Amino acid dipepetide frequency for Anaerobacillus arseniciselenatis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.579AlaAla: 4.579 ± 0.087	0.63AlaCys: 0.63 ± 0.029	2.947AlaAsp: 2.947 ± 0.066	4.2AlaGlu: 4.2 ± 0.075	3.124AlaPhe: 3.124 ± 0.058	4.505AlaGly: 4.505 ± 0.084	1.259AlaHis: 1.259 ± 0.036	5.925AlaIle: 5.925 ± 0.081	4.51AlaLys: 4.51 ± 0.075	6.719AlaLeu: 6.719 ± 0.096	1.927AlaMet: 1.927 ± 0.053	2.898AlaAsn: 2.898 ± 0.053	2.002AlaPro: 2.002 ± 0.051	1.961AlaGln: 1.961 ± 0.056	2.384AlaArg: 2.384 ± 0.059	3.812AlaSer: 3.812 ± 0.066	3.701AlaThr: 3.701 ± 0.062	4.859AlaVal: 4.859 ± 0.082	0.552AlaTrp: 0.552 ± 0.024	2.066AlaTyr: 2.066 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.432CysAla: 0.432 ± 0.023	0.12CysCys: 0.12 ± 0.013	0.443CysAsp: 0.443 ± 0.021	0.534CysGlu: 0.534 ± 0.026	0.353CysPhe: 0.353 ± 0.019	0.744CysGly: 0.744 ± 0.035	0.285CysHis: 0.285 ± 0.023	0.561CysIle: 0.561 ± 0.025	0.42CysLys: 0.42 ± 0.022	0.689CysLeu: 0.689 ± 0.028	0.179CysMet: 0.179 ± 0.013	0.405CysAsn: 0.405 ± 0.019	0.389CysPro: 0.389 ± 0.023	0.234CysGln: 0.234 ± 0.014	0.31CysArg: 0.31 ± 0.018	0.569CysSer: 0.569 ± 0.024	0.41CysThr: 0.41 ± 0.021	0.47CysVal: 0.47 ± 0.025	0.066CysTrp: 0.066 ± 0.007	0.278CysTyr: 0.278 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.091AspAla: 3.091 ± 0.048	0.415AspCys: 0.415 ± 0.024	2.827AspAsp: 2.827 ± 0.058	4.891AspGlu: 4.891 ± 0.073	2.526AspPhe: 2.526 ± 0.049	3.306AspGly: 3.306 ± 0.062	1.286AspHis: 1.286 ± 0.036	4.154AspIle: 4.154 ± 0.076	2.92AspLys: 2.92 ± 0.054	5.013AspLeu: 5.013 ± 0.078	1.244AspMet: 1.244 ± 0.033	1.815AspAsn: 1.815 ± 0.046	1.905AspPro: 1.905 ± 0.05	1.982AspGln: 1.982 ± 0.044	2.317AspArg: 2.317 ± 0.049	2.288AspSer: 2.288 ± 0.052	2.285AspThr: 2.285 ± 0.052	4.004AspVal: 4.004 ± 0.064	0.576AspTrp: 0.576 ± 0.028	2.125AspTyr: 2.125 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.544GluAla: 5.544 ± 0.082	0.402GluCys: 0.402 ± 0.024	3.987GluAsp: 3.987 ± 0.065	7.736GluGlu: 7.736 ± 0.115	2.632GluPhe: 2.632 ± 0.052	4.495GluGly: 4.495 ± 0.073	1.485GluHis: 1.485 ± 0.04	6.174GluIle: 6.174 ± 0.089	7.202GluLys: 7.202 ± 0.1	7.252GluLeu: 7.252 ± 0.091	2.341GluMet: 2.341 ± 0.051	4.172GluAsn: 4.172 ± 0.079	1.938GluPro: 1.938 ± 0.037	3.642GluGln: 3.642 ± 0.07	3.605GluArg: 3.605 ± 0.074	3.034GluSer: 3.034 ± 0.058	4.158GluThr: 4.158 ± 0.073	6.008GluVal: 6.008 ± 0.084	0.793GluTrp: 0.793 ± 0.032	2.169GluTyr: 2.169 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.855PheAla: 2.855 ± 0.059	0.4PheCys: 0.4 ± 0.02	2.44PheAsp: 2.44 ± 0.046	3.178PheGlu: 3.178 ± 0.058	2.642PhePhe: 2.642 ± 0.069	3.274PheGly: 3.274 ± 0.063	1.024PheHis: 1.024 ± 0.028	4.412PheIle: 4.412 ± 0.084	2.545PheLys: 2.545 ± 0.053	4.853PheLeu: 4.853 ± 0.078	1.183PheMet: 1.183 ± 0.035	2.086PheAsn: 2.086 ± 0.044	1.66PhePro: 1.66 ± 0.039	1.725PheGln: 1.725 ± 0.04	1.588PheArg: 1.588 ± 0.04	3.472PheSer: 3.472 ± 0.059	2.64PheThr: 2.64 ± 0.055	3.328PheVal: 3.328 ± 0.074	0.447PheTrp: 0.447 ± 0.022	1.806PheTyr: 1.806 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.452GlyAla: 4.452 ± 0.091	0.668GlyCys: 0.668 ± 0.028	3.209GlyAsp: 3.209 ± 0.066	4.669GlyGlu: 4.669 ± 0.077	3.427GlyPhe: 3.427 ± 0.064	4.616GlyGly: 4.616 ± 0.09	1.373GlyHis: 1.373 ± 0.04	5.639GlyIle: 5.639 ± 0.079	4.693GlyLys: 4.693 ± 0.075	6.237GlyLeu: 6.237 ± 0.083	1.947GlyMet: 1.947 ± 0.048	2.72GlyAsn: 2.72 ± 0.057	1.727GlyPro: 1.727 ± 0.044	2.135GlyGln: 2.135 ± 0.047	2.51GlyArg: 2.51 ± 0.051	3.605GlySer: 3.605 ± 0.061	3.705GlyThr: 3.705 ± 0.072	5.214GlyVal: 5.214 ± 0.084	0.667GlyTrp: 0.667 ± 0.029	2.679GlyTyr: 2.679 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.098HisAla: 1.098 ± 0.037	0.205HisCys: 0.205 ± 0.016	1.056HisAsp: 1.056 ± 0.038	1.479HisGlu: 1.479 ± 0.037	1.152HisPhe: 1.152 ± 0.032	1.359HisGly: 1.359 ± 0.039	0.649HisHis: 0.649 ± 0.033	1.504HisIle: 1.504 ± 0.038	1.087HisLys: 1.087 ± 0.036	2.144HisLeu: 2.144 ± 0.047	0.517HisMet: 0.517 ± 0.023	0.846HisAsn: 0.846 ± 0.03	1.1HisPro: 1.1 ± 0.035	0.81HisGln: 0.81 ± 0.027	0.866HisArg: 0.866 ± 0.032	1.247HisSer: 1.247 ± 0.033	0.952HisThr: 0.952 ± 0.028	1.323HisVal: 1.323 ± 0.041	0.224HisTrp: 0.224 ± 0.015	0.857HisTyr: 0.857 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.776IleAla: 5.776 ± 0.081	0.669IleCys: 0.669 ± 0.026	4.682IleAsp: 4.682 ± 0.061	6.501IleGlu: 6.501 ± 0.074	3.769IlePhe: 3.769 ± 0.076	5.923IleGly: 5.923 ± 0.094	1.594IleHis: 1.594 ± 0.049	6.515IleIle: 6.515 ± 0.101	5.087IleLys: 5.087 ± 0.08	7.038IleLeu: 7.038 ± 0.097	1.731IleMet: 1.731 ± 0.048	3.953IleAsn: 3.953 ± 0.069	3.35IlePro: 3.35 ± 0.06	2.612IleGln: 2.612 ± 0.049	2.904IleArg: 2.904 ± 0.054	5.446IleSer: 5.446 ± 0.084	4.655IleThr: 4.655 ± 0.071	5.94IleVal: 5.94 ± 0.083	0.628IleTrp: 0.628 ± 0.026	2.539IleTyr: 2.539 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.338LysAla: 