Amino acid dipepetide frequency for Tetranychus urticae (Two-spotted spider mite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.845AlaAla: 3.845 ± 0.059	0.954AlaCys: 0.954 ± 0.015	2.624AlaAsp: 2.624 ± 0.022	2.801AlaGlu: 2.801 ± 0.025	2.476AlaPhe: 2.476 ± 0.019	2.62AlaGly: 2.62 ± 0.031	1.15AlaHis: 1.15 ± 0.015	3.88AlaIle: 3.88 ± 0.028	3.467AlaLys: 3.467 ± 0.028	4.859AlaLeu: 4.859 ± 0.034	1.105AlaMet: 1.105 ± 0.012	2.98AlaAsn: 2.98 ± 0.025	2.189AlaPro: 2.189 ± 0.025	1.825AlaGln: 1.825 ± 0.022	2.294AlaArg: 2.294 ± 0.021	5.099AlaSer: 5.099 ± 0.042	3.132AlaThr: 3.132 ± 0.026	3.031AlaVal: 3.031 ± 0.024	0.494AlaTrp: 0.494 ± 0.01	1.643AlaTyr: 1.643 ± 0.017	0.001AlaXaa: 0.001 ± 0.0
Cys	0.961CysAla: 0.961 ± 0.013	0.487CysCys: 0.487 ± 0.01	1.227CysAsp: 1.227 ± 0.02	1.046CysGlu: 1.046 ± 0.016	1.076CysPhe: 1.076 ± 0.014	1.134CysGly: 1.134 ± 0.019	0.503CysHis: 0.503 ± 0.01	1.298CysIle: 1.298 ± 0.017	1.258CysLys: 1.258 ± 0.017	2.169CysLeu: 2.169 ± 0.022	0.347CysMet: 0.347 ± 0.007	1.07CysAsn: 1.07 ± 0.015	1.025CysPro: 1.025 ± 0.016	0.751CysGln: 0.751 ± 0.012	0.929CysArg: 0.929 ± 0.016	1.81CysSer: 1.81 ± 0.024	0.964CysThr: 0.964 ± 0.017	1.041CysVal: 1.041 ± 0.015	0.226CysTrp: 0.226 ± 0.006	0.71CysTyr: 0.71 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	2.621AspAla: 2.621 ± 0.022	1.252AspCys: 1.252 ± 0.02	4.096AspAsp: 4.096 ± 0.037	4.406AspGlu: 4.406 ± 0.034	2.551AspPhe: 2.551 ± 0.019	3.024AspGly: 3.024 ± 0.024	1.287AspHis: 1.287 ± 0.015	3.445AspIle: 3.445 ± 0.026	3.701AspLys: 3.701 ± 0.026	5.221AspLeu: 5.221 ± 0.034	0.974AspMet: 0.974 ± 0.013	2.929AspAsn: 2.929 ± 0.024	2.551AspPro: 2.551 ± 0.02	2.067AspGln: 2.067 ± 0.022	2.294AspArg: 2.294 ± 0.025	4.848AspSer: 4.848 ± 0.033	2.343AspThr: 2.343 ± 0.022	2.973AspVal: 2.973 ± 0.025	0.759AspTrp: 0.759 ± 0.012	2.339AspTyr: 2.339 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	3.38GluAla: 3.38 ± 0.03	1.034GluCys: 1.034 ± 0.018	3.628GluAsp: 3.628 ± 0.034	4.634GluGlu: 4.634 ± 0.054	2.172GluPhe: 2.172 ± 0.021	2.444GluGly: 2.444 ± 0.021	1.061GluHis: 1.061 ± 0.014	4.118GluIle: 4.118 ± 0.039	4.798GluLys: 4.798 ± 0.046	4.933GluLeu: 4.933 ± 0.033	1.534GluMet: 1.534 ± 0.016	3.424GluAsn: 3.424 ± 0.022	2.497GluPro: 2.497 ± 0.031	2.004GluGln: 2.004 ± 0.022	2.891GluArg: 2.891 ± 0.028	5.103GluSer: 5.103 ± 0.049	3.634GluThr: 3.634 ± 0.047	2.983GluVal: 2.983 ± 0.026	0.606GluTrp: 0.606 ± 0.011	1.812GluTyr: 1.812 ± 0.017	0.001GluXaa: 0.001 ± 0.0
Phe	2.461PheAla: 2.461 ± 0.022	0.999PheCys: 0.999 ± 0.013	2.765PheAsp: 2.765 ± 0.022	2.347PheGlu: 2.347 ± 0.022	2.098PhePhe: 2.098 ± 0.021	2.725PheGly: 2.725 ± 0.025	1.161PheHis: 1.161 ± 0.014	3.541PheIle: 3.541 ± 0.031	2.826PheLys: 2.826 ± 0.023	4.208PheLeu: 4.208 ± 0.036	1.015PheMet: 1.015 ± 0.014	2.876PheAsn: 2.876 ± 0.022	1.816PhePro: 1.816 ± 0.019	1.499PheGln: 1.499 ± 0.015	1.976PheArg: 1.976 ± 0.018	3.624PheSer: 3.624 ± 0.028	2.699PheThr: 2.699 ± 0.024	2.683PheVal: 2.683 ± 0.025	0.589PheTrp: 0.589 ± 0.01	1.735PheTyr: 1.735 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	2.599GlyAla: 2.599 ± 0.029	0.966GlyCys: 0.966 ± 0.015	2.841GlyAsp: 2.841 ± 0.025	2.613GlyGlu: 2.613 ± 0.026	2.612GlyPhe: 2.612 ± 0.025	3.212GlyGly: 3.212 ± 0.049	1.34GlyHis: 1.34 ± 0.019	3.242GlyIle: 3.242 ± 0.022	3.425GlyLys: 3.425 ± 0.026	4.825GlyLeu: 4.825 ± 0.036	0.963GlyMet: 0.963 ± 0.014	2.8GlyAsn: 2.8 ± 0.028	2.372GlyPro: 2.372 ± 0.036	1.918GlyGln: 1.918 ± 0.017	2.39GlyArg: 2.39 ± 0.024	5.269GlySer: 5.269 ± 0.071	2.663GlyThr: 2.663 ± 0.023	2.787GlyVal: 2.787 ± 0.028	0.575GlyTrp: 0.575 ± 0.011	2.118GlyTyr: 2.118 ± 0.022	0.001GlyXaa: 0.001 ± 0.0
His	0.922HisAla: 0.922 ± 0.013	0.576HisCys: 0.576 ± 0.009	1.107HisAsp: 1.107 ± 0.014	1.222HisGlu: 1.222 ± 0.012	1.226HisPhe: 1.226 ± 0.013	1.356HisGly: 1.356 ± 0.022	1.393HisHis: 1.393 ± 0.035	1.381HisIle: 1.381 ± 0.016	1.29HisLys: 1.29 ± 0.015	2.615HisLeu: 2.615 ± 0.023	0.418HisMet: 0.418 ± 0.008	1.209HisAsn: 1.209 ± 0.018	1.275HisPro: 1.275 ± 0.019	1.298HisGln: 1.298 ± 0.019	1.285HisArg: 1.285 ± 0.016	2.041HisSer: 2.041 ± 0.023	0.936HisThr: 0.936 ± 0.013	1.151HisVal: 1.151 ± 0.014	0.307HisTrp: 0.307 ± 0.007	0.972HisTyr: 0.972 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.767IleAla: 3.767 ± 0.026	1.469IleCys: 1.469 ± 0.017	4.187IleAsp: 4.187 ± 0.032	4.312IleGlu: 4.312 ± 0.046	3.23IlePhe: 3.23 ± 0.028	3.599IleGly: 3.599 ± 0.025	1.622IleHis: 1.622 ± 0.015	4.872IleIle: 4.872 ± 0.033	4.706IleLys: 4.706 ± 0.035	6.122IleLeu: 6.122 ± 0.04	1.393IleMet: 1.393 ± 0.015	4.288IleAsn: 4.288 ± 0.03	3.112IlePro: 3.112 ± 0.031	2.414IleGln: 2.414 ± 0.022	3.062IleArg: 3.062 ± 0.022	5.718IleSer: 5.718 ± 0.035	3.863IleThr: 3.863 ± 0.028	4.086IleVal: 4.086 ± 0.03	0.736IleTrp: 0.736 ± 0.012	2.428IleTyr: 2.428 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.45LysAla: 3.45 ± 0.028	1.343LysCys: 1.343 ± 0.018	3.679LysAsp: 3.679 ± 0.032	4.344LysGlu: 4.344 ± 0.042	2.716LysPhe: 2.716 ± 0.023	2.954LysGly: 2.954 ± 0.028	1.476LysHis: 1.476 ± 0.019	4.613LysIle: 4.613 ± 0.035	5.014LysLys: 5.014 ± 0.056	6.221LysLeu: 6.221 ± 0.035	1.658LysMet: 1.658 ± 0.016	3.323LysAsn: 3.323 ± 0.026	3.276LysPro: 3.276 ± 0.04	2.533LysGln: 2.533 ± 0.022	3.484LysArg: 3.484 ± 0.031	5.74LysSer: 5.74 ± 0.037	3.6LysThr: 3.6 ± 0.03	3.933LysVal: 3.933 ± 0.03	0.734LysTrp: 0.734 ± 0.011	2.307LysTyr: 2.307 ± 0.022	0.001LysXaa: 0.001 ± 0.0
Leu	5.275LeuAla: 5.275 ± 0.034	1.693LeuCys: 1.693 ± 0.019	5.094LeuAsp: 5.094 ± 0.031	5.193LeuGlu: 5.193 ± 0.037	4.31LeuPhe: 4.31 ± 0.034	4.356LeuGly: 4.356 ± 0.032	2.125LeuHis: 2.125 ± 0.02	7.019LeuIle: 7.019 ± 0.049	6.389LeuLys: 6.389 ± 0.04	8.723LeuLeu: 8.723 ± 0.062	2.165LeuMet: 2.165 ± 0.017	5.388LeuAsn: 5.388 ± 0.033	4.588LeuPro: 4.588 ± 0.03	3.365LeuGln: 3.365 ± 0.027	4.38LeuArg: 4.38 ± 0.03	8.091LeuSer: 8.091 ± 0.045	5.956LeuThr: 5.956 ± 0.038	5.433LeuVal: 5.433 ± 0.036	0.929LeuTrp: 0.929 ± 0.014	2.887LeuTyr: 2.887 ± 0.025	0.001LeuXaa: 0.001 ± 0.0
Met	1.423MetAla: 1.423 ± 0.015	0.338MetCys: 0.338 ± 0.007	1.354MetAsp: 1.354 ± 0.014	1.376MetGlu: 1.376 ± 0.017	0.946MetPhe: 0.946 ± 0.012	0.957MetGly: 0.957 ± 0.014	0.37MetHis: 0.37 ± 0.008	1.578MetIle: 1.578 ± 0.016	1.66MetLys: 1.66 ± 0.018	1.837MetLeu: 1.837 ± 0.019	0.629MetMet: 0.629 ± 0.011	1.251MetAsn: 1.251 ± 0.016	0.852MetPro: 0.852 ± 0.012	0.641MetGln: 0.641 ± 0.01	0.911MetArg: 0.911 ± 0.011	1.748MetSer: 1.748 ± 0.017	1.153MetThr: 1.153 ± 0.014	1.388MetVal: 1.388 ± 0.016	0.166MetTrp: 0.166 ± 0.005	0.599MetTyr: 0.599 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.544AsnAla: 2.544 ± 0.021	1.359AsnCys: 1.359 ± 0.019	3.114AsnAsp: 3.114 ± 0.022	3.529AsnGlu: 3.529 ± 0.025	2.504AsnPhe: 2.504 ± 0.023	3.623AsnGly: 3.623 ± 0.04	1.626AsnHis: 1.626 ± 0.017	3.641AsnIle: 3.641 ± 0.025	3.435AsnLys: 3.435 ± 0.027	5.743AsnLeu: 5.743 ± 0.034	1.108AsnMet: 1.108 ± 0.015	4.224AsnAsn: 4.224 ± 0.049	2.599AsnPro: 2.599 ± 0.023	2.769AsnGln: 2.769 ± 0.023	2.68AsnArg: 2.68 ± 0.025	5.205AsnSer: 5.205 ± 0.047	2.462AsnThr: 2.462 ± 0.023	3.139AsnVal: 3.139 ± 0.022	0.638AsnTrp: 0.638 ± 0.011	2.185AsnTyr: 2.185 ± 0.02	0.001AsnXaa: 0.001 ± 0.0
Pro	2.277ProAla: 2.277 ± 0.024	0.734ProCys: 0.734 ± 0.013	2.538ProAsp: 2.538 ± 0.023	2.901ProGlu: 2.901 ± 0.035	2.15ProPhe: 2.15 ± 0.021	2.537ProGly: 2.537 ± 0.041	1.012ProHis: 1.012 ± 0.017	3.172ProIle: 3.172 ± 0.025	2.88ProLys: 2.88 ± 0.027	4.067ProLeu: 4.067 ± 0.023	0.963ProMet: 0.963 ± 0.015	2.694ProAsn: 2.694 ± 0.026	3.163ProPro: 3.163 ± 0.056	1.691ProGln: 1.691 ± 0.027	1.895ProArg: 1.895 ± 0.021	5.046ProSer: 5.046 ± 0.044	2.842ProThr: 2.842 ± 0.027	2.977ProVal: 2.977 ± 0.029	0.506ProTrp: 0.506 ± 0.011	1.615ProTyr: 1.615 ± 0.019	0.001ProXaa: 0.001 ± 0.0
Gln	2.005GlnAla: 2.005 ± 0.025	0.743GlnCys: 0.743 ± 0.012	1.629GlnAsp: 1.629 ± 0.014	2.158GlnGlu: 2.158 ± 0.024	1.7GlnPhe: 1.7 ± 0.016	1.53GlnGly: 1.53 ± 0.021	0.979GlnHis: 0.979 ± 0.015	2.609GlnIle: 2.609 ± 0.023	2.154GlnLys: 2.154 ± 0.019	4.003GlnLeu: 4.003 ± 0.03	0.939GlnMet: 0.939 ± 0.011	1.917GlnAsn: 1.917 ± 0.018	2.007GlnPro: 2.007 ± 0.031	2.562GlnGln: 2.562 ± 0.067	1.851GlnArg: 1.851 ± 0.019	3.532GlnSer: 3.532 ± 0.031	2.044GlnThr: 2.044 ± 0.021	2.091GlnVal: 2.091 ± 0.018	0.384GlnTrp: 0.384 ± 0.009	1.208GlnTyr: 1.208 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	2.239ArgAla: 2.239 ± 0.02	0.93ArgCys: 0.93 ± 0.015	2.397ArgAsp: 2.397 ± 0.024	2.721ArgGlu: 2.721 ± 0.025	2.185ArgPhe: 2.185 ± 0.018	2.167ArgGly: 2.167 ± 0.024	1.095ArgHis: 1.095 ± 0.012	3.024ArgIle: 3.024 ± 0.026	3.557ArgLys: 3.557 ± 0.027	4.529ArgLeu: 4.529 ± 0.032	0.977ArgMet: 0.977 ± 0.014	2.53ArgAsn: 2.53 ± 0.021	2.115ArgPro: 2.115 ± 0.025	1.728ArgGln: 1.728 ± 0.02	2.998ArgArg: 2.998 ± 0.028	4.077ArgSer: 4.077 ± 0.036	2.237ArgThr: 2.237 ± 0.019	2.476ArgVal: 2.476 ± 0.02	0.539ArgTrp: 0.539 ± 0.009	1.761ArgTyr: 1.761 ± 0.019	0.001ArgXaa: 0.001 ± 0.0
Ser	4.476SerAla: 4.476 ± 0.041	1.731SerCys: 1.731 ± 0.022	4.815SerAsp: 4.815 ± 0.032	4.583SerGlu: 4.583 ± 0.039	4.053SerPhe: 4.053 ± 0.029	5.082SerGly: 5.082 ± 0.072	2.049SerHis: 2.049 ± 0.02	6.157SerIle: 6.157 ± 0.04	5.527SerLys: 5.527 ± 0.034	8.666SerLeu: 8.666 ± 0.04	1.858SerMet: 1.858 ± 0.02	5.683SerAsn: 5.683 ± 0.049	4.703SerPro: 4.703 ± 0.046	3.331SerGln: 3.331 ± 0.035	3.883SerArg: 3.883 ± 0.029	12.894SerSer: 12.894 ± 0.134	6.239SerThr: 6.239 ± 0.052	4.785SerVal: 4.785 ± 0.032	0.853SerTrp: 0.853 ± 0.012	2.775SerTyr: 2.775 ± 0.026	0.002SerXaa: 0.002 ± 0.001
Thr	2.868ThrAla: 2.868 ± 0.022	1.163ThrCys: 1.163 ± 0.018	2.733ThrAsp: 2.733 ± 0.022	3.006ThrGlu: 3.006 ± 0.032	2.631ThrPhe: 2.631 ± 0.023	3.119ThrGly: 3.119 ± 0.024	1.136ThrHis: 1.136 ± 0.014	4.3ThrIle: 4.3 ± 0.037	3.49ThrLys: 3.49 ± 0.029	5.296ThrLeu: 5.296 ± 0.033	1.108ThrMet: 1.108 ± 0.013	3.341ThrAsn: 3.341 ± 0.028	2.843ThrPro: 2.843 ± 0.031	1.906ThrGln: 1.906 ± 0.023	2.422ThrArg: 2.422 ± 0.022	5.773ThrSer: 5.773 ± 0.049	3.916ThrThr: 3.916 ± 0.063	3.325ThrVal: 3.325 ± 0.029	0.582ThrTrp: 0.582 ± 0.01	1.646ThrTyr: 1.646 ± 0.019	0.002ThrXaa: 0.002 ± 0.001
Val	3.208ValAla: 3.208 ± 0.024	1.175ValCys: 1.175 ± 0.018	3.374ValAsp: 3.374 ± 0.024	3.165ValGlu: 3.165 ± 0.032	2.46ValPhe: 2.46 ± 0.022	2.616ValGly: 2.616 ± 0.024	1.337ValHis: 1.337 ± 0.014	4.004ValIle: 4.004 ± 0.027	4.025ValLys: 4.025 ± 0.031	4.627ValLeu: 4.627 ± 0.031	1.083ValMet: 1.083 ± 0.014	3.728ValAsn: 3.728 ± 0.028	2.553ValPro: 2.553 ± 0.028	1.915ValGln: 1.915 ± 0.018	2.376ValArg: 2.376 ± 0.019	4.649ValSer: 4.649 ± 0.032	3.621ValThr: 3.621 ± 0.035	3.143ValVal: 3.143 ± 0.023	0.577ValTrp: 0.577 ± 0.01	1.994ValTyr: 1.994 ± 0.021	0.001ValXaa: 0.001 ± 0.0
Trp	0.499TrpAla: 0.499 ± 0.011	0.212TrpCys: 0.212 ± 0.006	0.558TrpAsp: 0.558 ± 0.01	0.503TrpGlu: 0.503 ± 0.01	0.582TrpPhe: 0.582 ± 0.01	0.462TrpGly: 0.462 ± 0.01	0.224TrpHis: 0.224 ± 0.006	0.886TrpIle: 0.886 ± 0.012	0.8TrpLys: 0.8 ± 0.012	1.087TrpLeu: 1.087 ± 0.015	0.278TrpMet: 0.278 ± 0.007	0.624TrpAsn: 0.624 ± 0.011	0.465TrpPro: 0.465 ± 0.009	0.336TrpGln: 0.336 ± 0.008	0.522TrpArg: 0.522 ± 0.009	1.003TrpSer: 1.003 ± 0.015	0.657TrpThr: 0.657 ± 0.011	0.548TrpVal: 0.548 ± 0.01	0.147TrpTrp: 0.147 ± 0.005	0.38TrpTyr: 0.38 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.646TyrAla: 1.646 ± 0.018	0.875TyrCys: 0.875 ± 0.013	1.925TyrAsp: 1.925 ± 0.02	1.831TyrGlu: 1.831 ± 0.017	1.965TyrPhe: 1.965 ± 0.022	2.009TyrGly: 2.009 ± 0.025	1.037TyrHis: 1.037 ± 0.015	2.21TyrIle: 2.21 ± 0.022	1.996TyrLys: 1.996 ± 0.02	3.609TyrLeu: 3.609 ± 0.03	0.653TyrMet: 0.653 ± 0.01	1.847TyrAsn: 1.847 ± 0.019	1.657TyrPro: 1.657 ± 0.018	1.488TyrGln: 1.488 ± 0.014	1.759TyrArg: 1.759 ± 0.018	2.872TyrSer: 2.872 ± 0.024	1.647TyrThr: 1.647 ± 0.016	1.66TyrVal: 1.66 ± 0.018	0.427TyrTrp: 0.427 ± 0.009	1.46TyrTyr: 1.46 ± 0.019	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.009XaaMet: 0.009 ± 0.001	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.189XaaXaa: 0.189 ± 0.045

Statistics based on 17526 proteins (6781689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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