Amino acid dipepetide frequency for Otariodibacter oris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.964AlaAla: 4.964 ± 0.143
0.954AlaCys: 0.954 ± 0.04
4.02AlaAsp: 4.02 ± 0.083
5.831AlaGlu: 5.831 ± 0.122
3.385AlaPhe: 3.385 ± 0.077
4.906AlaGly: 4.906 ± 0.105
1.322AlaHis: 1.322 ± 0.053
6.401AlaIle: 6.401 ± 0.113
5.451AlaLys: 5.451 ± 0.103
8.525AlaLeu: 8.525 ± 0.128
2.146AlaMet: 2.146 ± 0.07
3.589AlaAsn: 3.589 ± 0.095
2.222AlaPro: 2.222 ± 0.066
3.454AlaGln: 3.454 ± 0.086
3.154AlaArg: 3.154 ± 0.08
4.132AlaSer: 4.132 ± 0.086
4.101AlaThr: 4.101 ± 0.093
5.186AlaVal: 5.186 ± 0.106
0.832AlaTrp: 0.832 ± 0.036
2.297AlaTyr: 2.297 ± 0.066
0.002AlaXaa: 0.002 ± 0.001
Cys
0.599CysAla: 0.599 ± 0.034
0.132CysCys: 0.132 ± 0.015
0.513CysAsp: 0.513 ± 0.031
0.574CysGlu: 0.574 ± 0.034
0.424CysPhe: 0.424 ± 0.027
0.817CysGly: 0.817 ± 0.04
0.231CysHis: 0.231 ± 0.024
0.582CysIle: 0.582 ± 0.03
0.441CysLys: 0.441 ± 0.029
0.917CysLeu: 0.917 ± 0.039
0.149CysMet: 0.149 ± 0.019
0.36CysAsn: 0.36 ± 0.024
0.384CysPro: 0.384 ± 0.028
0.404CysGln: 0.404 ± 0.026
0.39CysArg: 0.39 ± 0.025
0.587CysSer: 0.587 ± 0.032
0.441CysThr: 0.441 ± 0.026
0.586CysVal: 0.586 ± 0.032
0.107CysTrp: 0.107 ± 0.013
0.345CysTyr: 0.345 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.566AspAla: 3.566 ± 0.088
0.458AspCys: 0.458 ± 0.031
2.808AspAsp: 2.808 ± 0.087
3.892AspGlu: 3.892 ± 0.092
2.595AspPhe: 2.595 ± 0.072
3.278AspGly: 3.278 ± 0.087
1.039AspHis: 1.039 ± 0.052
4.257AspIle: 4.257 ± 0.099
3.779AspLys: 3.779 ± 0.092
5.335AspLeu: 5.335 ± 0.095
1.239AspMet: 1.239 ± 0.043
2.679AspAsn: 2.679 ± 0.069
2.273AspPro: 2.273 ± 0.063
1.918AspGln: 1.918 ± 0.055
2.264AspArg: 2.264 ± 0.057
2.943AspSer: 2.943 ± 0.07
2.402AspThr: 2.402 ± 0.062
3.409AspVal: 3.409 ± 0.076
0.794AspTrp: 0.794 ± 0.038
2.224AspTyr: 2.224 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
4.605GluAla: 4.605 ± 0.105
0.428GluCys: 0.428 ± 0.029
3.132GluAsp: 3.132 ± 0.087
4.434GluGlu: 4.434 ± 0.125
2.517GluPhe: 2.517 ± 0.062
3.77GluGly: 3.77 ± 0.085
1.288GluHis: 1.288 ± 0.048
5.133GluIle: 5.133 ± 0.121
5.374GluLys: 5.374 ± 0.101
6.753GluLeu: 6.753 ± 0.121
1.776GluMet: 1.776 ± 0.057
3.724GluAsn: 3.724 ± 0.073
1.906GluPro: 1.906 ± 0.058
3.95GluGln: 3.95 ± 0.099
3.072GluArg: 3.072 ± 0.088
3.645GluSer: 3.645 ± 0.079
3.01GluThr: 3.01 ± 0.077
4.193GluVal: 4.193 ± 0.102
0.856GluTrp: 0.856 ± 0.044
