Amino acid dipepetide frequency for Chitinimonas sp. BJB300

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.324AlaAla: 13.324 ± 0.137
1.146AlaCys: 1.146 ± 0.03
6.184AlaAsp: 6.184 ± 0.074
6.783AlaGlu: 6.783 ± 0.089
3.695AlaPhe: 3.695 ± 0.057
9.243AlaGly: 9.243 ± 0.132
2.157AlaHis: 2.157 ± 0.046
5.758AlaIle: 5.758 ± 0.074
4.776AlaLys: 4.776 ± 0.072
12.597AlaLeu: 12.597 ± 0.112
3.131AlaMet: 3.131 ± 0.046
3.864AlaAsn: 3.864 ± 0.06
4.238AlaPro: 4.238 ± 0.076
4.806AlaGln: 4.806 ± 0.068
6.425AlaArg: 6.425 ± 0.076
6.226AlaSer: 6.226 ± 0.075
5.686AlaThr: 5.686 ± 0.08
7.538AlaVal: 7.538 ± 0.082
1.521AlaTrp: 1.521 ± 0.039
2.697AlaTyr: 2.697 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.926CysAla: 0.926 ± 0.031
0.145CysCys: 0.145 ± 0.011
0.526CysAsp: 0.526 ± 0.02
0.48CysGlu: 0.48 ± 0.019
0.357CysPhe: 0.357 ± 0.015
0.839CysGly: 0.839 ± 0.024
0.274CysHis: 0.274 ± 0.017
0.424CysIle: 0.424 ± 0.02
0.314CysLys: 0.314 ± 0.016
0.977CysLeu: 0.977 ± 0.024
0.213CysMet: 0.213 ± 0.013
0.325CysAsn: 0.325 ± 0.013
0.47CysPro: 0.47 ± 0.019
0.331CysGln: 0.331 ± 0.016
0.605CysArg: 0.605 ± 0.024
0.532CysSer: 0.532 ± 0.022
0.478CysThr: 0.478 ± 0.021
0.593CysVal: 0.593 ± 0.021
0.161CysTrp: 0.161 ± 0.011
0.262CysTyr: 0.262 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.217AspAla: 6.217 ± 0.101
0.49AspCys: 0.49 ± 0.019
2.617AspAsp: 2.617 ± 0.053
3.222AspGlu: 3.222 ± 0.055
2.198AspPhe: 2.198 ± 0.042
4.417AspGly: 4.417 ± 0.081
1.05AspHis: 1.05 ± 0.029
2.969AspIle: 2.969 ± 0.053
2.464AspLys: 2.464 ± 0.049
5.411AspLeu: 5.411 ± 0.063
1.246AspMet: 1.246 ± 0.029
1.756AspAsn: 1.756 ± 0.039
2.58AspPro: 2.58 ± 0.044
1.922AspGln: 1.922 ± 0.039
3.015AspArg: 3.015 ± 0.05
2.918AspSer: 2.918 ± 0.054
2.874AspThr: 2.874 ± 0.054
3.695AspVal: 3.695 ± 0.064
1.03AspTrp: 1.03 ± 0.025
1.721AspTyr: 1.721 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.567GluAla: 6.567 ± 0.083
0.427GluCys: 0.427 ± 0.019
2.256GluAsp: 2.256 ± 0.046
2.707GluGlu: 2.707 ± 0.06
1.735GluPhe: 1.735 ± 0.036
3.61GluGly: 3.61 ± 0.055
1.309GluHis: 1.309 ± 0.033
3.133GluIle: 3.133 ± 0.055
2.531GluLys: 2.531 ± 0.05
6.048GluLeu: 6.048 ± 0.081
1.381GluMet: 1.381 ± 0.036
1.668GluAsn: 1.668 ± 0.036
2.27GluPro: 2.27 ± 0.048
2.851GluGln: 2.851 ± 0.049
3.97GluArg: 3.97 ± 0.065
2.846GluSer: 2.846 ± 0.045
2.895GluThr: 2.895 ± 0.051
4.089GluVal: 4.089 ± 0.067
0.795GluTrp: 0.795 ± 0.025
1.386GluTyr: 1.386 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.67PheAla: 3.67 ± 0.057
0.401PheCys: 0.401 ± 0.019
2.592PheAsp: 2.592 ± 0.046
2.09PheGlu: 2.09 ± 0.041
1.303PhePhe: 1.303 ± 0.035
3.09PheGly: 3.09 ± 0.054
0.765PheHis: 0.765 ± 0.024
1.716PheIle: 1.716 ± 0.042
1.5PheLys: 1.5 ± 0.039
3.041PheLeu: 3.041 ± 0.063
0.812PheMet: 0.812 ± 0.026
1.453PheAsn: 1.453 ± 0.037
1.431PhePro: 1.431 ± 0.038
1.205PheGln: 1.205 ± 0.027
1.858PheArg: 1.858 ± 0.042
2.547PheSer: 2.547 ± 0.049
2.053PheThr: 2.053 ± 0.049
2.482PheVal: 2.482 ± 0.049
0.492PheTrp: 0.492 ± 0.02
1.028PheTyr: 1.028 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
6.697GlyAla: 6.697 ± 0.094
0.851GlyCys: 0.851 ± 0.026
3.97GlyAsp: 3.97 ± 0.062
4.424GlyGlu: 4.424 ± 0.06
3.131GlyPhe: 3.131 ± 0.05
6.143GlyGly: 6.143 ± 0.111
1.67GlyHis: 1.67 ± 0.041
4.025GlyIle: 4.025 ± 0.058
4.13GlyLys: 4.13 ± 0.073
8.27GlyLeu: 8.27 ± 0.095
2.224GlyMet: 2.224 ± 0.038
2.902GlyAsn: 2.902 ± 0.082
2.307GlyPro: 2.307 ± 0.045
3.433GlyGln: 3.433 ± 0.058
4.82GlyArg: 4.82 ± 0.083
4.568GlySer: 4.568 ± 0.084
4.044GlyThr: 4.044 ± 0.093
5.745GlyVal: 5.745 ± 0.073
1.284GlyTrp: 1.284 ± 0.037
2.457GlyTyr: 2.457 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.483HisAla: 2.483 ± 0.046
0.253HisCys: 0.253 ± 0.015
1.148HisAsp: 1.148 ± 0.029
1.15HisGlu: 1.15 ± 0.032
0.993HisPhe: 0.993 ± 0.029
1.769HisGly: 1.769 ± 0.041
0.612HisHis: 0.612 ± 0.022
1.11HisIle: 1.11 ± 0.029
0.709HisLys: 0.709 ± 0.02
2.317HisLeu: 2.317 ± 0.04
0.429HisMet: 0.429 ± 0.02
0.638HisAsn: 0.638 ± 0.023
1.277HisPro: 1.277 ± 0.036
0.865HisGln: 0.865 ± 0.025
1.277HisArg: 1.277 ± 0.035
1.183HisSer: 1.183 ± 0.028
1.176HisThr: 1.176 ± 0.032
1.3HisVal: 1.3 ± 0.029
0.403HisTrp: 0.403 ± 0.019
0.767HisTyr: 0.767 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.163IleAla: 6.163 ± 0.08
0.507IleCys: 0.507 ± 0.017
3.461IleAsp: 3.461 ± 0.051
3.353IleGlu: 3.353 ± 0.054
1.446IlePhe: 1.446 ± 0.038
4.343IleGly: 4.343 ± 0.061
1.031IleHis: 1.031 ± 0.029
2.092IleIle: 2.092 ± 0.049
2.221IleLys: 2.221 ± 0.043
4.125IleLeu: 4.125 ± 0.064
0.835IleMet: 0.835 ± 0.027
1.937IleAsn: 1.937 ± 0.044
2.263IlePro: 2.263 ± 0.047
1.824IleGln: 1.824 ± 0.039
2.935IleArg: 2.935 ± 0.05
3.222IleSer: 3.222 ± 0.055
2.97IleThr: 2.97 ± 0.058
3.514IleVal: 3.514 ± 0.052
0.607IleTrp: 0.607 ± 0.022
1.238IleTyr: 1.238 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.552LysAla: 4.552 ± 0.07
0.223LysCys: 0.223 ± 0.013
1.914LysAsp: 1.914 ± 0.046
1.965LysGlu: 1.965 ± 0.044
1.071LysPhe: 1.071 ± 0.032
2.716LysGly: 2.716 ± 0.045
0.928LysHis: 0.928 ± 0.025
2.016LysIle: 2.016 ± 0.045
1.772LysLys: 1.772 ± 0.045
5.195LysLeu: 5.195 ± 0.071
0.999LysMet: 0.999 ± 0.028
1.348LysAsn: 1.348 ± 0.038
2.641LysPro: 2.641 ± 0.048
2.297LysGln: 2.297 ± 0.047
2.683LysArg: 2.683 ± 0.051
2.318LysSer: 2.318 ± 0.044
2.451LysThr: 2.451 ± 0.055
3.04LysVal: 3.04 ± 0.057
0.475LysTrp: 0.475 ± 0.019
0.927LysTyr: 0.927 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
14.096LeuAla: 14.096 ± 0.148
1.044LeuCys: 1.044 ± 0.033
6.197LeuAsp: 6.197 ± 0.072
5.348LeuGlu: 5.348 ± 0.075
3.65LeuPhe: 3.65 ± 0.063
8.222LeuGly: 8.222 ± 0.086
2.253LeuHis: 2.253 ± 0.046
5.336LeuIle: 5.336 ± 0.069
4.615LeuLys: 4.615 ± 0.066
11.76LeuLeu: 11.76 ± 0.14
2.423LeuMet: 2.423 ± 0.049
3.931LeuAsn: 3.931 ± 0.062
6.079LeuPro: 6.079 ± 0.08
4.381LeuGln: 4.381 ± 0.068
6.665LeuArg: 6.665 ± 0.081
6.974LeuSer: 6.974 ± 0.073
6.077LeuThr: 6.077 ± 0.087
7.375LeuVal: 7.375 ± 0.081
1.124LeuTrp: 1.124 ± 0.033
2.41LeuTyr: 2.41 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.8MetAla: 2.8 ± 0.048
0.149MetCys: 0.149 ± 0.011
1.081MetAsp: 1.081 ± 0.028
1.067MetGlu: 1.067 ± 0.032
0.673MetPhe: 0.673 ± 0.022
1.767MetGly: 1.767 ± 0.042
0.568MetHis: 0.568 ± 0.019
0.964MetIle: 0.964 ± 0.03
1.002MetLys: 1.002 ± 0.028
2.751MetLeu: 2.751 ± 0.049
0.599MetMet: 0.599 ± 0.023
0.845MetAsn: 0.845 ± 0.026
1.419MetPro: 1.419 ± 0.036
1.304MetGln: 1.304 ± 0.035
1.551MetArg: 1.551 ± 0.031
1.595MetSer: 1.595 ± 0.032
1.36MetThr: 1.36 ± 0.033
1.719MetVal: 1.719 ± 0.041
0.175MetTrp: 0.175 ± 0.012
0.432MetTyr: 0.432 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.714AsnAla: 3.714 ± 0.062
0.314AsnCys: 0.314 ± 0.017
1.779AsnAsp: 1.779 ± 0.048
1.689AsnGlu: 1.689 ± 0.039
1.138AsnPhe: 1.138 ± 0.031
2.973AsnGly: 2.973 ± 0.067
0.75AsnHis: 0.75 ± 0.023
1.656AsnIle: 1.656 ± 0.041
1.433AsnLys: 1.433 ± 0.038
3.67AsnLeu: 3.67 ± 0.062
0.747AsnMet: 0.747 ± 0.025
1.311AsnAsn: 1.311 ± 0.042
2.068AsnPro: 2.068 ± 0.044
1.604AsnGln: 1.604 ± 0.046
2.196AsnArg: 2.196 ± 0.049
1.819AsnSer: 1.819 ± 0.039
1.957AsnThr: 1.957 ± 0.041
2.275AsnVal: 2.275 ± 0.045
0.554AsnTrp: 0.554 ± 0.02
0.97AsnTyr: 0.97 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
5.643ProAla: 5.643 ± 0.084
0.359ProCys: 0.359 ± 0.018
2.931ProAsp: 2.931 ± 0.051
2.824ProGlu: 2.824 ± 0.047
1.671ProPhe: 1.671 ± 0.036
3.353ProGly: 3.353 ± 0.052
1.003ProHis: 1.003 ± 0.03
2.404ProIle: 2.404 ± 0.045
1.846ProLys: 1.846 ± 0.037
4.874ProLeu: 4.874 ± 0.077
1.097ProMet: 1.097 ± 0.031
1.778ProAsn: 1.778 ± 0.039
2.305ProPro: 2.305 ± 0.062
1.784ProGln: 1.784 ± 0.038
2.236ProArg: 2.236 ± 0.057
2.825ProSer: 2.825 ± 0.051
2.791ProThr: 2.791 ± 0.067
3.714ProVal: 3.714 ± 0.061
0.622ProTrp: 0.622 ± 0.022
1.28ProTyr: 1.28 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
5.345GlnAla: 5.345 ± 0.073
0.308GlnCys: 0.308 ± 0.017
1.815GlnAsp: 1.815 ± 0.038
1.831GlnGlu: 1.831 ± 0.045
1.568GlnPhe: 1.568 ± 0.032
2.992GlnGly: 2.992 ± 0.06
1.141GlnHis: 1.141 ± 0.034
2.244GlnIle: 2.244 ± 0.043
1.556GlnLys: 1.556 ± 0.039
5.287GlnLeu: 5.287 ± 0.074
1.058GlnMet: 1.058 ± 0.028
1.201GlnAsn: 1.201 ± 0.03
2.329GlnPro: 2.329 ± 0.053
2.461GlnGln: 2.461 ± 0.056
3.084GlnArg: 3.084 ± 0.06
2.461GlnSer: 2.461 ± 0.049
2.429GlnThr: 2.429 ± 0.047
3.01GlnVal: 3.01 ± 0.052
0.569GlnTrp: 0.569 ± 0.022
1.21GlnTyr: 1.21 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
5.78ArgAla: 5.78 ± 0.081
0.532ArgCys: 0.532 ± 0.02
3.308ArgAsp: 3.308 ± 0.057
3.721ArgGlu: 3.721 ± 0.062
2.731ArgPhe: 2.731 ± 0.05
3.689ArgGly: 3.689 ± 0.063
1.604ArgHis: 1.604 ± 0.032
3.428ArgIle: 3.428 ± 0.05
2.326ArgLys: 2.326 ± 0.047
7.361ArgLeu: 7.361 ± 0.096
1.562ArgMet: 1.562 ± 0.03
2.097ArgAsn: 2.097 ± 0.041
2.47ArgPro: 2.47 ± 0.048
3.135ArgGln: 3.135 ± 0.055
3.843ArgArg: 3.843 ± 0.064
3.151ArgSer: 3.151 ± 0.053
2.963ArgThr: 2.963 ± 0.056
4.135ArgVal: 4.135 ± 0.058
1.028ArgTrp: 1.028 ± 0.034
2.156ArgTyr: 2.156 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
6.022SerAla: 6.022 ± 0.076
0.525SerCys: 0.525 ± 0.021
2.92SerAsp: 2.92 ± 0.048
2.968SerGlu: 2.968 ± 0.045
2.178SerPhe: 2.178 ± 0.042
4.945SerGly: 4.945 ± 0.072
1.221SerHis: 1.221 ± 0.032
2.928SerIle: 2.928 ± 0.054
2.238SerLys: 2.238 ± 0.046
6.736SerLeu: 6.736 ± 0.088
1.37SerMet: 1.37 ± 0.032
2.13SerAsn: 2.13 ± 0.05
2.818SerPro: 2.818 ± 0.054
2.539SerGln: 2.539 ± 0.05
3.477SerArg: 3.477 ± 0.055
3.397SerSer: 3.397 ± 0.056
3.327SerThr: 3.327 ± 0.056
3.928SerVal: 3.928 ± 0.056
0.798SerTrp: 0.798 ± 0.027
1.597SerTyr: 1.597 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.822ThrAla: 5.822 ± 0.081
0.429ThrCys: 0.429 ± 0.019
2.831ThrAsp: 2.831 ± 0.055
2.81ThrGlu: 2.81 ± 0.047
1.779ThrPhe: 1.779 ± 0.039
4.725ThrGly: 4.725 ± 0.085
1.207ThrHis: 1.207 ± 0.034
2.597ThrIle: 2.597 ± 0.058
1.757ThrLys: 1.757 ± 0.041
6.654ThrLeu: 6.654 ± 0.086
1.105ThrMet: 1.105 ± 0.031
1.742ThrAsn: 1.742 ± 0.043
3.413ThrPro: 3.413 ± 0.062
2.353ThrGln: 2.353 ± 0.047
3.009ThrArg: 3.009 ± 0.06
2.987ThrSer: 2.987 ± 0.062
3.279ThrThr: 3.279 ± 0.078
4.15ThrVal: 4.15 ± 0.075
0.634ThrTrp: 0.634 ± 0.024
1.463ThrTyr: 1.463 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
7.993ValAla: 7.993 ± 0.082
0.711ValCys: 0.711 ± 0.024
3.948ValAsp: 3.948 ± 0.062
4.255ValGlu: 4.255 ± 0.061
2.582ValPhe: 2.582 ± 0.046
5.344ValGly: 5.344 ± 0.067
1.352ValHis: 1.352 ± 0.03
3.594ValIle: 3.594 ± 0.054
2.918ValLys: 2.918 ± 0.054
7.679ValLeu: 7.679 ± 0.092
1.778ValMet: 1.778 ± 0.04
2.442ValAsn: 2.442 ± 0.043
3.071ValPro: 3.071 ± 0.052
2.587ValGln: 2.587 ± 0.043
4.166ValArg: 4.166 ± 0.065
4.257ValSer: 4.257 ± 0.063
3.872ValThr: 3.872 ± 0.092
5.61ValVal: 5.61 ± 0.074
0.884ValTrp: 0.884 ± 0.026
1.585ValTyr: 1.585 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.162TrpAla: 1.162 ± 0.035
0.149TrpCys: 0.149 ± 0.011
0.596TrpAsp: 0.596 ± 0.021
0.551TrpGlu: 0.551 ± 0.02
0.533TrpPhe: 0.533 ± 0.023
0.832TrpGly: 0.832 ± 0.026
0.404TrpHis: 0.404 ± 0.015
0.604TrpIle: 0.604 ± 0.023
0.488TrpLys: 0.488 ± 0.021
2.22TrpLeu: 2.22 ± 0.051
0.354TrpMet: 0.354 ± 0.016
0.402TrpAsn: 0.402 ± 0.018
0.611TrpPro: 0.611 ± 0.025
0.974TrpGln: 0.974 ± 0.031
1.193TrpArg: 1.193 ± 0.038
0.667TrpSer: 0.667 ± 0.027
0.59TrpThr: 0.59 ± 0.024
0.946TrpVal: 0.946 ± 0.028
0.25TrpTrp: 0.25 ± 0.015
0.305TrpTyr: 0.305 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.818TyrAla: 2.818 ± 0.05
0.271TyrCys: 0.271 ± 0.014
1.735TyrAsp: 1.735 ± 0.12
1.238TyrGlu: 1.238 ± 0.032
1.098TyrPhe: 1.098 ± 0.035
2.082TyrGly: 2.082 ± 0.046
0.559TyrHis: 0.559 ± 0.02
1.089TyrIle: 1.089 ± 0.027
0.936TyrLys: 0.936 ± 0.03
2.99TyrLeu: 2.99 ± 0.061
0.458TyrMet: 0.458 ± 0.018
0.846TyrAsn: 0.846 ± 0.028
1.277TyrPro: 1.277 ± 0.034
1.245TyrGln: 1.245 ± 0.034
2.013TyrArg: 2.013 ± 0.04
1.569TyrSer: 1.569 ± 0.037
1.473TyrThr: 1.473 ± 0.04
1.769TyrVal: 1.769 ± 0.036
0.425TyrTrp: 0.425 ± 0.022
0.762TyrTyr: 0.762 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4049 proteins (1312742 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski