Amino acid dipepetide frequency for Seonamhaeicola sp. S2-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.795AlaAla: 3.795 ± 0.078	0.602AlaCys: 0.602 ± 0.027	3.041AlaAsp: 3.041 ± 0.055	3.837AlaGlu: 3.837 ± 0.072	3.362AlaPhe: 3.362 ± 0.061	3.646AlaGly: 3.646 ± 0.064	1.096AlaHis: 1.096 ± 0.035	5.403AlaIle: 5.403 ± 0.076	4.865AlaLys: 4.865 ± 0.077	6.329AlaLeu: 6.329 ± 0.101	1.338AlaMet: 1.338 ± 0.037	3.774AlaAsn: 3.774 ± 0.07	1.803AlaPro: 1.803 ± 0.041	2.22AlaGln: 2.22 ± 0.051	1.821AlaArg: 1.821 ± 0.049	4.152AlaSer: 4.152 ± 0.066	3.497AlaThr: 3.497 ± 0.054	3.844AlaVal: 3.844 ± 0.076	0.596AlaTrp: 0.596 ± 0.026	2.531AlaTyr: 2.531 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.426CysAla: 0.426 ± 0.019	0.082CysCys: 0.082 ± 0.01	0.426CysAsp: 0.426 ± 0.023	0.458CysGlu: 0.458 ± 0.022	0.454CysPhe: 0.454 ± 0.021	0.553CysGly: 0.553 ± 0.029	0.206CysHis: 0.206 ± 0.017	0.593CysIle: 0.593 ± 0.027	0.537CysLys: 0.537 ± 0.021	0.655CysLeu: 0.655 ± 0.023	0.152CysMet: 0.152 ± 0.011	0.466CysAsn: 0.466 ± 0.021	0.312CysPro: 0.312 ± 0.018	0.215CysGln: 0.215 ± 0.016	0.181CysArg: 0.181 ± 0.013	0.588CysSer: 0.588 ± 0.025	0.427CysThr: 0.427 ± 0.023	0.477CysVal: 0.477 ± 0.021	0.069CysTrp: 0.069 ± 0.008	0.344CysTyr: 0.344 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.592AspAla: 3.592 ± 0.074	0.429AspCys: 0.429 ± 0.022	3.172AspAsp: 3.172 ± 0.069	3.718AspGlu: 3.718 ± 0.06	3.524AspPhe: 3.524 ± 0.059	3.534AspGly: 3.534 ± 0.08	0.725AspHis: 0.725 ± 0.029	4.723AspIle: 4.723 ± 0.073	4.171AspLys: 4.171 ± 0.071	4.906AspLeu: 4.906 ± 0.068	1.099AspMet: 1.099 ± 0.034	3.38AspAsn: 3.38 ± 0.069	1.416AspPro: 1.416 ± 0.043	1.158AspGln: 1.158 ± 0.032	1.642AspArg: 1.642 ± 0.04	3.039AspSer: 3.039 ± 0.052	2.897AspThr: 2.897 ± 0.052	3.783AspVal: 3.783 ± 0.065	0.711AspTrp: 0.711 ± 0.023	2.91AspTyr: 2.91 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.642GluAla: 4.642 ± 0.089	0.307GluCys: 0.307 ± 0.016	3.645GluAsp: 3.645 ± 0.065	4.522GluGlu: 4.522 ± 0.09	3.02GluPhe: 3.02 ± 0.056	3.57GluGly: 3.57 ± 0.065	1.162GluHis: 1.162 ± 0.034	5.327GluIle: 5.327 ± 0.072	5.467GluLys: 5.467 ± 0.087	6.054GluLeu: 6.054 ± 0.08	1.333GluMet: 1.333 ± 0.032	4.847GluAsn: 4.847 ± 0.073	1.616GluPro: 1.616 ± 0.039	2.248GluGln: 2.248 ± 0.05	2.354GluArg: 2.354 ± 0.057	3.39GluSer: 3.39 ± 0.055	3.981GluThr: 3.981 ± 0.057	4.152GluVal: 4.152 ± 0.066	0.577GluTrp: 0.577 ± 0.023	