2.023GluTyr: 2.023 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.49PheAla: 3.49 ± 0.091
0.536PheCys: 0.536 ± 0.032
2.891PheAsp: 2.891 ± 0.075
2.636PheGlu: 2.636 ± 0.072
2.147PhePhe: 2.147 ± 0.081
3.358PheGly: 3.358 ± 0.079
0.781PheHis: 0.781 ± 0.03
3.49PheIle: 3.49 ± 0.105
2.315PheLys: 2.315 ± 0.068
4.084PheLeu: 4.084 ± 0.094
1.002PheMet: 1.002 ± 0.04
2.365PheAsn: 2.365 ± 0.06
1.548PhePro: 1.548 ± 0.054
1.392PheGln: 1.392 ± 0.056
1.584PheArg: 1.584 ± 0.052
3.646PheSer: 3.646 ± 0.079
2.495PheThr: 2.495 ± 0.058
2.877PheVal: 2.877 ± 0.083
0.535PheTrp: 0.535 ± 0.032
1.635PheTyr: 1.635 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.651GlyAla: 4.651 ± 0.105
0.732GlyCys: 0.732 ± 0.04
3.293GlyAsp: 3.293 ± 0.096
4.227GlyGlu: 4.227 ± 0.103
3.176GlyPhe: 3.176 ± 0.07
4.519GlyGly: 4.519 ± 0.125
1.294GlyHis: 1.294 ± 0.058
5.461GlyIle: 5.461 ± 0.106
4.879GlyLys: 4.879 ± 0.091
6.819GlyLeu: 6.819 ± 0.099
1.794GlyMet: 1.794 ± 0.06
2.796GlyAsn: 2.796 ± 0.08
1.244GlyPro: 1.244 ± 0.05
2.422GlyGln: 2.422 ± 0.062
2.884GlyArg: 2.884 ± 0.073
3.818GlySer: 3.818 ± 0.084
3.181GlyThr: 3.181 ± 0.084
5.059GlyVal: 5.059 ± 0.099
0.883GlyTrp: 0.883 ± 0.037
2.606GlyTyr: 2.606 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.226HisAla: 1.226 ± 0.049
0.282HisCys: 0.282 ± 0.024
0.878HisAsp: 0.878 ± 0.048
0.85HisGlu: 0.85 ± 0.04
1.132HisPhe: 1.132 ± 0.045
1.222HisGly: 1.222 ± 0.046
0.579HisHis: 0.579 ± 0.038
1.568HisIle: 1.568 ± 0.052
1.136HisLys: 1.136 ± 0.045
2.169HisLeu: 2.169 ± 0.064
0.334HisMet: 0.334 ± 0.026
1.044HisAsn: 1.044 ± 0.041
1.073HisPro: 1.073 ± 0.046
1.042HisGln: 1.042 ± 0.042
1.013HisArg: 1.013 ± 0.037
1.38HisSer: 1.38 ± 0.048
1.0HisThr: 1.0 ± 0.046
0.876HisVal: 0.876 ± 0.043
0.319HisTrp: 0.319 ± 0.022
0.864HisTyr: 0.864 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.678IleAla: 6.678 ± 0.107
0.749IleCys: 0.749 ± 0.037
4.466IleAsp: 4.466 ± 0.103
5.261IleGlu: 5.261 ± 0.1
3.072IlePhe: 3.072 ± 0.086
5.235IleGly: 5.235 ± 0.096
1.363IleHis: 1.363 ± 0.053
5.235IleIle: 5.235 ± 0.136
4.29IleLys: 4.29 ± 0.101
7.104IleLeu: 7.104 ± 0.138
1.338IleMet: 1.338 ± 0.048
3.522IleAsn: 3.522 ± 0.076
3.067IlePro: 3.067 ± 0.082
2.943IleGln: 2.943 ± 0.076
3.096IleArg: 3.096 ± 0.069
4.962IleSer: 4.962 ± 0.103
4.123IleThr: 4.123 ± 0.09
4.802IleVal: 4.802 ± 0.103
0.662IleTrp: 0.662 ± 0.034
2.302IleTyr: 2.302 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
