Amino acid dipepetide frequency for Vibrio atlanticus (strain LGP32) (Vibrio splendidus (strain Mel32))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.118AlaAla: 7.118 ± 0.103	0.861AlaCys: 0.861 ± 0.024	4.369AlaAsp: 4.369 ± 0.062	5.331AlaGlu: 5.331 ± 0.069	3.418AlaPhe: 3.418 ± 0.051	5.532AlaGly: 5.532 ± 0.072	1.571AlaHis: 1.571 ± 0.038	5.868AlaIle: 5.868 ± 0.078	4.843AlaLys: 4.843 ± 0.07	9.27AlaLeu: 9.27 ± 0.092	2.697AlaMet: 2.697 ± 0.054	3.541AlaAsn: 3.541 ± 0.056	2.762AlaPro: 2.762 ± 0.051	3.738AlaGln: 3.738 ± 0.062	3.288AlaArg: 3.288 ± 0.049	5.532AlaSer: 5.532 ± 0.07	4.461AlaThr: 4.461 ± 0.064	5.591AlaVal: 5.591 ± 0.06	0.943AlaTrp: 0.943 ± 0.029	2.229AlaTyr: 2.229 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.688CysAla: 0.688 ± 0.023	0.158CysCys: 0.158 ± 0.012	0.593CysAsp: 0.593 ± 0.022	0.635CysGlu: 0.635 ± 0.023	0.47CysPhe: 0.47 ± 0.021	0.851CysGly: 0.851 ± 0.027	0.345CysHis: 0.345 ± 0.019	0.614CysIle: 0.614 ± 0.02	0.469CysLys: 0.469 ± 0.017	0.943CysLeu: 0.943 ± 0.024	0.237CysMet: 0.237 ± 0.014	0.358CysAsn: 0.358 ± 0.014	0.414CysPro: 0.414 ± 0.016	0.41CysGln: 0.41 ± 0.017	0.434CysArg: 0.434 ± 0.017	0.732CysSer: 0.732 ± 0.023	0.508CysThr: 0.508 ± 0.019	0.654CysVal: 0.654 ± 0.023	0.137CysTrp: 0.137 ± 0.01	0.318CysTyr: 0.318 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.287AspAla: 4.287 ± 0.061	0.536AspCys: 0.536 ± 0.024	3.098AspAsp: 3.098 ± 0.063	3.864AspGlu: 3.864 ± 0.069	2.505AspPhe: 2.505 ± 0.041	3.862AspGly: 3.862 ± 0.119	1.156AspHis: 1.156 ± 0.034	4.087AspIle: 4.087 ± 0.066	3.361AspLys: 3.361 ± 0.05	5.383AspLeu: 5.383 ± 0.069	1.502AspMet: 1.502 ± 0.038	2.57AspAsn: 2.57 ± 0.054	1.985AspPro: 1.985 ± 0.043	2.092AspGln: 2.092 ± 0.041	2.23AspArg: 2.23 ± 0.038	3.648AspSer: 3.648 ± 0.053	2.787AspThr: 2.787 ± 0.055	4.167AspVal: 4.167 ± 0.082	0.856AspTrp: 0.856 ± 0.026	2.061AspTyr: 2.061 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.335GluAla: 5.335 ± 0.067	0.578GluCys: 0.578 ± 0.021	3.114GluAsp: 3.114 ± 0.074	4.009GluGlu: 4.009 ± 0.072	2.694GluPhe: 2.694 ± 0.045	3.818GluGly: 3.818 ± 0.055	1.602GluHis: 1.602 ± 0.04	3.752GluIle: 3.752 ± 0.053	3.899GluLys: 3.899 ± 0.064	7.417GluLeu: 7.417 ± 0.082	1.812GluMet: 1.812 ± 0.037	2.758GluAsn: 2.758 ± 0.055	2.105GluPro: 2.105 ± 0.053	4.064GluGln: 4.064 ± 0.066	3.222GluArg: 3.222 ± 0.057	4.198GluSer: 4.198 ± 0.055	3.354GluThr: 3.354 ± 0.047	4.592GluVal: 4.592 ± 0.065	0.865GluTrp: 0.865 ± 0.024	1.877GluTyr: 1.877 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.576PheAla: 3.576 ± 0.049	0.481PheCys: 0.481 ± 0.02	2.832PheAsp: 2.832 ± 0.051	2.811PheGlu: 2.811 ± 0.048	1.723PhePhe: 1.723 ± 0.037	3.306PheGly: 3.306 ± 0.062	0.819PheHis: 0.819 ± 0.021	2.783PheIle: 2.783 ± 0.044	2.08PheLys: 2.08 ± 0.037	3.431PheLeu: 3.431 ± 0.057	1.077PheMet: 1.077 ± 0.029	2.122PheAsn: 2.122 ± 0.042	1.439PhePro: 1.439 ± 0.033	1.276PheGln: 1.276 ± 0.028	1.455PheArg: 1.455 ± 0.032	3.474PheSer: 3.474 ± 0.056	2.428PheThr: 2.428 ± 0.049	2.919PheVal: 2.919 ± 0.048	0.55PheTrp: 0.55 ± 0.02	1.334PheTyr: 1.334 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.032GlyAla: 5.032 ± 0.074	0.872GlyCys: 0.872 ± 0.026	3.697GlyAsp: 3.697 ± 0.102	4.472GlyGlu: 4.472 ± 0.062	3.262GlyPhe: 3.262 ± 0.048	4.711GlyGly: 4.711 ± 0.068	1.486GlyHis: 1.486 ± 0.037	4.677GlyIle: 4.677 ± 0.062	3.946GlyLys: 3.946 ± 0.056	6.791GlyLeu: 6.791 ± 0.073	1.978GlyMet: 1.978 ± 0.046	2.632GlyAsn: 2.632 ± 0.054	1.522GlyPro: 1.522 ± 0.037	2.74GlyGln: 2.74 ± 0.054	2.898GlyArg: 2.898 ± 0.052	4.35GlySer: 4.35 ± 0.07	3.568GlyThr: 3.568 ± 0.078	5.268GlyVal: 5.268 ± 0.064	0.942GlyTrp: 0.942 ± 0.03	2.543GlyTyr: 2.543 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.545HisAla: 1.545 ± 0.035	0.3HisCys: 0.3 ± 0.014	1.167HisAsp: 1.167 ± 0.03	1.136HisGlu: 1.136 ± 0.03	1.057HisPhe: 1.057 ± 0.032	1.472HisGly: 1.472 ± 0.036	0.708HisHis: 0.708 ± 0.025	1.367HisIle: 1.367 ± 0.036	1.086HisLys: 1.086 ± 0.032	2.162HisLeu: 2.162 ± 0.041	0.502HisMet: 0.502 ± 0.021	0.93HisAsn: 0.93 ± 0.026	1.058HisPro: 1.058 ± 0.031	1.205HisGln: 1.205 ± 0.035	0.981HisArg: 0.981 ± 0.029	1.524HisSer: 1.524 ± 0.032	1.147HisThr: 1.147 ± 0.027	1.29HisVal: 1.29 ± 0.036	0.322HisTrp: 0.322 ± 0.014	0.826HisTyr: 0.826 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.167IleAla: 6.167 ± 0.085	0.647IleCys: 0.647 ± 0.018	4.264IleAsp: 4.264 ± 0.059	5.073IleGlu: 5.073 ± 0.067	2.237IlePhe: 2.237 ± 0.045	4.679IleGly: 4.679 ± 0.066	1.219IleHis: 1.219 ± 0.029	3.627IleIle: 3.627 ± 0.058	3.388IleLys: 3.388 ± 0.052	5.316IleLeu: 5.316 ± 0.076	1.328IleMet: 1.328 ± 0.032	2.938IleAsn: 2.938 ± 0.045	2.68IlePro: 2.68 ± 0.046	2.432IleGln: 2.432 ± 0.036	2.579IleArg: 2.579 ± 0.049	4.775IleSer: 4.775 ± 0.054	3.801IleThr: 3.801 ± 0.075	4.214IleVal: 4.214 ± 0.055	0.609IleTrp: 0.609 ± 0.02	1.76IleTyr: 1.76 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.916LysAla: 4.916 ± 0.073	0.358LysCys: 0.358 ± 0.016	2.888LysAsp: 2.888 ± 0.044	3.614LysGlu: 3.614 ± 0.06	1.686LysPhe: 1.686 ± 0.038	3.482LysGly: 3.482 ± 0.058	1.32LysHis: 1.32 ± 0.032	2.966LysIle: 2.966 ± 0.045	3.159LysLys: 3.159 ± 0.06	5.677LysLeu: 5.677 ± 0.07	1.5LysMet: 1.5 ± 0.033	2.226LysAsn: 2.226 ± 0.039	2.504LysPro: 2.504 ± 0.037	2.996LysGln: 2.996 ± 0.052	2.675LysArg: 2.675 ± 0.044	3.388LysSer: 3.388 ± 0.053	2.933LysThr: 2.933 ± 0.041	3.909LysVal: 3.909 ± 0.053	0.598LysTrp: 0.598 ± 0.022	1.438LysTyr: 1.438 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	9.275LeuAla: 9.275 ± 0.091	1.02LeuCys: 1.02 ± 0.025	5.929LeuAsp: 5.929 ± 0.072	6.549LeuGlu: 6.549 ± 0.084	4.253LeuPhe: 4.253 ± 0.066	6.885LeuGly: 6.885 ± 0.077	1.935LeuHis: 1.935 ± 0.042	6.177LeuIle: 6.177 ± 0.079	5.5LeuLys: 5.5 ± 0.064	10.101LeuLeu: 10.101 ± 0.11	2.813LeuMet: 2.813 ± 0.056	4.627LeuAsn: 4.627 ± 0.057	4.629LeuPro: 4.629 ± 0.055	3.341LeuGln: 3.341 ± 0.053	4.047LeuArg: 4.047 ± 0.065	8.248LeuSer: 8.248 ± 0.097	6.118LeuThr: 6.118 ± 0.081	7.27LeuVal: 7.27 ± 0.071	0.99LeuTrp: 0.99 ± 0.026	2.545LeuTyr: 2.545 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.448MetAla: 2.448 ± 0.054	0.241MetCys: 0.241 ± 0.012	1.334MetAsp: 1.334 ± 0.028	1.38MetGlu: 1.38 ± 0.033	1.041MetPhe: 1.041 ± 0.027	1.797MetGly: 1.797 ± 0.041	0.507MetHis: 0.507 ± 0.019	1.59MetIle: 1.59 ± 0.037	1.628MetLys: 1.628 ± 0.034	2.81MetLeu: 2.81 ± 0.047	0.893MetMet: 0.893 ± 0.025	1.284MetAsn: 1.284 ± 0.033	1.212MetPro: 1.212 ± 0.028	1.06MetGln: 1.06 ± 0.031	1.149MetArg: 1.149 ± 0.03	2.129MetSer: 2.129 ± 0.045	1.725MetThr: 1.725 ± 0.031	1.916MetVal: 1.916 ± 0.037	0.255MetTrp: 0.255 ± 0.016	0.611MetTyr: 0.611 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.352AsnAla: 3.352 ± 0.051	0.406AsnCys: 0.406 ± 0.016	2.484AsnAsp: 2.484 ± 0.061	2.631AsnGlu: 2.631 ± 0.052	1.704AsnPhe: 1.704 ± 0.045	3.072AsnGly: 3.072 ± 0.07	1.036AsnHis: 1.036 ± 0.026	2.844AsnIle: 2.844 ± 0.046	2.389AsnLys: 2.389 ± 0.037	4.056AsnLeu: 4.056 ± 0.051	1.054AsnMet: 1.054 ± 0.024	1.985AsnAsn: 1.985 ± 0.042	2.09AsnPro: 2.09 ± 0.044	2.33AsnGln: 2.33 ± 0.04	1.962AsnArg: 1.962 ± 0.04	2.838AsnSer: 2.838 ± 0.054	2.373AsnThr: 2.373 ± 0.044	2.863AsnVal: 2.863 ± 0.051	0.578AsnTrp: 0.578 ± 0.021	1.373AsnTyr: 1.373 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.912ProAla: 2.912 ± 0.051	0.307ProCys: 0.307 ± 0.016	2.183ProAsp: 2.183 ± 0.043	3.113ProGlu: 3.113 ± 0.058	1.704ProPhe: 1.704 ± 0.034	2.0ProGly: 2.0 ± 0.04	0.824ProHis: 0.824 ± 0.025	2.619ProIle: 2.619 ± 0.049	2.025ProLys: 2.025 ± 0.043	3.856ProLeu: 3.856 ± 0.061	1.063ProMet: 1.063 ± 0.028	1.795ProAsn: 1.795 ± 0.041	1.025ProPro: 1.025 ± 0.03	1.639ProGln: 1.639 ± 0.034	1.281ProArg: 1.281 ± 0.034	2.636ProSer: 2.636 ± 0.05	2.31ProThr: 2.31 ± 0.044	3.011ProVal: 3.011 ± 0.055	0.491ProTrp: 0.491 ± 0.019	1.214ProTyr: 1.214 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.203GlnAla: 4.203 ± 0.064	0.364GlnCys: 0.364 ± 0.017	2.172GlnAsp: 2.172 ± 0.038	2.584GlnGlu: 2.584 ± 0.046	1.801GlnPhe: 1.801 ± 0.036	2.915GlnGly: 2.915 ± 0.047	1.132GlnHis: 1.132 ± 0.031	2.548GlnIle: 2.548 ± 0.037	2.133GlnLys: 2.133 ± 0.038	5.032GlnLeu: 5.032 ± 0.071	1.084GlnMet: 1.084 ± 0.027	1.673GlnAsn: 1.673 ± 0.035	1.667GlnPro: 1.667 ± 0.036	2.764GlnGln: 2.764 ± 0.057	2.102GlnArg: 2.102 ± 0.039	3.007GlnSer: 3.007 ± 0.056	2.251GlnThr: 2.251 ± 0.04	3.298GlnVal: 3.298 ± 0.041	0.618GlnTrp: 0.618 ± 0.018	1.39GlnTyr: 1.39 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.054ArgAla: 3.054 ± 0.051	0.432ArgCys: 0.432 ± 0.016	2.392ArgAsp: 2.392 ± 0.046	2.837ArgGlu: 2.837 ± 0.048	2.129ArgPhe: 2.129 ± 0.04	2.399ArgGly: 2.399 ± 0.051	1.017ArgHis: 1.017 ± 0.027	2.861ArgIle: 2.861 ± 0.049	2.289ArgLys: 2.289 ± 0.049	4.644ArgLeu: 4.644 ± 0.064	1.185ArgMet: 1.185 ± 0.031	1.843ArgAsn: 1.843 ± 0.033	1.395ArgPro: 1.395 ± 0.029	1.875ArgGln: 1.875 ± 0.035	2.02ArgArg: 2.02 ± 0.048	2.694ArgSer: 2.694 ± 0.046	2.207ArgThr: 2.207 ± 0.042	3.047ArgVal: 3.047 ± 0.047	0.582ArgTrp: 0.582 ± 0.02	1.597ArgTyr: 1.597 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.388SerAla: 5.388 ± 0.062	0.612SerCys: 0.612 ± 0.025	4.004SerAsp: 4.004 ± 0.079	4.562SerGlu: 4.562 ± 0.059	3.093SerPhe: 3.093 ± 0.058	5.073SerGly: 5.073 ± 0.08	1.555SerHis: 1.555 ± 0.041	4.624SerIle: 4.624 ± 0.061	3.704SerLys: 3.704 ± 0.051	7.288SerLeu: 7.288 ± 0.088	1.904SerMet: 1.904 ± 0.039	3.143SerAsn: 3.143 ± 0.057	2.514SerPro: 2.514 ± 0.045	3.14SerGln: 3.14 ± 0.054	2.879SerArg: 2.879 ± 0.054	5.098SerSer: 5.098 ± 0.073	3.602SerThr: 3.602 ± 0.055	5.078SerVal: 5.078 ± 0.065	0.835SerTrp: 0.835 ± 0.024	2.163SerTyr: 2.163 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.385ThrAla: 4.385 ± 0.06	0.488ThrCys: 0.488 ± 0.019	2.99ThrAsp: 2.99 ± 0.067	3.323ThrGlu: 3.323 ± 0.055	2.257ThrPhe: 2.257 ± 0.05	3.945ThrGly: 3.945 ± 0.058	1.212ThrHis: 1.212 ± 0.033	3.542ThrIle: 3.542 ± 0.064	2.609ThrLys: 2.609 ± 0.046	6.318ThrLeu: 6.318 ± 0.079	1.279ThrMet: 1.279 ± 0.031	2.234ThrAsn: 2.234 ± 0.047	2.736ThrPro: 2.736 ± 0.048	2.583ThrGln: 2.583 ± 0.043	2.203ThrArg: 2.203 ± 0.039	3.74ThrSer: 3.74 ± 0.061	3.096ThrThr: 3.096 ± 0.056	3.898ThrVal: 3.898 ± 0.08	0.604ThrTrp: 0.604 ± 0.02	1.576ThrTyr: 1.576 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	6.27ValAla: 6.27 ± 0.074	0.785ValCys: 0.785 ± 0.023	4.265ValAsp: 4.265 ± 0.056	4.99ValGlu: 4.99 ± 0.071	2.889ValPhe: 2.889 ± 0.049	4.798ValGly: 4.798 ± 0.057	1.264ValHis: 1.264 ± 0.035	4.837ValIle: 4.837 ± 0.059	3.711ValLys: 3.711 ± 0.061	6.81ValLeu: 6.81 ± 0.074	2.079ValMet: 2.079 ± 0.041	3.028ValAsn: 3.028 ± 0.054	2.54ValPro: 2.54 ± 0.039	2.321ValGln: 2.321 ± 0.043	2.904ValArg: 2.904 ± 0.047	5.284ValSer: 5.284 ± 0.079	4.288ValThr: 4.288 ± 0.083	5.631ValVal: 5.631 ± 0.073	0.802ValTrp: 0.802 ± 0.029	1.864ValTyr: 1.864 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.843TrpAla: 0.843 ± 0.025	0.153TrpCys: 0.153 ± 0.01	0.614TrpAsp: 0.614 ± 0.022	0.573TrpGlu: 0.573 ± 0.02	0.612TrpPhe: 0.612 ± 0.021	0.777TrpGly: 0.777 ± 0.026	0.31TrpHis: 0.31 ± 0.015	0.694TrpIle: 0.694 ± 0.026	0.597TrpLys: 0.597 ± 0.02	1.685TrpLeu: 1.685 ± 0.041	0.346TrpMet: 0.346 ± 0.018	0.527TrpAsn: 0.527 ± 0.019	0.436TrpPro: 0.436 ± 0.016	0.774TrpGln: 0.774 ± 0.029	0.591TrpArg: 0.591 ± 0.021	0.757TrpSer: 0.757 ± 0.026	0.512TrpThr: 0.512 ± 0.02	0.881TrpVal: 0.881 ± 0.026	0.186TrpTrp: 0.186 ± 0.011	0.375TrpTyr: 0.375 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.168TyrAla: 2.168 ± 0.043	0.368TyrCys: 0.368 ± 0.016	1.649TyrAsp: 1.649 ± 0.037	1.576TyrGlu: 1.576 ± 0.037	1.382TyrPhe: 1.382 ± 0.028	2.014TyrGly: 2.014 ± 0.045	0.767TyrHis: 0.767 ± 0.024	1.656TyrIle: 1.656 ± 0.034	1.415TyrLys: 1.415 ± 0.036	3.262TyrLeu: 3.262 ± 0.057	0.678TyrMet: 0.678 ± 0.019	1.207TyrAsn: 1.207 ± 0.032	1.297TyrPro: 1.297 ± 0.028	1.957TyrGln: 1.957 ± 0.038	1.599TyrArg: 1.599 ± 0.033	2.207TyrSer: 2.207 ± 0.048	1.552TyrThr: 1.552 ± 0.042	1.864TyrVal: 1.864 ± 0.036	0.479TyrTrp: 0.479 ± 0.02	1.006TyrTyr: 1.006 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4420 proteins (1422917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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