2.429GluTyr: 2.429 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.685PheAla: 2.685 ± 0.051	0.466PheCys: 0.466 ± 0.021	3.061PheAsp: 3.061 ± 0.058	3.422PheGlu: 3.422 ± 0.06	2.632PhePhe: 2.632 ± 0.06	3.495PheGly: 3.495 ± 0.064	0.808PheHis: 0.808 ± 0.028	4.117PheIle: 4.117 ± 0.072	4.54PheLys: 4.54 ± 0.069	4.7PheLeu: 4.7 ± 0.076	1.067PheMet: 1.067 ± 0.032	3.902PheAsn: 3.902 ± 0.067	1.652PhePro: 1.652 ± 0.036	1.439PheGln: 1.439 ± 0.035	1.485PheArg: 1.485 ± 0.035	4.017PheSer: 4.017 ± 0.066	3.091PheThr: 3.091 ± 0.066	2.939PheVal: 2.939 ± 0.055	0.568PheTrp: 0.568 ± 0.023	2.134PheTyr: 2.134 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.024GlyAla: 4.024 ± 0.079	0.614GlyCys: 0.614 ± 0.031	3.266GlyAsp: 3.266 ± 0.067	3.55GlyGlu: 3.55 ± 0.055	3.56GlyPhe: 3.56 ± 0.065	4.143GlyGly: 4.143 ± 0.085	1.057GlyHis: 1.057 ± 0.031	5.147GlyIle: 5.147 ± 0.075	4.806GlyLys: 4.806 ± 0.072	5.563GlyLeu: 5.563 ± 0.079	1.435GlyMet: 1.435 ± 0.043	3.74GlyAsn: 3.74 ± 0.069	1.244GlyPro: 1.244 ± 0.034	1.649GlyGln: 1.649 ± 0.042	1.949GlyArg: 1.949 ± 0.048	3.777GlySer: 3.777 ± 0.067	3.902GlyThr: 3.902 ± 0.094	4.375GlyVal: 4.375 ± 0.073	0.725GlyTrp: 0.725 ± 0.027	2.871GlyTyr: 2.871 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.982HisAla: 0.982 ± 0.028	0.179HisCys: 0.179 ± 0.014	0.854HisAsp: 0.854 ± 0.031	0.936HisGlu: 0.936 ± 0.036	1.163HisPhe: 1.163 ± 0.033	1.105HisGly: 1.105 ± 0.036	0.463HisHis: 0.463 ± 0.023	1.532HisIle: 1.532 ± 0.038	1.358HisLys: 1.358 ± 0.038	1.824HisLeu: 1.824 ± 0.043	0.315HisMet: 0.315 ± 0.016	1.09HisAsn: 1.09 ± 0.03	0.853HisPro: 0.853 ± 0.027	0.655HisGln: 0.655 ± 0.028	0.616HisArg: 0.616 ± 0.026	1.023HisSer: 1.023 ± 0.029	0.926HisThr: 0.926 ± 0.028	1.01HisVal: 1.01 ± 0.03	0.212HisTrp: 0.212 ± 0.014	0.863HisTyr: 0.863 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.471IleAla: 5.471 ± 0.079	0.598IleCys: 0.598 ± 0.027	5.066IleAsp: 5.066 ± 0.076	5.84IleGlu: 5.84 ± 0.075	3.57IlePhe: 3.57 ± 0.075	4.894IleGly: 4.894 ± 0.08	1.382IleHis: 1.382 ± 0.036	6.432IleIle: 6.432 ± 0.098	6.788IleLys: 6.788 ± 0.104	6.969IleLeu: 6.969 ± 0.108	1.367IleMet: 1.367 ± 0.039	5.449IleAsn: 5.449 ± 0.079	3.205IlePro: 3.205 ± 0.057	2.339IleGln: 2.339 ± 0.049	2.363IleArg: 2.363 ± 0.049	5.716IleSer: 5.716 ± 0.082	4.993IleThr: 4.993 ± 0.074	4.709IleVal: 4.709 ± 0.073	0.716IleTrp: 0.716 ± 0.027	2.91IleTyr: 2.91 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.385LysAla: 