5.281LysAla: 5.281 ± 0.109
0.336LysCys: 0.336 ± 0.027
3.178LysAsp: 3.178 ± 0.088
4.383LysGlu: 4.383 ± 0.116
2.169LysPhe: 2.169 ± 0.067
3.943LysGly: 3.943 ± 0.084
1.139LysHis: 1.139 ± 0.037
4.497LysIle: 4.497 ± 0.118
4.361LysLys: 4.361 ± 0.103
6.245LysLeu: 6.245 ± 0.117
1.808LysMet: 1.808 ± 0.057
3.495LysAsn: 3.495 ± 0.096
2.397LysPro: 2.397 ± 0.077
3.29LysGln: 3.29 ± 0.081
2.947LysArg: 2.947 ± 0.068
3.712LysSer: 3.712 ± 0.081
3.334LysThr: 3.334 ± 0.081
4.327LysVal: 4.327 ± 0.096
0.676LysTrp: 0.676 ± 0.037
1.927LysTyr: 1.927 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
8.97LeuAla: 8.97 ± 0.141
0.856LeuCys: 0.856 ± 0.041
5.895LeuAsp: 5.895 ± 0.099
5.987LeuGlu: 5.987 ± 0.118
4.848LeuPhe: 4.848 ± 0.119
7.063LeuGly: 7.063 ± 0.115
1.957LeuHis: 1.957 ± 0.056
6.921LeuIle: 6.921 ± 0.14
5.999LeuLys: 5.999 ± 0.095
10.487LeuLeu: 10.487 ± 0.201
2.399LeuMet: 2.399 ± 0.062
4.972LeuAsn: 4.972 ± 0.108
4.773LeuPro: 4.773 ± 0.092
3.986LeuGln: 3.986 ± 0.082
4.293LeuArg: 4.293 ± 0.094
7.88LeuSer: 7.88 ± 0.135
5.731LeuThr: 5.731 ± 0.111
6.715LeuVal: 6.715 ± 0.122
1.039LeuTrp: 1.039 ± 0.045
2.835LeuTyr: 2.835 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
2.214MetAla: 2.214 ± 0.069
0.177MetCys: 0.177 ± 0.018
1.132MetAsp: 1.132 ± 0.041
1.243MetGlu: 1.243 ± 0.044
0.862MetPhe: 0.862 ± 0.041
1.56MetGly: 1.56 ± 0.057
0.39MetHis: 0.39 ± 0.025
1.63MetIle: 1.63 ± 0.055
1.698MetLys: 1.698 ± 0.056
2.427MetLeu: 2.427 ± 0.065
0.687MetMet: 0.687 ± 0.032
1.222MetAsn: 1.222 ± 0.041
1.037MetPro: 1.037 ± 0.043
1.159MetGln: 1.159 ± 0.047
1.022MetArg: 1.022 ± 0.041
1.645MetSer: 1.645 ± 0.055
1.363MetThr: 1.363 ± 0.045
1.458MetVal: 1.458 ± 0.057
0.202MetTrp: 0.202 ± 0.02
0.518MetTyr: 0.518 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.609AsnAla: 3.609 ± 0.078
0.385AsnCys: 0.385 ± 0.027
2.334AsnAsp: 2.334 ± 0.07
2.884AsnGlu: 2.884 ± 0.071
2.001AsnPhe: 2.001 ± 0.054
3.315AsnGly: 3.315 ± 0.11
1.071AsnHis: 1.071 ± 0.04
3.857AsnIle: 3.857 ± 0.091
3.061AsnLys: 3.061 ± 0.07
4.987AsnLeu: 4.987 ± 0.095
1.108AsnMet: 1.108 ± 0.046
2.536AsnAsn: 2.536 ± 0.077
2.365AsnPro: 2.365 ± 0.066
2.354AsnGln: 2.354 ± 0.072
2.086AsnArg: 2.086 ± 0.053
2.745AsnSer: 2.745 ± 0.075
2.524AsnThr: 2.524 ± 0.078
3.173AsnVal: 3.173 ± 0.08
0.633AsnTrp: 0.633 ± 0.039
1.748AsnTyr: 1.748 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
