Amino acid dipepetide frequency for Wenxinia marina DSM 24838

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.515AlaAla: 21.515 ± 0.225	1.112AlaCys: 1.112 ± 0.036	8.158AlaAsp: 8.158 ± 0.105	9.676AlaGlu: 9.676 ± 0.129	4.463AlaPhe: 4.463 ± 0.064	12.686AlaGly: 12.686 ± 0.123	2.316AlaHis: 2.316 ± 0.043	5.887AlaIle: 5.887 ± 0.072	2.627AlaLys: 2.627 ± 0.054	15.282AlaLeu: 15.282 ± 0.153	3.891AlaMet: 3.891 ± 0.067	2.335AlaAsn: 2.335 ± 0.047	6.997AlaPro: 6.997 ± 0.101	3.72AlaGln: 3.72 ± 0.061	10.557AlaArg: 10.557 ± 0.131	5.427AlaSer: 5.427 ± 0.078	6.494AlaThr: 6.494 ± 0.076	9.491AlaVal: 9.491 ± 0.094	1.792AlaTrp: 1.792 ± 0.041	2.497AlaTyr: 2.497 ± 0.043	0.002AlaXaa: 0.002 ± 0.002
Cys	1.041CysAla: 1.041 ± 0.035	0.091CysCys: 0.091 ± 0.009	0.559CysAsp: 0.559 ± 0.02	0.433CysGlu: 0.433 ± 0.019	0.274CysPhe: 0.274 ± 0.013	0.988CysGly: 0.988 ± 0.028	0.26CysHis: 0.26 ± 0.014	0.341CysIle: 0.341 ± 0.016	0.105CysLys: 0.105 ± 0.009	0.866CysLeu: 0.866 ± 0.026	0.129CysMet: 0.129 ± 0.011	0.155CysAsn: 0.155 ± 0.01	0.475CysPro: 0.475 ± 0.02	0.175CysGln: 0.175 ± 0.012	0.611CysArg: 0.611 ± 0.023	0.348CysSer: 0.348 ± 0.018	0.416CysThr: 0.416 ± 0.019	0.535CysVal: 0.535 ± 0.02	0.107CysTrp: 0.107 ± 0.01	0.167CysTyr: 0.167 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.079AspAla: 8.079 ± 0.092	0.483AspCys: 0.483 ± 0.021	3.599AspAsp: 3.599 ± 0.09	4.073AspGlu: 4.073 ± 0.067	2.106AspPhe: 2.106 ± 0.05	6.533AspGly: 6.533 ± 0.108	1.186AspHis: 1.186 ± 0.035	2.653AspIle: 2.653 ± 0.047	1.07AspLys: 1.07 ± 0.028	6.753AspLeu: 6.753 ± 0.09	1.357AspMet: 1.357 ± 0.035	0.965AspAsn: 0.965 ± 0.035	4.196AspPro: 4.196 ± 0.062	1.397AspGln: 1.397 ± 0.038	5.23AspArg: 5.23 ± 0.066	2.069AspSer: 2.069 ± 0.063	2.762AspThr: 2.762 ± 0.072	4.455AspVal: 4.455 ± 0.071	1.336AspTrp: 1.336 ± 0.031	1.493AspTyr: 1.493 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	9.793GluAla: 9.793 ± 0.104	0.352GluCys: 0.352 ± 0.016	3.4GluAsp: 3.4 ± 0.05	3.914GluGlu: 3.914 ± 0.068	1.636GluPhe: 1.636 ± 0.04	5.778GluGly: 5.778 ± 0.071	1.04GluHis: 1.04 ± 0.03	3.301GluIle: 3.301 ± 0.052	1.411GluLys: 1.411 ± 0.043	4.874GluLeu: 4.874 ± 0.076	1.784GluMet: 1.784 ± 0.042	1.325GluAsn: 1.325 ± 0.033	2.858GluPro: 2.858 ± 0.058	1.615GluGln: 1.615 ± 0.042	5.01GluArg: 5.01 ± 0.077	2.223GluSer: 2.223 ± 0.042	3.895GluThr: 3.895 ± 0.055	4.996GluVal: 4.996 ± 0.071	0.836GluTrp: 0.836 ± 0.029	0.972GluTyr: 0.972 ± 0.034	0.002GluXaa: 0.002 ± 0.001
Phe	4.578PheAla: 4.578 ± 0.063	0.379PheCys: 0.379 ± 0.019	2.631PheAsp: 2.631 ± 0.051	2.093PheGlu: 2.093 ± 0.037	1.262PhePhe: 1.262 ± 0.033	3.637PheGly: 3.637 ± 0.063	0.699PheHis: 0.699 ± 0.025	1.164PheIle: 1.164 ± 0.035	0.527PheLys: 0.527 ± 0.021	3.347PheLeu: 3.347 ± 0.062	0.652PheMet: 0.652 ± 0.019	0.801PheAsn: 0.801 ± 0.03	1.531PhePro: 1.531 ± 0.037	0.831PheGln: 0.831 ± 0.023	2.438PheArg: 2.438 ± 0.043	1.651PheSer: 1.651 ± 0.046	1.838PheThr: 1.838 ± 0.044	2.732PheVal: 2.732 ± 0.056	0.576PheTrp: 0.576 ± 0.022	0.857PheTyr: 0.857 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.557GlyAla: 11.557 ± 0.113	0.807GlyCys: 0.807 ± 0.026	5.235GlyAsp: 5.235 ± 0.108	5.525GlyGlu: 5.525 ± 0.08	3.451GlyPhe: 3.451 ± 0.056	8.774GlyGly: 8.774 ± 0.154	1.948GlyHis: 1.948 ± 0.048	4.366GlyIle: 4.366 ± 0.069	2.117GlyLys: 2.117 ± 0.043	9.895GlyLeu: 9.895 ± 0.104	2.509GlyMet: 2.509 ± 0.049	1.843GlyAsn: 1.843 ± 0.059	4.734GlyPro: 4.734 ± 0.069	2.868GlyGln: 2.868 ± 0.047	7.893GlyArg: 7.893 ± 0.088	4.122GlySer: 4.122 ± 0.087	5.434GlyThr: 5.434 ± 0.099	6.68GlyVal: 6.68 ± 0.074	1.785GlyTrp: 1.785 ± 0.042	2.283GlyTyr: 2.283 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.294HisAla: 2.294 ± 0.044	0.203HisCys: 0.203 ± 0.013	1.254HisAsp: 1.254 ± 0.031	1.059HisGlu: 1.059 ± 0.029	0.727HisPhe: 0.727 ± 0.025	1.974HisGly: 1.974 ± 0.038	0.51HisHis: 0.51 ± 0.021	0.699HisIle: 0.699 ± 0.026	0.338HisLys: 0.338 ± 0.018	2.028HisLeu: 2.028 ± 0.045	0.439HisMet: 0.439 ± 0.019	0.331HisAsn: 0.331 ± 0.017	1.397HisPro: 1.397 ± 0.041	0.45HisGln: 0.45 ± 0.019	1.555HisArg: 1.555 ± 0.038	0.767HisSer: 0.767 ± 0.026	0.729HisThr: 0.729 ± 0.026	1.587HisVal: 1.587 ± 0.039	0.33HisTrp: 0.33 ± 0.015	0.504HisTyr: 0.504 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.79IleAla: 6.79 ± 0.088	0.477IleCys: 0.477 ± 0.02	3.307IleAsp: 3.307 ± 0.066	3.209IleGlu: 3.209 ± 0.049	1.481IlePhe: 1.481 ± 0.041	4.637IleGly: 4.637 ± 0.07	0.809IleHis: 0.809 ± 0.022	1.421IleIle: 1.421 ± 0.04	0.748IleLys: 0.748 ± 0.029	4.489IleLeu: 4.489 ± 0.071	0.805IleMet: 0.805 ± 0.025	0.964IleAsn: 0.964 ± 0.036	2.108IlePro: 2.108 ± 0.042	0.889IleGln: 0.889 ± 0.027	3.332IleArg: 3.332 ± 0.053	2.033IleSer: 2.033 ± 0.047	2.13IleThr: 2.13 ± 0.044	3.886IleVal: 3.886 ± 0.062	0.607IleTrp: 0.607 ± 0.022	0.955IleTyr: 0.955 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.782LysAla: 2.782 ± 0.054	0.122LysCys: 0.122 ± 0.01	1.25LysAsp: 1.25 ± 0.032	1.112LysGlu: 1.112 ± 0.037	0.564LysPhe: 0.564 ± 0.025	1.955LysGly: 1.955 ± 0.05	0.384LysHis: 0.384 ± 0.018	0.891LysIle: 0.891 ± 0.033	0.691LysLys: 0.691 ± 0.031	1.864LysLeu: 1.864 ± 0.043	0.527LysMet: 0.527 ± 0.021	0.461LysAsn: 0.461 ± 0.02	1.118LysPro: 1.118 ± 0.032	0.526LysGln: 0.526 ± 0.022	1.585LysArg: 1.585 ± 0.044	1.157LysSer: 1.157 ± 0.032	1.202LysThr: 1.202 ± 0.037	1.804LysVal: 1.804 ± 0.04	0.26LysTrp: 0.26 ± 0.015	0.383LysTyr: 0.383 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.034LeuAla: 15.034 ± 0.148	0.842LeuCys: 0.842 ± 0.028	6.37LeuAsp: 6.37 ± 0.088	4.953LeuGlu: 4.953 ± 0.064	3.435LeuPhe: 3.435 ± 0.068	8.868LeuGly: 8.868 ± 0.08	1.831LeuHis: 1.831 ± 0.047	4.772LeuIle: 4.772 ± 0.076	2.433LeuLys: 2.433 ± 0.058	9.068LeuLeu: 9.068 ± 0.126	2.45LeuMet: 2.45 ± 0.049	2.191LeuAsn: 2.191 ± 0.042	6.081LeuPro: 6.081 ± 0.082	2.455LeuGln: 2.455 ± 0.053	7.579LeuArg: 7.579 ± 0.093	6.196LeuSer: 6.196 ± 0.08	6.317LeuThr: 6.317 ± 0.078	7.422LeuVal: 7.422 ± 0.085	1.523LeuTrp: 1.523 ± 0.038	1.959LeuTyr: 1.959 ± 0.044	0.001LeuXaa: 0.001 ± 0.001
Met	3.358MetAla: 3.358 ± 0.05	0.162MetCys: 0.162 ± 0.011	1.359MetAsp: 1.359 ± 0.037	1.298MetGlu: 1.298 ± 0.034	0.7MetPhe: 0.7 ± 0.025	2.067MetGly: 2.067 ± 0.042	0.428MetHis: 0.428 ± 0.022	1.281MetIle: 1.281 ± 0.035	0.724MetLys: 0.724 ± 0.026	2.275MetLeu: 2.275 ± 0.048	0.646MetMet: 0.646 ± 0.026	0.652MetAsn: 0.652 ± 0.024	1.484MetPro: 1.484 ± 0.04	0.749MetGln: 0.749 ± 0.027	1.988MetArg: 1.988 ± 0.039	1.518MetSer: 1.518 ± 0.042	1.957MetThr: 1.957 ± 0.042	1.742MetVal: 1.742 ± 0.039	0.258MetTrp: 0.258 ± 0.015	0.293MetTyr: 0.293 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.661AsnAla: 2.661 ± 0.051	0.205AsnCys: 0.205 ± 0.015	1.16AsnAsp: 1.16 ± 0.044	1.027AsnGlu: 1.027 ± 0.03	0.756AsnPhe: 0.756 ± 0.025	1.963AsnGly: 1.963 ± 0.052	0.397AsnHis: 0.397 ± 0.017	0.908AsnIle: 0.908 ± 0.029	0.35AsnLys: 0.35 ± 0.019	2.141AsnLeu: 2.141 ± 0.048	0.494AsnMet: 0.494 ± 0.02	0.458AsnAsn: 0.458 ± 0.02	1.566AsnPro: 1.566 ± 0.033	0.481AsnGln: 0.481 ± 0.02	1.541AsnArg: 1.541 ± 0.038	0.853AsnSer: 0.853 ± 0.029	0.931AsnThr: 0.931 ± 0.038	1.704AsnVal: 1.704 ± 0.04	0.351AsnTrp: 0.351 ± 0.016	0.526AsnTyr: 0.526 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.418ProAla: 7.418 ± 0.102	0.366ProCys: 0.366 ± 0.017	4.497ProAsp: 4.497 ± 0.062	4.354ProGlu: 4.354 ± 0.072	1.924ProPhe: 1.924 ± 0.041	5.597ProGly: 5.597 ± 0.072	1.054ProHis: 1.054 ± 0.036	1.964ProIle: 1.964 ± 0.041	1.167ProLys: 1.167 ± 0.035	5.085ProLeu: 5.085 ± 0.069	1.262ProMet: 1.262 ± 0.03	1.086ProAsn: 1.086 ± 0.027	3.344ProPro: 3.344 ± 0.084	1.632ProGln: 1.632 ± 0.034	3.646ProArg: 3.646 ± 0.068	2.45ProSer: 2.45 ± 0.048	2.576ProThr: 2.576 ± 0.046	4.731ProVal: 4.731 ± 0.071	0.761ProTrp: 0.761 ± 0.026	1.131ProTyr: 1.131 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.577GlnAla: 3.577 ± 0.057	0.15GlnCys: 0.15 ± 0.012	1.458GlnAsp: 1.458 ± 0.032	1.406GlnGlu: 1.406 ± 0.036	0.821GlnPhe: 0.821 ± 0.027	2.325GlnGly: 2.325 ± 0.046	0.456GlnHis: 0.456 ± 0.019	1.511GlnIle: 1.511 ± 0.04	0.671GlnLys: 0.671 ± 0.025	2.381GlnLeu: 2.381 ± 0.045	0.807GlnMet: 0.807 ± 0.027	0.61GlnAsn: 0.61 ± 0.024	1.518GlnPro: 1.518 ± 0.041	0.889GlnGln: 0.889 ± 0.032	2.083GlnArg: 2.083 ± 0.046	1.359GlnSer: 1.359 ± 0.038	1.509GlnThr: 1.509 ± 0.035	2.137GlnVal: 2.137 ± 0.042	0.344GlnTrp: 0.344 ± 0.017	0.489GlnTyr: 0.489 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.009ArgAla: 10.009 ± 0.124	0.495ArgCys: 0.495 ± 0.019	4.655ArgAsp: 4.655 ± 0.063	4.384ArgGlu: 4.384 ± 0.068	2.76ArgPhe: 2.76 ± 0.051	5.83ArgGly: 5.83 ± 0.072	1.788ArgHis: 1.788 ± 0.038	4.094ArgIle: 4.094 ± 0.056	1.595ArgLys: 1.595 ± 0.04	9.077ArgLeu: 9.077 ± 0.123	2.141ArgMet: 2.141 ± 0.039	1.564ArgAsn: 1.564 ± 0.034	4.591ArgPro: 4.591 ± 0.076	2.422ArgGln: 2.422 ± 0.05	6.944ArgArg: 6.944 ± 0.116	3.366ArgSer: 3.366 ± 0.054	3.983ArgThr: 3.983 ± 0.056	5.296ArgVal: 5.296 ± 0.059	1.226ArgTrp: 1.226 ± 0.035	1.593ArgTyr: 1.593 ± 0.04	0.001ArgXaa: 0.001 ± 0.001
Ser	5.511SerAla: 5.511 ± 0.074	0.389SerCys: 0.389 ± 0.019	2.968SerAsp: 2.968 ± 0.06	2.453SerGlu: 2.453 ± 0.045	1.859SerPhe: 1.859 ± 0.039	5.209SerGly: 5.209 ± 0.088	0.93SerHis: 0.93 ± 0.028	2.055SerIle: 2.055 ± 0.051	0.858SerLys: 0.858 ± 0.029	4.628SerLeu: 4.628 ± 0.065	1.12SerMet: 1.12 ± 0.03	1.052SerAsn: 1.052 ± 0.039	2.507SerPro: 2.507 ± 0.044	1.17SerGln: 1.17 ± 0.031	3.417SerArg: 3.417 ± 0.054	2.165SerSer: 2.165 ± 0.06	2.188SerThr: 2.188 ± 0.051	3.527SerVal: 3.527 ± 0.07	0.673SerTrp: 0.673 ± 0.024	1.071SerTyr: 1.071 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.582ThrAla: 6.582 ± 0.087	0.465ThrCys: 0.465 ± 0.023	3.384ThrAsp: 3.384 ± 0.058	3.094ThrGlu: 3.094 ± 0.054	2.067ThrPhe: 2.067 ± 0.048	5.758ThrGly: 5.758 ± 0.092	0.96ThrHis: 0.96 ± 0.031	2.514ThrIle: 2.514 ± 0.06	0.958ThrLys: 0.958 ± 0.034	6.089ThrLeu: 6.089 ± 0.07	1.218ThrMet: 1.218 ± 0.031	1.112ThrAsn: 1.112 ± 0.041	3.369ThrPro: 3.369 ± 0.058	1.208ThrGln: 1.208 ± 0.029	3.689ThrArg: 3.689 ± 0.062	2.401ThrSer: 2.401 ± 0.055	2.693ThrThr: 2.693 ± 0.067	4.589ThrVal: 4.589 ± 0.072	0.779ThrTrp: 0.779 ± 0.028	1.197ThrTyr: 1.197 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.262ValAla: 10.262 ± 0.098	0.635ValCys: 0.635 ± 0.026	4.086ValAsp: 4.086 ± 0.063	4.977ValGlu: 4.977 ± 0.072	2.627ValPhe: 2.627 ± 0.047	5.989ValGly: 5.989 ± 0.067	1.382ValHis: 1.382 ± 0.037	3.771ValIle: 3.771 ± 0.054	1.549ValLys: 1.549 ± 0.044	7.686ValLeu: 7.686 ± 0.103	1.897ValMet: 1.897 ± 0.038	1.679ValAsn: 1.679 ± 0.037	4.299ValPro: 4.299 ± 0.059	1.882ValGln: 1.882 ± 0.04	5.559ValArg: 5.559 ± 0.077	3.86ValSer: 3.86 ± 0.077	5.098ValThr: 5.098 ± 0.068	6.085ValVal: 6.085 ± 0.081	1.165ValTrp: 1.165 ± 0.033	1.425ValTyr: 1.425 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.557TrpAla: 1.557 ± 0.042	0.15TrpCys: 0.15 ± 0.011	0.914TrpAsp: 0.914 ± 0.03	0.763TrpGlu: 0.763 ± 0.025	0.538TrpPhe: 0.538 ± 0.022	1.159TrpGly: 1.159 ± 0.031	0.352TrpHis: 0.352 ± 0.018	0.74TrpIle: 0.74 ± 0.025	0.335TrpLys: 0.335 ± 0.016	1.822TrpLeu: 1.822 ± 0.046	0.412TrpMet: 0.412 ± 0.016	0.395TrpAsn: 0.395 ± 0.021	0.843TrpPro: 0.843 ± 0.029	0.587TrpGln: 0.587 ± 0.021	1.447TrpArg: 1.447 ± 0.039	0.817TrpSer: 0.817 ± 0.026	0.995TrpThr: 0.995 ± 0.032	0.968TrpVal: 0.968 ± 0.031	0.265TrpTrp: 0.265 ± 0.018	0.281TrpTyr: 0.281 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.526TyrAla: 2.526 ± 0.046	0.193TyrCys: 0.193 ± 0.012	1.548TyrAsp: 1.548 ± 0.038	1.214TyrGlu: 1.214 ± 0.036	0.772TyrPhe: 0.772 ± 0.026	2.096TyrGly: 2.096 ± 0.049	0.446TyrHis: 0.446 ± 0.016	0.744TyrIle: 0.744 ± 0.023	0.365TyrLys: 0.365 ± 0.019	2.13TyrLeu: 2.13 ± 0.041	0.397TyrMet: 0.397 ± 0.021	0.492TyrAsn: 0.492 ± 0.021	1.026TyrPro: 1.026 ± 0.032	0.559TyrGln: 0.559 ± 0.022	1.709TyrArg: 1.709 ± 0.04	0.965TyrSer: 0.965 ± 0.027	0.978TyrThr: 0.978 ± 0.035	1.547TyrVal: 1.547 ± 0.037	0.368TyrTrp: 0.368 ± 0.018	0.488TyrTyr: 0.488 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4030 proteins (1236898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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