4.338 ± 0.077	0.409LysCys: 0.409 ± 0.022	3.657LysAsp: 3.657 ± 0.065	6.914LysGlu: 6.914 ± 0.088	2.202LysPhe: 2.202 ± 0.044	4.328LysGly: 4.328 ± 0.065	1.348LysHis: 1.348 ± 0.039	5.053LysIle: 5.053 ± 0.066	6.399LysLys: 6.399 ± 0.086	6.22LysLeu: 6.22 ± 0.092	2.034LysMet: 2.034 ± 0.045	3.59LysAsn: 3.59 ± 0.066	2.064LysPro: 2.064 ± 0.044	3.389LysGln: 3.389 ± 0.058	3.281LysArg: 3.281 ± 0.066	3.535LysSer: 3.535 ± 0.06	3.577LysThr: 3.577 ± 0.061	5.085LysVal: 5.085 ± 0.077	0.735LysTrp: 0.735 ± 0.032	2.288LysTyr: 2.288 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.883LeuAla: 6.883 ± 0.089	0.723LeuCys: 0.723 ± 0.026	4.507LeuAsp: 4.507 ± 0.061	6.688LeuGlu: 6.688 ± 0.093	4.944LeuPhe: 4.944 ± 0.085	6.189LeuGly: 6.189 ± 0.085	1.901LeuHis: 1.901 ± 0.047	7.56LeuIle: 7.56 ± 0.108	7.088LeuLys: 7.088 ± 0.098	9.978LeuLeu: 9.978 ± 0.139	2.565LeuMet: 2.565 ± 0.053	4.742LeuAsn: 4.742 ± 0.067	3.668LeuPro: 3.668 ± 0.058	3.755LeuGln: 3.755 ± 0.072	3.607LeuArg: 3.607 ± 0.067	6.541LeuSer: 6.541 ± 0.08	5.632LeuThr: 5.632 ± 0.068	6.468LeuVal: 6.468 ± 0.089	0.775LeuTrp: 0.775 ± 0.028	3.104LeuTyr: 3.104 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.828MetAla: 1.828 ± 0.044	0.153MetCys: 0.153 ± 0.012	1.29MetAsp: 1.29 ± 0.036	1.909MetGlu: 1.909 ± 0.041	1.202MetPhe: 1.202 ± 0.035	1.554MetGly: 1.554 ± 0.043	0.416MetHis: 0.416 ± 0.021	2.181MetIle: 2.181 ± 0.047	2.44MetLys: 2.44 ± 0.045	2.562MetLeu: 2.562 ± 0.054	0.783MetMet: 0.783 ± 0.026	1.514MetAsn: 1.514 ± 0.04	0.99MetPro: 0.99 ± 0.035	0.82MetGln: 0.82 ± 0.028	0.983MetArg: 0.983 ± 0.034	1.633MetSer: 1.633 ± 0.044	1.557MetThr: 1.557 ± 0.035	1.835MetVal: 1.835 ± 0.042	0.188MetTrp: 0.188 ± 0.014	0.748MetTyr: 0.748 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.561AsnAla: 2.561 ± 0.053	0.395AsnCys: 0.395 ± 0.021	2.742AsnAsp: 2.742 ± 0.062	4.431AsnGlu: 4.431 ± 0.077	1.975AsnPhe: 1.975 ± 0.049	3.134AsnGly: 3.134 ± 0.063	1.041AsnHis: 1.041 ± 0.032	3.835AsnIle: 3.835 ± 0.064	3.288AsnLys: 3.288 ± 0.065	4.004AsnLeu: 4.004 ± 0.06	1.245AsnMet: 1.245 ± 0.037	2.415AsnAsn: 2.415 ± 0.062	1.932AsnPro: 1.932 ± 0.042	1.825AsnGln: 1.825 ± 0.042	1.979AsnArg: 1.979 ± 0.047	2.604AsnSer: 2.604 ± 0.052	2.213AsnThr: 2.213 ± 0.043	3.418AsnVal: 3.418 ± 0.063	0.529AsnTrp: 0.529 ± 0.023	1.828AsnTyr: 1.828 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.92ProAla: 1.92 ± 0.04	0.228ProCys: 0.228 ± 0.014	1.71ProAsp: 1.71 ± 0.047	2.808ProGlu: 2.808 ± 0.06	2.013ProPhe: 2.013 ± 0.052	2.112ProGly: 2.112 ± 0.052	0.78ProHis: 0.78 ± 0.031	3.025ProIle: 3.025 ± 0.052	2.223ProLys: 2.223 ± 0.042	3.476ProLeu: 3.476 ± 0.06	0.839ProMet: 0.839 ± 0.033	1.753ProAsn: 1.753 ± 0.044	1.07ProPro: 1.07 ± 0.049	1.076ProGln: 1.076 ± 0.039	1.098ProArg: 1.098 ± 0.035	2.142ProSer: 2.142 ± 0.053	2.035ProThr: 2.035 ± 0.042	2.479ProVal: 2.479 ± 0.055	0.372ProTrp: 0.372 ± 0.019	1.44ProTyr: 1.44 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.272GlnAla: 2.272 ± 0.053	0.272GlnCys: 0.272 ± 0.018	1.441GlnAsp: 1.441 ± 0.045	2.715GlnGlu: 2.715 ± 0.057	1.846GlnPhe: 1.846 ± 0.048	2.102GlnGly: 2.102 ± 0.053	0.744GlnHis: 0.744 ± 0.027	2.681GlnIle: 2.681 ± 0.051	2.706GlnLys: 2.706 ± 0.057	4.562GlnLeu: 4.562 ± 0.074	1.155GlnMet: 1.155 ± 0.038	1.609GlnAsn: 1.609 ± 0.037	1.197GlnPro: 1.197 ± 0.035	2.063GlnGln: 2.063 ± 0.068	1.494GlnArg: 1.494 ± 0.039	2.03GlnSer: 2.03 ± 0.053	1.867GlnThr: 1.867 ± 0.041	2.387GlnVal: 2.387 ± 0.048	0.434GlnTrp: 0.434 ± 0.022	1.299GlnTyr: 1.299 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.287ArgAla: 2.287 ± 0.049	0.28ArgCys: 0.28 ± 0.017	2.004ArgAsp: 2.004 ± 0.039	3.105ArgGlu: 3.105 ± 0.056	1.859ArgPhe: 1.859 ± 0.036	2.444ArgGly: 2.444 ± 0.052	0.748ArgHis: 0.748 ± 0.033	3.009ArgIle: 3.009 ± 0.055	3.178ArgLys: 3.178 ± 0.065	3.84ArgLeu: 3.84 ± 0.078	1.151ArgMet: 1.151 ± 0.03	2.016ArgAsn: 2.016 ± 0.048	1.302ArgPro: 1.302 ± 0.037	1.477ArgGln: 1.477 ± 0.039	1.83ArgArg: 1.83 ± 0.05	2.353ArgSer: 2.353 ± 0.051	1.956ArgThr: 1.956 ± 0.048	2.62ArgVal: 2.62 ± 0.057	0.436ArgTrp: 0.436 ± 0.021	1.504ArgTyr: 1.504 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.374SerAla: 3.374 ± 0.062	0.506SerCys: 0.506 ± 0.027	2.884SerAsp: 2.884 ± 0.056	4.258SerGlu: 4.258 ± 0.074	3.413SerPhe: 3.413 ± 0.052	4.025SerGly: 4.025 ± 0.071	1.129SerHis: 1.129 ± 0.04	5.089SerIle: 5.089 ± 0.07	3.793SerLys: 3.793 ± 0.064	6.139SerLeu: 6.139 ± 0.085	1.545SerMet: 1.545 ± 0.039	2.833SerAsn: 2.833 ± 0.055	1.985SerPro: 1.985 ± 0.05	1.87SerGln: 1.87 ± 0.046	2.17SerArg: 2.17 ± 0.05	3.84SerSer: 3.84 ± 0.08	3.101SerThr: 3.101 ± 0.052	4.076SerVal: 4.076 ± 0.079	0.648SerTrp: 0.648 ± 0.026	2.181SerTyr: 2.181 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.6ThrAla: 3.6 ± 0.067	0.381ThrCys: 0.381 ± 0.019	2.668ThrAsp: 2.668 ± 0.05	3.719ThrGlu: 3.719 ± 0.064	2.784ThrPhe: 2.784 ± 0.047	3.835ThrGly: 3.835 ± 0.063	0.996ThrHis: 0.996 ± 0.032	4.609ThrIle: 4.609 ± 0.065	3.509ThrLys: 3.509 ± 0.058	5.282ThrLeu: 5.282 ± 0.066	1.357ThrMet: 1.357 ± 0.038	2.647ThrAsn: 2.647 ± 0.049	2.182ThrPro: 2.182 ± 0.048	1.426ThrGln: 1.426 ± 0.032	1.856ThrArg: 1.856 ± 0.047	3.25ThrSer: 3.25 ± 0.059	3.114ThrThr: 3.114 ± 0.06	4.384ThrVal: 4.384 ± 0.07	0.487ThrTrp: 0.487 ± 0.023	1.896ThrTyr: 1.896 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	5.278ValAla: 5.278 ± 0.075	0.625ValCys: 0.625 ± 0.026	3.944ValAsp: 3.944 ± 0.073	5.516ValGlu: 5.516 ± 0.077	3.188ValPhe: 3.188 ± 0.064	4.982ValGly: 4.982 ± 0.08	1.386ValHis: 1.386 ± 0.037	6.1ValIle: 6.1 ± 0.087	4.638ValLys: 4.638 ± 0.066	6.701ValLeu: 6.701 ± 0.09	1.773ValMet: 1.773 ± 0.044	3.316ValAsn: 3.316 ± 0.057	2.616ValPro: 2.616 ± 0.049	2.339ValGln: 2.339 ± 0.054	2.675ValArg: 2.675 ± 0.054	4.665ValSer: 4.665 ± 0.073	4.281ValThr: 4.281 ± 0.073	5.682ValVal: 5.682 ± 0.077	0.639ValTrp: 0.639 ± 0.027	2.206ValTyr: 2.206 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.556TrpAla: 0.556 ± 0.026	0.073TrpCys: 0.073 ± 0.008	0.513TrpAsp: 0.513 ± 0.024	0.684TrpGlu: 0.684 ± 0.029	0.529TrpPhe: 0.529 ± 0.027	0.635TrpGly: 0.635 ± 0.026	0.192TrpHis: 0.192 ± 0.014	0.764TrpIle: 0.764 ± 0.031	0.655TrpLys: 0.655 ± 0.031	1.154TrpLeu: 1.154 ± 0.042	0.285TrpMet: 0.285 ± 0.017	0.487TrpAsn: 0.487 ± 0.022	0.245TrpPro: 0.245 ± 0.017	0.38TrpGln: 0.38 ± 0.02	0.397TrpArg: 0.397 ± 0.018	0.568TrpSer: 0.568 ± 0.023	0.449TrpThr: 0.449 ± 0.024	0.644TrpVal: 0.644 ± 0.029	0.148TrpTrp: 0.148 ± 0.013	0.349TrpTyr: 0.349 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.839TyrAla: 1.839 ± 0.042	0.333TyrCys: 0.333 ± 0.021	2.016TyrAsp: 2.016 ± 0.039	2.834TyrGlu: 2.834 ± 0.057	1.976TyrPhe: 1.976 ± 0.045	2.329TyrGly: 2.329 ± 0.054	0.841TyrHis: 0.841 ± 0.024	2.524TyrIle: 2.524 ± 0.049	2.063TyrLys: 2.063 ± 0.057	3.455TyrLeu: 3.455 ± 0.062	0.785TyrMet: 0.785 ± 0.028	1.575TyrAsn: 1.575 ± 0.043	1.276TyrPro: 1.276 ± 0.036	1.354TyrGln: 1.354 ± 0.039	1.545TyrArg: 1.545 ± 0.038	2.223TyrSer: 2.223 ± 0.048	1.699TyrThr: 1.699 ± 0.049	2.327TyrVal: 2.327 ± 0.052	0.364TyrTrp: 0.364 ± 0.02	1.498TyrTyr: 1.498 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3587 proteins (1023233 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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