2.478ProAla: 2.478 ± 0.064
0.258ProCys: 0.258 ± 0.02
2.012ProAsp: 2.012 ± 0.061
3.361ProGlu: 3.361 ± 0.082
1.864ProPhe: 1.864 ± 0.058
1.409ProGly: 1.409 ± 0.058
0.881ProHis: 0.881 ± 0.039
2.848ProIle: 2.848 ± 0.064
2.307ProLys: 2.307 ± 0.062
3.848ProLeu: 3.848 ± 0.089
0.915ProMet: 0.915 ± 0.039
2.159ProAsn: 2.159 ± 0.053
1.059ProPro: 1.059 ± 0.046
1.658ProGln: 1.658 ± 0.058
1.295ProArg: 1.295 ± 0.044
2.19ProSer: 2.19 ± 0.062
2.348ProThr: 2.348 ± 0.057
2.73ProVal: 2.73 ± 0.074
0.37ProTrp: 0.37 ± 0.029
1.378ProTyr: 1.378 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
3.908GlnAla: 3.908 ± 0.099
0.324GlnCys: 0.324 ± 0.025
2.088GlnAsp: 2.088 ± 0.063
2.638GlnGlu: 2.638 ± 0.077
2.264GlnPhe: 2.264 ± 0.07
2.811GlnGly: 2.811 ± 0.073
0.976GlnHis: 0.976 ± 0.039
3.213GlnIle: 3.213 ± 0.073
2.93GlnLys: 2.93 ± 0.088
4.705GlnLeu: 4.705 ± 0.109
0.978GlnMet: 0.978 ± 0.042
2.231GlnAsn: 2.231 ± 0.064
1.631GlnPro: 1.631 ± 0.054
2.996GlnGln: 2.996 ± 0.101
2.197GlnArg: 2.197 ± 0.064
2.599GlnSer: 2.599 ± 0.079
2.046GlnThr: 2.046 ± 0.071
2.767GlnVal: 2.767 ± 0.076
0.592GlnTrp: 0.592 ± 0.031
1.579GlnTyr: 1.579 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
2.921ArgAla: 2.921 ± 0.077
0.407ArgCys: 0.407 ± 0.027
2.322ArgAsp: 2.322 ± 0.064
3.106ArgGlu: 3.106 ± 0.094
2.232ArgPhe: 2.232 ± 0.064
2.514ArgGly: 2.514 ± 0.072
0.951ArgHis: 0.951 ± 0.045
3.156ArgIle: 3.156 ± 0.08
2.645ArgLys: 2.645 ± 0.077
4.68ArgLeu: 4.68 ± 0.094
0.92ArgMet: 0.92 ± 0.039
1.937ArgAsn: 1.937 ± 0.058
1.519ArgPro: 1.519 ± 0.056
2.091ArgGln: 2.091 ± 0.066
2.057ArgArg: 2.057 ± 0.075
2.434ArgSer: 2.434 ± 0.07
1.956ArgThr: 1.956 ± 0.06
2.889ArgVal: 2.889 ± 0.073
0.514ArgTrp: 0.514 ± 0.033
1.774ArgTyr: 1.774 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.812SerAla: 4.812 ± 0.109
0.501SerCys: 0.501 ± 0.03
3.395SerAsp: 3.395 ± 0.08
3.916SerGlu: 3.916 ± 0.094
2.818SerPhe: 2.818 ± 0.087
4.646SerGly: 4.646 ± 0.12
1.45SerHis: 1.45 ± 0.051
4.366SerIle: 4.366 ± 0.082
3.315SerLys: 3.315 ± 0.084
6.814SerLeu: 6.814 ± 0.126
1.501SerMet: 1.501 ± 0.05
2.872SerAsn: 2.872 ± 0.075
2.346SerPro: 2.346 ± 0.068
2.918SerGln: 2.918 ± 0.076
2.609SerArg: 2.609 ± 0.069
4.096SerSer: 4.096 ± 0.101
3.176SerThr: 3.176 ± 0.074
4.137SerVal: 4.137 ± 0.08
0.723SerTrp: 0.723 ± 0.032
2.161SerTyr: 2.161 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
4.23ThrAla: 4.23 ± 0.107
