Amino acid dipepetide frequency for Tenacibaculum sp. KUL118

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.861AlaAla: 5.861 ± 0.06	0.766AlaCys: 0.766 ± 0.021	3.987AlaAsp: 3.987 ± 0.051	4.705AlaGlu: 4.705 ± 0.05	3.538AlaPhe: 3.538 ± 0.039	4.922AlaGly: 4.922 ± 0.06	1.485AlaHis: 1.485 ± 0.028	5.589AlaIle: 5.589 ± 0.056	5.121AlaLys: 5.121 ± 0.055	8.398AlaLeu: 8.398 ± 0.082	2.14AlaMet: 2.14 ± 0.036	3.688AlaAsn: 3.688 ± 0.041	2.554AlaPro: 2.554 ± 0.034	3.14AlaGln: 3.14 ± 0.043	2.975AlaArg: 2.975 ± 0.043	5.235AlaSer: 5.235 ± 0.059	4.205AlaThr: 4.205 ± 0.051	5.001AlaVal: 5.001 ± 0.054	0.75AlaTrp: 0.75 ± 0.018	2.48AlaTyr: 2.48 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.621CysAla: 0.621 ± 0.018	0.117CysCys: 0.117 ± 0.008	0.492CysAsp: 0.492 ± 0.016	0.571CysGlu: 0.571 ± 0.018	0.419CysPhe: 0.419 ± 0.012	0.654CysGly: 0.654 ± 0.017	0.225CysHis: 0.225 ± 0.011	0.55CysIle: 0.55 ± 0.016	0.502CysLys: 0.502 ± 0.015	0.744CysLeu: 0.744 ± 0.019	0.18CysMet: 0.18 ± 0.009	0.391CysAsn: 0.391 ± 0.013	0.346CysPro: 0.346 ± 0.014	0.295CysGln: 0.295 ± 0.013	0.319CysArg: 0.319 ± 0.013	0.588CysSer: 0.588 ± 0.016	0.404CysThr: 0.404 ± 0.013	0.533CysVal: 0.533 ± 0.017	0.088CysTrp: 0.088 ± 0.006	0.277CysTyr: 0.277 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.56AspAla: 4.56 ± 0.053	0.453AspCys: 0.453 ± 0.013	3.186AspAsp: 3.186 ± 0.041	4.116AspGlu: 4.116 ± 0.039	2.993AspPhe: 2.993 ± 0.043	3.722AspGly: 3.722 ± 0.048	0.865AspHis: 0.865 ± 0.019	4.385AspIle: 4.385 ± 0.039	3.896AspLys: 3.896 ± 0.039	4.806AspLeu: 4.806 ± 0.051	1.299AspMet: 1.299 ± 0.025	3.045AspAsn: 3.045 ± 0.042	1.71AspPro: 1.71 ± 0.032	1.322AspGln: 1.322 ± 0.024	1.956AspArg: 1.956 ± 0.03	3.252AspSer: 3.252 ± 0.042	3.125AspThr: 3.125 ± 0.039	4.171AspVal: 4.171 ± 0.046	0.774AspTrp: 0.774 ± 0.018	2.295AspTyr: 2.295 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.158GluAla: 5.158 ± 0.049	0.39GluCys: 0.39 ± 0.013	3.45GluAsp: 3.45 ± 0.038	4.894GluGlu: 4.894 ± 0.051	2.747GluPhe: 2.747 ± 0.036	4.03GluGly: 4.03 ± 0.048	1.405GluHis: 1.405 ± 0.029	4.544GluIle: 4.544 ± 0.054	5.305GluLys: 5.305 ± 0.054	6.485GluLeu: 6.485 ± 0.059	1.576GluMet: 1.576 ± 0.027	4.007GluAsn: 4.007 ± 0.05	1.798GluPro: 1.798 ± 0.028	2.994GluGln: 2.994 ± 0.04	3.026GluArg: 3.026 ± 0.04	3.774GluSer: 3.774 ± 0.038	3.608GluThr: 3.608 ± 0.037	4.525GluVal: 4.525 ± 0.048	0.703GluTrp: 0.703 ± 0.019	2.274GluTyr: 2.274 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.255PheAla: 3.255 ± 0.044	0.452PheCys: 0.452 ± 0.014	3.113PheAsp: 3.113 ± 0.046	3.025PheGlu: 3.025 ± 0.037	2.227PhePhe: 2.227 ± 0.037	3.301PheGly: 3.301 ± 0.04	0.795PheHis: 0.795 ± 0.018	3.33PheIle: 3.33 ± 0.042	2.971PheLys: 2.971 ± 0.045	3.97PheLeu: 3.97 ± 0.046	1.037PheMet: 1.037 ± 0.023	2.747PheAsn: 2.747 ± 0.035	1.492PhePro: 1.492 ± 0.027	1.266PheGln: 1.266 ± 0.023	1.544PheArg: 1.544 ± 0.027	3.801PheSer: 3.801 ± 0.042	2.88PheThr: 2.88 ± 0.035	2.921PheVal: 2.921 ± 0.032	0.553PheTrp: 0.553 ± 0.015	1.778PheTyr: 1.778 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.853GlyAla: 4.853 ± 0.057	0.648GlyCys: 0.648 ± 0.018	3.527GlyAsp: 3.527 ± 0.045	4.157GlyGlu: 4.157 ± 0.045	3.467GlyPhe: 3.467 ± 0.04	4.572GlyGly: 4.572 ± 0.06	1.294GlyHis: 1.294 ± 0.023	4.824GlyIle: 4.824 ± 0.052	4.577GlyLys: 4.577 ± 0.054	6.054GlyLeu: 6.054 ± 0.059	1.745GlyMet: 1.745 ± 0.031	3.238GlyAsn: 3.238 ± 0.046	1.427GlyPro: 1.427 ± 0.03	2.109GlyGln: 2.109 ± 0.032	2.534GlyArg: 2.534 ± 0.038	3.864GlySer: 3.864 ± 0.047	3.675GlyThr: 3.675 ± 0.05	4.89GlyVal: 4.89 ± 0.05	0.81GlyTrp: 0.81 ± 0.018	2.607GlyTyr: 2.607 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	1.423HisAla: 1.423 ± 0.029	0.24HisCys: 0.24 ± 0.01	0.988HisAsp: 0.988 ± 0.02	1.16HisGlu: 1.16 ± 0.026	1.094HisPhe: 1.094 ± 0.022	1.263HisGly: 1.263 ± 0.024	0.569HisHis: 0.569 ± 0.017	1.448HisIle: 1.448 ± 0.025	1.219HisLys: 1.219 ± 0.023	1.905HisLeu: 1.905 ± 0.029	0.409HisMet: 0.409 ± 0.014	0.986HisAsn: 0.986 ± 0.022	1.003HisPro: 1.003 ± 0.021	0.825HisGln: 0.825 ± 0.021	0.847HisArg: 0.847 ± 0.022	1.21HisSer: 1.21 ± 0.026	1.076HisThr: 1.076 ± 0.022	1.211HisVal: 1.211 ± 0.026	0.284HisTrp: 0.284 ± 0.011	0.833HisTyr: 0.833 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.954IleAla: 5.954 ± 0.057	0.557IleCys: 0.557 ± 0.018	4.629IleAsp: 4.629 ± 0.046	5.13IleGlu: 5.13 ± 0.055	2.639IlePhe: 2.639 ± 0.038	4.627IleGly: 4.627 ± 0.056	1.273IleHis: 1.273 ± 0.025	4.583IleIle: 4.583 ± 0.052	4.697IleLys: 4.697 ± 0.057	5.517IleLeu: 5.517 ± 0.065	1.231IleMet: 1.231 ± 0.026	4.072IleAsn: 4.072 ± 0.047	2.783IlePro: 2.783 ± 0.033	2.387IleGln: 2.387 ± 0.036	2.588IleArg: 2.588 ± 0.033	4.903IleSer: 4.903 ± 0.049	4.295IleThr: 4.295 ± 0.049	4.478IleVal: 4.478 ± 0.051	0.588IleTrp: 0.588 ± 0.016	2.119IleTyr: 2.119 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	5.243LysAla: 5.243 ± 0.063	0.35LysCys: 0.35 ± 0.014	3.647LysAsp: 3.647 ± 0.044	5.37LysGlu: 5.37 ± 0.054	2.242LysPhe: 2.242 ± 0.035	4.192LysGly: 4.192 ± 0.047	1.461LysHis: 1.461 ± 0.028	4.465LysIle: 4.465 ± 0.056	5.412LysLys: 5.412 ± 0.077	6.085LysLeu: 6.085 ± 0.058	1.649LysMet: 1.649 ± 0.031	3.982LysAsn: 3.982 ± 0.053	2.433LysPro: 2.433 ± 0.03	2.956LysGln: 2.956 ± 0.039	3.187LysArg: 3.187 ± 0.043	4.012LysSer: 4.012 ± 0.045	4.019LysThr: 4.019 ± 0.048	4.469LysVal: 4.469 ± 0.048	0.737LysTrp: 0.737 ± 0.018	2.285LysTyr: 2.285 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.721LeuAla: 7.721 ± 0.07	0.799LeuCys: 0.799 ± 0.019	5.208LeuAsp: 5.208 ± 0.045	5.997LeuGlu: 5.997 ± 0.061	4.477LeuPhe: 4.477 ± 0.057	6.085LeuGly: 6.085 ± 0.051	1.875LeuHis: 1.875 ± 0.029	6.131LeuIle: 6.131 ± 0.07	6.458LeuLys: 6.458 ± 0.073	9.15LeuLeu: 9.15 ± 0.088	2.132LeuMet: 2.132 ± 0.038	5.198LeuAsn: 5.198 ± 0.052	4.08LeuPro: 4.08 ± 0.041	3.531LeuGln: 3.531 ± 0.046	3.743LeuArg: 3.743 ± 0.037	7.454LeuSer: 7.454 ± 0.063	5.588LeuThr: 5.588 ± 0.049	6.002LeuVal: 6.002 ± 0.059	0.887LeuTrp: 0.887 ± 0.021	2.846LeuTyr: 2.846 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.937MetAla: 1.937 ± 0.031	0.18MetCys: 0.18 ± 0.008	1.131MetAsp: 1.131 ± 0.024	1.231MetGlu: 1.231 ± 0.025	0.883MetPhe: 0.883 ± 0.02	1.479MetGly: 1.479 ± 0.025	0.449MetHis: 0.449 ± 0.013	1.296MetIle: 1.296 ± 0.023	1.74MetLys: 1.74 ± 0.032	2.375MetLeu: 2.375 ± 0.036	0.632MetMet: 0.632 ± 0.017	1.13MetAsn: 1.13 ± 0.02	1.052MetPro: 1.052 ± 0.02	1.025MetGln: 1.025 ± 0.02	1.077MetArg: 1.077 ± 0.024	1.623MetSer: 1.623 ± 0.029	1.331MetThr: 1.331 ± 0.027	1.478MetVal: 1.478 ± 0.027	0.204MetTrp: 0.204 ± 0.008	0.643MetTyr: 0.643 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	4.077AsnAla: 4.077 ± 0.048	0.426AsnCys: 0.426 ± 0.013	3.01AsnAsp: 3.01 ± 0.037	3.424AsnGlu: 3.424 ± 0.042	2.362AsnPhe: 2.362 ± 0.04	3.615AsnGly: 3.615 ± 0.048	1.011AsnHis: 1.011 ± 0.021	3.926AsnIle: 3.926 ± 0.047	3.696AsnLys: 3.696 ± 0.052	4.617AsnLeu: 4.617 ± 0.048	1.109AsnMet: 1.109 ± 0.021	3.225AsnAsn: 3.225 ± 0.055	2.344AsnPro: 2.344 ± 0.035	1.988AsnGln: 1.988 ± 0.032	2.073AsnArg: 2.073 ± 0.031	3.345AsnSer: 3.345 ± 0.045	3.347AsnThr: 3.347 ± 0.046	3.498AsnVal: 3.498 ± 0.039	0.685AsnTrp: 0.685 ± 0.018	2.167AsnTyr: 2.167 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.422ProAla: 2.422 ± 0.034	0.26ProCys: 0.26 ± 0.011	2.137ProAsp: 2.137 ± 0.033	2.802ProGlu: 2.802 ± 0.041	1.807ProPhe: 1.807 ± 0.027	2.031ProGly: 2.031 ± 0.033	0.775ProHis: 0.775 ± 0.019	2.548ProIle: 2.548 ± 0.034	2.32ProLys: 2.32 ± 0.031	3.414ProLeu: 3.414 ± 0.038	0.786ProMet: 0.786 ± 0.019	2.009ProAsn: 2.009 ± 0.032	1.003ProPro: 1.003 ± 0.024	1.31ProGln: 1.31 ± 0.024	1.148ProArg: 1.148 ± 0.024	2.512ProSer: 2.512 ± 0.033	2.179ProThr: 2.179 ± 0.032	2.729ProVal: 2.729 ± 0.036	0.412ProTrp: 0.412 ± 0.013	1.275ProTyr: 1.275 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	2.989GlnAla: 2.989 ± 0.042	0.274GlnCys: 0.274 ± 0.012	1.663GlnAsp: 1.663 ± 0.03	2.408GlnGlu: 2.408 ± 0.034	1.732GlnPhe: 1.732 ± 0.033	2.214GlnGly: 2.214 ± 0.031	0.898GlnHis: 0.898 ± 0.019	2.358GlnIle: 2.358 ± 0.035	2.597GlnLys: 2.597 ± 0.035	4.008GlnLeu: 4.008 ± 0.045	0.877GlnMet: 0.877 ± 0.02	1.926GlnAsn: 1.926 ± 0.035	1.31GlnPro: 1.31 ± 0.021	2.125GlnGln: 2.125 ± 0.041	1.775GlnArg: 1.775 ± 0.03	2.351GlnSer: 2.351 ± 0.035	2.083GlnThr: 2.083 ± 0.031	2.381GlnVal: 2.381 ± 0.036	0.471GlnTrp: 0.471 ± 0.017	1.333GlnTyr: 1.333 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	2.923ArgAla: 2.923 ± 0.042	0.3ArgCys: 0.3 ± 0.012	2.177ArgAsp: 2.177 ± 0.034	2.804ArgGlu: 2.804 ± 0.033	2.121ArgPhe: 2.121 ± 0.03	2.328ArgGly: 2.328 ± 0.035	0.864ArgHis: 0.864 ± 0.021	2.836ArgIle: 2.836 ± 0.037	2.672ArgLys: 2.672 ± 0.038	4.05ArgLeu: 4.05 ± 0.042	1.003ArgMet: 1.003 ± 0.02	2.031ArgAsn: 2.031 ± 0.034	1.331ArgPro: 1.331 ± 0.029	1.548ArgGln: 1.548 ± 0.025	1.77ArgArg: 1.77 ± 0.031	2.179ArgSer: 2.179 ± 0.031	2.034ArgThr: 2.034 ± 0.027	2.833ArgVal: 2.833 ± 0.042	0.499ArgTrp: 0.499 ± 0.014	1.662ArgTyr: 1.662 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	4.926SerAla: 4.926 ± 0.051	0.588SerCys: 0.588 ± 0.015	3.81SerAsp: 3.81 ± 0.049	4.393SerGlu: 4.393 ± 0.048	3.422SerPhe: 3.422 ± 0.046	4.513SerGly: 4.513 ± 0.058	1.303SerHis: 1.303 ± 0.025	4.591SerIle: 4.591 ± 0.047	4.251SerLys: 4.251 ± 0.051	6.657SerLeu: 6.657 ± 0.06	1.491SerMet: 1.491 ± 0.027	3.3SerAsn: 3.3 ± 0.04	2.338SerPro: 2.338 ± 0.034	2.493SerGln: 2.493 ± 0.036	2.577SerArg: 2.577 ± 0.038	4.583SerSer: 4.583 ± 0.051	3.628SerThr: 3.628 ± 0.048	4.628SerVal: 4.628 ± 0.052	0.747SerTrp: 0.747 ± 0.02	2.426SerTyr: 2.426 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.136ThrAla: 4.136 ± 0.045	0.44ThrCys: 0.44 ± 0.014	3.128ThrAsp: 3.128 ± 0.046	3.341ThrGlu: 3.341 ± 0.036	2.686ThrPhe: 2.686 ± 0.037	4.058ThrGly: 4.058 ± 0.051	1.203ThrHis: 1.203 ± 0.024	4.192ThrIle: 4.192 ± 0.047	3.378ThrLys: 3.378 ± 0.043	6.016ThrLeu: 6.016 ± 0.052	1.064ThrMet: 1.064 ± 0.023	2.852ThrAsn: 2.852 ± 0.044	2.769ThrPro: 2.769 ± 0.04	2.268ThrGln: 2.268 ± 0.039	2.064ThrArg: 2.064 ± 0.031	3.91ThrSer: 3.91 ± 0.045	3.408ThrThr: 3.408 ± 0.05	3.989ThrVal: 3.989 ± 0.049	0.609ThrTrp: 0.609 ± 0.016	2.044ThrTyr: 2.044 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	5.346ValAla: 5.346 ± 0.062	0.628ValCys: 0.628 ± 0.018	4.032ValAsp: 4.032 ± 0.042	4.449ValGlu: 4.449 ± 0.043	3.137ValPhe: 3.137 ± 0.039	4.25ValGly: 4.25 ± 0.039	1.181ValHis: 1.181 ± 0.025	4.654ValIle: 4.654 ± 0.052	4.279ValLys: 4.279 ± 0.048	6.393ValLeu: 6.393 ± 0.062	1.569ValMet: 1.569 ± 0.027	3.604ValAsn: 3.604 ± 0.041	2.445ValPro: 2.445 ± 0.032	2.026ValGln: 2.026 ± 0.035	2.548ValArg: 2.548 ± 0.034	5.097ValSer: 5.097 ± 0.047	4.109ValThr: 4.109 ± 0.053	4.961ValVal: 4.961 ± 0.056	0.679ValTrp: 0.679 ± 0.019	2.127ValTyr: 2.127 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.713TrpAla: 0.713 ± 0.017	0.111TrpCys: 0.111 ± 0.007	0.592TrpAsp: 0.592 ± 0.018	0.622TrpGlu: 0.622 ± 0.016	0.586TrpPhe: 0.586 ± 0.015	0.694TrpGly: 0.694 ± 0.018	0.287TrpHis: 0.287 ± 0.01	0.673TrpIle: 0.673 ± 0.018	0.68TrpLys: 0.68 ± 0.018	1.308TrpLeu: 1.308 ± 0.024	0.314TrpMet: 0.314 ± 0.011	0.563TrpAsn: 0.563 ± 0.017	0.321TrpPro: 0.321 ± 0.013	0.603TrpGln: 0.603 ± 0.019	0.569TrpArg: 0.569 ± 0.015	0.661TrpSer: 0.661 ± 0.018	0.502TrpThr: 0.502 ± 0.017	0.748TrpVal: 0.748 ± 0.019	0.162TrpTrp: 0.162 ± 0.009	0.411TrpTyr: 0.411 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.42TyrAla: 2.42 ± 0.033	0.336TyrCys: 0.336 ± 0.013	2.025TyrAsp: 2.025 ± 0.034	2.093TyrGlu: 2.093 ± 0.03	1.878TyrPhe: 1.878 ± 0.033	2.324TyrGly: 2.324 ± 0.034	0.776TyrHis: 0.776 ± 0.02	2.129TyrIle: 2.129 ± 0.035	2.423TyrLys: 2.423 ± 0.037	3.412TyrLeu: 3.412 ± 0.041	0.648TyrMet: 0.648 ± 0.016	1.955TyrAsn: 1.955 ± 0.039	1.338TyrPro: 1.338 ± 0.021	1.564TyrGln: 1.564 ± 0.026	1.644TyrArg: 1.644 ± 0.026	2.309TyrSer: 2.309 ± 0.033	2.061TyrThr: 2.061 ± 0.036	2.069TyrVal: 2.069 ± 0.035	0.479TyrTrp: 0.479 ± 0.014	1.39TyrTyr: 1.39 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6803 proteins (2271612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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