Amino acid dipepetide frequency for Enterococcus avium ATCC 14025

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.9AlaAla: 5.9 ± 0.094	0.62AlaCys: 0.62 ± 0.026	3.885AlaAsp: 3.885 ± 0.079	5.218AlaGlu: 5.218 ± 0.068	3.251AlaPhe: 3.251 ± 0.058	5.171AlaGly: 5.171 ± 0.074	1.105AlaHis: 1.105 ± 0.028	5.951AlaIle: 5.951 ± 0.078	5.067AlaLys: 5.067 ± 0.073	6.99AlaLeu: 6.99 ± 0.085	2.041AlaMet: 2.041 ± 0.046	3.004AlaAsn: 3.004 ± 0.05	2.062AlaPro: 2.062 ± 0.042	2.545AlaGln: 2.545 ± 0.048	2.429AlaArg: 2.429 ± 0.044	4.003AlaSer: 4.003 ± 0.066	3.878AlaThr: 3.878 ± 0.059	5.007AlaVal: 5.007 ± 0.064	0.562AlaTrp: 0.562 ± 0.021	2.308AlaTyr: 2.308 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.462CysAla: 0.462 ± 0.018	0.104CysCys: 0.104 ± 0.009	0.41CysAsp: 0.41 ± 0.018	0.474CysGlu: 0.474 ± 0.022	0.392CysPhe: 0.392 ± 0.018	0.71CysGly: 0.71 ± 0.024	0.227CysHis: 0.227 ± 0.015	0.495CysIle: 0.495 ± 0.021	0.335CysLys: 0.335 ± 0.02	0.792CysLeu: 0.792 ± 0.027	0.194CysMet: 0.194 ± 0.013	0.255CysAsn: 0.255 ± 0.014	0.344CysPro: 0.344 ± 0.021	0.315CysGln: 0.315 ± 0.017	0.267CysArg: 0.267 ± 0.015	0.51CysSer: 0.51 ± 0.023	0.35CysThr: 0.35 ± 0.016	0.508CysVal: 0.508 ± 0.018	0.072CysTrp: 0.072 ± 0.008	0.3CysTyr: 0.3 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.408AspAla: 3.408 ± 0.077	0.464AspCys: 0.464 ± 0.017	2.592AspAsp: 2.592 ± 0.054	4.311AspGlu: 4.311 ± 0.061	2.938AspPhe: 2.938 ± 0.05	3.493AspGly: 3.493 ± 0.063	1.049AspHis: 1.049 ± 0.03	3.729AspIle: 3.729 ± 0.052	3.296AspLys: 3.296 ± 0.06	5.278AspLeu: 5.278 ± 0.069	1.283AspMet: 1.283 ± 0.032	2.063AspAsn: 2.063 ± 0.042	1.983AspPro: 1.983 ± 0.041	2.489AspGln: 2.489 ± 0.047	2.112AspArg: 2.112 ± 0.044	3.101AspSer: 3.101 ± 0.065	2.652AspThr: 2.652 ± 0.047	3.509AspVal: 3.509 ± 0.056	0.611AspTrp: 0.611 ± 0.021	2.65AspTyr: 2.65 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.541GluAla: 5.541 ± 0.076	0.434GluCys: 0.434 ± 0.019	3.628GluAsp: 3.628 ± 0.058	6.591GluGlu: 6.591 ± 0.085	2.65GluPhe: 2.65 ± 0.048	3.819GluGly: 3.819 ± 0.067	1.256GluHis: 1.256 ± 0.034	5.764GluIle: 5.764 ± 0.078	7.127GluLys: 7.127 ± 0.083	7.409GluLeu: 7.409 ± 0.096	2.344GluMet: 2.344 ± 0.045	4.033GluAsn: 4.033 ± 0.066	1.978GluPro: 1.978 ± 0.042	3.182GluGln: 3.182 ± 0.054	3.146GluArg: 3.146 ± 0.049	3.509GluSer: 3.509 ± 0.091	4.13GluThr: 4.13 ± 0.063	4.808GluVal: 4.808 ± 0.065	0.677GluTrp: 0.677 ± 0.026	2.313GluTyr: 2.313 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.111PheAla: 3.111 ± 0.056	0.444PheCys: 0.444 ± 0.019	2.784PheAsp: 2.784 ± 0.051	2.972PheGlu: 2.972 ± 0.056	2.598PhePhe: 2.598 ± 0.062	3.404PheGly: 3.404 ± 0.061	0.808PheHis: 0.808 ± 0.025	3.574PheIle: 3.574 ± 0.066	2.414PheLys: 2.414 ± 0.049	4.792PheLeu: 4.792 ± 0.074	1.177PheMet: 1.177 ± 0.032	2.011PheAsn: 2.011 ± 0.04	1.688PhePro: 1.688 ± 0.036	1.71PheGln: 1.71 ± 0.037	1.529PheArg: 1.529 ± 0.038	3.619PheSer: 3.619 ± 0.055	2.568PheThr: 2.568 ± 0.049	3.21PheVal: 3.21 ± 0.053	0.446PheTrp: 0.446 ± 0.023	1.875PheTyr: 1.875 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.652GlyAla: 4.652 ± 0.072	0.594GlyCys: 0.594 ± 0.023	3.105GlyAsp: 3.105 ± 0.054	4.073GlyGlu: 4.073 ± 0.054	3.25GlyPhe: 3.25 ± 0.066	4.496GlyGly: 4.496 ± 0.082	1.099GlyHis: 1.099 ± 0.032	6.033GlyIle: 6.033 ± 0.08	4.794GlyLys: 4.794 ± 0.061	6.43GlyLeu: 6.43 ± 0.08	2.043GlyMet: 2.043 ± 0.044	2.939GlyAsn: 2.939 ± 0.053	1.494GlyPro: 1.494 ± 0.03	2.179GlyGln: 2.179 ± 0.044	2.38GlyArg: 2.38 ± 0.051	3.926GlySer: 3.926 ± 0.061	3.945GlyThr: 3.945 ± 0.062	4.798GlyVal: 4.798 ± 0.066	0.664GlyTrp: 0.664 ± 0.025	2.639GlyTyr: 2.639 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.132HisAla: 1.132 ± 0.029	0.169HisCys: 0.169 ± 0.011	0.902HisAsp: 0.902 ± 0.028	1.167HisGlu: 1.167 ± 0.028	1.069HisPhe: 1.069 ± 0.03	1.251HisGly: 1.251 ± 0.033	0.497HisHis: 0.497 ± 0.023	1.106HisIle: 1.106 ± 0.025	0.829HisLys: 0.829 ± 0.027	1.969HisLeu: 1.969 ± 0.046	0.418HisMet: 0.418 ± 0.019	0.631HisAsn: 0.631 ± 0.022	0.849HisPro: 0.849 ± 0.027	0.851HisGln: 0.851 ± 0.028	0.711HisArg: 0.711 ± 0.023	1.073HisSer: 1.073 ± 0.031	0.883HisThr: 0.883 ± 0.026	1.143HisVal: 1.143 ± 0.029	0.192HisTrp: 0.192 ± 0.013	0.849HisTyr: 0.849 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.036IleAla: 6.036 ± 0.068	0.74IleCys: 0.74 ± 0.024	4.65IleAsp: 4.65 ± 0.064	5.537IleGlu: 5.537 ± 0.072	3.52IlePhe: 3.52 ± 0.065	5.702IleGly: 5.702 ± 0.081	1.434IleHis: 1.434 ± 0.034	5.512IleIle: 5.512 ± 0.082	4.711IleLys: 4.711 ± 0.06	7.355IleLeu: 7.355 ± 0.086	1.783IleMet: 1.783 ± 0.038	3.581IleAsn: 3.581 ± 0.052	3.257IlePro: 3.257 ± 0.052	3.023IleGln: 3.023 ± 0.06	2.892IleArg: 2.892 ± 0.05	5.108IleSer: 5.108 ± 0.09	4.228IleThr: 4.228 ± 0.065	5.482IleVal: 5.482 ± 0.078	0.565IleTrp: 0.565 ± 0.021	2.522IleTyr: 2.522 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.705LysAla: 4.705 ± 0.07	0.267LysCys: 0.267 ± 0.017	3.94LysAsp: 3.94 ± 0.069	6.973LysGlu: 6.973 ± 0.083	2.136LysPhe: 2.136 ± 0.04	3.833LysGly: 3.833 ± 0.059	1.107LysHis: 1.107 ± 0.029	5.476LysIle: 5.476 ± 0.068	6.69LysLys: 6.69 ± 0.089	5.781LysLeu: 5.781 ± 0.062	2.203LysMet: 2.203 ± 0.039	4.089LysAsn: 4.089 ± 0.067	1.876LysPro: 1.876 ± 0.044	3.286LysGln: 3.286 ± 0.052	3.229LysArg: 3.229 ± 0.055	3.433LysSer: 3.433 ± 0.059	3.814LysThr: 3.814 ± 0.055	4.5LysVal: 4.5 ± 0.063	0.577LysTrp: 0.577 ± 0.022	2.397LysTyr: 2.397 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.882LeuAla: 7.882 ± 0.098	0.726LeuCys: 0.726 ± 0.024	5.033LeuAsp: 5.033 ± 0.063	6.518LeuGlu: 6.518 ± 0.086	4.934LeuPhe: 4.934 ± 0.077	6.452LeuGly: 6.452 ± 0.096	1.545LeuHis: 1.545 ± 0.035	7.553LeuIle: 7.553 ± 0.097	6.665LeuLys: 6.665 ± 0.069	10.413LeuLeu: 10.413 ± 0.134	2.64LeuMet: 2.64 ± 0.048	4.489LeuAsn: 4.489 ± 0.057	4.052LeuPro: 4.052 ± 0.06	3.368LeuGln: 3.368 ± 0.06	3.644LeuArg: 3.644 ± 0.059	6.852LeuSer: 6.852 ± 0.08	6.16LeuThr: 6.16 ± 0.074	6.564LeuVal: 6.564 ± 0.078	0.741LeuTrp: 0.741 ± 0.029	3.015LeuTyr: 3.015 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.893MetAla: 1.893 ± 0.04	0.162MetCys: 0.162 ± 0.01	1.464MetAsp: 1.464 ± 0.035	1.863MetGlu: 1.863 ± 0.04	0.989MetPhe: 0.989 ± 0.031	1.786MetGly: 1.786 ± 0.038	0.408MetHis: 0.408 ± 0.017	2.476MetIle: 2.476 ± 0.043	2.334MetLys: 2.334 ± 0.041	2.426MetLeu: 2.426 ± 0.047	0.919MetMet: 0.919 ± 0.03	1.623MetAsn: 1.623 ± 0.035	0.958MetPro: 0.958 ± 0.028	0.91MetGln: 0.91 ± 0.024	1.077MetArg: 1.077 ± 0.033	1.572MetSer: 1.572 ± 0.034	1.791MetThr: 1.791 ± 0.039	1.731MetVal: 1.731 ± 0.044	0.149MetTrp: 0.149 ± 0.012	0.782MetTyr: 0.782 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.767AsnAla: 2.767 ± 0.048	0.365AsnCys: 0.365 ± 0.02	2.584AsnAsp: 2.584 ± 0.046	3.438AsnGlu: 3.438 ± 0.057	2.067AsnPhe: 2.067 ± 0.04	3.256AsnGly: 3.256 ± 0.058	1.03AsnHis: 1.03 ± 0.03	3.134AsnIle: 3.134 ± 0.052	2.93AsnLys: 2.93 ± 0.046	4.316AsnLeu: 4.316 ± 0.07	1.131AsnMet: 1.131 ± 0.029	2.122AsnAsn: 2.122 ± 0.043	2.01AsnPro: 2.01 ± 0.041	2.574AsnGln: 2.574 ± 0.045	1.981AsnArg: 1.981 ± 0.042	2.556AsnSer: 2.556 ± 0.053	2.208AsnThr: 2.208 ± 0.046	2.98AsnVal: 2.98 ± 0.057	0.508AsnTrp: 0.508 ± 0.021	2.204AsnTyr: 2.204 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.443ProAla: 2.443 ± 0.042	0.182ProCys: 0.182 ± 0.012	1.91ProAsp: 1.91 ± 0.04	3.268ProGlu: 3.268 ± 0.055	1.781ProPhe: 1.781 ± 0.04	1.865ProGly: 1.865 ± 0.039	0.662ProHis: 0.662 ± 0.023	2.807ProIle: 2.807 ± 0.045	2.316ProLys: 2.316 ± 0.042	3.26ProLeu: 3.26 ± 0.052	0.89ProMet: 0.89 ± 0.025	1.626ProAsn: 1.626 ± 0.034	0.668ProPro: 0.668 ± 0.025	1.297ProGln: 1.297 ± 0.029	1.024ProArg: 1.024 ± 0.03	1.907ProSer: 1.907 ± 0.042	2.133ProThr: 2.133 ± 0.041	2.541ProVal: 2.541 ± 0.048	0.29ProTrp: 0.29 ± 0.015	1.324ProTyr: 1.324 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.306GlnAla: 3.306 ± 0.062	0.182GlnCys: 0.182 ± 0.012	1.696GlnAsp: 1.696 ± 0.04	3.277GlnGlu: 3.277 ± 0.055	1.555GlnPhe: 1.555 ± 0.039	2.191GlnGly: 2.191 ± 0.041	0.674GlnHis: 0.674 ± 0.021	2.911GlnIle: 2.911 ± 0.045	3.157GlnLys: 3.157 ± 0.054	4.614GlnLeu: 4.614 ± 0.075	1.195GlnMet: 1.195 ± 0.027	1.752GlnAsn: 1.752 ± 0.036	1.29GlnPro: 1.29 ± 0.034	2.254GlnGln: 2.254 ± 0.059	1.832GlnArg: 1.832 ± 0.039	2.158GlnSer: 2.158 ± 0.035	2.477GlnThr: 2.477 ± 0.047	2.693GlnVal: 2.693 ± 0.044	0.365GlnTrp: 0.365 ± 0.018	1.247GlnTyr: 1.247 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.151ArgAla: 2.151 ± 0.04	0.291ArgCys: 0.291 ± 0.017	1.801ArgAsp: 1.801 ± 0.046	2.909ArgGlu: 2.909 ± 0.048	1.967ArgPhe: 1.967 ± 0.034	2.132ArgGly: 2.132 ± 0.04	0.699ArgHis: 0.699 ± 0.024	3.073ArgIle: 3.073 ± 0.049	3.242ArgLys: 3.242 ± 0.056	3.998ArgLeu: 3.998 ± 0.058	1.204ArgMet: 1.204 ± 0.032	1.828ArgAsn: 1.828 ± 0.04	1.25ArgPro: 1.25 ± 0.033	1.726ArgGln: 1.726 ± 0.037	1.933ArgArg: 1.933 ± 0.039	2.112ArgSer: 2.112 ± 0.041	1.98ArgThr: 1.98 ± 0.042	2.408ArgVal: 2.408 ± 0.045	0.377ArgTrp: 0.377 ± 0.019	1.635ArgTyr: 1.635 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.902SerAla: 3.902 ± 0.065	0.399SerCys: 0.399 ± 0.021	3.259SerAsp: 3.259 ± 0.056	4.425SerGlu: 4.425 ± 0.108	3.223SerPhe: 3.223 ± 0.06	4.341SerGly: 4.341 ± 0.068	1.027SerHis: 1.027 ± 0.028	4.724SerIle: 4.724 ± 0.085	3.84SerLys: 3.84 ± 0.062	6.167SerLeu: 6.167 ± 0.085	1.604SerMet: 1.604 ± 0.036	2.689SerAsn: 2.689 ± 0.058	1.878SerPro: 1.878 ± 0.041	2.286SerGln: 2.286 ± 0.045	2.14SerArg: 2.14 ± 0.038	4.038SerSer: 4.038 ± 0.07	3.353SerThr: 3.353 ± 0.095	4.089SerVal: 4.089 ± 0.053	0.594SerTrp: 0.594 ± 0.021	2.338SerTyr: 2.338 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.979ThrAla: 3.979 ± 0.058	0.355ThrCys: 0.355 ± 0.016	3.103ThrAsp: 3.103 ± 0.047	3.776ThrGlu: 3.776 ± 0.061	2.657ThrPhe: 2.657 ± 0.044	4.071ThrGly: 4.071 ± 0.065	0.969ThrHis: 0.969 ± 0.029	5.079ThrIle: 5.079 ± 0.067	3.802ThrLys: 3.802 ± 0.058	5.328ThrLeu: 5.328 ± 0.057	1.406ThrMet: 1.406 ± 0.035	2.603ThrAsn: 2.603 ± 0.043	2.309ThrPro: 2.309 ± 0.048	1.815ThrGln: 1.815 ± 0.04	1.813ThrArg: 1.813 ± 0.036	3.503ThrSer: 3.503 ± 0.084	3.315ThrThr: 3.315 ± 0.055	4.111ThrVal: 4.111 ± 0.063	0.492ThrTrp: 0.492 ± 0.02	1.924ThrTyr: 1.924 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	5.02ValAla: 5.02 ± 0.068	0.603ValCys: 0.603 ± 0.025	3.773ValAsp: 3.773 ± 0.052	4.606ValGlu: 4.606 ± 0.071	3.223ValPhe: 3.223 ± 0.058	4.587ValGly: 4.587 ± 0.064	1.079ValHis: 1.079 ± 0.033	5.408ValIle: 5.408 ± 0.068	4.346ValLys: 4.346 ± 0.07	6.677ValLeu: 6.677 ± 0.081	1.856ValMet: 1.856 ± 0.041	2.91ValAsn: 2.91 ± 0.048	2.558ValPro: 2.558 ± 0.045	2.217ValGln: 2.217 ± 0.037	2.42ValArg: 2.42 ± 0.044	4.499ValSer: 4.499 ± 0.057	4.255ValThr: 4.255 ± 0.059	4.981ValVal: 4.981 ± 0.067	0.503ValTrp: 0.503 ± 0.02	2.167ValTyr: 2.167 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.488TrpAla: 0.488 ± 0.021	0.079TrpCys: 0.079 ± 0.006	0.434TrpAsp: 0.434 ± 0.019	0.575TrpGlu: 0.575 ± 0.023	0.458TrpPhe: 0.458 ± 0.023	0.638TrpGly: 0.638 ± 0.022	0.172TrpHis: 0.172 ± 0.01	0.647TrpIle: 0.647 ± 0.021	0.563TrpLys: 0.563 ± 0.021	1.062TrpLeu: 1.062 ± 0.033	0.253TrpMet: 0.253 ± 0.014	0.428TrpAsn: 0.428 ± 0.019	0.216TrpPro: 0.216 ± 0.014	0.507TrpGln: 0.507 ± 0.021	0.425TrpArg: 0.425 ± 0.02	0.555TrpSer: 0.555 ± 0.021	0.477TrpThr: 0.477 ± 0.019	0.492TrpVal: 0.492 ± 0.021	0.107TrpTrp: 0.107 ± 0.009	0.323TrpTyr: 0.323 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.218TyrAla: 2.218 ± 0.042	0.336TyrCys: 0.336 ± 0.017	2.059TyrAsp: 2.059 ± 0.042	2.368TyrGlu: 2.368 ± 0.053	2.076TyrPhe: 2.076 ± 0.044	2.332TyrGly: 2.332 ± 0.037	0.846TyrHis: 0.846 ± 0.025	2.191TyrIle: 2.191 ± 0.043	1.857TyrLys: 1.857 ± 0.039	4.19TyrLeu: 4.19 ± 0.061	0.73TyrMet: 0.73 ± 0.023	1.485TyrAsn: 1.485 ± 0.037	1.476TyrPro: 1.476 ± 0.037	2.289TyrGln: 2.289 ± 0.042	1.731TyrArg: 1.731 ± 0.038	2.279TyrSer: 2.279 ± 0.041	1.811TyrThr: 1.811 ± 0.042	2.133TyrVal: 2.133 ± 0.046	0.405TyrTrp: 0.405 ± 0.021	1.646TyrTyr: 1.646 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4469 proteins (1305096 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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