5.385 ± 0.084	0.391LysCys: 0.391 ± 0.02	4.595LysAsp: 4.595 ± 0.064	6.308LysGlu: 6.308 ± 0.1	3.155LysPhe: 3.155 ± 0.059	4.737LysGly: 4.737 ± 0.07	1.797LysHis: 1.797 ± 0.043	6.381LysIle: 6.381 ± 0.085	7.345LysLys: 7.345 ± 0.1	7.272LysLeu: 7.272 ± 0.101	1.828LysMet: 1.828 ± 0.039	6.01LysAsn: 6.01 ± 0.086	2.893LysPro: 2.893 ± 0.059	3.244LysGln: 3.244 ± 0.064	3.041LysArg: 3.041 ± 0.055	4.742LysSer: 4.742 ± 0.076	5.419LysThr: 5.419 ± 0.074	4.831LysVal: 4.831 ± 0.074	0.812LysTrp: 0.812 ± 0.026	3.265LysTyr: 3.265 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.491LeuAla: 5.491 ± 0.095	0.708LeuCys: 0.708 ± 0.028	4.885LeuAsp: 4.885 ± 0.061	5.975LeuGlu: 5.975 ± 0.083	4.803LeuPhe: 4.803 ± 0.078	5.675LeuGly: 5.675 ± 0.083	1.554LeuHis: 1.554 ± 0.039	7.051LeuIle: 7.051 ± 0.111	8.769LeuLys: 8.769 ± 0.105	8.467LeuLeu: 8.467 ± 0.12	1.904LeuMet: 1.904 ± 0.045	6.533LeuAsn: 6.533 ± 0.096	3.488LeuPro: 3.488 ± 0.056	2.99LeuGln: 2.99 ± 0.053	2.956LeuArg: 2.956 ± 0.059	6.54LeuSer: 6.54 ± 0.081	5.106LeuThr: 5.106 ± 0.071	5.449LeuVal: 5.449 ± 0.074	0.823LeuTrp: 0.823 ± 0.032	3.34LeuTyr: 3.34 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.539MetAla: 1.539 ± 0.04	0.136MetCys: 0.136 ± 0.012	0.955MetAsp: 0.955 ± 0.03	1.124MetGlu: 1.124 ± 0.033	0.922MetPhe: 0.922 ± 0.033	1.274MetGly: 1.274 ± 0.035	0.354MetHis: 0.354 ± 0.016	1.32MetIle: 1.32 ± 0.04	2.0MetLys: 2.0 ± 0.037	1.875MetLeu: 1.875 ± 0.045	0.51MetMet: 0.51 ± 0.023	1.226MetAsn: 1.226 ± 0.035	0.844MetPro: 0.844 ± 0.028	0.757MetGln: 0.757 ± 0.026	0.785MetArg: 0.785 ± 0.028	1.331MetSer: 1.331 ± 0.03	0.987MetThr: 0.987 ± 0.031	1.315MetVal: 1.315 ± 0.035	0.158MetTrp: 0.158 ± 0.012	0.682MetTyr: 0.682 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.075AsnAla: 4.075 ± 0.068	0.504AsnCys: 0.504 ± 0.025	3.481AsnAsp: 3.481 ± 0.058	4.126AsnGlu: 4.126 ± 0.067	3.362AsnPhe: 3.362 ± 0.064	4.076AsnGly: 4.076 ± 0.088	1.222AsnHis: 1.222 ± 0.033	5.636AsnIle: 5.636 ± 0.084	5.483AsnLys: 5.483 ± 0.083	6.097AsnLeu: 6.097 ± 0.08	1.325AsnMet: 1.325 ± 0.038	5.216AsnAsn: 5.216 ± 0.096	2.901AsnPro: 2.901 ± 0.06	2.406AsnGln: 2.406 ± 0.048	2.16AsnArg: 2.16 ± 0.047	4.231AsnSer: 4.231 ± 0.077	4.321AsnThr: 4.321 ± 0.082	3.853AsnVal: 3.853 ± 0.068	0.851AsnTrp: 0.851 ± 0.028	3.258AsnTyr: 3.258 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.632ProAla: 1.632 ± 0.046	0.223ProCys: 0.223 ± 0.015	1.99ProAsp: 1.99 ± 0.049	2.818ProGlu: 2.818 ± 0.056	1.863ProPhe: 1.863 ± 0.043	1.708ProGly: 1.708 ± 0.044	0.646ProHis: 0.646 ± 0.026	2.8ProIle: 2.8 ± 0.055	2.818ProLys: 2.818 ± 0.056	2.951ProLeu: 2.951 ± 0.057	0.653ProMet: 0.653 ± 0.024	2.5ProAsn: 2.5 ± 0.051	0.819ProPro: 0.819 ± 0.032	1.096ProGln: 1.096 ± 0.028	0.886ProArg: 0.886 ± 0.032	2.075ProSer: 2.075 ± 0.042	1.901ProThr: 1.901 ± 0.046	2.232ProVal: 2.232 ± 0.046	0.331ProTrp: 0.331 ± 0.018	1.428ProTyr: 1.428 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.947GlnAla: 1.947 ± 0.047	0.173GlnCys: 0.173 ± 0.013	1.621GlnAsp: 1.621 ± 0.042	2.074GlnGlu: 2.074 ± 0.05	1.64GlnPhe: 1.64 ± 0.038	1.745GlnGly: 1.745 ± 0.046	0.6GlnHis: 0.6 ± 0.023	2.684GlnIle: 2.684 ± 0.058	2.652GlnLys: 2.652 ± 0.057	3.343GlnLeu: 3.343 ± 0.062	0.727GlnMet: 0.727 ± 0.025	2.206GlnAsn: 2.206 ± 0.048	1.059GlnPro: 1.059 ± 0.029	1.309GlnGln: 1.309 ± 0.042	1.149GlnArg: 1.149 ± 0.034	1.808GlnSer: 1.808 ± 0.039	1.869GlnThr: 1.869 ± 0.04	1.882GlnVal: 1.882 ± 0.041	0.343GlnTrp: 0.343 ± 0.016	1.33GlnTyr: 1.33 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.976ArgAla: 1.976 ± 0.043	0.209ArgCys: 0.209 ± 0.014	1.637ArgAsp: 1.637 ± 0.037	1.955ArgGlu: 1.955 ± 0.048	1.801ArgPhe: 1.801 ± 0.035	1.889ArgGly: 1.889 ± 0.04	0.633ArgHis: 0.633 ± 0.026	2.69ArgIle: 2.69 ± 0.051	2.628ArgLys: 2.628 ± 0.056	3.142ArgLeu: 3.142 ± 0.059	0.694ArgMet: 0.694 ± 0.023	2.028ArgAsn: 2.028 ± 0.051	1.026ArgPro: 1.026 ± 0.033	1.031ArgGln: 1.031 ± 0.032	1.225ArgArg: 1.225 ± 0.04	1.694ArgSer: 1.694 ± 0.043	1.727ArgThr: 1.727 ± 0.047	2.015ArgVal: 2.015 ± 0.036	0.401ArgTrp: 0.401 ± 0.022	1.457ArgTyr: 1.457 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.513SerAla: 3.513 ± 0.061	0.637SerCys: 0.637 ± 0.025	3.226SerAsp: 3.226 ± 0.056	3.736SerGlu: 3.736 ± 0.055	3.697SerPhe: 3.697 ± 0.065	4.391SerGly: 4.391 ± 0.081	1.118SerHis: 1.118 ± 0.032	5.36SerIle: 5.36 ± 0.082	5.617SerLys: 5.617 ± 0.073	5.86SerLeu: 5.86 ± 0.085	1.178SerMet: 1.178 ± 0.036	4.473SerAsn: 4.473 ± 0.071	1.938SerPro: 1.938 ± 0.047	1.976SerGln: 1.976 ± 0.042	1.945SerArg: 1.945 ± 0.048	4.243SerSer: 4.243 ± 0.075	3.549SerThr: 3.549 ± 0.067	4.05SerVal: 4.05 ± 0.065	0.725SerTrp: 0.725 ± 0.028	2.79SerTyr: 2.79 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.383ThrAla: 3.383 ± 0.068	0.399ThrCys: 0.399 ± 0.023	3.147ThrAsp: 3.147 ± 0.068	3.469ThrGlu: 3.469 ± 0.063	3.082ThrPhe: 3.082 ± 0.062	3.887ThrGly: 3.887 ± 0.077	1.068ThrHis: 1.068 ± 0.028	5.108ThrIle: 5.108 ± 0.065	4.357ThrLys: 4.357 ± 0.068	5.631ThrLeu: 5.631 ± 0.073	0.923ThrMet: 0.923 ± 0.034	3.862ThrAsn: 3.862 ± 0.078	2.553ThrPro: 2.553 ± 0.061	1.853ThrGln: 1.853 ± 0.049	1.524ThrArg: 1.524 ± 0.041	3.959ThrSer: 3.959 ± 0.084	3.58ThrThr: 3.58 ± 0.083	3.837ThrVal: 3.837 ± 0.084	0.594ThrTrp: 0.594 ± 0.025	2.584ThrTyr: 2.584 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	3.914ValAla: 3.914 ± 0.07	0.522ValCys: 0.522 ± 0.023	3.585ValAsp: 3.585 ± 0.067	3.935ValGlu: 3.935 ± 0.067	3.492ValPhe: 3.492 ± 0.052	3.757ValGly: 3.757 ± 0.06	0.975ValHis: 0.975 ± 0.034	4.908ValIle: 4.908 ± 0.069	4.885ValLys: 4.885 ± 0.068	5.973ValLeu: 5.973 ± 0.091	1.212ValMet: 1.212 ± 0.033	3.909ValAsn: 3.909 ± 0.06	2.052ValPro: 2.052 ± 0.047	1.601ValGln: 1.601 ± 0.037	1.851ValArg: 1.851 ± 0.045	4.479ValSer: 4.479 ± 0.067	3.564ValThr: 3.564 ± 0.078	4.176ValVal: 4.176 ± 0.075	0.589ValTrp: 0.589 ± 0.025	2.504ValTyr: 2.504 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.578TrpAla: 0.578 ± 0.025	0.111TrpCys: 0.111 ± 0.01	0.638TrpAsp: 0.638 ± 0.028	0.672TrpGlu: 0.672 ± 0.027	0.586TrpPhe: 0.586 ± 0.024	0.658TrpGly: 0.658 ± 0.027	0.259TrpHis: 0.259 ± 0.015	0.687TrpIle: 0.687 ± 0.027	0.781TrpLys: 0.781 ± 0.03	1.001TrpLeu: 1.001 ± 0.035	0.266TrpMet: 0.266 ± 0.014	0.712TrpAsn: 0.712 ± 0.025	0.223TrpPro: 0.223 ± 0.015	0.418TrpGln: 0.418 ± 0.019	0.391TrpArg: 0.391 ± 0.021	0.608TrpSer: 0.608 ± 0.024	0.559TrpThr: 0.559 ± 0.028	0.69TrpVal: 0.69 ± 0.027	0.159TrpTrp: 0.159 ± 0.012	0.457TrpTyr: 0.457 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.504TyrAla: 2.504 ± 0.049	0.332TyrCys: 0.332 ± 0.019	2.236TyrAsp: 2.236 ± 0.05	2.169TyrGlu: 2.169 ± 0.047	2.531TyrPhe: 2.531 ± 0.052	2.658TyrGly: 2.658 ± 0.052	0.836TyrHis: 0.836 ± 0.031	2.88TyrIle: 2.88 ± 0.058	3.587TyrLys: 3.587 ± 0.065	3.893TyrLeu: 3.893 ± 0.064	0.768TyrMet: 0.768 ± 0.024	3.261TyrAsn: 3.261 ± 0.065	1.475TyrPro: 1.475 ± 0.036	1.556TyrGln: 1.556 ± 0.039	1.532TyrArg: 1.532 ± 0.035	2.609TyrSer: 2.609 ± 0.055	2.503TyrThr: 2.503 ± 0.06	2.263TyrVal: 2.263 ± 0.045	0.494TyrTrp: 0.494 ± 0.024	2.028TyrTyr: 2.028 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3101 proteins (1092078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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