Amino acid dipepetide frequency for Desulfosporosinus sp. OL

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.282AlaAla: 6.282 ± 0.096	0.949AlaCys: 0.949 ± 0.028	3.573AlaAsp: 3.573 ± 0.051	5.161AlaGlu: 5.161 ± 0.067	2.973AlaPhe: 2.973 ± 0.049	5.901AlaGly: 5.901 ± 0.073	1.462AlaHis: 1.462 ± 0.032	5.464AlaIle: 5.464 ± 0.07	4.762AlaLys: 4.762 ± 0.067	8.619AlaLeu: 8.619 ± 0.089	2.192AlaMet: 2.192 ± 0.038	2.795AlaAsn: 2.795 ± 0.049	2.323AlaPro: 2.323 ± 0.041	3.13AlaGln: 3.13 ± 0.058	3.571AlaArg: 3.571 ± 0.046	4.193AlaSer: 4.193 ± 0.061	3.891AlaThr: 3.891 ± 0.071	5.852AlaVal: 5.852 ± 0.07	0.817AlaTrp: 0.817 ± 0.025	2.284AlaTyr: 2.284 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.733CysAla: 0.733 ± 0.025	0.188CysCys: 0.188 ± 0.013	0.547CysAsp: 0.547 ± 0.019	0.632CysGlu: 0.632 ± 0.025	0.463CysPhe: 0.463 ± 0.019	1.167CysGly: 1.167 ± 0.036	0.291CysHis: 0.291 ± 0.019	0.699CysIle: 0.699 ± 0.024	0.562CysLys: 0.562 ± 0.02	1.056CysLeu: 1.056 ± 0.026	0.268CysMet: 0.268 ± 0.015	0.395CysAsn: 0.395 ± 0.016	0.675CysPro: 0.675 ± 0.026	0.442CysGln: 0.442 ± 0.018	0.57CysArg: 0.57 ± 0.022	0.748CysSer: 0.748 ± 0.023	0.581CysThr: 0.581 ± 0.022	0.714CysVal: 0.714 ± 0.024	0.11CysTrp: 0.11 ± 0.009	0.357CysTyr: 0.357 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.389AspAla: 3.389 ± 0.052	0.564AspCys: 0.564 ± 0.023	2.152AspAsp: 2.152 ± 0.039	3.633AspGlu: 3.633 ± 0.058	2.428AspPhe: 2.428 ± 0.038	3.278AspGly: 3.278 ± 0.053	1.001AspHis: 1.001 ± 0.028	3.735AspIle: 3.735 ± 0.054	2.901AspLys: 2.901 ± 0.053	5.501AspLeu: 5.501 ± 0.058	1.29AspMet: 1.29 ± 0.031	1.739AspAsn: 1.739 ± 0.036	2.222AspPro: 2.222 ± 0.045	1.843AspGln: 1.843 ± 0.04	2.362AspArg: 2.362 ± 0.042	2.572AspSer: 2.572 ± 0.039	2.353AspThr: 2.353 ± 0.046	3.569AspVal: 3.569 ± 0.06	0.601AspTrp: 0.601 ± 0.021	2.015AspTyr: 2.015 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.281GluAla: 5.281 ± 0.082	0.641GluCys: 0.641 ± 0.022	3.253GluAsp: 3.253 ± 0.061	5.565GluGlu: 5.565 ± 0.087	2.527GluPhe: 2.527 ± 0.047	4.487GluGly: 4.487 ± 0.06	1.329GluHis: 1.329 ± 0.032	5.344GluIle: 5.344 ± 0.066	5.106GluLys: 5.106 ± 0.058	7.164GluLeu: 7.164 ± 0.083	2.005GluMet: 2.005 ± 0.039	3.071GluAsn: 3.071 ± 0.048	1.88GluPro: 1.88 ± 0.038	3.052GluGln: 3.052 ± 0.057	3.932GluArg: 3.932 ± 0.059	3.327GluSer: 3.327 ± 0.056	3.345GluThr: 3.345 ± 0.055	4.963GluVal: 4.963 ± 0.068	0.717GluTrp: 0.717 ± 0.026	2.054GluTyr: 2.054 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.96PheAla: 2.96 ± 0.052	0.535PheCys: 0.535 ± 0.02	2.062PheAsp: 2.062 ± 0.037	2.389PheGlu: 2.389 ± 0.047	1.815PhePhe: 1.815 ± 0.047	3.221PheGly: 3.221 ± 0.047	0.78PheHis: 0.78 ± 0.023	2.808PheIle: 2.808 ± 0.047	2.146PheLys: 2.146 ± 0.039	4.31PheLeu: 4.31 ± 0.064	1.075PheMet: 1.075 ± 0.026	1.637PheAsn: 1.637 ± 0.032	1.686PhePro: 1.686 ± 0.036	1.432PheGln: 1.432 ± 0.032	1.834PheArg: 1.834 ± 0.034	2.796PheSer: 2.796 ± 0.049	2.111PheThr: 2.111 ± 0.04	2.806PheVal: 2.806 ± 0.049	0.493PheTrp: 0.493 ± 0.018	1.438PheTyr: 1.438 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.339GlyAla: 5.339 ± 0.078	1.055GlyCys: 1.055 ± 0.035	3.252GlyAsp: 3.252 ± 0.045	4.591GlyGlu: 4.591 ± 0.058	3.192GlyPhe: 3.192 ± 0.047	5.578GlyGly: 5.578 ± 0.089	1.412GlyHis: 1.412 ± 0.031	6.22GlyIle: 6.22 ± 0.069	5.174GlyLys: 5.174 ± 0.068	7.618GlyLeu: 7.618 ± 0.083	2.368GlyMet: 2.368 ± 0.042	2.866GlyAsn: 2.866 ± 0.05	1.92GlyPro: 1.92 ± 0.037	2.749GlyGln: 2.749 ± 0.044	3.335GlyArg: 3.335 ± 0.054	4.315GlySer: 4.315 ± 0.062	4.335GlyThr: 4.335 ± 0.066	5.825GlyVal: 5.825 ± 0.077	0.874GlyTrp: 0.874 ± 0.03	2.712GlyTyr: 2.712 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.26HisAla: 1.26 ± 0.031	0.291HisCys: 0.291 ± 0.014	0.918HisAsp: 0.918 ± 0.023	1.178HisGlu: 1.178 ± 0.032	0.876HisPhe: 0.876 ± 0.021	1.415HisGly: 1.415 ± 0.035	0.515HisHis: 0.515 ± 0.022	1.224HisIle: 1.224 ± 0.027	0.9HisLys: 0.9 ± 0.022	2.122HisLeu: 2.122 ± 0.04	0.457HisMet: 0.457 ± 0.018	0.745HisAsn: 0.745 ± 0.023	1.153HisPro: 1.153 ± 0.029	0.774HisGln: 0.774 ± 0.026	0.991HisArg: 0.991 ± 0.029	1.193HisSer: 1.193 ± 0.032	1.036HisThr: 1.036 ± 0.028	1.204HisVal: 1.204 ± 0.028	0.268HisTrp: 0.268 ± 0.015	0.711HisTyr: 0.711 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.875IleAla: 5.875 ± 0.075	0.797IleCys: 0.797 ± 0.026	3.618IleAsp: 3.618 ± 0.056	4.75IleGlu: 4.75 ± 0.06	2.747IlePhe: 2.747 ± 0.05	5.424IleGly: 5.424 ± 0.073	1.401IleHis: 1.401 ± 0.032	4.976IleIle: 4.976 ± 0.078	3.942IleLys: 3.942 ± 0.058	7.396IleLeu: 7.396 ± 0.087	1.854IleMet: 1.854 ± 0.035	2.976IleAsn: 2.976 ± 0.044	3.482IlePro: 3.482 ± 0.054	2.538IleGln: 2.538 ± 0.042	3.427IleArg: 3.427 ± 0.049	4.752IleSer: 4.752 ± 0.054	3.93IleThr: 3.93 ± 0.051	4.98IleVal: 4.98 ± 0.069	0.609IleTrp: 0.609 ± 0.021	2.032IleTyr: 2.032 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.842LysAla: 4.842 ± 0.06	0.503LysCys: 0.503 ± 0.018	3.259LysAsp: 3.259 ± 0.058	4.891LysGlu: 4.891 ± 0.06	1.858LysPhe: 1.858 ± 0.036	4.259LysGly: 4.259 ± 0.058	1.049LysHis: 1.049 ± 0.029	4.451LysIle: 4.451 ± 0.057	4.05LysLys: 4.05 ± 0.066	5.611LysLeu: 5.611 ± 0.066	1.761LysMet: 1.761 ± 0.033	2.651LysAsn: 2.651 ± 0.047	2.209LysPro: 2.209 ± 0.04	2.255LysGln: 2.255 ± 0.037	3.106LysArg: 3.106 ± 0.049	3.337LysSer: 3.337 ± 0.046	3.516LysThr: 3.516 ± 0.05	4.739LysVal: 4.739 ± 0.058	0.556LysTrp: 0.556 ± 0.021	1.898LysTyr: 1.898 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	8.813LeuAla: 8.813 ± 0.097	1.038LeuCys: 1.038 ± 0.027	5.367LeuAsp: 5.367 ± 0.06	7.115LeuGlu: 7.115 ± 0.078	4.04LeuPhe: 4.04 ± 0.06	8.084LeuGly: 8.084 ± 0.099	1.831LeuHis: 1.831 ± 0.04	6.84LeuIle: 6.84 ± 0.077	6.616LeuLys: 6.616 ± 0.07	10.235LeuLeu: 10.235 ± 0.109	2.693LeuMet: 2.693 ± 0.04	4.326LeuAsn: 4.326 ± 0.054	4.428LeuPro: 4.428 ± 0.055	3.692LeuGln: 3.692 ± 0.053	5.094LeuArg: 5.094 ± 0.068	6.983LeuSer: 6.983 ± 0.074	6.082LeuThr: 6.082 ± 0.065	7.053LeuVal: 7.053 ± 0.072	1.038LeuTrp: 1.038 ± 0.028	2.818LeuTyr: 2.818 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.411MetAla: 2.411 ± 0.041	0.241MetCys: 0.241 ± 0.012	1.502MetAsp: 1.502 ± 0.032	1.85MetGlu: 1.85 ± 0.038	0.913MetPhe: 0.913 ± 0.026	2.226MetGly: 2.226 ± 0.04	0.48MetHis: 0.48 ± 0.016	1.865MetIle: 1.865 ± 0.041	1.785MetLys: 1.785 ± 0.038	2.505MetLeu: 2.505 ± 0.043	0.787MetMet: 0.787 ± 0.027	1.203MetAsn: 1.203 ± 0.03	1.086MetPro: 1.086 ± 0.032	0.935MetGln: 0.935 ± 0.027	1.326MetArg: 1.326 ± 0.031	1.714MetSer: 1.714 ± 0.032	1.552MetThr: 1.552 ± 0.036	2.046MetVal: 2.046 ± 0.04	0.176MetTrp: 0.176 ± 0.01	0.584MetTyr: 0.584 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.8AsnAla: 2.8 ± 0.048	0.49AsnCys: 0.49 ± 0.02	1.818AsnAsp: 1.818 ± 0.038	2.355AsnGlu: 2.355 ± 0.045	1.566AsnPhe: 1.566 ± 0.029	2.917AsnGly: 2.917 ± 0.048	0.836AsnHis: 0.836 ± 0.027	2.903AsnIle: 2.903 ± 0.051	2.318AsnLys: 2.318 ± 0.043	4.251AsnLeu: 4.251 ± 0.06	1.045AsnMet: 1.045 ± 0.028	1.675AsnAsn: 1.675 ± 0.035	2.334AsnPro: 2.334 ± 0.044	1.659AsnGln: 1.659 ± 0.034	1.949AsnArg: 1.949 ± 0.036	2.521AsnSer: 2.521 ± 0.049	2.03AsnThr: 2.03 ± 0.041	2.878AsnVal: 2.878 ± 0.042	0.466AsnTrp: 0.466 ± 0.02	1.536AsnTyr: 1.536 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.604ProAla: 2.604 ± 0.047	0.404ProCys: 0.404 ± 0.017	2.278ProAsp: 2.278 ± 0.046	3.418ProGlu: 3.418 ± 0.048	1.706ProPhe: 1.706 ± 0.032	2.802ProGly: 2.802 ± 0.044	0.781ProHis: 0.781 ± 0.023	2.669ProIle: 2.669 ± 0.049	2.22ProLys: 2.22 ± 0.039	4.076ProLeu: 4.076 ± 0.049	0.957ProMet: 0.957 ± 0.028	1.608ProAsn: 1.608 ± 0.034	1.328ProPro: 1.328 ± 0.04	1.529ProGln: 1.529 ± 0.038	1.555ProArg: 1.555 ± 0.035	2.531ProSer: 2.531 ± 0.042	2.157ProThr: 2.157 ± 0.045	3.059ProVal: 3.059 ± 0.048	0.493ProTrp: 0.493 ± 0.022	1.335ProTyr: 1.335 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.271GlnAla: 3.271 ± 0.054	0.365GlnCys: 0.365 ± 0.019	1.869GlnAsp: 1.869 ± 0.036	3.039GlnGlu: 3.039 ± 0.058	1.296GlnPhe: 1.296 ± 0.028	2.918GlnGly: 2.918 ± 0.045	0.703GlnHis: 0.703 ± 0.021	2.654GlnIle: 2.654 ± 0.044	2.463GlnLys: 2.463 ± 0.04	3.578GlnLeu: 3.578 ± 0.046	1.111GlnMet: 1.111 ± 0.027	1.559GlnAsn: 1.559 ± 0.031	1.276GlnPro: 1.276 ± 0.03	1.633GlnGln: 1.633 ± 0.042	1.976GlnArg: 1.976 ± 0.044	2.123GlnSer: 2.123 ± 0.043	2.165GlnThr: 2.165 ± 0.045	2.847GlnVal: 2.847 ± 0.048	0.461GlnTrp: 0.461 ± 0.019	1.116GlnTyr: 1.116 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.199ArgAla: 3.199 ± 0.051	0.528ArgCys: 0.528 ± 0.02	2.322ArgAsp: 2.322 ± 0.038	3.825ArgGlu: 3.825 ± 0.059	2.11ArgPhe: 2.11 ± 0.034	2.958ArgGly: 2.958 ± 0.048	0.95ArgHis: 0.95 ± 0.026	3.599ArgIle: 3.599 ± 0.046	3.087ArgLys: 3.087 ± 0.048	5.299ArgLeu: 5.299 ± 0.073	1.372ArgMet: 1.372 ± 0.031	1.957ArgAsn: 1.957 ± 0.038	1.744ArgPro: 1.744 ± 0.035	2.071ArgGln: 2.071 ± 0.043	2.553ArgArg: 2.553 ± 0.051	2.62ArgSer: 2.62 ± 0.046	2.388ArgThr: 2.388 ± 0.043	3.5ArgVal: 3.5 ± 0.058	0.573ArgTrp: 0.573 ± 0.019	1.719ArgTyr: 1.719 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.242SerAla: 4.242 ± 0.066	0.652SerCys: 0.652 ± 0.023	2.804SerAsp: 2.804 ± 0.05	3.847SerGlu: 3.847 ± 0.057	2.62SerPhe: 2.62 ± 0.04	4.982SerGly: 4.982 ± 0.06	1.116SerHis: 1.116 ± 0.027	4.154SerIle: 4.154 ± 0.058	3.425SerLys: 3.425 ± 0.052	6.633SerLeu: 6.633 ± 0.07	1.679SerMet: 1.679 ± 0.039	2.339SerAsn: 2.339 ± 0.044	2.458SerPro: 2.458 ± 0.044	2.318SerGln: 2.318 ± 0.041	2.794SerArg: 2.794 ± 0.045	4.083SerSer: 4.083 ± 0.082	3.22SerThr: 3.22 ± 0.053	4.259SerVal: 4.259 ± 0.052	0.713SerTrp: 0.713 ± 0.024	1.913SerTyr: 1.913 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.145ThrAla: 4.145 ± 0.065	0.543ThrCys: 0.543 ± 0.021	2.575ThrAsp: 2.575 ± 0.049	3.32ThrGlu: 3.32 ± 0.057	2.183ThrPhe: 2.183 ± 0.038	4.612ThrGly: 4.612 ± 0.067	1.098ThrHis: 1.098 ± 0.031	3.81ThrIle: 3.81 ± 0.048	2.923ThrLys: 2.923 ± 0.047	5.888ThrLeu: 5.888 ± 0.071	1.379ThrMet: 1.379 ± 0.033	2.111ThrAsn: 2.111 ± 0.04	2.598ThrPro: 2.598 ± 0.042	1.929ThrGln: 1.929 ± 0.04	2.234ThrArg: 2.234 ± 0.043	3.18ThrSer: 3.18 ± 0.058	3.072ThrThr: 3.072 ± 0.066	4.192ThrVal: 4.192 ± 0.065	0.588ThrTrp: 0.588 ± 0.019	1.64ThrTyr: 1.64 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.686ValAla: 5.686 ± 0.067	0.857ValCys: 0.857 ± 0.025	3.764ValAsp: 3.764 ± 0.052	4.795ValGlu: 4.795 ± 0.067	3.093ValPhe: 3.093 ± 0.055	5.187ValGly: 5.187 ± 0.064	1.301ValHis: 1.301 ± 0.03	5.384ValIle: 5.384 ± 0.068	4.117ValLys: 4.117 ± 0.055	7.642ValLeu: 7.642 ± 0.088	1.908ValMet: 1.908 ± 0.032	2.948ValAsn: 2.948 ± 0.049	2.937ValPro: 2.937 ± 0.048	2.577ValGln: 2.577 ± 0.042	3.465ValArg: 3.465 ± 0.058	4.657ValSer: 4.657 ± 0.064	4.052ValThr: 4.052 ± 0.067	5.644ValVal: 5.644 ± 0.069	0.751ValTrp: 0.751 ± 0.026	2.113ValTyr: 2.113 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.746TrpAla: 0.746 ± 0.023	0.11TrpCys: 0.11 ± 0.008	0.566TrpAsp: 0.566 ± 0.021	0.741TrpGlu: 0.741 ± 0.02	0.429TrpPhe: 0.429 ± 0.019	0.845TrpGly: 0.845 ± 0.028	0.201TrpHis: 0.201 ± 0.011	0.724TrpIle: 0.724 ± 0.024	0.624TrpLys: 0.624 ± 0.023	1.189TrpLeu: 1.189 ± 0.032	0.274TrpMet: 0.274 ± 0.016	0.507TrpAsn: 0.507 ± 0.018	0.357TrpPro: 0.357 ± 0.017	0.566TrpGln: 0.566 ± 0.02	0.593TrpArg: 0.593 ± 0.023	0.612TrpSer: 0.612 ± 0.02	0.52TrpThr: 0.52 ± 0.021	0.778TrpVal: 0.778 ± 0.022	0.158TrpTrp: 0.158 ± 0.011	0.318TrpTyr: 0.318 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.314TyrAla: 2.314 ± 0.042	0.446TyrCys: 0.446 ± 0.018	1.654TyrAsp: 1.654 ± 0.039	1.947TyrGlu: 1.947 ± 0.039	1.497TyrPhe: 1.497 ± 0.035	2.469TyrGly: 2.469 ± 0.052	0.694TyrHis: 0.694 ± 0.023	1.983TyrIle: 1.983 ± 0.036	1.684TyrLys: 1.684 ± 0.035	3.493TyrLeu: 3.493 ± 0.052	0.709TyrMet: 0.709 ± 0.024	1.24TyrAsn: 1.24 ± 0.03	1.417TyrPro: 1.417 ± 0.038	1.299TyrGln: 1.299 ± 0.03	1.707TyrArg: 1.707 ± 0.034	1.992TyrSer: 1.992 ± 0.041	1.683TyrThr: 1.683 ± 0.043	1.971TyrVal: 1.971 ± 0.04	0.393TyrTrp: 0.393 ± 0.019	1.188TyrTyr: 1.188 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5425 proteins (1464743 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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