Amino acid dipepetide frequency for Coraliomargarita sinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.315AlaAla: 9.315 ± 0.132
1.04AlaCys: 1.04 ± 0.039
5.344AlaAsp: 5.344 ± 0.086
6.676AlaGlu: 6.676 ± 0.099
3.629AlaPhe: 3.629 ± 0.067
7.269AlaGly: 7.269 ± 0.09
1.748AlaHis: 1.748 ± 0.039
5.09AlaIle: 5.09 ± 0.078
4.292AlaLys: 4.292 ± 0.097
9.333AlaLeu: 9.333 ± 0.123
2.234AlaMet: 2.234 ± 0.054
3.076AlaAsn: 3.076 ± 0.081
3.721AlaPro: 3.721 ± 0.086
2.9AlaGln: 2.9 ± 0.061
4.931AlaArg: 4.931 ± 0.087
5.675AlaSer: 5.675 ± 0.078
4.804AlaThr: 4.804 ± 0.115
6.101AlaVal: 6.101 ± 0.105
1.178AlaTrp: 1.178 ± 0.035
2.758AlaTyr: 2.758 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.895CysAla: 0.895 ± 0.031
0.162CysCys: 0.162 ± 0.013
0.564CysAsp: 0.564 ± 0.027
0.646CysGlu: 0.646 ± 0.026
0.484CysPhe: 0.484 ± 0.022
0.943CysGly: 0.943 ± 0.033
0.312CysHis: 0.312 ± 0.02
0.587CysIle: 0.587 ± 0.025
0.358CysLys: 0.358 ± 0.022
1.061CysLeu: 1.061 ± 0.035
0.225CysMet: 0.225 ± 0.016
0.276CysAsn: 0.276 ± 0.02
0.518CysPro: 0.518 ± 0.024
0.343CysGln: 0.343 ± 0.016
0.625CysArg: 0.625 ± 0.026
0.661CysSer: 0.661 ± 0.028
0.436CysThr: 0.436 ± 0.024
0.66CysVal: 0.66 ± 0.024
0.122CysTrp: 0.122 ± 0.013
0.308CysTyr: 0.308 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.711AspAla: 5.711 ± 0.112
0.573AspCys: 0.573 ± 0.026
3.374AspAsp: 3.374 ± 0.1
4.158AspGlu: 4.158 ± 0.064
3.056AspPhe: 3.056 ± 0.058
5.21AspGly: 5.21 ± 0.135
1.204AspHis: 1.204 ± 0.035
3.106AspIle: 3.106 ± 0.06
2.432AspLys: 2.432 ± 0.057
6.023AspLeu: 6.023 ± 0.089
1.153AspMet: 1.153 ± 0.03
1.89AspAsn: 1.89 ± 0.069
3.521AspPro: 3.521 ± 0.075
1.897AspGln: 1.897 ± 0.041
3.265AspArg: 3.265 ± 0.062
3.704AspSer: 3.704 ± 0.1
2.965AspThr: 2.965 ± 0.099
3.649AspVal: 3.649 ± 0.075
1.171AspTrp: 1.171 ± 0.039
2.287AspTyr: 2.287 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
7.524GluAla: 7.524 ± 0.108
0.522GluCys: 0.522 ± 0.025
3.916GluAsp: 3.916 ± 0.075
5.137GluGlu: 5.137 ± 0.104
2.536GluPhe: 2.536 ± 0.051
5.071GluGly: 5.071 ± 0.074
1.479GluHis: 1.479 ± 0.04
4.374GluIle: 4.374 ± 0.08
4.075GluLys: 4.075 ± 0.074
7.018GluLeu: 7.018 ± 0.107
1.66GluMet: 1.66 ± 0.049
2.741GluAsn: 2.741 ± 0.055
2.924GluPro: 2.924 ± 0.059
2.684GluGln: 2.684 ± 0.063
4.388GluArg: 4.388 ± 0.091
4.284GluSer: 4.284 ± 0.068
3.639GluThr: 3.639 ± 0.064
4.831GluVal: 4.831 ± 0.071
0.987GluTrp: 0.987 ± 0.034
1.705GluTyr: 1.705 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.646PheAla: 3.646 ± 0.057
0.557PheCys: 0.557 ± 0.026
2.918PheAsp: 2.918 ± 0.065
2.902PheGlu: 2.902 ± 0.058
1.936PhePhe: 1.936 ± 0.053
3.441PheGly: 3.441 ± 0.062
0.87PheHis: 0.87 ± 0.029
2.254PheIle: 2.254 ± 0.055
1.838PheLys: 1.838 ± 0.048
3.853PheLeu: 3.853 ± 0.083
0.832PheMet: 0.832 ± 0.025
1.614PheAsn: 1.614 ± 0.044
1.766PhePro: 1.766 ± 0.045
1.291PheGln: 1.291 ± 0.036
2.222PheArg: 2.222 ± 0.056
3.018PheSer: 3.018 ± 0.061
2.432PheThr: 2.432 ± 0.073
2.565PheVal: 2.565 ± 0.056
0.628PheTrp: 0.628 ± 0.027
1.427PheTyr: 1.427 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
6.261GlyAla: 6.261 ± 0.1
0.891GlyCys: 0.891 ± 0.037
4.581GlyAsp: 4.581 ± 0.105
5.236GlyGlu: 5.236 ± 0.086
3.428GlyPhe: 3.428 ± 0.057
6.12GlyGly: 6.12 ± 0.113
1.723GlyHis: 1.723 ± 0.042
4.611GlyIle: 4.611 ± 0.081
4.053GlyLys: 4.053 ± 0.078
7.482GlyLeu: 7.482 ± 0.085
1.999GlyMet: 1.999 ± 0.045
2.926GlyAsn: 2.926 ± 0.07
2.891GlyPro: 2.891 ± 0.057
2.749GlyGln: 2.749 ± 0.057
4.274GlyArg: 4.274 ± 0.082
5.226GlySer: 5.226 ± 0.11
4.447GlyThr: 4.447 ± 0.152
5.036GlyVal: 5.036 ± 0.086
1.245GlyTrp: 1.245 ± 0.034
2.602GlyTyr: 2.602 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.815HisAla: 1.815 ± 0.046
0.299HisCys: 0.299 ± 0.018
1.153HisAsp: 1.153 ± 0.034
1.248HisGlu: 1.248 ± 0.039
1.028HisPhe: 1.028 ± 0.033
1.599HisGly: 1.599 ± 0.043
0.609HisHis: 0.609 ± 0.029
1.054HisIle: 1.054 ± 0.03
0.819HisLys: 0.819 ± 0.032
2.235HisLeu: 2.235 ± 0.054
0.431HisMet: 0.431 ± 0.022
0.712HisAsn: 0.712 ± 0.027
1.351HisPro: 1.351 ± 0.04
0.695HisGln: 0.695 ± 0.028
1.307HisArg: 1.307 ± 0.039
1.242HisSer: 1.242 ± 0.033
1.059HisThr: 1.059 ± 0.031
1.242HisVal: 1.242 ± 0.037
0.386HisTrp: 0.386 ± 0.022
0.773HisTyr: 0.773 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.236IleAla: 5.236 ± 0.076
0.744IleCys: 0.744 ± 0.028
3.958IleAsp: 3.958 ± 0.062
4.623IleGlu: 4.623 ± 0.078
2.259IlePhe: 2.259 ± 0.057
4.497IleGly: 4.497 ± 0.079
1.227IleHis: 1.227 ± 0.044
2.956IleIle: 2.956 ± 0.067
2.335IleLys: 2.335 ± 0.06
5.268IleLeu: 5.268 ± 0.083
0.994IleMet: 0.994 ± 0.036
2.025IleAsn: 2.025 ± 0.045
2.654IlePro: 2.654 ± 0.055
1.886IleGln: 1.886 ± 0.047
3.372IleArg: 3.372 ± 0.06
3.658IleSer: 3.658 ± 0.064
3.126IleThr: 3.126 ± 0.082
3.734IleVal: 3.734 ± 0.064
0.683IleTrp: 0.683 ± 0.03
1.67IleTyr: 1.67 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.434LysAla: 4.434 ± 0.093
0.331LysCys: 0.331 ± 0.022
2.759LysAsp: 2.759 ± 0.062
3.608LysGlu: 3.608 ± 0.082
1.531LysPhe: 1.531 ± 0.04
3.205LysGly: 3.205 ± 0.072
1.014LysHis: 1.014 ± 0.034
2.741LysIle: 2.741 ± 0.06
3.087LysLys: 3.087 ± 0.095
4.609LysLeu: 4.609 ± 0.082
1.14LysMet: 1.14 ± 0.038
1.799LysAsn: 1.799 ± 0.048
2.403LysPro: 2.403 ± 0.06
1.85LysGln: 1.85 ± 0.046
2.93LysArg: 2.93 ± 0.068
2.907LysSer: 2.907 ± 0.069
2.665LysThr: 2.665 ± 0.056
3.244LysVal: 3.244 ± 0.066
0.578LysTrp: 0.578 ± 0.026
1.196LysTyr: 1.196 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
9.019LeuAla: 9.019 ± 0.113
1.117LeuCys: 1.117 ± 0.036
5.787LeuAsp: 5.787 ± 0.078
6.818LeuGlu: 6.818 ± 0.103
3.827LeuPhe: 3.827 ± 0.077
7.201LeuGly: 7.201 ± 0.089
1.981LeuHis: 1.981 ± 0.051
5.552LeuIle: 5.552 ± 0.095
5.266LeuLys: 5.266 ± 0.088
9.442LeuLeu: 9.442 ± 0.153
2.023LeuMet: 2.023 ± 0.045
3.71LeuAsn: 3.71 ± 0.07
5.006LeuPro: 5.006 ± 0.085
3.249LeuGln: 3.249 ± 0.059
5.631LeuArg: 5.631 ± 0.112
6.951LeuSer: 6.951 ± 0.097
5.125LeuThr: 5.125 ± 0.103
6.149LeuVal: 6.149 ± 0.093
1.103LeuTrp: 1.103 ± 0.033
2.562LeuTyr: 2.562 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.042MetAla: 2.042 ± 0.058
0.164MetCys: 0.164 ± 0.012
1.2MetAsp: 1.2 ± 0.032
1.425MetGlu: 1.425 ± 0.038
0.657MetPhe: 0.657 ± 0.025
1.562MetGly: 1.562 ± 0.043
0.478MetHis: 0.478 ± 0.021
1.241MetIle: 1.241 ± 0.041
1.371MetLys: 1.371 ± 0.042
2.094MetLeu: 2.094 ± 0.05
0.508MetMet: 0.508 ± 0.026
0.897MetAsn: 0.897 ± 0.027
1.223MetPro: 1.223 ± 0.033
0.873MetGln: 0.873 ± 0.026
1.427MetArg: 1.427 ± 0.043
1.508MetSer: 1.508 ± 0.043
1.247MetThr: 1.247 ± 0.033
1.36MetVal: 1.36 ± 0.039
0.189MetTrp: 0.189 ± 0.014
0.333MetTyr: 0.333 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.027AsnAla: 3.027 ± 0.064
0.369AsnCys: 0.369 ± 0.02
2.078AsnAsp: 2.078 ± 0.089
2.246AsnGlu: 2.246 ± 0.046
1.598AsnPhe: 1.598 ± 0.041
3.001AsnGly: 3.001 ± 0.095
0.783AsnHis: 0.783 ± 0.029
1.916AsnIle: 1.916 ± 0.049
1.467AsnLys: 1.467 ± 0.037
3.457AsnLeu: 3.457 ± 0.07
0.733AsnMet: 0.733 ± 0.028
1.285AsnAsn: 1.285 ± 0.042
2.376AsnPro: 2.376 ± 0.052
1.355AsnGln: 1.355 ± 0.038
2.094AsnArg: 2.094 ± 0.043
2.22AsnSer: 2.22 ± 0.063
1.902AsnThr: 1.902 ± 0.057
2.109AsnVal: 2.109 ± 0.049
0.631AsnTrp: 0.631 ± 0.026
1.284AsnTyr: 1.284 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.156ProAla: 4.156 ± 0.078
0.347ProCys: 0.347 ± 0.02
3.563ProAsp: 3.563 ± 0.066
4.701ProGlu: 4.701 ± 0.088
1.931ProPhe: 1.931 ± 0.046
3.784ProGly: 3.784 ± 0.069
1.019ProHis: 1.019 ± 0.03
2.303ProIle: 2.303 ± 0.048
2.385ProLys: 2.385 ± 0.054
3.989ProLeu: 3.989 ± 0.066
0.972ProMet: 0.972 ± 0.032
1.716ProAsn: 1.716 ± 0.053
1.811ProPro: 1.811 ± 0.046
1.48ProGln: 1.48 ± 0.039
2.132ProArg: 2.132 ± 0.054
2.863ProSer: 2.863 ± 0.058
2.349ProThr: 2.349 ± 0.058
3.595ProVal: 3.595 ± 0.064
0.656ProTrp: 0.656 ± 0.024
1.366ProTyr: 1.366 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.44GlnAla: 3.44 ± 0.059
0.276GlnCys: 0.276 ± 0.016
1.654GlnAsp: 1.654 ± 0.046
1.982GlnGlu: 1.982 ± 0.043
1.304GlnPhe: 1.304 ± 0.033
2.217GlnGly: 2.217 ± 0.042
0.738GlnHis: 0.738 ± 0.026
2.187GlnIle: 2.187 ± 0.046
1.767GlnLys: 1.767 ± 0.047
3.605GlnLeu: 3.605 ± 0.059
0.739GlnMet: 0.739 ± 0.023
1.237GlnAsn: 1.237 ± 0.039
1.59GlnPro: 1.59 ± 0.038
1.349GlnGln: 1.349 ± 0.043
2.187GlnArg: 2.187 ± 0.047
2.322GlnSer: 2.322 ± 0.046
1.824GlnThr: 1.824 ± 0.038
2.301GlnVal: 2.301 ± 0.044
0.47GlnTrp: 0.47 ± 0.02
0.863GlnTyr: 0.863 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
4.476ArgAla: 4.476 ± 0.079
0.485ArgCys: 0.485 ± 0.025
3.161ArgAsp: 3.161 ± 0.06
4.498ArgGlu: 4.498 ± 0.092
2.742ArgPhe: 2.742 ± 0.061
3.594ArgGly: 3.594 ± 0.061
1.276ArgHis: 1.276 ± 0.044
3.928ArgIle: 3.928 ± 0.072
3.088ArgLys: 3.088 ± 0.077
5.667ArgLeu: 5.667 ± 0.095
1.487ArgMet: 1.487 ± 0.041
2.041ArgAsn: 2.041 ± 0.044
2.465ArgPro: 2.465 ± 0.052
2.089ArgGln: 2.089 ± 0.056
3.616ArgArg: 3.616 ± 0.096
3.543ArgSer: 3.543 ± 0.075
2.563ArgThr: 2.563 ± 0.05
3.591ArgVal: 3.591 ± 0.068
0.859ArgTrp: 0.859 ± 0.028
1.987ArgTyr: 1.987 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.57SerAla: 5.57 ± 0.095
0.616SerCys: 0.616 ± 0.03
4.035SerAsp: 4.035 ± 0.098
4.482SerGlu: 4.482 ± 0.071
2.926SerPhe: 2.926 ± 0.065
6.257SerGly: 6.257 ± 0.125
1.208SerHis: 1.208 ± 0.033
3.732SerIle: 3.732 ± 0.066
2.748SerLys: 2.748 ± 0.062
6.201SerLeu: 6.201 ± 0.076
1.433SerMet: 1.433 ± 0.033
2.19SerAsn: 2.19 ± 0.06
2.852SerPro: 2.852 ± 0.057
2.084SerGln: 2.084 ± 0.047
3.448SerArg: 3.448 ± 0.068
4.266SerSer: 4.266 ± 0.093
3.189SerThr: 3.189 ± 0.076
4.297SerVal: 4.297 ± 0.071
0.913SerTrp: 0.913 ± 0.029
1.988SerTyr: 1.988 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
4.851ThrAla: 4.851 ± 0.122
0.48ThrCys: 0.48 ± 0.023
3.233ThrAsp: 3.233 ± 0.1
3.315ThrGlu: 3.315 ± 0.056
2.237ThrPhe: 2.237 ± 0.068
4.678ThrGly: 4.678 ± 0.091
1.034ThrHis: 1.034 ± 0.036
3.191ThrIle: 3.191 ± 0.074
1.985ThrLys: 1.985 ± 0.042
5.466ThrLeu: 5.466 ± 0.117
1.047ThrMet: 1.047 ± 0.033
1.778ThrAsn: 1.778 ± 0.062
2.959ThrPro: 2.959 ± 0.071
1.556ThrGln: 1.556 ± 0.037
2.622ThrArg: 2.622 ± 0.049
3.156ThrSer: 3.156 ± 0.071
3.007ThrThr: 3.007 ± 0.094
4.01ThrVal: 4.01 ± 0.138
0.676ThrTrp: 0.676 ± 0.025
1.729ThrTyr: 1.729 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
6.062ValAla: 6.062 ± 0.1
0.721ValCys: 0.721 ± 0.029
4.289ValAsp: 4.289 ± 0.082
4.856ValGlu: 4.856 ± 0.08
2.86ValPhe: 2.86 ± 0.056
4.787ValGly: 4.787 ± 0.076
1.278ValHis: 1.278 ± 0.039
3.86ValIle: 3.86 ± 0.074
2.801ValLys: 2.801 ± 0.058
6.238ValLeu: 6.238 ± 0.092
1.327ValMet: 1.327 ± 0.039
2.358ValAsn: 2.358 ± 0.061
3.075ValPro: 3.075 ± 0.062
1.971ValGln: 1.971 ± 0.041
3.799ValArg: 3.799 ± 0.069
4.414ValSer: 4.414 ± 0.089
3.746ValThr: 3.746 ± 0.089
4.822ValVal: 4.822 ± 0.086
0.795ValTrp: 0.795 ± 0.033
1.783ValTyr: 1.783 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
1.05TrpAla: 1.05 ± 0.029
0.131TrpCys: 0.131 ± 0.013
0.796TrpAsp: 0.796 ± 0.028
0.871TrpGlu: 0.871 ± 0.031
0.632TrpPhe: 0.632 ± 0.022
0.93TrpGly: 0.93 ± 0.03
0.375TrpHis: 0.375 ± 0.019
0.815TrpIle: 0.815 ± 0.032
0.72TrpLys: 0.72 ± 0.029
1.513TrpLeu: 1.513 ± 0.044
0.352TrpMet: 0.352 ± 0.021
0.598TrpAsn: 0.598 ± 0.024
0.591TrpPro: 0.591 ± 0.027
0.604TrpGln: 0.604 ± 0.029
0.865TrpArg: 0.865 ± 0.03
0.898TrpSer: 0.898 ± 0.031
0.789TrpThr: 0.789 ± 0.03
0.853TrpVal: 0.853 ± 0.032
0.283TrpTrp: 0.283 ± 0.016
0.389TrpTyr: 0.389 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.582TyrAla: 2.582 ± 0.05
0.361TyrCys: 0.361 ± 0.018
1.986TyrAsp: 1.986 ± 0.059
2.067TyrGlu: 2.067 ± 0.046
1.411TyrPhe: 1.411 ± 0.033
2.414TyrGly: 2.414 ± 0.052
0.701TyrHis: 0.701 ± 0.029
1.409TyrIle: 1.409 ± 0.041
1.144TyrLys: 1.144 ± 0.036
2.966TyrLeu: 2.966 ± 0.055
0.511TyrMet: 0.511 ± 0.022
1.064TyrAsn: 1.064 ± 0.034
1.423TyrPro: 1.423 ± 0.038
1.147TyrGln: 1.147 ± 0.037
2.023TyrArg: 2.023 ± 0.05
1.916TyrSer: 1.916 ± 0.059
1.693TyrThr: 1.693 ± 0.071
1.693TyrVal: 1.693 ± 0.046
0.5TyrTrp: 0.5 ± 0.022
1.14TyrTyr: 1.14 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2981 proteins (1056829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski