Amino acid dipepetide frequency for Kluyvera genomosp. 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.535AlaAla: 10.535 ± 0.209
1.155AlaCys: 1.155 ± 0.049
5.32AlaAsp: 5.32 ± 0.111
6.084AlaGlu: 6.084 ± 0.129
3.481AlaPhe: 3.481 ± 0.095
7.356AlaGly: 7.356 ± 0.131
1.904AlaHis: 1.904 ± 0.059
5.777AlaIle: 5.777 ± 0.122
4.365AlaLys: 4.365 ± 0.117
11.329AlaLeu: 11.329 ± 0.186
3.006AlaMet: 3.006 ± 0.077
3.313AlaAsn: 3.313 ± 0.096
3.261AlaPro: 3.261 ± 0.083
4.667AlaGln: 4.667 ± 0.107
5.322AlaArg: 5.322 ± 0.121
5.579AlaSer: 5.579 ± 0.12
5.019AlaThr: 5.019 ± 0.127
6.848AlaVal: 6.848 ± 0.126
1.476AlaTrp: 1.476 ± 0.056
2.055AlaTyr: 2.055 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.044CysAla: 1.044 ± 0.046
0.255CysCys: 0.255 ± 0.023
0.653CysAsp: 0.653 ± 0.035
0.611CysGlu: 0.611 ± 0.036
0.439CysPhe: 0.439 ± 0.028
1.06CysGly: 1.06 ± 0.048
0.319CysHis: 0.319 ± 0.03
0.57CysIle: 0.57 ± 0.029
0.369CysLys: 0.369 ± 0.03
1.036CysLeu: 1.036 ± 0.045
0.272CysMet: 0.272 ± 0.021
0.352CysAsn: 0.352 ± 0.027
0.504CysPro: 0.504 ± 0.034
0.513CysGln: 0.513 ± 0.034
0.764CysArg: 0.764 ± 0.044
0.758CysSer: 0.758 ± 0.042
0.607CysThr: 0.607 ± 0.036
0.782CysVal: 0.782 ± 0.039
0.179CysTrp: 0.179 ± 0.018
0.336CysTyr: 0.336 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
5.499AspAla: 5.499 ± 0.115
0.509AspCys: 0.509 ± 0.031
3.294AspAsp: 3.294 ± 0.086
3.625AspGlu: 3.625 ± 0.093
2.135AspPhe: 2.135 ± 0.066
4.208AspGly: 4.208 ± 0.1
1.033AspHis: 1.033 ± 0.045
3.44AspIle: 3.44 ± 0.081
2.722AspLys: 2.722 ± 0.087
4.844AspLeu: 4.844 ± 0.095
1.351AspMet: 1.351 ± 0.053
2.473AspAsn: 2.473 ± 0.075
2.154AspPro: 2.154 ± 0.072
1.552AspGln: 1.552 ± 0.06
2.565AspArg: 2.565 ± 0.079
2.862AspSer: 2.862 ± 0.082
2.726AspThr: 2.726 ± 0.079
3.938AspVal: 3.938 ± 0.079
0.723AspTrp: 0.723 ± 0.042
2.088AspTyr: 2.088 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
5.518GluAla: 5.518 ± 0.121
0.533GluCys: 0.533 ± 0.031
2.411GluAsp: 2.411 ± 0.075
3.473GluGlu: 3.473 ± 0.101
1.976GluPhe: 1.976 ± 0.059
3.677GluGly: 3.677 ± 0.084
1.493GluHis: 1.493 ± 0.051
3.52GluIle: 3.52 ± 0.092
3.337GluLys: 3.337 ± 0.088
5.763GluLeu: 5.763 ± 0.118
1.985GluMet: 1.985 ± 0.057
2.289GluAsn: 2.289 ± 0.065
1.869GluPro: 1.869 ± 0.057
3.389GluGln: 3.389 ± 0.084
3.714GluArg: 3.714 ± 0.097
3.057GluSer: 3.057 ± 0.071
2.991GluThr: 2.991 ± 0.071
4.025GluVal: 4.025 ± 0.088
0.743GluTrp: 0.743 ± 0.039
1.579GluTyr: 1.579 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.572PheAla: 3.572 ± 0.086
0.579PheCys: 0.579 ± 0.035
2.326PheAsp: 2.326 ± 0.063
1.911PheGlu: 1.911 ± 0.061
1.766PhePhe: 1.766 ± 0.065
2.942PheGly: 2.942 ± 0.084
0.836PheHis: 0.836 ± 0.043
2.534PheIle: 2.534 ± 0.078
1.497PheLys: 1.497 ± 0.053
3.177PheLeu: 3.177 ± 0.088
0.97PheMet: 0.97 ± 0.043
1.886PheAsn: 1.886 ± 0.056
1.386PhePro: 1.386 ± 0.06
1.149PheGln: 1.149 ± 0.047
1.861PheArg: 1.861 ± 0.052
3.138PheSer: 3.138 ± 0.076
2.477PheThr: 2.477 ± 0.067
2.545PheVal: 2.545 ± 0.074
0.55PheTrp: 0.55 ± 0.034
1.241PheTyr: 1.241 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.896GlyAla: 5.896 ± 0.111
1.087GlyCys: 1.087 ± 0.051
3.897GlyAsp: 3.897 ± 0.084
4.515GlyGlu: 4.515 ± 0.102
3.173GlyPhe: 3.173 ± 0.089
5.26GlyGly: 5.26 ± 0.116
1.707GlyHis: 1.707 ± 0.059
4.739GlyIle: 4.739 ± 0.112
4.066GlyLys: 4.066 ± 0.085
6.889GlyLeu: 6.889 ± 0.12
2.304GlyMet: 2.304 ± 0.072
2.829GlyAsn: 2.829 ± 0.083
1.923GlyPro: 1.923 ± 0.06
2.841GlyGln: 2.841 ± 0.077
3.751GlyArg: 3.751 ± 0.088
4.311GlySer: 4.311 ± 0.095
3.774GlyThr: 3.774 ± 0.095
5.719GlyVal: 5.719 ± 0.118
1.25GlyTrp: 1.25 ± 0.052
2.615GlyTyr: 2.615 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
1.952HisAla: 1.952 ± 0.068
0.296HisCys: 0.296 ± 0.026
1.237HisAsp: 1.237 ± 0.048
1.089HisGlu: 1.089 ± 0.054
1.066HisPhe: 1.066 ± 0.046
1.721HisGly: 1.721 ± 0.06
0.788HisHis: 0.788 ± 0.049
1.396HisIle: 1.396 ± 0.055
0.778HisLys: 0.778 ± 0.043
2.182HisLeu: 2.182 ± 0.064
0.618HisMet: 0.618 ± 0.039
0.908HisAsn: 0.908 ± 0.044
1.334HisPro: 1.334 ± 0.053
1.215HisGln: 1.215 ± 0.045
1.209HisArg: 1.209 ± 0.052
1.322HisSer: 1.322 ± 0.048
1.103HisThr: 1.103 ± 0.053
1.313HisVal: 1.313 ± 0.052
0.389HisTrp: 0.389 ± 0.028
0.896HisTyr: 0.896 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.57IleAla: 6.57 ± 0.129
0.649IleCys: 0.649 ± 0.035
3.7IleAsp: 3.7 ± 0.098
3.403IleGlu: 3.403 ± 0.101
2.174IlePhe: 2.174 ± 0.072
4.385IleGly: 4.385 ± 0.087
1.281IleHis: 1.281 ± 0.05
3.37IleIle: 3.37 ± 0.099
2.561IleLys: 2.561 ± 0.076
4.589IleLeu: 4.589 ± 0.099
1.283IleMet: 1.283 ± 0.055
2.783IleAsn: 2.783 ± 0.072
2.553IlePro: 2.553 ± 0.075
1.847IleGln: 1.847 ± 0.065
2.895IleArg: 2.895 ± 0.089
3.78IleSer: 3.78 ± 0.089
3.696IleThr: 3.696 ± 0.1
4.165IleVal: 4.165 ± 0.087
0.681IleTrp: 0.681 ± 0.041