0.39ThrCys: 0.39 ± 0.033
2.762ThrAsp: 2.762 ± 0.077
3.356ThrGlu: 3.356 ± 0.07
2.229ThrPhe: 2.229 ± 0.059
3.745ThrGly: 3.745 ± 0.082
1.086ThrHis: 1.086 ± 0.042
3.774ThrIle: 3.774 ± 0.089
2.867ThrLys: 2.867 ± 0.073
5.934ThrLeu: 5.934 ± 0.103
1.063ThrMet: 1.063 ± 0.038
2.198ThrAsn: 2.198 ± 0.072
2.422ThrPro: 2.422 ± 0.069
2.465ThrGln: 2.465 ± 0.063
2.066ThrArg: 2.066 ± 0.056
2.989ThrSer: 2.989 ± 0.06
2.857ThrThr: 2.857 ± 0.087
3.342ThrVal: 3.342 ± 0.076
0.506ThrTrp: 0.506 ± 0.032
1.555ThrTyr: 1.555 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
5.51ValAla: 5.51 ± 0.102
0.596ValCys: 0.596 ± 0.036
3.667ValAsp: 3.667 ± 0.076
4.78ValGlu: 4.78 ± 0.109
2.638ValPhe: 2.638 ± 0.07
4.717ValGly: 4.717 ± 0.103
1.081ValHis: 1.081 ± 0.043
5.004ValIle: 5.004 ± 0.096
4.099ValLys: 4.099 ± 0.089
6.676ValLeu: 6.676 ± 0.123
1.665ValMet: 1.665 ± 0.056
3.074ValAsn: 3.074 ± 0.079
2.417ValPro: 2.417 ± 0.07
2.161ValGln: 2.161 ± 0.062
2.718ValArg: 2.718 ± 0.068
4.444ValSer: 4.444 ± 0.095
3.646ValThr: 3.646 ± 0.077
4.996ValVal: 4.996 ± 0.105
0.614ValTrp: 0.614 ± 0.033
1.754ValTyr: 1.754 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.752TrpAla: 0.752 ± 0.035
0.114TrpCys: 0.114 ± 0.011
0.598TrpAsp: 0.598 ± 0.034
0.603TrpGlu: 0.603 ± 0.032
0.601TrpPhe: 0.601 ± 0.034
0.708TrpGly: 0.708 ± 0.038
0.258TrpHis: 0.258 ± 0.019
0.842TrpIle: 0.842 ± 0.041
0.771TrpLys: 0.771 ± 0.038
1.543TrpLeu: 1.543 ± 0.055
0.226TrpMet: 0.226 ± 0.021
0.545TrpAsn: 0.545 ± 0.028
0.158TrpPro: 0.158 ± 0.017
0.847TrpGln: 0.847 ± 0.043
0.548TrpArg: 0.548 ± 0.033
0.565TrpSer: 0.565 ± 0.031
0.469TrpThr: 0.469 ± 0.033
0.808TrpVal: 0.808 ± 0.035
0.151TrpTrp: 0.151 ± 0.018
0.365TrpTyr: 0.365 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.405TyrAla: 2.405 ± 0.058
0.368TyrCys: 0.368 ± 0.027
1.772TyrAsp: 1.772 ± 0.056
1.628TyrGlu: 1.628 ± 0.056
1.83TyrPhe: 1.83 ± 0.075
2.2TyrGly: 2.2 ± 0.071
0.85TyrHis: 0.85 ± 0.041
2.035TyrIle: 2.035 ± 0.064
1.728TyrLys: 1.728 ± 0.067
3.551TyrLeu: 3.551 ± 0.085
0.598TyrMet: 0.598 ± 0.03
1.458TyrAsn: 1.458 ± 0.054
1.526TyrPro: 1.526 ± 0.05
2.02TyrGln: 2.02 ± 0.069
1.73TyrArg: 1.73 ± 0.056
2.161TyrSer: 2.161 ± 0.07
1.635TyrThr: 1.635 ± 0.053
1.93TyrVal: 1.93 ± 0.061
0.462TyrTrp: 0.462 ± 0.022
1.224TyrTyr: 1.224 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 1851 proteins (589099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski