Amino acid dipepetide frequency for Rhodobacter vinaykumarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.063AlaAla: 23.063 ± 0.302	1.176AlaCys: 1.176 ± 0.037	7.627AlaAsp: 7.627 ± 0.108	10.048AlaGlu: 10.048 ± 0.131	4.314AlaPhe: 4.314 ± 0.079	13.158AlaGly: 13.158 ± 0.152	2.723AlaHis: 2.723 ± 0.064	5.589AlaIle: 5.589 ± 0.078	2.652AlaLys: 2.652 ± 0.065	16.427AlaLeu: 16.427 ± 0.203	3.838AlaMet: 3.838 ± 0.067	2.371AlaAsn: 2.371 ± 0.061	8.786AlaPro: 8.786 ± 0.176	5.133AlaGln: 5.133 ± 0.085	13.448AlaArg: 13.448 ± 0.162	5.326AlaSer: 5.326 ± 0.077	6.112AlaThr: 6.112 ± 0.085	8.898AlaVal: 8.898 ± 0.107	1.639AlaTrp: 1.639 ± 0.048	2.324AlaTyr: 2.324 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.206CysAla: 1.206 ± 0.038	0.1CysCys: 0.1 ± 0.011	0.564CysAsp: 0.564 ± 0.023	0.428CysGlu: 0.428 ± 0.023	0.26CysPhe: 0.26 ± 0.016	0.917CysGly: 0.917 ± 0.035	0.248CysHis: 0.248 ± 0.017	0.352CysIle: 0.352 ± 0.018	0.157CysLys: 0.157 ± 0.014	0.861CysLeu: 0.861 ± 0.029	0.146CysMet: 0.146 ± 0.011	0.177CysAsn: 0.177 ± 0.014	0.563CysPro: 0.563 ± 0.026	0.197CysGln: 0.197 ± 0.015	0.615CysArg: 0.615 ± 0.025	0.357CysSer: 0.357 ± 0.02	0.395CysThr: 0.395 ± 0.02	0.51CysVal: 0.51 ± 0.024	0.102CysTrp: 0.102 ± 0.011	0.156CysTyr: 0.156 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.546AspAla: 7.546 ± 0.104	0.46AspCys: 0.46 ± 0.021	3.156AspAsp: 3.156 ± 0.092	2.997AspGlu: 2.997 ± 0.065	2.279AspPhe: 2.279 ± 0.054	5.252AspGly: 5.252 ± 0.109	1.299AspHis: 1.299 ± 0.041	2.521AspIle: 2.521 ± 0.057	1.196AspLys: 1.196 ± 0.037	7.228AspLeu: 7.228 ± 0.094	1.511AspMet: 1.511 ± 0.038	0.994AspAsn: 0.994 ± 0.034	4.255AspPro: 4.255 ± 0.075	1.564AspGln: 1.564 ± 0.044	4.665AspArg: 4.665 ± 0.075	1.821AspSer: 1.821 ± 0.049	2.956AspThr: 2.956 ± 0.08	3.575AspVal: 3.575 ± 0.074	1.187AspTrp: 1.187 ± 0.035	1.312AspTyr: 1.312 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	9.122GluAla: 9.122 ± 0.125	0.385GluCys: 0.385 ± 0.018	3.279GluAsp: 3.279 ± 0.058	3.119GluGlu: 3.119 ± 0.073	1.613GluPhe: 1.613 ± 0.044	5.259GluGly: 5.259 ± 0.08	1.054GluHis: 1.054 ± 0.038	3.806GluIle: 3.806 ± 0.064	1.81GluLys: 1.81 ± 0.054	4.748GluLeu: 4.748 ± 0.068	1.887GluMet: 1.887 ± 0.047	1.4GluAsn: 1.4 ± 0.036	2.437GluPro: 2.437 ± 0.058	1.502GluGln: 1.502 ± 0.042	4.566GluArg: 4.566 ± 0.075	2.012GluSer: 2.012 ± 0.049	4.16GluThr: 4.16 ± 0.078	4.275GluVal: 4.275 ± 0.074	0.685GluTrp: 0.685 ± 0.029	0.913GluTyr: 0.913 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.482PheAla: 4.482 ± 0.065	0.37PheCys: 0.37 ± 0.019	2.625PheAsp: 2.625 ± 0.046	2.071PheGlu: 2.071 ± 0.051	1.231PhePhe: 1.231 ± 0.034	3.443PheGly: 3.443 ± 0.065	0.735PheHis: 0.735 ± 0.027	1.273PheIle: 1.273 ± 0.035	0.661PheLys: 0.661 ± 0.03	3.347PheLeu: 3.347 ± 0.063	0.718PheMet: 0.718 ± 0.029	0.84PheAsn: 0.84 ± 0.028	1.498PhePro: 1.498 ± 0.036	0.842PheGln: 0.842 ± 0.032	2.263PheArg: 2.263 ± 0.049	1.878PheSer: 1.878 ± 0.045	1.909PheThr: 1.909 ± 0.045	2.612PheVal: 2.612 ± 0.057	0.517PheTrp: 0.517 ± 0.024	0.721PheTyr: 0.721 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	12.713GlyAla: 12.713 ± 0.146	0.913GlyCys: 0.913 ± 0.035	4.615GlyAsp: 4.615 ± 0.111	4.155GlyGlu: 4.155 ± 0.073	3.575GlyPhe: 3.575 ± 0.061	7.994GlyGly: 7.994 ± 0.145	2.046GlyHis: 2.046 ± 0.044	4.043GlyIle: 4.043 ± 0.071	2.639GlyLys: 2.639 ± 0.065	10.301GlyLeu: 10.301 ± 0.139	2.609GlyMet: 2.609 ± 0.053	1.873GlyAsn: 1.873 ± 0.071	4.659GlyPro: 4.659 ± 0.072	3.066GlyGln: 3.066 ± 0.057	7.328GlyArg: 7.328 ± 0.09	3.617GlySer: 3.617 ± 0.067	4.759GlyThr: 4.759 ± 0.083	6.5GlyVal: 6.5 ± 0.083	1.536GlyTrp: 1.536 ± 0.043	1.978GlyTyr: 1.978 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.663HisAla: 2.663 ± 0.061	0.233HisCys: 0.233 ± 0.016	1.414HisAsp: 1.414 ± 0.041	1.09HisGlu: 1.09 ± 0.033	0.817HisPhe: 0.817 ± 0.033	1.942HisGly: 1.942 ± 0.048	0.524HisHis: 0.524 ± 0.023	0.771HisIle: 0.771 ± 0.028	0.369HisLys: 0.369 ± 0.018	2.219HisLeu: 2.219 ± 0.054	0.486HisMet: 0.486 ± 0.024	0.376HisAsn: 0.376 ± 0.018	1.463HisPro: 1.463 ± 0.042	0.52HisGln: 0.52 ± 0.023	1.508HisArg: 1.508 ± 0.041	0.808HisSer: 0.808 ± 0.029	0.713HisThr: 0.713 ± 0.027	1.578HisVal: 1.578 ± 0.041	0.359HisTrp: 0.359 ± 0.02	0.512HisTyr: 0.512 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.959IleAla: 6.959 ± 0.084	0.512IleCys: 0.512 ± 0.021	3.157IleAsp: 3.157 ± 0.065	3.471IleGlu: 3.471 ± 0.061	1.526IlePhe: 1.526 ± 0.038	4.226IleGly: 4.226 ± 0.072	0.863IleHis: 0.863 ± 0.035	1.547IleIle: 1.547 ± 0.044	0.988IleLys: 0.988 ± 0.038	4.387IleLeu: 4.387 ± 0.067	0.829IleMet: 0.829 ± 0.031	1.046IleAsn: 1.046 ± 0.035	2.195IlePro: 2.195 ± 0.052	0.957IleGln: 0.957 ± 0.036	3.292IleArg: 3.292 ± 0.055	2.36IleSer: 2.36 ± 0.053	2.513IleThr: 2.513 ± 0.049	3.503IleVal: 3.503 ± 0.068	0.699IleTrp: 0.699 ± 0.027	0.965IleTyr: 0.965 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.208LysAla: 3.208 ± 0.076	0.136LysCys: 0.136 ± 0.011	1.278LysAsp: 1.278 ± 0.031	1.006LysGlu: 1.006 ± 0.034	0.698LysPhe: 0.698 ± 0.029	2.202LysGly: 2.202 ± 0.054	0.442LysHis: 0.442 ± 0.019	1.258LysIle: 1.258 ± 0.035	0.851LysLys: 0.851 ± 0.04	2.411LysLeu: 2.411 ± 0.053	0.673LysMet: 0.673 ± 0.031	0.565LysAsn: 0.565 ± 0.028	1.528LysPro: 1.528 ± 0.045	0.593LysGln: 0.593 ± 0.027	1.738LysArg: 1.738 ± 0.05	1.338LysSer: 1.338 ± 0.042	1.508LysThr: 1.508 ± 0.042	1.898LysVal: 1.898 ± 0.055	0.295LysTrp: 0.295 ± 0.019	0.471LysTyr: 0.471 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	16.071LeuAla: 16.071 ± 0.188	0.938LeuCys: 0.938 ± 0.032	6.167LeuAsp: 6.167 ± 0.083	5.651LeuGlu: 5.651 ± 0.083	3.298LeuPhe: 3.298 ± 0.073	9.476LeuGly: 9.476 ± 0.112	2.009LeuHis: 2.009 ± 0.048	4.866LeuIle: 4.866 ± 0.067	2.611LeuLys: 2.611 ± 0.056	8.617LeuLeu: 8.617 ± 0.134	2.723LeuMet: 2.723 ± 0.052	2.179LeuAsn: 2.179 ± 0.045	6.171LeuPro: 6.171 ± 0.093	2.116LeuGln: 2.116 ± 0.042	8.442LeuArg: 8.442 ± 0.102	6.526LeuSer: 6.526 ± 0.092	5.465LeuThr: 5.465 ± 0.078	7.245LeuVal: 7.245 ± 0.085	1.453LeuTrp: 1.453 ± 0.045	1.838LeuTyr: 1.838 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.764MetAla: 3.764 ± 0.068	0.145MetCys: 0.145 ± 0.011	1.214MetAsp: 1.214 ± 0.039	1.197MetGlu: 1.197 ± 0.036	0.699MetPhe: 0.699 ± 0.027	2.365MetGly: 2.365 ± 0.05	0.418MetHis: 0.418 ± 0.02	1.383MetIle: 1.383 ± 0.038	0.915MetLys: 0.915 ± 0.031	2.438MetLeu: 2.438 ± 0.054	0.681MetMet: 0.681 ± 0.031	0.751MetAsn: 0.751 ± 0.024	1.465MetPro: 1.465 ± 0.04	0.892MetGln: 0.892 ± 0.028	2.063MetArg: 2.063 ± 0.052	1.614MetSer: 1.614 ± 0.041	1.911MetThr: 1.911 ± 0.042	1.748MetVal: 1.748 ± 0.045	0.236MetTrp: 0.236 ± 0.017	0.249MetTyr: 0.249 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.832AsnAla: 2.832 ± 0.061	0.22AsnCys: 0.22 ± 0.015	1.327AsnAsp: 1.327 ± 0.061	0.888AsnGlu: 0.888 ± 0.031	0.734AsnPhe: 0.734 ± 0.028	1.863AsnGly: 1.863 ± 0.047	0.425AsnHis: 0.425 ± 0.025	1.034AsnIle: 1.034 ± 0.035	0.442AsnLys: 0.442 ± 0.02	2.234AsnLeu: 2.234 ± 0.048	0.565AsnMet: 0.565 ± 0.027	0.409AsnAsn: 0.409 ± 0.022	1.59AsnPro: 1.59 ± 0.044	0.48AsnGln: 0.48 ± 0.022	1.63AsnArg: 1.63 ± 0.046	0.904AsnSer: 0.904 ± 0.028	1.049AsnThr: 1.049 ± 0.037	1.498AsnVal: 1.498 ± 0.041	0.33AsnTrp: 0.33 ± 0.017	0.457AsnTyr: 0.457 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.657ProAla: 8.657 ± 0.14	0.389ProCys: 0.389 ± 0.02	4.256ProAsp: 4.256 ± 0.082	5.144ProGlu: 5.144 ± 0.086	1.945ProPhe: 1.945 ± 0.044	5.629ProGly: 5.629 ± 0.083	1.134ProHis: 1.134 ± 0.035	2.032ProIle: 2.032 ± 0.045	1.262ProLys: 1.262 ± 0.038	5.001ProLeu: 5.001 ± 0.079	1.351ProMet: 1.351 ± 0.033	1.022ProAsn: 1.022 ± 0.033	3.385ProPro: 3.385 ± 0.085	1.773ProGln: 1.773 ± 0.045	4.068ProArg: 4.068 ± 0.081	2.23ProSer: 2.23 ± 0.049	2.392ProThr: 2.392 ± 0.047	4.544ProVal: 4.544 ± 0.068	0.755ProTrp: 0.755 ± 0.029	0.978ProTyr: 0.978 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.234GlnAla: 4.234 ± 0.071	0.159GlnCys: 0.159 ± 0.013	1.348GlnAsp: 1.348 ± 0.041	1.242GlnGlu: 1.242 ± 0.038	0.882GlnPhe: 0.882 ± 0.028	2.725GlnGly: 2.725 ± 0.057	0.465GlnHis: 0.465 ± 0.023	1.835GlnIle: 1.835 ± 0.044	0.845GlnLys: 0.845 ± 0.033	2.427GlnLeu: 2.427 ± 0.054	0.981GlnMet: 0.981 ± 0.035	0.735GlnAsn: 0.735 ± 0.029	1.582GlnPro: 1.582 ± 0.038	0.721GlnGln: 0.721 ± 0.027	2.023GlnArg: 2.023 ± 0.054	1.409GlnSer: 1.409 ± 0.036	1.625GlnThr: 1.625 ± 0.038	2.317GlnVal: 2.317 ± 0.042	0.3GlnTrp: 0.3 ± 0.018	0.417GlnTyr: 0.417 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	12.047ArgAla: 12.047 ± 0.137	0.468ArgCys: 0.468 ± 0.022	4.442ArgAsp: 4.442 ± 0.064	4.117ArgGlu: 4.117 ± 0.078	2.816ArgPhe: 2.816 ± 0.062	5.831ArgGly: 5.831 ± 0.083	1.849ArgHis: 1.849 ± 0.051	4.191ArgIle: 4.191 ± 0.075	2.067ArgLys: 2.067 ± 0.057	9.086ArgLeu: 9.086 ± 0.123	2.238ArgMet: 2.238 ± 0.046	1.618ArgAsn: 1.618 ± 0.04	4.717ArgPro: 4.717 ± 0.073	2.333ArgGln: 2.333 ± 0.053	6.586ArgArg: 6.586 ± 0.101	3.23ArgSer: 3.23 ± 0.057	3.125ArgThr: 3.125 ± 0.061	5.345ArgVal: 5.345 ± 0.084	1.023ArgTrp: 1.023 ± 0.037	1.501ArgTyr: 1.501 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.864SerAla: 5.864 ± 0.087	0.396SerCys: 0.396 ± 0.023	2.662SerAsp: 2.662 ± 0.054	2.523SerGlu: 2.523 ± 0.054	1.887SerPhe: 1.887 ± 0.049	5.144SerGly: 5.144 ± 0.086	0.966SerHis: 0.966 ± 0.035	1.899SerIle: 1.899 ± 0.056	1.054SerLys: 1.054 ± 0.033	4.501SerLeu: 4.501 ± 0.07	1.129SerMet: 1.129 ± 0.035	0.991SerAsn: 0.991 ± 0.038	2.476SerPro: 2.476 ± 0.059	1.231SerGln: 1.231 ± 0.039	3.127SerArg: 3.127 ± 0.057	2.097SerSer: 2.097 ± 0.055	2.217SerThr: 2.217 ± 0.052	3.304SerVal: 3.304 ± 0.058	0.657SerTrp: 0.657 ± 0.029	1.064SerTyr: 1.064 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.583ThrAla: 6.583 ± 0.088	0.416ThrCys: 0.416 ± 0.02	2.944ThrAsp: 2.944 ± 0.056	2.87ThrGlu: 2.87 ± 0.058	1.682ThrPhe: 1.682 ± 0.042	5.465ThrGly: 5.465 ± 0.081	1.049ThrHis: 1.049 ± 0.03	2.381ThrIle: 2.381 ± 0.06	0.997ThrLys: 0.997 ± 0.032	5.983ThrLeu: 5.983 ± 0.09	1.022ThrMet: 1.022 ± 0.035	1.056ThrAsn: 1.056 ± 0.035	3.712ThrPro: 3.712 ± 0.059	1.375ThrGln: 1.375 ± 0.037	4.111ThrArg: 4.111 ± 0.067	2.152ThrSer: 2.152 ± 0.045	2.69ThrThr: 2.69 ± 0.068	3.4ThrVal: 3.4 ± 0.062	0.61ThrTrp: 0.61 ± 0.025	0.996ThrTyr: 0.996 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.723ValAla: 9.723 ± 0.106	0.568ValCys: 0.568 ± 0.024	3.639ValAsp: 3.639 ± 0.067	4.336ValGlu: 4.336 ± 0.069	2.579ValPhe: 2.579 ± 0.051	5.103ValGly: 5.103 ± 0.078	1.314ValHis: 1.314 ± 0.038	3.855ValIle: 3.855 ± 0.062	1.72ValLys: 1.72 ± 0.05	7.934ValLeu: 7.934 ± 0.099	1.993ValMet: 1.993 ± 0.045	1.704ValAsn: 1.704 ± 0.046	3.73ValPro: 3.73 ± 0.069	1.885ValGln: 1.885 ± 0.042	4.489ValArg: 4.489 ± 0.067	3.875ValSer: 3.875 ± 0.072	4.393ValThr: 4.393 ± 0.078	5.741ValVal: 5.741 ± 0.087	0.924ValTrp: 0.924 ± 0.031	1.235ValTyr: 1.235 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.617TrpAla: 1.617 ± 0.044	0.129TrpCys: 0.129 ± 0.012	0.698TrpAsp: 0.698 ± 0.027	0.617TrpGlu: 0.617 ± 0.027	0.494TrpPhe: 0.494 ± 0.02	1.127TrpGly: 1.127 ± 0.04	0.354TrpHis: 0.354 ± 0.019	0.629TrpIle: 0.629 ± 0.03	0.414TrpLys: 0.414 ± 0.022	1.667TrpLeu: 1.667 ± 0.047	0.351TrpMet: 0.351 ± 0.021	0.313TrpAsn: 0.313 ± 0.018	0.773TrpPro: 0.773 ± 0.03	0.558TrpGln: 0.558 ± 0.024	1.236TrpArg: 1.236 ± 0.042	0.761TrpSer: 0.761 ± 0.029	0.688TrpThr: 0.688 ± 0.032	0.955TrpVal: 0.955 ± 0.034	0.224TrpTrp: 0.224 ± 0.016	0.222TrpTyr: 0.222 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.298TyrAla: 2.298 ± 0.043	0.199TyrCys: 0.199 ± 0.014	1.359TyrAsp: 1.359 ± 0.044	1.061TyrGlu: 1.061 ± 0.04	0.706TyrPhe: 0.706 ± 0.028	1.8TyrGly: 1.8 ± 0.045	0.45TyrHis: 0.45 ± 0.022	0.732TyrIle: 0.732 ± 0.028	0.446TyrLys: 0.446 ± 0.023	2.044TyrLeu: 2.044 ± 0.045	0.416TyrMet: 0.416 ± 0.02	0.492TyrAsn: 0.492 ± 0.023	0.958TyrPro: 0.958 ± 0.029	0.536TyrGln: 0.536 ± 0.022	1.435TyrArg: 1.435 ± 0.042	0.872TyrSer: 0.872 ± 0.032	0.915TyrThr: 0.915 ± 0.036	1.293TyrVal: 1.293 ± 0.039	0.295TyrTrp: 0.295 ± 0.016	0.488TyrTyr: 0.488 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3255 proteins (1023962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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