1.631IleTyr: 1.631 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.622LysAla: 4.622 ± 0.118
0.36LysCys: 0.36 ± 0.033
2.345LysAsp: 2.345 ± 0.07
2.631LysGlu: 2.631 ± 0.083
1.211LysPhe: 1.211 ± 0.049
3.08LysGly: 3.08 ± 0.085
0.891LysHis: 0.891 ± 0.047
2.66LysIle: 2.66 ± 0.073
2.532LysLys: 2.532 ± 0.089
4.457LysLeu: 4.457 ± 0.095
1.54LysMet: 1.54 ± 0.057
1.913LysAsn: 1.913 ± 0.063
2.221LysPro: 2.221 ± 0.078
2.158LysGln: 2.158 ± 0.068
2.831LysArg: 2.831 ± 0.078
2.394LysSer: 2.394 ± 0.07
2.714LysThr: 2.714 ± 0.071
3.212LysVal: 3.212 ± 0.086
0.49LysTrp: 0.49 ± 0.031
1.278LysTyr: 1.278 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
10.656LeuAla: 10.656 ± 0.165
1.318LeuCys: 1.318 ± 0.051
5.338LeuAsp: 5.338 ± 0.118
5.481LeuGlu: 5.481 ± 0.13
3.988LeuPhe: 3.988 ± 0.096
6.681LeuGly: 6.681 ± 0.142
2.234LeuHis: 2.234 ± 0.074
5.594LeuIle: 5.594 ± 0.126
4.725LeuLys: 4.725 ± 0.102
11.017LeuLeu: 11.017 ± 0.206
2.864LeuMet: 2.864 ± 0.077
4.295LeuAsn: 4.295 ± 0.091
5.069LeuPro: 5.069 ± 0.123
3.852LeuGln: 3.852 ± 0.093
5.931LeuArg: 5.931 ± 0.125
7.101LeuSer: 7.101 ± 0.129
6.197LeuThr: 6.197 ± 0.122
6.769LeuVal: 6.769 ± 0.118
1.307LeuTrp: 1.307 ± 0.062
2.508LeuTyr: 2.508 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.915MetAla: 2.915 ± 0.09
0.218MetCys: 0.218 ± 0.02
1.223MetAsp: 1.223 ± 0.051
1.223MetGlu: 1.223 ± 0.047
0.949MetPhe: 0.949 ± 0.048
1.74MetGly: 1.74 ± 0.061
0.543MetHis: 0.543 ± 0.03
1.472MetIle: 1.472 ± 0.056
1.631MetLys: 1.631 ± 0.058
3.033MetLeu: 3.033 ± 0.084
0.887MetMet: 0.887 ± 0.046
1.221MetAsn: 1.221 ± 0.047
1.371MetPro: 1.371 ± 0.053
1.289MetGln: 1.289 ± 0.049
1.561MetArg: 1.561 ± 0.051
2.003MetSer: 2.003 ± 0.056
2.049MetThr: 2.049 ± 0.062
2.038MetVal: 2.038 ± 0.062
0.286MetTrp: 0.286 ± 0.029
0.583MetTyr: 0.583 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.801AsnAla: 3.801 ± 0.087
0.373AsnCys: 0.373 ± 0.031
2.259AsnAsp: 2.259 ± 0.075
2.032AsnGlu: 2.032 ± 0.067
1.439AsnPhe: 1.439 ± 0.053
3.642AsnGly: 3.642 ± 0.108
0.904AsnHis: 0.904 ± 0.044
2.518AsnIle: 2.518 ± 0.07
1.773AsnLys: 1.773 ± 0.069
3.502AsnLeu: 3.502 ± 0.083
0.951AsnMet: 0.951 ± 0.039
1.845AsnAsn: 1.845 ± 0.073
1.978AsnPro: 1.978 ± 0.058
1.554AsnGln: 1.554 ± 0.062
1.979AsnArg: 1.979 ± 0.058
2.193AsnSer: 2.193 ± 0.076
2.119AsnThr: 2.119 ± 0.075
2.884AsnVal: 2.884 ± 0.091
0.578AsnTrp: 0.578 ± 0.034
1.26AsnTyr: 1.26 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
4.056ProAla: 4.056 ± 0.094
0.383ProCys: 0.383 ± 0.028
2.582ProAsp: 2.582 ± 0.066
3.037ProGlu: 3.037 ± 0.076
1.729ProPhe: 1.729 ± 0.06
3.063ProGly: 3.063 ± 0.081
1.066ProHis: 1.066 ± 0.049
1.82ProIle: 1.82 ± 0.066
1.602ProLys: 1.602 ± 0.061
4.496ProLeu: 4.496 ± 0.092
1.106ProMet: 1.106 ± 0.047
1.281ProAsn: 1.281 ± 0.053
1.466ProPro: 1.466 ± 0.043
2.217ProGln: 2.217 ± 0.064
1.839ProArg: 1.839 ± 0.059
2.059ProSer: 2.059 ± 0.06
2.219ProThr: 2.219 ± 0.071
3.485ProVal: 3.485 ± 0.095
0.671ProTrp: 0.671 ± 0.039
1.165ProTyr: 1.165 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
4.556GlnAla: 4.556 ± 0.113
0.381GlnCys: 0.381 ± 0.028
1.888GlnAsp: 1.888 ± 0.061
2.374GlnGlu: 2.374 ± 0.074
1.515GlnPhe: 1.515 ± 0.053
2.932GlnGly: 2.932 ± 0.082
1.198GlnHis: 1.198 ± 0.05
2.277GlnIle: 2.277 ± 0.073
1.948GlnLys: 1.948 ± 0.071
4.727GlnLeu: 4.727 ± 0.096
1.2GlnMet: 1.2 ± 0.047
1.589GlnAsn: 1.589 ± 0.058
2.125GlnPro: 2.125 ± 0.068
3.238GlnGln: 3.238 ± 0.096
2.934GlnArg: 2.934 ± 0.103
2.353GlnSer: 2.353 ± 0.076
2.298GlnThr: 2.298 ± 0.079
3.047GlnVal: 3.047 ± 0.078
0.632GlnTrp: 0.632 ± 0.032
1.217GlnTyr: 1.217 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
4.55ArgAla: 4.55 ± 0.102
0.753ArgCys: 0.753 ± 0.045
2.862ArgAsp: 2.862 ± 0.089
3.798ArgGlu: 3.798 ± 0.094
2.506ArgPhe: 2.506 ± 0.067
3.329ArgGly: 3.329 ± 0.079
1.46ArgHis: 1.46 ± 0.052
3.356ArgIle: 3.356 ± 0.077
2.483ArgLys: 2.483 ± 0.077
5.973ArgLeu: 5.973 ± 0.115
1.781ArgMet: 1.781 ± 0.063
2.106ArgAsn: 2.106 ± 0.07
2.032ArgPro: 2.032 ± 0.068
3.01ArgGln: 3.01 ± 0.092
3.574ArgArg: 3.574 ± 0.099
2.847ArgSer: 2.847 ± 0.076
2.448ArgThr: 2.448 ± 0.071
4.025ArgVal: 4.025 ± 0.103
0.875ArgTrp: 0.875 ± 0.045
2.11ArgTyr: 2.11 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
5.989SerAla: 5.989 ± 0.134
0.614SerCys: 0.614 ± 0.033
3.187SerAsp: 3.187 ± 0.092
3.193SerGlu: 3.193 ± 0.081
2.32SerPhe: 2.32 ± 0.065
5.235SerGly: 5.235 ± 0.112
1.416SerHis: 1.416 ± 0.054
3.166SerIle: 3.166 ± 0.078
2.355SerLys: 2.355 ± 0.073
6.452SerLeu: 6.452 ± 0.111
1.493SerMet: 1.493 ± 0.052
2.09SerAsn: 2.09 ± 0.069
2.401SerPro: 2.401 ± 0.067
2.596SerGln: 2.596 ± 0.074
3.506SerArg: 3.506 ± 0.073
3.864SerSer: 3.864 ± 0.103
3.187SerThr: 3.187 ± 0.091
4.274SerVal: 4.274 ± 0.091
0.908SerTrp: 0.908 ± 0.043
1.678SerTyr: 1.678 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.326ThrAla: 5.326 ± 0.121
0.579ThrCys: 0.579 ± 0.038
3.006ThrAsp: 3.006 ± 0.079
2.666ThrGlu: 2.666 ± 0.076
2.061ThrPhe: 2.061 ± 0.067
4.433ThrGly: 4.433 ± 0.099
1.287ThrHis: 1.287 ± 0.05
3.016ThrIle: 3.016 ± 0.075
1.752ThrLys: 1.752 ± 0.058
7.414ThrLeu: 7.414 ± 0.132
1.159ThrMet: 1.159 ± 0.044
1.806ThrAsn: 1.806 ± 0.066
3.049ThrPro: 3.049 ± 0.074
2.275ThrGln: 2.275 ± 0.078
3.035ThrArg: 3.035 ± 0.068
3.026ThrSer: 3.026 ± 0.082
3.193ThrThr: 3.193 ± 0.091
4.225ThrVal: 4.225 ± 0.12
0.791ThrTrp: 0.791 ± 0.039
1.32ThrTyr: 1.32 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
7.156ValAla: 7.156 ± 0.134
0.805ValCys: 0.805 ± 0.037
3.967ValAsp: 3.967 ± 0.078
4.253ValGlu: 4.253 ± 0.098
2.555ValPhe: 2.555 ± 0.071
4.743ValGly: 4.743 ± 0.117
1.303ValHis: 1.303 ± 0.043
4.601ValIle: 4.601 ± 0.106
3.395ValLys: 3.395 ± 0.084
6.843ValLeu: 6.843 ± 0.128
2.357ValMet: 2.357 ± 0.067
3.078ValAsn: 3.078 ± 0.081
2.742ValPro: 2.742 ± 0.079
2.427ValGln: 2.427 ± 0.079
3.747ValArg: 3.747 ± 0.093
4.77ValSer: 4.77 ± 0.106
4.57ValThr: 4.57 ± 0.113
5.713ValVal: 5.713 ± 0.108
0.881ValTrp: 0.881 ± 0.039
1.89ValTyr: 1.89 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.029TrpAla: 1.029 ± 0.054
0.187TrpCys: 0.187 ± 0.019
0.578TrpAsp: 0.578 ± 0.029
0.638TrpGlu: 0.638 ± 0.035
0.618TrpPhe: 0.618 ± 0.039
0.659TrpGly: 0.659 ± 0.034
0.432TrpHis: 0.432 ± 0.023
0.727TrpIle: 0.727 ± 0.037
0.537TrpLys: 0.537 ± 0.036
2.114TrpLeu: 2.114 ± 0.074
0.443TrpMet: 0.443 ± 0.032
0.48TrpAsn: 0.48 ± 0.03
0.628TrpPro: 0.628 ± 0.035
1.021TrpGln: 1.021 ± 0.044
0.949TrpArg: 0.949 ± 0.043
0.807TrpSer: 0.807 ± 0.041
0.554TrpThr: 0.554 ± 0.031
0.959TrpVal: 0.959 ± 0.045
0.22TrpTrp: 0.22 ± 0.02
0.43TrpTyr: 0.43 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.609TyrAla: 2.609 ± 0.072
0.389TyrCys: 0.389 ± 0.028
1.668TyrAsp: 1.668 ± 0.057
1.305TyrGlu: 1.305 ± 0.046
1.244TyrPhe: 1.244 ± 0.054
2.401TyrGly: 2.401 ± 0.065
0.718TyrHis: 0.718 ± 0.044
1.447TyrIle: 1.447 ± 0.056
1.11TyrLys: 1.11 ± 0.05
3.09TyrLeu: 3.09 ± 0.067
0.661TyrMet: 0.661 ± 0.034
1.046TyrAsn: 1.046 ± 0.051
1.276TyrPro: 1.276 ± 0.055
1.62TyrGln: 1.62 ± 0.058
1.909TyrArg: 1.909 ± 0.059
1.699TyrSer: 1.699 ± 0.057
1.48TyrThr: 1.48 ± 0.058
1.83TyrVal: 1.83 ± 0.06
0.379TyrTrp: 0.379 ± 0.026
0.978TyrTyr: 0.978 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2234 proteins (514278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski