Amino acid dipepetide frequency for Streptomyces oceani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.944AlaAla: 18.944 ± 0.184	1.061AlaCys: 1.061 ± 0.025	8.059AlaAsp: 8.059 ± 0.086	9.902AlaGlu: 9.902 ± 0.104	3.226AlaPhe: 3.226 ± 0.051	12.836AlaGly: 12.836 ± 0.113	2.8AlaHis: 2.8 ± 0.049	3.062AlaIle: 3.062 ± 0.053	2.467AlaLys: 2.467 ± 0.052	13.841AlaLeu: 13.841 ± 0.131	2.503AlaMet: 2.503 ± 0.045	1.877AlaAsn: 1.877 ± 0.037	6.49AlaPro: 6.49 ± 0.08	3.688AlaGln: 3.688 ± 0.06	10.421AlaArg: 10.421 ± 0.11	5.907AlaSer: 5.907 ± 0.069	6.732AlaThr: 6.732 ± 0.065	11.425AlaVal: 11.425 ± 0.097	1.593AlaTrp: 1.593 ± 0.032	2.678AlaTyr: 2.678 ± 0.041	0.003AlaXaa: 0.003 ± 0.001
Cys	1.133CysAla: 1.133 ± 0.027	0.103CysCys: 0.103 ± 0.01	0.481CysAsp: 0.481 ± 0.021	0.467CysGlu: 0.467 ± 0.017	0.228CysPhe: 0.228 ± 0.013	1.012CysGly: 1.012 ± 0.028	0.204CysHis: 0.204 ± 0.011	0.124CysIle: 0.124 ± 0.009	0.099CysLys: 0.099 ± 0.008	0.743CysLeu: 0.743 ± 0.025	0.13CysMet: 0.13 ± 0.009	0.12CysAsn: 0.12 ± 0.01	0.5CysPro: 0.5 ± 0.02	0.206CysGln: 0.206 ± 0.011	0.664CysArg: 0.664 ± 0.022	0.466CysSer: 0.466 ± 0.021	0.47CysThr: 0.47 ± 0.019	0.739CysVal: 0.739 ± 0.022	0.131CysTrp: 0.131 ± 0.009	0.161CysTyr: 0.161 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.404AspAla: 7.404 ± 0.079	0.441AspCys: 0.441 ± 0.017	3.327AspAsp: 3.327 ± 0.052	4.296AspGlu: 4.296 ± 0.055	1.744AspPhe: 1.744 ± 0.035	6.318AspGly: 6.318 ± 0.066	1.347AspHis: 1.347 ± 0.032	1.828AspIle: 1.828 ± 0.038	1.108AspLys: 1.108 ± 0.035	5.872AspLeu: 5.872 ± 0.075	0.942AspMet: 0.942 ± 0.026	0.877AspAsn: 0.877 ± 0.025	4.601AspPro: 4.601 ± 0.06	1.81AspGln: 1.81 ± 0.034	4.844AspArg: 4.844 ± 0.06	3.093AspSer: 3.093 ± 0.052	3.515AspThr: 3.515 ± 0.053	4.629AspVal: 4.629 ± 0.058	1.077AspTrp: 1.077 ± 0.028	1.204AspTyr: 1.204 ± 0.031	0.001AspXaa: 0.001 ± 0.001
Glu	7.882GluAla: 7.882 ± 0.102	0.477GluCys: 0.477 ± 0.018	3.268GluAsp: 3.268 ± 0.052	4.362GluGlu: 4.362 ± 0.064	1.618GluPhe: 1.618 ± 0.035	4.963GluGly: 4.963 ± 0.065	1.861GluHis: 1.861 ± 0.039	2.226GluIle: 2.226 ± 0.046	1.483GluLys: 1.483 ± 0.039	7.797GluLeu: 7.797 ± 0.076	1.014GluMet: 1.014 ± 0.025	1.012GluAsn: 1.012 ± 0.027	4.097GluPro: 4.097 ± 0.069	2.557GluGln: 2.557 ± 0.051	6.671GluArg: 6.671 ± 0.078	3.252GluSer: 3.252 ± 0.057	3.101GluThr: 3.101 ± 0.045	5.203GluVal: 5.203 ± 0.071	0.844GluTrp: 0.844 ± 0.025	1.223GluTyr: 1.223 ± 0.032	0.001GluXaa: 0.001 ± 0.001
Phe	3.476PheAla: 3.476 ± 0.052	0.259PheCys: 0.259 ± 0.013	1.97PheAsp: 1.97 ± 0.041	1.554PheGlu: 1.554 ± 0.036	0.866PhePhe: 0.866 ± 0.031	3.018PheGly: 3.018 ± 0.058	0.614PheHis: 0.614 ± 0.02	0.674PheIle: 0.674 ± 0.022	0.421PheLys: 0.421 ± 0.02	2.623PheLeu: 2.623 ± 0.047	0.39PheMet: 0.39 ± 0.016	0.5PheAsn: 0.5 ± 0.019	1.361PhePro: 1.361 ± 0.035	0.707PheGln: 0.707 ± 0.02	1.894PheArg: 1.894 ± 0.042	1.435PheSer: 1.435 ± 0.033	1.814PheThr: 1.814 ± 0.035	2.285PheVal: 2.285 ± 0.043	0.392PheTrp: 0.392 ± 0.016	0.543PheTyr: 0.543 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.903GlyAla: 10.903 ± 0.108	0.874GlyCys: 0.874 ± 0.03	5.219GlyAsp: 5.219 ± 0.065	5.939GlyGlu: 5.939 ± 0.073	2.832GlyPhe: 2.832 ± 0.05	9.281GlyGly: 9.281 ± 0.101	2.328GlyHis: 2.328 ± 0.042	3.058GlyIle: 3.058 ± 0.052	2.25GlyLys: 2.25 ± 0.053	9.333GlyLeu: 9.333 ± 0.091	2.25GlyMet: 2.25 ± 0.04	1.624GlyAsn: 1.624 ± 0.037	5.176GlyPro: 5.176 ± 0.073	2.933GlyGln: 2.933 ± 0.05	7.461GlyArg: 7.461 ± 0.069	5.683GlySer: 5.683 ± 0.062	6.09GlyThr: 6.09 ± 0.076	7.845GlyVal: 7.845 ± 0.104	1.714GlyTrp: 1.714 ± 0.036	2.279GlyTyr: 2.279 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.782HisAla: 2.782 ± 0.053	0.224HisCys: 0.224 ± 0.013	1.321HisAsp: 1.321 ± 0.032	1.321HisGlu: 1.321 ± 0.033	0.669HisPhe: 0.669 ± 0.023	2.566HisGly: 2.566 ± 0.049	0.639HisHis: 0.639 ± 0.022	0.622HisIle: 0.622 ± 0.021	0.326HisLys: 0.326 ± 0.017	2.324HisLeu: 2.324 ± 0.043	0.342HisMet: 0.342 ± 0.015	0.366HisAsn: 0.366 ± 0.015	1.779HisPro: 1.779 ± 0.039	0.746HisGln: 0.746 ± 0.024	2.06HisArg: 2.06 ± 0.038	1.141HisSer: 1.141 ± 0.029	1.39HisThr: 1.39 ± 0.033	1.747HisVal: 1.747 ± 0.034	0.365HisTrp: 0.365 ± 0.017	0.487HisTyr: 0.487 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.202IleAla: 4.202 ± 0.063	0.285IleCys: 0.285 ± 0.015	2.027IleAsp: 2.027 ± 0.038	1.909IleGlu: 1.909 ± 0.033	0.71IlePhe: 0.71 ± 0.023	3.253IleGly: 3.253 ± 0.051	0.55IleHis: 0.55 ± 0.021	0.814IleIle: 0.814 ± 0.023	0.656IleLys: 0.656 ± 0.023	2.141IleLeu: 2.141 ± 0.039	0.441IleMet: 0.441 ± 0.019	0.668IleAsn: 0.668 ± 0.02	1.586IlePro: 1.586 ± 0.033	0.7IleGln: 0.7 ± 0.024	2.119IleArg: 2.119 ± 0.046	1.683IleSer: 1.683 ± 0.033	1.936IleThr: 1.936 ± 0.04	2.458IleVal: 2.458 ± 0.048	0.334IleTrp: 0.334 ± 0.014	0.49IleTyr: 0.49 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.347LysAla: 2.347 ± 0.048	0.117LysCys: 0.117 ± 0.01	1.131LysAsp: 1.131 ± 0.036	1.13LysGlu: 1.13 ± 0.032	0.399LysPhe: 0.399 ± 0.018	1.608LysGly: 1.608 ± 0.045	0.451LysHis: 0.451 ± 0.017	0.713LysIle: 0.713 ± 0.023	0.765LysLys: 0.765 ± 0.043	1.922LysLeu: 1.922 ± 0.033	0.357LysMet: 0.357 ± 0.018	0.412LysAsn: 0.412 ± 0.02	1.28LysPro: 1.28 ± 0.033	0.721LysGln: 0.721 ± 0.028	1.509LysArg: 1.509 ± 0.035	1.149LysSer: 1.149 ± 0.031	1.114LysThr: 1.114 ± 0.033	1.544LysVal: 1.544 ± 0.036	0.227LysTrp: 0.227 ± 0.013	0.406LysTyr: 0.406 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.914LeuAla: 14.914 ± 0.127	0.883LeuCys: 0.883 ± 0.027	6.799LeuAsp: 6.799 ± 0.068	5.455LeuGlu: 5.455 ± 0.078	2.619LeuPhe: 2.619 ± 0.047	9.418LeuGly: 9.418 ± 0.091	2.278LeuHis: 2.278 ± 0.047	2.924LeuIle: 2.924 ± 0.051	1.609LeuLys: 1.609 ± 0.038	11.754LeuLeu: 11.754 ± 0.119	1.544LeuMet: 1.544 ± 0.035	1.679LeuAsn: 1.679 ± 0.032	6.477LeuPro: 6.477 ± 0.077	2.041LeuGln: 2.041 ± 0.042	9.412LeuArg: 9.412 ± 0.094	5.862LeuSer: 5.862 ± 0.072	6.701LeuThr: 6.701 ± 0.07	8.895LeuVal: 8.895 ± 0.097	1.285LeuTrp: 1.285 ± 0.033	1.794LeuTyr: 1.794 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.318MetAla: 2.318 ± 0.046	0.136MetCys: 0.136 ± 0.01	0.94MetAsp: 0.94 ± 0.027	0.837MetGlu: 0.837 ± 0.027	0.455MetPhe: 0.455 ± 0.02	1.348MetGly: 1.348 ± 0.033	0.349MetHis: 0.349 ± 0.014	0.644MetIle: 0.644 ± 0.025	0.372MetLys: 0.372 ± 0.016	1.877MetLeu: 1.877 ± 0.037	0.308MetMet: 0.308 ± 0.015	0.393MetAsn: 0.393 ± 0.017	1.184MetPro: 1.184 ± 0.027	0.445MetGln: 0.445 ± 0.017	1.522MetArg: 1.522 ± 0.031	1.348MetSer: 1.348 ± 0.031	1.501MetThr: 1.501 ± 0.035	1.325MetVal: 1.325 ± 0.036	0.206MetTrp: 0.206 ± 0.012	0.332MetTyr: 0.332 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	2.031AsnAla: 2.031 ± 0.044	0.173AsnCys: 0.173 ± 0.01	0.935AsnAsp: 0.935 ± 0.028	0.83AsnGlu: 0.83 ± 0.025	0.451AsnPhe: 0.451 ± 0.019	1.649AsnGly: 1.649 ± 0.037	0.395AsnHis: 0.395 ± 0.016	0.642AsnIle: 0.642 ± 0.02	0.412AsnLys: 0.412 ± 0.02	1.592AsnLeu: 1.592 ± 0.031	0.288AsnMet: 0.288 ± 0.016	0.368AsnAsn: 0.368 ± 0.018	1.282AsnPro: 1.282 ± 0.031	0.553AsnGln: 0.553 ± 0.018	1.277AsnArg: 1.277 ± 0.034	0.928AsnSer: 0.928 ± 0.029	1.064AsnThr: 1.064 ± 0.029	1.267AsnVal: 1.267 ± 0.026	0.283AsnTrp: 0.283 ± 0.014	0.396AsnTyr: 0.396 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.041ProAla: 8.041 ± 0.092	0.335ProCys: 0.335 ± 0.017	4.561ProAsp: 4.561 ± 0.059	5.288ProGlu: 5.288 ± 0.065	1.47ProPhe: 1.47 ± 0.032	6.52ProGly: 6.52 ± 0.08	1.419ProHis: 1.419 ± 0.033	1.269ProIle: 1.269 ± 0.031	1.106ProLys: 1.106 ± 0.033	5.188ProLeu: 5.188 ± 0.072	0.977ProMet: 0.977 ± 0.026	0.942ProAsn: 0.942 ± 0.027	3.508ProPro: 3.508 ± 0.075	1.65ProGln: 1.65 ± 0.038	4.143ProArg: 4.143 ± 0.057	3.228ProSer: 3.228 ± 0.054	3.097ProThr: 3.097 ± 0.043	5.197ProVal: 5.197 ± 0.073	0.869ProTrp: 0.869 ± 0.026	1.44ProTyr: 1.44 ± 0.032	0.003ProXaa: 0.003 ± 0.001
Gln	3.584GlnAla: 3.584 ± 0.061	0.173GlnCys: 0.173 ± 0.01	1.519GlnAsp: 1.519 ± 0.03	1.678GlnGlu: 1.678 ± 0.037	0.659GlnPhe: 0.659 ± 0.021	2.27GlnGly: 2.27 ± 0.04	0.818GlnHis: 0.818 ± 0.03	0.933GlnIle: 0.933 ± 0.025	0.498GlnLys: 0.498 ± 0.02	3.588GlnLeu: 3.588 ± 0.055	0.45GlnMet: 0.45 ± 0.017	0.433GlnAsn: 0.433 ± 0.019	2.027GlnPro: 2.027 ± 0.046	1.403GlnGln: 1.403 ± 0.042	2.956GlnArg: 2.956 ± 0.047	1.323GlnSer: 1.323 ± 0.032	1.273GlnThr: 1.273 ± 0.037	2.358GlnVal: 2.358 ± 0.045	0.392GlnTrp: 0.392 ± 0.017	0.518GlnTyr: 0.518 ± 0.02	0.001GlnXaa: 0.001 ± 0.001
Arg	10.074ArgAla: 10.074 ± 0.093	0.676ArgCys: 0.676 ± 0.024	4.692ArgAsp: 4.692 ± 0.05	5.651ArgGlu: 5.651 ± 0.068	2.373ArgPhe: 2.373 ± 0.042	6.238ArgGly: 6.238 ± 0.07	2.205ArgHis: 2.205 ± 0.037	2.987ArgIle: 2.987 ± 0.05	1.672ArgLys: 1.672 ± 0.043	9.036ArgLeu: 9.036 ± 0.089	1.901ArgMet: 1.901 ± 0.041	1.387ArgAsn: 1.387 ± 0.031	4.758ArgPro: 4.758 ± 0.065	2.658ArgGln: 2.658 ± 0.046	7.74ArgArg: 7.74 ± 0.093	4.195ArgSer: 4.195 ± 0.057	5.489ArgThr: 5.489 ± 0.065	6.507ArgVal: 6.507 ± 0.068	1.451ArgTrp: 1.451 ± 0.031	1.871ArgTyr: 1.871 ± 0.032	0.001ArgXaa: 0.001 ± 0.001
Ser	7.09SerAla: 7.09 ± 0.079	0.451SerCys: 0.451 ± 0.019	2.973SerAsp: 2.973 ± 0.046	3.177SerGlu: 3.177 ± 0.057	1.544SerPhe: 1.544 ± 0.034	6.39SerGly: 6.39 ± 0.077	1.055SerHis: 1.055 ± 0.026	1.29SerIle: 1.29 ± 0.031	0.964SerLys: 0.964 ± 0.026	4.986SerLeu: 4.986 ± 0.068	1.156SerMet: 1.156 ± 0.028	0.886SerAsn: 0.886 ± 0.026	3.233SerPro: 3.233 ± 0.045	1.416SerGln: 1.416 ± 0.032	3.942SerArg: 3.942 ± 0.056	3.04SerSer: 3.04 ± 0.053	3.175SerThr: 3.175 ± 0.045	4.619SerVal: 4.619 ± 0.058	0.957SerTrp: 0.957 ± 0.025	1.239SerTyr: 1.239 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.027ThrAla: 8.027 ± 0.081	0.377ThrCys: 0.377 ± 0.018	3.729ThrAsp: 3.729 ± 0.046	3.87ThrGlu: 3.87 ± 0.053	1.515ThrPhe: 1.515 ± 0.034	6.495ThrGly: 6.495 ± 0.078	1.206ThrHis: 1.206 ± 0.028	1.489ThrIle: 1.489 ± 0.035	1.069ThrLys: 1.069 ± 0.031	5.808ThrLeu: 5.808 ± 0.072	1.005ThrMet: 1.005 ± 0.029	0.998ThrAsn: 0.998 ± 0.025	3.786ThrPro: 3.786 ± 0.056	1.327ThrGln: 1.327 ± 0.031	3.908ThrArg: 3.908 ± 0.055	3.248ThrSer: 3.248 ± 0.045	3.433ThrThr: 3.433 ± 0.05	5.929ThrVal: 5.929 ± 0.069	0.718ThrTrp: 0.718 ± 0.022	1.265ThrTyr: 1.265 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.043ValAla: 10.043 ± 0.092	0.785ValCys: 0.785 ± 0.023	4.994ValAsp: 4.994 ± 0.071	5.073ValGlu: 5.073 ± 0.085	2.328ValPhe: 2.328 ± 0.047	6.609ValGly: 6.609 ± 0.086	1.928ValHis: 1.928 ± 0.039	2.794ValIle: 2.794 ± 0.047	1.421ValLys: 1.421 ± 0.034	9.962ValLeu: 9.962 ± 0.095	1.334ValMet: 1.334 ± 0.031	1.618ValAsn: 1.618 ± 0.035	5.23ValPro: 5.23 ± 0.068	2.01ValGln: 2.01 ± 0.033	7.879ValArg: 7.879 ± 0.075	4.714ValSer: 4.714 ± 0.065	5.33ValThr: 5.33 ± 0.061	7.524ValVal: 7.524 ± 0.1	1.105ValTrp: 1.105 ± 0.032	1.465ValTyr: 1.465 ± 0.029	0.001ValXaa: 0.001 ± 0.001
Trp	1.477TrpAla: 1.477 ± 0.031	0.164TrpCys: 0.164 ± 0.009	0.84TrpAsp: 0.84 ± 0.028	0.79TrpGlu: 0.79 ± 0.022	0.486TrpPhe: 0.486 ± 0.018	1.011TrpGly: 1.011 ± 0.026	0.355TrpHis: 0.355 ± 0.016	0.476TrpIle: 0.476 ± 0.019	0.294TrpLys: 0.294 ± 0.015	1.843TrpLeu: 1.843 ± 0.035	0.287TrpMet: 0.287 ± 0.016	0.324TrpAsn: 0.324 ± 0.015	0.784TrpPro: 0.784 ± 0.025	0.596TrpGln: 0.596 ± 0.019	1.416TrpArg: 1.416 ± 0.032	0.957TrpSer: 0.957 ± 0.027	0.902TrpThr: 0.902 ± 0.026	0.977TrpVal: 0.977 ± 0.027	0.316TrpTrp: 0.316 ± 0.016	0.333TrpTyr: 0.333 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.84TyrAla: 2.84 ± 0.046	0.189TyrCys: 0.189 ± 0.013	1.492TyrAsp: 1.492 ± 0.037	1.38TyrGlu: 1.38 ± 0.033	0.603TyrPhe: 0.603 ± 0.021	2.272TyrGly: 2.272 ± 0.045	0.413TyrHis: 0.413 ± 0.018	0.394TyrIle: 0.394 ± 0.016	0.31TyrLys: 0.31 ± 0.014	2.112TyrLeu: 2.112 ± 0.037	0.219TyrMet: 0.219 ± 0.011	0.33TyrAsn: 0.33 ± 0.016	1.112TyrPro: 1.112 ± 0.031	0.687TyrGln: 0.687 ± 0.02	1.723TyrArg: 1.723 ± 0.033	0.928TyrSer: 0.928 ± 0.026	1.077TyrThr: 1.077 ± 0.027	1.674TyrVal: 1.674 ± 0.036	0.369TyrTrp: 0.369 ± 0.017	0.401TyrTyr: 0.401 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4624 proteins (1511313 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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