Amino acid dipepetide frequency for Gongylonema pulchrum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.246AlaAla: 8.246 ± 0.072	1.35AlaCys: 1.35 ± 0.019	3.842AlaAsp: 3.842 ± 0.031	5.055AlaGlu: 5.055 ± 0.041	2.981AlaPhe: 2.981 ± 0.026	4.101AlaGly: 4.101 ± 0.04	1.627AlaHis: 1.627 ± 0.018	3.72AlaIle: 3.72 ± 0.031	3.993AlaLys: 3.993 ± 0.034	6.803AlaLeu: 6.803 ± 0.04	1.8AlaMet: 1.8 ± 0.019	2.812AlaAsn: 2.812 ± 0.025	3.423AlaPro: 3.423 ± 0.036	2.928AlaGln: 2.928 ± 0.026	3.914AlaArg: 3.914 ± 0.037	5.835AlaSer: 5.835 ± 0.04	4.332AlaThr: 4.332 ± 0.032	5.834AlaVal: 5.834 ± 0.038	0.649AlaTrp: 0.649 ± 0.011	1.931AlaTyr: 1.931 ± 0.019	0.021AlaXaa: 0.021 ± 0.002
Cys	1.587CysAla: 1.587 ± 0.02	0.772CysCys: 0.772 ± 0.019	1.194CysAsp: 1.194 ± 0.019	1.222CysGlu: 1.222 ± 0.021	1.214CysPhe: 1.214 ± 0.017	1.362CysGly: 1.362 ± 0.017	0.502CysHis: 0.502 ± 0.011	1.282CysIle: 1.282 ± 0.017	1.086CysLys: 1.086 ± 0.014	2.021CysLeu: 2.021 ± 0.022	0.689CysMet: 0.689 ± 0.019	0.861CysAsn: 0.861 ± 0.015	1.048CysPro: 1.048 ± 0.018	0.758CysGln: 0.758 ± 0.013	1.395CysArg: 1.395 ± 0.02	1.982CysSer: 1.982 ± 0.023	1.142CysThr: 1.142 ± 0.016	1.421CysVal: 1.421 ± 0.019	0.286CysTrp: 0.286 ± 0.007	0.691CysTyr: 0.691 ± 0.013	0.009CysXaa: 0.009 ± 0.002
Asp	3.864AspAla: 3.864 ± 0.032	1.138AspCys: 1.138 ± 0.017	3.887AspAsp: 3.887 ± 0.041	4.734AspGlu: 4.734 ± 0.037	2.412AspPhe: 2.412 ± 0.021	3.504AspGly: 3.504 ± 0.044	1.051AspHis: 1.051 ± 0.017	2.796AspIle: 2.796 ± 0.024	2.468AspLys: 2.468 ± 0.027	4.586AspLeu: 4.586 ± 0.034	1.183AspMet: 1.183 ± 0.019	1.944AspAsn: 1.944 ± 0.022	2.197AspPro: 2.197 ± 0.023	1.672AspGln: 1.672 ± 0.018	2.881AspArg: 2.881 ± 0.026	3.888AspSer: 3.888 ± 0.034	2.353AspThr: 2.353 ± 0.023	3.565AspVal: 3.565 ± 0.029	0.647AspTrp: 0.647 ± 0.013	1.801AspTyr: 1.801 ± 0.038	0.01AspXaa: 0.01 ± 0.002
Glu	4.672GluAla: 4.672 ± 0.041	1.247GluCys: 1.247 ± 0.015	3.337GluAsp: 3.337 ± 0.026	5.664GluGlu: 5.664 ± 0.066	2.281GluPhe: 2.281 ± 0.025	2.922GluGly: 2.922 ± 0.028	1.56GluHis: 1.56 ± 0.015	3.568GluIle: 3.568 ± 0.03	5.025GluLys: 5.025 ± 0.051	6.025GluLeu: 6.025 ± 0.041	1.919GluMet: 1.919 ± 0.021	3.267GluAsn: 3.267 ± 0.026	2.435GluPro: 2.435 ± 0.036	3.369GluGln: 3.369 ± 0.031	4.262GluArg: 4.262 ± 0.04	4.215GluSer: 4.215 ± 0.029	3.385GluThr: 3.385 ± 0.03	3.746GluVal: 3.746 ± 0.032	0.727GluTrp: 0.727 ± 0.013	1.812GluTyr: 1.812 ± 0.024	0.015GluXaa: 0.015 ± 0.002
Phe	3.161PheAla: 3.161 ± 0.026	1.32PheCys: 1.32 ± 0.018	2.387PheAsp: 2.387 ± 0.023	2.504PheGlu: 2.504 ± 0.025	2.833PhePhe: 2.833 ± 0.032	2.79PheGly: 2.79 ± 0.026	1.105PheHis: 1.105 ± 0.014	2.538PheIle: 2.538 ± 0.022	1.827PheLys: 1.827 ± 0.02	4.513PheLeu: 4.513 ± 0.034	1.258PheMet: 1.258 ± 0.015	1.475PheAsn: 1.475 ± 0.021	1.844PhePro: 1.844 ± 0.021	1.622PheGln: 1.622 ± 0.021	2.52PheArg: 2.52 ± 0.02	3.658PheSer: 3.658 ± 0.032	2.225PheThr: 2.225 ± 0.023	3.126PheVal: 3.126 ± 0.028	0.591PheTrp: 0.591 ± 0.011	1.526PheTyr: 1.526 ± 0.018	0.016PheXaa: 0.016 ± 0.002
Gly	4.089GlyAla: 4.089 ± 0.037	1.122GlyCys: 1.122 ± 0.019	2.944GlyAsp: 2.944 ± 0.03	3.352GlyGlu: 3.352 ± 0.038	2.343GlyPhe: 2.343 ± 0.024	4.012GlyGly: 4.012 ± 0.059	1.279GlyHis: 1.279 ± 0.018	3.092GlyIle: 3.092 ± 0.028	3.18GlyLys: 3.18 ± 0.032	4.278GlyLeu: 4.278 ± 0.039	1.418GlyMet: 1.418 ± 0.019	2.295GlyAsn: 2.295 ± 0.026	2.273GlyPro: 2.273 ± 0.042	2.099GlyGln: 2.099 ± 0.022	3.474GlyArg: 3.474 ± 0.039	4.42GlySer: 4.42 ± 0.033	3.278GlyThr: 3.278 ± 0.027	3.333GlyVal: 3.333 ± 0.029	0.628GlyTrp: 0.628 ± 0.01	1.8GlyTyr: 1.8 ± 0.025	0.016GlyXaa: 0.016 ± 0.002
His	1.485HisAla: 1.485 ± 0.02	0.672HisCys: 0.672 ± 0.013	1.069HisAsp: 1.069 ± 0.02	1.352HisGlu: 1.352 ± 0.017	1.409HisPhe: 1.409 ± 0.019	1.317HisGly: 1.317 ± 0.016	0.713HisHis: 0.713 ± 0.015	1.383HisIle: 1.383 ± 0.017	1.012HisLys: 1.012 ± 0.017	2.389HisLeu: 2.389 ± 0.021	0.636HisMet: 0.636 ± 0.013	0.861HisAsn: 0.861 ± 0.013	1.227HisPro: 1.227 ± 0.017	0.966HisGln: 0.966 ± 0.013	1.595HisArg: 1.595 ± 0.015	1.936HisSer: 1.936 ± 0.023	1.093HisThr: 1.093 ± 0.016	1.406HisVal: 1.406 ± 0.017	0.323HisTrp: 0.323 ± 0.008	0.853HisTyr: 0.853 ± 0.014	0.006HisXaa: 0.006 ± 0.001
Ile	4.231IleAla: 4.231 ± 0.029	1.415IleCys: 1.415 ± 0.016	3.049IleAsp: 3.049 ± 0.027	3.279IleGlu: 3.279 ± 0.027	2.707IlePhe: 2.707 ± 0.028	2.963IleGly: 2.963 ± 0.025	1.315IleHis: 1.315 ± 0.017	3.068IleIle: 3.068 ± 0.03	2.52IleLys: 2.52 ± 0.025	4.875IleLeu: 4.875 ± 0.036	1.297IleMet: 1.297 ± 0.024	2.068IleAsn: 2.068 ± 0.022	2.608IlePro: 2.608 ± 0.029	1.891IleGln: 1.891 ± 0.02	3.36IleArg: 3.36 ± 0.029	4.527IleSer: 4.527 ± 0.032	3.031IleThr: 3.031 ± 0.026	3.664IleVal: 3.664 ± 0.029	0.65IleTrp: 0.65 ± 0.012	1.733IleTyr: 1.733 ± 0.021	0.01IleXaa: 0.01 ± 0.001
Lys	3.616LysAla: 3.616 ± 0.031	1.22LysCys: 1.22 ± 0.018	2.496LysAsp: 2.496 ± 0.03	3.984LysGlu: 3.984 ± 0.047	2.169LysPhe: 2.169 ± 0.02	2.459LysGly: 2.459 ± 0.028	1.326LysHis: 1.326 ± 0.016	3.187LysIle: 3.187 ± 0.026	4.52LysLys: 4.52 ± 0.048	5.267LysLeu: 5.267 ± 0.039	1.711LysMet: 1.711 ± 0.021	2.633LysAsn: 2.633 ± 0.029	2.414LysPro: 2.414 ± 0.031	2.59LysGln: 2.59 ± 0.026	3.89LysArg: 3.89 ± 0.037	3.759LysSer: 3.759 ± 0.031	2.993LysThr: 2.993 ± 0.028	3.205LysVal: 3.205 ± 0.022	0.671LysTrp: 0.671 ± 0.012	1.793LysTyr: 1.793 ± 0.024	0.015LysXaa: 0.015 ± 0.002
Leu	6.612LeuAla: 6.612 ± 0.037	2.153LeuCys: 2.153 ± 0.024	4.582LeuAsp: 4.582 ± 0.032	5.656LeuGlu: 5.656 ± 0.041	4.38LeuPhe: 4.38 ± 0.033	4.112LeuGly: 4.112 ± 0.032	2.467LeuHis: 2.467 ± 0.025	5.11LeuIle: 5.11 ± 0.033	5.426LeuLys: 5.426 ± 0.036	10.177LeuLeu: 10.177 ± 0.071	2.457LeuMet: 2.457 ± 0.025	3.871LeuAsn: 3.871 ± 0.029	4.733LeuPro: 4.733 ± 0.053	4.283LeuGln: 4.283 ± 0.035	5.963LeuArg: 5.963 ± 0.037	7.407LeuSer: 7.407 ± 0.041	4.609LeuThr: 4.609 ± 0.03	5.353LeuVal: 5.353 ± 0.035	1.0LeuTrp: 1.0 ± 0.016	2.702LeuTyr: 2.702 ± 0.024	0.026LeuXaa: 0.026 ± 0.002
Met	1.871MetAla: 1.871 ± 0.019	0.554MetCys: 0.554 ± 0.011	1.454MetAsp: 1.454 ± 0.017	1.75MetGlu: 1.75 ± 0.02	1.072MetPhe: 1.072 ± 0.015	1.18MetGly: 1.18 ± 0.014	0.723MetHis: 0.723 ± 0.012	1.459MetIle: 1.459 ± 0.025	1.65MetLys: 1.65 ± 0.019	2.66MetLeu: 2.66 ± 0.026	0.79MetMet: 0.79 ± 0.019	1.202MetAsn: 1.202 ± 0.016	1.315MetPro: 1.315 ± 0.018	1.308MetGln: 1.308 ± 0.019	1.669MetArg: 1.669 ± 0.019	1.8MetSer: 1.8 ± 0.021	1.265MetThr: 1.265 ± 0.02	1.509MetVal: 1.509 ± 0.018	0.263MetTrp: 0.263 ± 0.008	0.768MetTyr: 0.768 ± 0.018	0.004MetXaa: 0.004 ± 0.001
Asn	3.095AsnAla: 3.095 ± 0.024	0.937AsnCys: 0.937 ± 0.016	2.327AsnAsp: 2.327 ± 0.026	3.012AsnGlu: 3.012 ± 0.029	1.961AsnPhe: 1.961 ± 0.021	2.763AsnGly: 2.763 ± 0.025	0.822AsnHis: 0.822 ± 0.014	2.354AsnIle: 2.354 ± 0.024	2.004AsnLys: 2.004 ± 0.021	3.598AsnLeu: 3.598 ± 0.028	1.025AsnMet: 1.025 ± 0.015	1.795AsnAsn: 1.795 ± 0.034	1.862AsnPro: 1.862 ± 0.021	1.372AsnGln: 1.372 ± 0.017	2.374AsnArg: 2.374 ± 0.026	3.327AsnSer: 3.327 ± 0.033	1.995AsnThr: 1.995 ± 0.022	2.776AsnVal: 2.776 ± 0.024	0.488AsnTrp: 0.488 ± 0.01	1.36AsnTyr: 1.36 ± 0.018	0.008AsnXaa: 0.008 ± 0.001
Pro	3.464ProAla: 3.464 ± 0.036	0.794ProCys: 0.794 ± 0.015	2.393ProAsp: 2.393 ± 0.032	3.211ProGlu: 3.211 ± 0.029	1.95ProPhe: 1.95 ± 0.019	2.868ProGly: 2.868 ± 0.073	1.046ProHis: 1.046 ± 0.015	2.141ProIle: 2.141 ± 0.026	2.356ProLys: 2.356 ± 0.023	4.052ProLeu: 4.052 ± 0.046	1.017ProMet: 1.017 ± 0.016	1.856ProAsn: 1.856 ± 0.018	3.736ProPro: 3.736 ± 0.066	1.862ProGln: 1.862 ± 0.028	2.42ProArg: 2.42 ± 0.024	4.082ProSer: 4.082 ± 0.042	2.581ProThr: 2.581 ± 0.055	3.398ProVal: 3.398 ± 0.038	0.43ProTrp: 0.43 ± 0.011	1.368ProTyr: 1.368 ± 0.019	0.01ProXaa: 0.01 ± 0.001
Gln	2.586GlnAla: 2.586 ± 0.026	0.959GlnCys: 0.959 ± 0.014	1.487GlnAsp: 1.487 ± 0.018	2.325GlnGlu: 2.325 ± 0.027	1.7GlnPhe: 1.7 ± 0.019	1.549GlnGly: 1.549 ± 0.02	1.195GlnHis: 1.195 ± 0.016	2.37GlnIle: 2.37 ± 0.024	2.661GlnLys: 2.661 ± 0.025	4.371GlnLeu: 4.371 ± 0.036	1.273GlnMet: 1.273 ± 0.016	1.881GlnAsn: 1.881 ± 0.02	2.022GlnPro: 2.022 ± 0.032	3.63GlnGln: 3.63 ± 0.072	2.798GlnArg: 2.798 ± 0.026	2.732GlnSer: 2.732 ± 0.025	1.987GlnThr: 1.987 ± 0.019	2.349GlnVal: 2.349 ± 0.022	0.508GlnTrp: 0.508 ± 0.011	1.284GlnTyr: 1.284 ± 0.015	0.011GlnXaa: 0.011 ± 0.002
Arg	3.931ArgAla: 3.931 ± 0.031	1.423ArgCys: 1.423 ± 0.019	2.838ArgAsp: 2.838 ± 0.025	3.71ArgGlu: 3.71 ± 0.036	2.684ArgPhe: 2.684 ± 0.024	2.924ArgGly: 2.924 ± 0.032	1.6ArgHis: 1.6 ± 0.02	3.694ArgIle: 3.694 ± 0.029	4.106ArgLys: 4.106 ± 0.037	5.723ArgLeu: 5.723 ± 0.038	1.739ArgMet: 1.739 ± 0.019	2.837ArgAsn: 2.837 ± 0.023	2.547ArgPro: 2.547 ± 0.033	2.591ArgGln: 2.591 ± 0.028	4.888ArgArg: 4.888 ± 0.042	4.73ArgSer: 4.73 ± 0.038	3.126ArgThr: 3.126 ± 0.027	3.241ArgVal: 3.241 ± 0.03	0.72ArgTrp: 0.72 ± 0.011	2.01ArgTyr: 2.01 ± 0.021	0.014ArgXaa: 0.014 ± 0.002
Ser	6.237SerAla: 6.237 ± 0.039	1.611SerCys: 1.611 ± 0.019	4.365SerAsp: 4.365 ± 0.033	4.86SerGlu: 4.86 ± 0.041	3.56SerPhe: 3.56 ± 0.026	5.01SerGly: 5.01 ± 0.044	1.581SerHis: 1.581 ± 0.018	3.725SerIle: 3.725 ± 0.03	3.894SerLys: 3.894 ± 0.032	7.038SerLeu: 7.038 ± 0.044	1.953SerMet: 1.953 ± 0.022	3.143SerAsn: 3.143 ± 0.032	3.648SerPro: 3.648 ± 0.037	2.729SerGln: 2.729 ± 0.027	4.485SerArg: 4.485 ± 0.037	8.74SerSer: 8.74 ± 0.083	4.683SerThr: 4.683 ± 0.04	5.33SerVal: 5.33 ± 0.042	0.808SerTrp: 0.808 ± 0.013	2.099SerTyr: 2.099 ± 0.023	0.023SerXaa: 0.023 ± 0.002
Thr	4.696ThrAla: 4.696 ± 0.034	1.025ThrCys: 1.025 ± 0.015	2.878ThrAsp: 2.878 ± 0.05	3.328ThrGlu: 3.328 ± 0.032	2.244ThrPhe: 2.244 ± 0.025	3.209ThrGly: 3.209 ± 0.031	1.109ThrHis: 1.109 ± 0.017	2.766ThrIle: 2.766 ± 0.029	2.661ThrLys: 2.661 ± 0.023	4.57ThrLeu: 4.57 ± 0.034	1.279ThrMet: 1.279 ± 0.018	2.134ThrAsn: 2.134 ± 0.024	2.663ThrPro: 2.663 ± 0.029	1.748ThrGln: 1.748 ± 0.023	2.607ThrArg: 2.607 ± 0.023	4.452ThrSer: 4.452 ± 0.043	3.531ThrThr: 3.531 ± 0.04	4.321ThrVal: 4.321 ± 0.034	0.489ThrTrp: 0.489 ± 0.012	1.447ThrTyr: 1.447 ± 0.018	0.014ThrXaa: 0.014 ± 0.001
Val	5.062ValAla: 5.062 ± 0.042	1.719ValCys: 1.719 ± 0.027	3.662ValAsp: 3.662 ± 0.04	4.05ValGlu: 4.05 ± 0.036	2.832ValPhe: 2.832 ± 0.026	3.239ValGly: 3.239 ± 0.031	1.595ValHis: 1.595 ± 0.019	3.666ValIle: 3.666 ± 0.034	3.31ValLys: 3.31 ± 0.028	6.221ValLeu: 6.221 ± 0.043	1.599ValMet: 1.599 ± 0.02	2.554ValAsn: 2.554 ± 0.023	3.252ValPro: 3.252 ± 0.028	2.619ValGln: 2.619 ± 0.024	3.788ValArg: 3.788 ± 0.031	4.969ValSer: 4.969 ± 0.033	3.49ValThr: 3.49 ± 0.029	4.693ValVal: 4.693 ± 0.061	0.685ValTrp: 0.685 ± 0.012	1.816ValTyr: 1.816 ± 0.021	0.016ValXaa: 0.016 ± 0.002
Trp	0.655TrpAla: 0.655 ± 0.013	0.231TrpCys: 0.231 ± 0.007	0.592TrpAsp: 0.592 ± 0.011	0.59TrpGlu: 0.59 ± 0.011	0.482TrpPhe: 0.482 ± 0.011	0.454TrpGly: 0.454 ± 0.012	0.296TrpHis: 0.296 ± 0.008	0.708TrpIle: 0.708 ± 0.015	0.761TrpLys: 0.761 ± 0.016	1.148TrpLeu: 1.148 ± 0.017	0.385TrpMet: 0.385 ± 0.009	0.592TrpAsn: 0.592 ± 0.011	0.498TrpPro: 0.498 ± 0.01	0.479TrpGln: 0.479 ± 0.01	0.751TrpArg: 0.751 ± 0.013	0.841TrpSer: 0.841 ± 0.015	0.62TrpThr: 0.62 ± 0.012	0.516TrpVal: 0.516 ± 0.011	0.171TrpTrp: 0.171 ± 0.006	0.365TrpTyr: 0.365 ± 0.01	0.003TrpXaa: 0.003 ± 0.001
Tyr	2.019TyrAla: 2.019 ± 0.021	0.85TyrCys: 0.85 ± 0.013	1.788TyrAsp: 1.788 ± 0.037	1.809TyrGlu: 1.809 ± 0.024	1.61TyrPhe: 1.61 ± 0.02	1.976TyrGly: 1.976 ± 0.025	0.782TyrHis: 0.782 ± 0.014	1.62TyrIle: 1.62 ± 0.018	1.442TyrLys: 1.442 ± 0.018	2.74TyrLeu: 2.74 ± 0.023	0.823TyrMet: 0.823 ± 0.015	1.17TyrAsn: 1.17 ± 0.016	1.275TyrPro: 1.275 ± 0.026	1.155TyrGln: 1.155 ± 0.017	2.022TyrArg: 2.022 ± 0.022	2.2TyrSer: 2.2 ± 0.025	1.438TyrThr: 1.438 ± 0.02	2.035TyrVal: 2.035 ± 0.024	0.401TyrTrp: 0.401 ± 0.01	1.142TyrTyr: 1.142 ± 0.019	0.008TyrXaa: 0.008 ± 0.001
Xaa	0.017XaaAla: 0.017 ± 0.002	0.009XaaCys: 0.009 ± 0.002	0.011XaaAsp: 0.011 ± 0.001	0.009XaaGlu: 0.009 ± 0.001	0.016XaaPhe: 0.016 ± 0.002	0.013XaaGly: 0.013 ± 0.002	0.007XaaHis: 0.007 ± 0.001	0.015XaaIle: 0.015 ± 0.002	0.014XaaLys: 0.014 ± 0.002	0.022XaaLeu: 0.022 ± 0.002	0.011XaaMet: 0.011 ± 0.001	0.008XaaAsn: 0.008 ± 0.001	0.012XaaPro: 0.012 ± 0.001	0.008XaaGln: 0.008 ± 0.001	0.02XaaArg: 0.02 ± 0.002	0.02XaaSer: 0.02 ± 0.002	0.014XaaThr: 0.014 ± 0.002	0.016XaaVal: 0.016 ± 0.002	0.005XaaTrp: 0.005 ± 0.001	0.004XaaTyr: 0.004 ± 0.001	1.188XaaXaa: 1.188 ± 0.07

Statistics based on 26895 proteins (4856716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---