Amino acid dipepetide frequency for Aeromonas phage 4_L372XY

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.907AlaAla: 3.907 ± 0.555
0.628AlaCys: 0.628 ± 0.121
2.431AlaAsp: 2.431 ± 0.238
3.497AlaGlu: 3.497 ± 0.35
1.776AlaPhe: 1.776 ± 0.276
3.961AlaGly: 3.961 ± 0.488
0.847AlaHis: 0.847 ± 0.145
3.333AlaIle: 3.333 ± 0.322
4.289AlaLys: 4.289 ± 0.367
4.207AlaLeu: 4.207 ± 0.39
1.284AlaMet: 1.284 ± 0.215
1.83AlaAsn: 1.83 ± 0.259
1.421AlaPro: 1.421 ± 0.238
1.994AlaGln: 1.994 ± 0.323
1.94AlaArg: 1.94 ± 0.238
3.415AlaSer: 3.415 ± 0.353
3.169AlaThr: 3.169 ± 0.34
2.732AlaVal: 2.732 ± 0.288
0.574AlaTrp: 0.574 ± 0.118
2.186AlaTyr: 2.186 ± 0.291
0.0AlaXaa: 0.0 ± 0.0
Cys
0.983CysAla: 0.983 ± 0.179
0.355CysCys: 0.355 ± 0.103
1.038CysAsp: 1.038 ± 0.206
1.257CysGlu: 1.257 ± 0.211
0.902CysPhe: 0.902 ± 0.137
1.366CysGly: 1.366 ± 0.185
0.41CysHis: 0.41 ± 0.136
1.12CysIle: 1.12 ± 0.177
1.639CysLys: 1.639 ± 0.221
1.229CysLeu: 1.229 ± 0.197
0.546CysMet: 0.546 ± 0.112
0.71CysAsn: 0.71 ± 0.157
0.847CysPro: 0.847 ± 0.178
0.492CysGln: 0.492 ± 0.109
0.519CysArg: 0.519 ± 0.149
1.284CysSer: 1.284 ± 0.191
0.71CysThr: 0.71 ± 0.13
0.956CysVal: 0.956 ± 0.142
0.41CysTrp: 0.41 ± 0.115
0.902CysTyr: 0.902 ± 0.151
0.0CysXaa: 0.0 ± 0.0
Asp
2.349AspAla: 2.349 ± 0.267
1.147AspCys: 1.147 ± 0.184
3.06AspAsp: 3.06 ± 0.334
3.907AspGlu: 3.907 ± 0.371
3.852AspPhe: 3.852 ± 0.314
4.617AspGly: 4.617 ± 0.327
0.765AspHis: 0.765 ± 0.135
4.699AspIle: 4.699 ± 0.384
6.256AspLys: 6.256 ± 0.493
4.754AspLeu: 4.754 ± 0.367
1.912AspMet: 1.912 ± 0.216
3.825AspAsn: 3.825 ± 0.294
2.131AspPro: 2.131 ± 0.259
1.284AspGln: 1.284 ± 0.201
2.131AspArg: 2.131 ± 0.242
3.524AspSer: 3.524 ± 0.282
3.306AspThr: 3.306 ± 0.293
4.016AspVal: 4.016 ± 0.364
1.448AspTrp: 1.448 ± 0.169
3.907AspTyr: 3.907 ± 0.332
0.0AspXaa: 0.0 ± 0.0
Glu
3.688GluAla: 3.688 ± 0.308
1.257GluCys: 1.257 ± 0.212
5.409GluAsp: 5.409 ± 0.405
6.065GluGlu: 6.065 ± 0.509
3.415GluPhe: 3.415 ± 0.304
3.552GluGly: 3.552 ± 0.325
1.202GluHis: 1.202 ± 0.19
5.191GluIle: 5.191 ± 0.363
5.327GluLys: 5.327 ± 0.413
6.939GluLeu: 6.939 ± 0.501
2.677GluMet: 2.677 ± 0.269
3.989GluAsn: 3.989 ± 0.329
1.776GluPro: 1.776 ± 0.197
4.016GluGln: 4.016 ± 0.385
3.224GluArg: 3.224 ± 0.343
4.207GluSer: 4.207 ± 0.338
3.415GluThr: 3.415 ± 0.275
5.218GluVal: 5.218 ± 0.401
1.202GluTrp: 1.202 ± 0.173
4.098GluTyr: 4.098 ± 0.327
0.0GluXaa: 0.0 ± 0.0
Phe
1.967PheAla: 1.967 ± 0.231
0.874PheCys: 0.874 ± 0.137
3.77PheAsp: 3.77 ± 0.307
3.497PheGlu: 3.497 ± 0.301
1.038PhePhe: 1.038 ± 0.168
2.677PheGly: 2.677 ± 0.267
0.601PheHis: 0.601 ± 0.136
4.453PheIle: 4.453 ± 0.374
3.879PheLys: 3.879 ± 0.317
2.814PheLeu: 2.814 ± 0.273
1.421PheMet: 1.421 ± 0.193
2.869PheAsn: 2.869 ± 0.239
0.902PhePro: 0.902 ± 0.143
1.339PheGln: 1.339 ± 0.175
1.612PheArg: 1.612 ± 0.235
3.032PheSer: 3.032 ± 0.296
2.513PheThr: 2.513 ± 0.235
4.153PheVal: 4.153 ± 0.326
0.601PheTrp: 0.601 ± 0.155
1.912PheTyr: 1.912 ± 0.234
0.0PheXaa: 0.0 ± 0.0
Gly
2.896GlyAla: 2.896 ± 0.441
1.366GlyCys: 1.366 ± 0.244
2.732GlyAsp: 2.732 ± 0.296
3.251GlyGlu: 3.251 ± 0.299
3.251GlyPhe: 3.251 ± 0.33
3.797GlyGly: 3.797 ± 0.464
1.038GlyHis: 1.038 ± 0.187
3.934GlyIle: 3.934 ± 0.335
5.573GlyLys: 5.573 ± 0.41
4.535GlyLeu: 4.535 ± 0.393
1.093GlyMet: 1.093 ± 0.191
3.47GlyAsn: 3.47 ± 0.388
0.902GlyPro: 0.902 ± 0.155
2.404GlyGln: 2.404 ± 0.267
3.005GlyArg: 3.005 ± 0.298
3.797GlySer: 3.797 ± 0.413
3.442GlyThr: 3.442 ± 0.315
4.48GlyVal: 4.48 ± 0.332
1.311GlyTrp: 1.311 ± 0.178
3.633GlyTyr: 3.633 ± 0.292
0.0GlyXaa: 0.0 ± 0.0
His
0.464HisAla: 0.464 ± 0.123
0.519HisCys: 0.519 ± 0.1
0.983HisAsp: 0.983 ± 0.155
1.065HisGlu: 1.065 ± 0.162
1.065HisPhe: 1.065 ± 0.188
1.366HisGly: 1.366 ± 0.253
0.246HisHis: 0.246 ± 0.077
1.038HisIle: 1.038 ± 0.19
1.721HisLys: 1.721 ± 0.237
1.284HisLeu: 1.284 ± 0.198
0.41HisMet: 0.41 ± 0.089
1.339HisAsn: 1.339 ± 0.225
0.519HisPro: 0.519 ± 0.127
0.82HisGln: 0.82 ± 0.162
0.847HisArg: 0.847 ± 0.182
1.147HisSer: 1.147 ± 0.174
1.175HisThr: 1.175 ± 0.218
1.202HisVal: 1.202 ± 0.179
0.246HisTrp: 0.246 ± 0.075
1.147HisTyr: 1.147 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
3.087IleAla: 3.087 ± 0.326
0.929IleCys: 0.929 ± 0.158
4.699IleAsp: 4.699 ± 0.356
5.054IleGlu: 5.054 ± 0.387
3.005IlePhe: 3.005 ± 0.308
4.098IleGly: 4.098 ± 0.395
1.666IleHis: 1.666 ± 0.247
4.098IleIle: 4.098 ± 0.324
6.12IleLys: 6.12 ± 0.462
4.672IleLeu: 4.672 ± 0.364
1.721IleMet: 1.721 ± 0.202
4.535IleAsn: 4.535 ± 0.341
2.131IlePro: 2.131 ± 0.248
2.759IleGln: 2.759 ± 0.283
2.486IleArg: 2.486 ± 0.266
4.262IleSer: 4.262 ± 0.361
3.142IleThr: 3.142 ± 0.271
4.945IleVal: 4.945 ± 0.328
0.71IleTrp: 0.71 ± 0.163
2.732IleTyr: 2.732 ± 0.23
0.0IleXaa: 0.0 ± 0.0
Lys
4.972LysAla: 4.972 ± 0.452
1.421LysCys: 1.421 ± 0.246
6.283LysAsp: 6.283 ± 0.427
7.486LysGlu: 7.486 ± 0.51
3.907LysPhe: 3.907 ± 0.319
4.426LysGly: 4.426 ± 0.371
1.858LysHis: 1.858 ± 0.219
5.71LysIle: 5.71 ± 0.356
5.6LysLys: 5.6 ± 0.487
7.567LysLeu: 7.567 ± 0.457
2.896LysMet: 2.896 ± 0.297
4.672LysAsn: 4.672 ± 0.34
2.431LysPro: 2.431 ± 0.293
4.426LysGln: 4.426 ± 0.39
2.513LysArg: 2.513 ± 0.288
5.327LysSer: 5.327 ± 0.422
4.781LysThr: 4.781 ± 0.357
6.038LysVal: 6.038 ± 0.355
1.229LysTrp: 1.229 ± 0.183
3.934LysTyr: 3.934 ± 0.392
0.0LysXaa: 0.0 ± 0.0
Leu
3.77LeuAla: 3.77 ± 0.327
0.929LeuCys: 0.929 ± 0.133
5.464LeuAsp: 5.464 ± 0.374
6.475LeuGlu: 6.475 ± 0.464
3.907LeuPhe: 3.907 ± 0.31
4.535LeuGly: 4.535 ± 0.383
1.694LeuHis: 1.694 ± 0.22
4.262LeuIle: 4.262 ± 0.307
7.813LeuLys: 7.813 ± 0.464
6.256LeuLeu: 6.256 ± 0.518
1.94LeuMet: 1.94 ± 0.245
5.163LeuAsn: 5.163 ± 0.378
3.06LeuPro: 3.06 ± 0.263
3.36LeuGln: 3.36 ± 0.305
3.306LeuArg: 3.306 ± 0.329
4.999LeuSer: 4.999 ± 0.422
4.207LeuThr: 4.207 ± 0.382
4.371LeuVal: 4.371 ± 0.352
1.065LeuTrp: 1.065 ± 0.163
2.814LeuTyr: 2.814 ± 0.26
0.027LeuXaa: 0.027 ± 0.027
Met
1.421MetAla: 1.421 ± 0.165
0.41MetCys: 0.41 ± 0.116
1.093MetAsp: 1.093 ± 0.182
2.076MetGlu: 2.076 ± 0.236
1.12MetPhe: 1.12 ± 0.179
1.038MetGly: 1.038 ± 0.143
0.492MetHis: 0.492 ± 0.135
2.049MetIle: 2.049 ± 0.237
3.032MetLys: 3.032 ± 0.318
1.967MetLeu: 1.967 ± 0.236
0.464MetMet: 0.464 ± 0.111
1.475MetAsn: 1.475 ± 0.193
0.683MetPro: 0.683 ± 0.152
0.983MetGln: 0.983 ± 0.133
0.929MetArg: 0.929 ± 0.183
2.049MetSer: 2.049 ± 0.347
1.585MetThr: 1.585 ± 0.216
1.093MetVal: 1.093 ± 0.169
0.246MetTrp: 0.246 ± 0.093
1.202MetTyr: 1.202 ± 0.18
0.0MetXaa: 0.0 ± 0.0
Asn
2.677AsnAla: 2.677 ± 0.335
1.229AsnCys: 1.229 ± 0.21
2.841AsnAsp: 2.841 ± 0.294
3.442AsnGlu: 3.442 ± 0.273
2.349AsnPhe: 2.349 ± 0.253
4.098AsnGly: 4.098 ± 0.345
1.257AsnHis: 1.257 ± 0.202
3.688AsnIle: 3.688 ± 0.311
6.721AsnLys: 6.721 ± 0.428
4.999AsnLeu: 4.999 ± 0.391
1.065AsnMet: 1.065 ± 0.189
3.77AsnAsn: 3.77 ± 0.337
2.022AsnPro: 2.022 ± 0.26
1.748AsnGln: 1.748 ± 0.218
2.595AsnArg: 2.595 ± 0.308
3.333AsnSer: 3.333 ± 0.349
3.005AsnThr: 3.005 ± 0.251
3.087AsnVal: 3.087 ± 0.273
0.628AsnTrp: 0.628 ± 0.127
2.513AsnTyr: 2.513 ± 0.252
0.0AsnXaa: 0.0 ± 0.0
Pro
1.257ProAla: 1.257 ± 0.181
0.765ProCys: 0.765 ± 0.153
2.322ProAsp: 2.322 ± 0.238
3.278ProGlu: 3.278 ± 0.305
1.585ProPhe: 1.585 ± 0.2
0.574ProGly: 0.574 ± 0.149
0.328ProHis: 0.328 ± 0.087
1.748ProIle: 1.748 ± 0.243
2.186ProLys: 2.186 ± 0.233
2.049ProLeu: 2.049 ± 0.244
0.765ProMet: 0.765 ± 0.159
1.339ProAsn: 1.339 ± 0.181
0.601ProPro: 0.601 ± 0.122
1.093ProGln: 1.093 ± 0.186
0.847ProArg: 0.847 ± 0.152
2.595ProSer: 2.595 ± 0.307
1.748ProThr: 1.748 ± 0.221
2.158ProVal: 2.158 ± 0.261
0.301ProTrp: 0.301 ± 0.096
1.339ProTyr: 1.339 ± 0.188
0.0ProXaa: 0.0 ± 0.0
Gln
1.912GlnAla: 1.912 ± 0.249
0.519GlnCys: 0.519 ± 0.139
2.322GlnAsp: 2.322 ± 0.275
3.743GlnGlu: 3.743 ± 0.332
1.994GlnPhe: 1.994 ± 0.233
2.158GlnGly: 2.158 ± 0.222
0.656GlnHis: 0.656 ± 0.123
2.841GlnIle: 2.841 ± 0.337
2.896GlnLys: 2.896 ± 0.283
3.852GlnLeu: 3.852 ± 0.309
1.175GlnMet: 1.175 ± 0.157
2.295GlnAsn: 2.295 ± 0.253
1.12GlnPro: 1.12 ± 0.155
2.213GlnGln: 2.213 ± 0.238
1.776GlnArg: 1.776 ± 0.22
1.94GlnSer: 1.94 ± 0.259
1.94GlnThr: 1.94 ± 0.247
2.213GlnVal: 2.213 ± 0.257
0.437GlnTrp: 0.437 ± 0.103
1.912GlnTyr: 1.912 ± 0.231
0.0GlnXaa: 0.0 ± 0.0
Arg
1.666ArgAla: 1.666 ± 0.226
0.628ArgCys: 0.628 ± 0.141
2.158ArgAsp: 2.158 ± 0.304
3.196ArgGlu: 3.196 ± 0.333
1.858ArgPhe: 1.858 ± 0.203
2.24ArgGly: 2.24 ± 0.268
0.738ArgHis: 0.738 ± 0.14
2.759ArgIle: 2.759 ± 0.297
3.388ArgLys: 3.388 ± 0.332
3.224ArgLeu: 3.224 ± 0.321
0.874ArgMet: 0.874 ± 0.142
2.431ArgAsn: 2.431 ± 0.215
0.847ArgPro: 0.847 ± 0.164
1.53ArgGln: 1.53 ± 0.207
1.639ArgArg: 1.639 ± 0.233
2.869ArgSer: 2.869 ± 0.278
1.94ArgThr: 1.94 ± 0.242
1.885ArgVal: 1.885 ± 0.231
0.738ArgTrp: 0.738 ± 0.147
1.83ArgTyr: 1.83 ± 0.221
0.0ArgXaa: 0.0 ± 0.0
Ser
3.552SerAla: 3.552 ± 0.301
1.284SerCys: 1.284 ± 0.157
3.661SerAsp: 3.661 ± 0.295
4.781SerGlu: 4.781 ± 0.321
3.251SerPhe: 3.251 ± 0.342
4.699SerGly: 4.699 ± 0.438
0.983SerHis: 0.983 ± 0.158
4.617SerIle: 4.617 ± 0.332
5.737SerLys: 5.737 ± 0.353
4.754SerLeu: 4.754 ± 0.342
1.503SerMet: 1.503 ± 0.196
3.524SerAsn: 3.524 ± 0.295
1.885SerPro: 1.885 ± 0.246
1.967SerGln: 1.967 ± 0.25
2.787SerArg: 2.787 ± 0.245
3.715SerSer: 3.715 ± 0.317
2.978SerThr: 2.978 ± 0.234
4.289SerVal: 4.289 ± 0.323
1.257SerTrp: 1.257 ± 0.216
2.623SerTyr: 2.623 ± 0.287
0.0SerXaa: 0.0 ± 0.0
Thr
2.486ThrAla: 2.486 ± 0.284
0.738ThrCys: 0.738 ± 0.137
3.032ThrAsp: 3.032 ± 0.322
4.071ThrGlu: 4.071 ± 0.36
2.459ThrPhe: 2.459 ± 0.237
3.661ThrGly: 3.661 ± 0.366
1.475ThrHis: 1.475 ± 0.233
3.797ThrIle: 3.797 ± 0.303
4.754ThrLys: 4.754 ± 0.35
4.153ThrLeu: 4.153 ± 0.41
0.847ThrMet: 0.847 ± 0.146
2.759ThrAsn: 2.759 ± 0.237
1.858ThrPro: 1.858 ± 0.231
2.459ThrGln: 2.459 ± 0.262
1.666ThrArg: 1.666 ± 0.195
2.841ThrSer: 2.841 ± 0.261
3.415ThrThr: 3.415 ± 0.334
3.989ThrVal: 3.989 ± 0.393
0.765ThrTrp: 0.765 ± 0.157
2.268ThrTyr: 2.268 ± 0.264
0.0ThrXaa: 0.0 ± 0.0
Val
3.77ValAla: 3.77 ± 0.314
1.421ValCys: 1.421 ± 0.21
5.245ValAsp: 5.245 ± 0.348
5.3ValGlu: 5.3 ± 0.387
2.268ValPhe: 2.268 ± 0.238
4.153ValGly: 4.153 ± 0.332
1.12ValHis: 1.12 ± 0.161
3.825ValIle: 3.825 ± 0.295
5.081ValLys: 5.081 ± 0.379
5.027ValLeu: 5.027 ± 0.411
1.311ValMet: 1.311 ± 0.168
3.087ValAsn: 3.087 ± 0.31
1.721ValPro: 1.721 ± 0.206
2.431ValGln: 2.431 ± 0.303
2.131ValArg: 2.131 ± 0.246
4.863ValSer: 4.863 ± 0.422
4.043ValThr: 4.043 ± 0.318
6.147ValVal: 6.147 ± 0.522
0.792ValTrp: 0.792 ± 0.144
3.169ValTyr: 3.169 ± 0.253
0.0ValXaa: 0.0 ± 0.0
Trp
0.683TrpAla: 0.683 ± 0.173
0.355TrpCys: 0.355 ± 0.105
1.284TrpAsp: 1.284 ± 0.202
0.902TrpGlu: 0.902 ± 0.154
0.765TrpPhe: 0.765 ± 0.141
0.601TrpGly: 0.601 ± 0.137
0.219TrpHis: 0.219 ± 0.076
0.929TrpIle: 0.929 ± 0.144
1.257TrpLys: 1.257 ± 0.18
1.557TrpLeu: 1.557 ± 0.184
0.464TrpMet: 0.464 ± 0.121
0.738TrpAsn: 0.738 ± 0.145
0.246TrpPro: 0.246 ± 0.079
0.792TrpGln: 0.792 ± 0.166
0.382TrpArg: 0.382 ± 0.103
1.065TrpSer: 1.065 ± 0.162
0.71TrpThr: 0.71 ± 0.145
0.738TrpVal: 0.738 ± 0.159
0.219TrpTrp: 0.219 ± 0.079
0.82TrpTyr: 0.82 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.912TyrAla: 1.912 ± 0.231
0.902TyrCys: 0.902 ± 0.16
3.06TyrAsp: 3.06 ± 0.322
3.552TyrGlu: 3.552 ± 0.291
2.158TyrPhe: 2.158 ± 0.231
2.295TyrGly: 2.295 ± 0.217
1.011TyrHis: 1.011 ± 0.17
2.759TyrIle: 2.759 ± 0.264
4.207TyrLys: 4.207 ± 0.35
3.579TyrLeu: 3.579 ± 0.299
1.011TyrMet: 1.011 ± 0.214
3.251TyrAsn: 3.251 ± 0.268
1.748TyrPro: 1.748 ± 0.208
1.803TyrGln: 1.803 ± 0.213
2.104TyrArg: 2.104 ± 0.222
3.579TyrSer: 3.579 ± 0.393
2.268TyrThr: 2.268 ± 0.272
3.196TyrVal: 3.196 ± 0.284
0.546TyrTrp: 0.546 ± 0.142
2.322TyrTyr: 2.322 ± 0.3
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.027XaaPro: 0.027 ± 0.027
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 221 proteins (36605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski