.046	4.194GlyIle: 4.194 ± 0.063	3.956GlyLys: 3.956 ± 0.067	8.017GlyLeu: 8.017 ± 0.096	2.108GlyMet: 2.108 ± 0.039	2.48GlyAsn: 2.48 ± 0.068	3.388GlyPro: 3.388 ± 0.056	2.557GlyGln: 2.557 ± 0.054	5.436GlyArg: 5.436 ± 0.076	4.711GlySer: 4.711 ± 0.074	5.26GlyThr: 5.26 ± 0.125	6.741GlyVal: 6.741 ± 0.097	1.308GlyTrp: 1.308 ± 0.039	2.389GlyTyr: 2.389 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.516HisAla: 2.516 ± 0.054	0.243HisCys: 0.243 ± 0.014	1.107HisAsp: 1.107 ± 0.03	1.157HisGlu: 1.157 ± 0.033	0.931HisPhe: 0.931 ± 0.027	1.874HisGly: 1.874 ± 0.049	0.567HisHis: 0.567 ± 0.026	0.829HisIle: 0.829 ± 0.028	0.596HisLys: 0.596 ± 0.025	2.005HisLeu: 2.005 ± 0.046	0.402HisMet: 0.402 ± 0.022	0.451HisAsn: 0.451 ± 0.021	1.346HisPro: 1.346 ± 0.034	0.546HisGln: 0.546 ± 0.02	1.383HisArg: 1.383 ± 0.042	0.951HisSer: 0.951 ± 0.026	0.88HisThr: 0.88 ± 0.026	1.719HisVal: 1.719 ± 0.042	0.345HisTrp: 0.345 ± 0.016	0.599HisTyr: 0.599 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.218IleAla: 7.218 ± 0.087	0.445IleCys: 0.445 ± 0.021	3.13IleAsp: 3.13 ± 0.054	3.339IleGlu: 3.339 ± 0.055	1.584IlePhe: 1.584 ± 0.041	4.269IleGly: 4.269 ± 0.07	0.881IleHis: 0.881 ± 0.027	1.674IleIle: 1.674 ± 0.041	1.524IleLys: 1.524 ± 0.037	3.98IleLeu: 3.98 ± 0.061	0.708IleMet: 0.708 ± 0.025	1.296IleAsn: 1.296 ± 0.043	2.488IlePro: 2.488 ± 0.046	1.207IleGln: 1.207 ± 0.035	2.848IleArg: 2.848 ± 0.054	2.421IleSer: 2.421 ± 0.044	2.858IleThr: 2.858 ± 0.074	4.262IleVal: 4.262 ± 0.06	0.455IleTrp: 0.455 ± 0.019	1.105IleTyr: 1.105 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.742LysAla: 4.742 ± 0.087	0.267LysCys: 0.267 ± 0.017	2.224LysAsp: 2.224 ± 0.051	2.135LysGlu: 2.135 ± 0.048	1.208LysPhe: 1.208 ± 0.031	3.186LysGly: 3.186 ± 0.055	0.818LysHis: 0.818 ± 0.028	1.881LysIle: 1.881 ± 0.043	1.971LysLys: 1.971 ± 0.063	4.101LysLeu: 4.101 ± 0.06	1.077LysMet: 1.077 ± 0.026	1.134LysAsn: 1.134 ± 0.034	2.55LysPro: 2.55 ± 0.056	1.177LysGln: 1.177 ± 0.035	2.807LysArg: 2.807 ± 0.05	2.157LysSer: 2.157 ± 0.046	2.126LysThr: 2.126 ± 0.044	3.201LysVal: 3.201 ± 0.054	0.498LysTrp: 0.498 ± 0.021	0.854LysTyr: 0.854 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.611LeuAla: 14.611 ± 0.154	0.813LeuCys: 0.813 ± 0.025	5.43LeuAsp: 5.43 ± 0.078	5.783LeuGlu: 5.783 ± 0.081	3.517LeuPhe: 3.517 ± 0.067	7.903LeuGly: 7.903 ± 0.084	1.866LeuHis: 1.866 ± 0.041	3.958LeuIle: 3.958 ± 0.071	3.895LeuLys: 3.895 ± 0.067	9.066LeuLeu: 9.066 ± 0.125	2.135LeuMet: 2.135 ± 0.045	2.416LeuAsn: 2.416 ± 0.048	5.108LeuPro: 5.108 ± 0.072	2.649LeuGln: 2.649 ± 0.048	6.663LeuArg: 6.663 ± 0.095	5.308LeuSer: 5.308 ± 0.068	5.356LeuThr: 5.356 ± 0.121	7.942LeuVal: 7.942 ± 0.087	1.22LeuTrp: 1.22 ± 0.034	2.105LeuTyr: 2.105 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.676MetAla: 2.676 ± 0.054	0.167MetCys: 0.167 ± 0.012	1.044MetAsp: 1.044 ± 0.03	1.097MetGlu: 1.097 ± 0.029	0.728MetPhe: 0.728 ± 0.027	1.846MetGly: 1.846 ± 0.038	0.473MetHis: 0.473 ± 0.02	1.105MetIle: 1.105 ± 0.031	1.384MetLys: 1.384 ± 0.037	2.361MetLeu: 2.361 ± 0.046	0.542MetMet: 0.542 ± 0.022	0.882MetAsn: 0.882 ± 0.029	1.4MetPro: 1.4 ± 0.034	0.788MetGln: 0.788 ± 0.026	1.812MetArg: 1.812 ± 0.045	1.427MetSer: 1.427 ± 0.033	1.528MetThr: 1.528 ± 0.04	1.682MetVal: 1.682 ± 0.039	0.21MetTrp: 0.21 ± 0.014	0.385MetTyr: 0.385 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.469AsnAla: 3.469 ± 0.073	0.3AsnCys: 0.3 ± 0.019	1.455AsnAsp: 1.455 ± 0.041	1.317AsnGlu: 1.317 ± 0.034	1.117AsnPhe: 1.117 ± 0.035	2.375AsnGly: 2.375 ± 0.072	0.512AsnHis: 0.512 ± 0.02	1.334AsnIle: 1.334 ± 0.035	0.908AsnLys: 0.908 ± 0.03	2.78AsnLeu: 2.78 ± 0.052	0.553AsnMet: 0.553 ± 0.021	0.876AsnAsn: 0.876 ± 0.042	2.112AsnPro: 2.112 ± 0.052	0.779AsnGln: 0.779 ± 0.029	1.776AsnArg: 1.776 ± 0.043	1.265AsnSer: 1.265 ± 0.045	1.539AsnThr: 1.539 ± 0.059	2.381AsnVal: 2.381 ± 0.059	0.418AsnTrp: 0.418 ± 0.018	0.735AsnTyr: 0.735 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.94ProAla: 6.94 ± 0.099	0.362ProCys: 0.362 ± 0.017	3.116ProAsp: 3.116 ± 0.058	3.476ProGlu: 3.476 ± 0.061	1.962ProPhe: 1.962 ± 0.041	4.796ProGly: 4.796 ± 0.064	0.988ProHis: 0.988 ± 0.027	2.274ProIle: 2.274 ± 0.043	2.047ProLys: 2.047 ± 0.049	4.509ProLeu: 4.509 ± 0.056	1.292ProMet: 1.292 ± 0.033	1.493ProAsn: 1.493 ± 0.044	3.073ProPro: 3.073 ± 0.069	1.601ProGln: 1.601 ± 0.04	3.171ProArg: 3.171 ± 0.063	2.721ProSer: 2.721 ± 0.047	2.875ProThr: 2.875 ± 0.053	4.347ProVal: 4.347 ± 0.06	0.745ProTrp: 0.745 ± 0.024	1.205ProTyr: 1.205 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.73GlnAla: 3.73 ± 0.071	0.254GlnCys: 0.254 ± 0.013	1.297GlnAsp: 1.297 ± 0.035	1.374GlnGlu: 1.374 ± 0.034	1.112GlnPhe: 1.112 ± 0.029	2.453GlnGly: 2.453 ± 0.049	0.565GlnHis: 0.565 ± 0.022	1.45GlnIle: 1.45 ± 0.034	1.16GlnLys: 1.16 ± 0.035	2.939GlnLeu: 2.939 ± 0.052	0.785GlnMet: 0.785 ± 0.025	0.759GlnAsn: 0.759 ± 0.033	1.649GlnPro: 1.649 ± 0.038	1.103GlnGln: 1.103 ± 0.038	2.304GlnArg: 2.304 ± 0.048	1.59GlnSer: 1.59 ± 0.032	1.397GlnThr: 1.397 ± 0.038	2.649GlnVal: 2.649 ± 0.049	0.462GlnTrp: 0.462 ± 0.019	0.708GlnTyr: 0.708 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.857ArgAla: 7.857 ± 0.108	0.509ArgCys: 0.509 ± 0.02	3.87ArgAsp: 3.87 ± 0.073	4.806ArgGlu: 4.806 ± 0.086	2.993ArgPhe: 2.993 ± 0.058	4.928ArgGly: 4.928 ± 0.067	1.594ArgHis: 1.594 ± 0.04	3.827ArgIle: 3.827 ± 0.058	2.526ArgLys: 2.526 ± 0.052	6.937ArgLeu: 6.937 ± 0.095	1.875ArgMet: 1.875 ± 0.042	1.907ArgAsn: 1.907 ± 0.038	2.992ArgPro: 2.992 ± 0.052	2.014ArgGln: 2.014 ± 0.043	4.77ArgArg: 4.77 ± 0.089	3.438ArgSer: 3.438 ± 0.061	3.469ArgThr: 3.469 ± 0.059	5.403ArgVal: 5.403 ± 0.064	1.031ArgTrp: 1.031 ± 0.034	1.879ArgTyr: 1.879 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.954SerAla: 5.954 ± 0.069	0.518SerCys: 0.518 ± 0.028	2.484SerAsp: 2.484 ± 0.044	2.597SerGlu: 2.597 ± 0.052	2.17SerPhe: 2.17 ± 0.042	5.4SerGly: 5.4 ± 0.084	1.128SerHis: 1.128 ± 0.034	2.699SerIle: 2.699 ± 0.045	1.804SerLys: 1.804 ± 0.04	5.317SerLeu: 5.317 ± 0.065	1.321SerMet: 1.321 ± 0.036	1.467SerAsn: 1.467 ± 0.04	3.026SerPro: 3.026 ± 0.059	1.577SerGln: 1.577 ± 0.037	3.653SerArg: 3.653 ± 0.058	2.913SerSer: 2.913 ± 0.06	2.945SerThr: 2.945 ± 0.066	3.961SerVal: 3.961 ± 0.064	0.755SerTrp: 0.755 ± 0.026	1.308SerTyr: 1.308 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.069ThrAla: 6.069 ± 0.108	0.578ThrCys: 0.578 ± 0.03	2.591ThrAsp: 2.591 ± 0.054	2.491ThrGlu: 2.491 ± 0.045	2.258ThrPhe: 2.258 ± 0.062	5.103ThrGly: 5.103 ± 0.113	1.138ThrHis: 1.138 ± 0.033	2.823ThrIle: 2.823 ± 0.095	1.817ThrLys: 1.817 ± 0.044	6.23ThrLeu: 6.23 ± 0.098	1.187ThrMet: 1.187 ± 0.033	1.632ThrAsn: 1.632 ± 0.096	3.595ThrPro: 3.595 ± 0.078	1.661ThrGln: 1.661 ± 0.039	3.523ThrArg: 3.523 ± 0.058	2.985ThrSer: 2.985 ± 0.076	3.176ThrThr: 3.176 ± 0.09	4.601ThrVal: 4.601 ± 0.093	0.813ThrTrp: 0.813 ± 0.031	1.379ThrTyr: 1.379 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.222ValAla: 10.222 ± 0.109	0.693ValCys: 0.693 ± 0.022	4.142ValAsp: 4.142 ± 0.061	4.631ValGlu: 4.631 ± 0.07	2.867ValPhe: 2.867 ± 0.051	5.947ValGly: 5.947 ± 0.076	1.534ValHis: 1.534 ± 0.041	4.034ValIle: 4.034 ± 0.072	3.292ValLys: 3.292 ± 0.06	7.754ValLeu: 7.754 ± 0.09	1.867ValMet: 1.867 ± 0.04	2.413ValAsn: 2.413 ± 0.064	4.188ValPro: 4.188 ± 0.055	2.2ValGln: 2.2 ± 0.046	5.198ValArg: 5.198 ± 0.073	4.251ValSer: 4.251 ± 0.063	4.921ValThr: 4.921 ± 0.135	6.827ValVal: 6.827 ± 0.087	0.877ValTrp: 0.877 ± 0.028	1.745ValTyr: 1.745 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.188TrpAla: 1.188 ± 0.035	0.148TrpCys: 0.148 ± 0.011	0.646TrpAsp: 0.646 ± 0.023	0.653TrpGlu: 0.653 ± 0.024	0.579TrpPhe: 0.579 ± 0.022	1.023TrpGly: 1.023 ± 0.032	0.338TrpHis: 0.338 ± 0.017	0.753TrpIle: 0.753 ± 0.031	0.69TrpLys: 0.69 ± 0.027	1.611TrpLeu: 1.611 ± 0.046	0.381TrpMet: 0.381 ± 0.019	0.482TrpAsn: 0.482 ± 0.021	0.614TrpPro: 0.614 ± 0.025	0.488TrpGln: 0.488 ± 0.021	1.14TrpArg: 1.14 ± 0.035	0.818TrpSer: 0.818 ± 0.03	0.752TrpThr: 0.752 ± 0.023	1.009TrpVal: 1.009 ± 0.031	0.267TrpTrp: 0.267 ± 0.017	0.351TrpTyr: 0.351 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.602TyrAla: 2.602 ± 0.046	0.25TyrCys: 0.25 ± 0.013	1.35TyrAsp: 1.35 ± 0.042	1.289TyrGlu: 1.289 ± 0.034	1.067TyrPhe: 1.067 ± 0.032	2.033TyrGly: 2.033 ± 0.045	0.459TyrHis: 0.459 ± 0.022	0.892TyrIle: 0.892 ± 0.026	0.842TyrLys: 0.842 ± 0.027	2.323TyrLeu: 2.323 ± 0.047	0.474TyrMet: 0.474 ± 0.021	0.733TyrAsn: 0.733 ± 0.027	1.2TyrPro: 1.2 ± 0.031	0.756TyrGln: 0.756 ± 0.029	1.89TyrArg: 1.89 ± 0.046	1.332TyrSer: 1.332 ± 0.032	1.452TyrThr: 1.452 ± 0.043	1.867TyrVal: 1.867 ± 0.036	0.397TyrTrp: 0.397 ± 0.018	0.714TyrTyr: 0.714 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3756 proteins (1238078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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