Amino acid dipepetide frequency for Geobacillus sp. CAMR12739

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.233AlaAla: 11.233 ± 0.261
0.872AlaCys: 0.872 ± 0.058
4.556AlaAsp: 4.556 ± 0.137
6.203AlaGlu: 6.203 ± 0.146
3.706AlaPhe: 3.706 ± 0.104
6.652AlaGly: 6.652 ± 0.156
1.665AlaHis: 1.665 ± 0.068
5.874AlaIle: 5.874 ± 0.15
5.694AlaLys: 5.694 ± 0.147
9.36AlaLeu: 9.36 ± 0.208
2.623AlaMet: 2.623 ± 0.082
2.839AlaAsn: 2.839 ± 0.096
3.23AlaPro: 3.23 ± 0.111
2.547AlaGln: 2.547 ± 0.097
5.026AlaArg: 5.026 ± 0.142
4.45AlaSer: 4.45 ± 0.119
3.635AlaThr: 3.635 ± 0.11
7.972AlaVal: 7.972 ± 0.192
0.967AlaTrp: 0.967 ± 0.05
2.72AlaTyr: 2.72 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.778CysAla: 0.778 ± 0.048
0.177CysCys: 0.177 ± 0.024
0.512CysAsp: 0.512 ± 0.044
0.592CysGlu: 0.592 ± 0.047
0.424CysPhe: 0.424 ± 0.036
0.833CysGly: 0.833 ± 0.056
0.302CysHis: 0.302 ± 0.029
0.479CysIle: 0.479 ± 0.036
0.351CysLys: 0.351 ± 0.032
0.942CysLeu: 0.942 ± 0.059
0.204CysMet: 0.204 ± 0.023
0.25CysAsn: 0.25 ± 0.025
0.528CysPro: 0.528 ± 0.04
0.366CysGln: 0.366 ± 0.031
0.802CysArg: 0.802 ± 0.056
0.54CysSer: 0.54 ± 0.036
0.43CysThr: 0.43 ± 0.04
0.616CysVal: 0.616 ± 0.047
0.125CysTrp: 0.125 ± 0.02
0.311CysTyr: 0.311 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
3.678AspAla: 3.678 ± 0.109
0.421AspCys: 0.421 ± 0.034
2.58AspAsp: 2.58 ± 0.097
4.819AspGlu: 4.819 ± 0.131
1.876AspPhe: 1.876 ± 0.071
4.169AspGly: 4.169 ± 0.123
1.086AspHis: 1.086 ± 0.062
3.486AspIle: 3.486 ± 0.116
2.126AspLys: 2.126 ± 0.085
4.325AspLeu: 4.325 ± 0.115
1.26AspMet: 1.26 ± 0.065
1.135AspAsn: 1.135 ± 0.067
2.242AspPro: 2.242 ± 0.085
1.418AspGln: 1.418 ± 0.064
3.154AspArg: 3.154 ± 0.12
1.915AspSer: 1.915 ± 0.065
1.717AspThr: 1.717 ± 0.084
4.523AspVal: 4.523 ± 0.122
0.625AspTrp: 0.625 ± 0.043
1.857AspTyr: 1.857 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
7.268GluAla: 7.268 ± 0.16
0.448GluCys: 0.448 ± 0.036
2.754GluAsp: 2.754 ± 0.09
6.746GluGlu: 6.746 ± 0.2
2.272GluPhe: 2.272 ± 0.081
4.248GluGly: 4.248 ± 0.127
1.723GluHis: 1.723 ± 0.079
4.059GluIle: 4.059 ± 0.118
5.078GluLys: 5.078 ± 0.133
7.445GluLeu: 7.445 ± 0.157
2.257GluMet: 2.257 ± 0.085
2.391GluAsn: 2.391 ± 0.093
2.29GluPro: 2.29 ± 0.088
4.441GluGln: 4.441 ± 0.134
6.002GluArg: 6.002 ± 0.159
2.409GluSer: 2.409 ± 0.083
4.157GluThr: 4.157 ± 0.116
4.462GluVal: 4.462 ± 0.125
1.189GluTrp: 1.189 ± 0.07
1.973GluTyr: 1.973 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
4.151PheAla: 4.151 ± 0.117
0.509PheCys: 0.509 ± 0.039
2.016PheAsp: 2.016 ± 0.073
2.092PheGlu: 2.092 ± 0.079
2.034PhePhe: 2.034 ± 0.09
3.333PheGly: 3.333 ± 0.116
1.165PheHis: 1.165 ± 0.066
2.687PheIle: 2.687 ± 0.105
1.33PheLys: 1.33 ± 0.06
4.343PheLeu: 4.343 ± 0.14
1.049PheMet: 1.049 ± 0.064
1.095PheAsn: 1.095 ± 0.059
1.885PhePro: 1.885 ± 0.075
1.433PheGln: 1.433 ± 0.061
2.522PheArg: 2.522 ± 0.09
2.717PheSer: 2.717 ± 0.096
2.086PheThr: 2.086 ± 0.097
3.309PheVal: 3.309 ± 0.099
0.576PheTrp: 0.576 ± 0.044
1.485PheTyr: 1.485 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
6.435GlyAla: 6.435 ± 0.164
0.784GlyCys: 0.784 ± 0.055
3.315GlyAsp: 3.315 ± 0.106
4.788GlyGlu: 4.788 ± 0.113
2.983GlyPhe: 2.983 ± 0.094
5.34GlyGly: 5.34 ± 0.135
1.677GlyHis: 1.677 ± 0.065
4.563GlyIle: 4.563 ± 0.111
4.877GlyLys: 4.877 ± 0.132
6.496GlyLeu: 6.496 ± 0.171
2.29GlyMet: 2.29 ± 0.084
2.043GlyAsn: 2.043 ± 0.084
2.034GlyPro: 2.034 ± 0.081
2.495GlyGln: 2.495 ± 0.095
4.77GlyArg: 4.77 ± 0.136
3.379GlySer: 3.379 ± 0.109
3.87GlyThr: 3.87 ± 0.108
5.627GlyVal: 5.627 ± 0.139
0.924GlyTrp: 0.924 ± 0.056
2.638GlyTyr: 2.638 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.635HisAla: 1.635 ± 0.074
0.274HisCys: 0.274 ± 0.031
1.098HisAsp: 1.098 ± 0.059
1.671HisGlu: 1.671 ± 0.068
1.141HisPhe: 1.141 ± 0.063
1.778HisGly: 1.778 ± 0.083
0.909HisHis: 0.909 ± 0.06
1.54HisIle: 1.54 ± 0.064
0.784HisLys: 0.784 ± 0.043
2.306HisLeu: 2.306 ± 0.092
0.637HisMet: 0.637 ± 0.05
0.686HisAsn: 0.686 ± 0.042
1.607HisPro: 1.607 ± 0.083
0.915HisGln: 0.915 ± 0.063
1.543HisArg: 1.543 ± 0.075
1.046HisSer: 1.046 ± 0.057
0.921HisThr: 0.921 ± 0.06
1.79HisVal: 1.79 ± 0.067
0.317HisTrp: 0.317 ± 0.032
0.982HisTyr: 0.982 ± 0.056
0.0HisXaa: 0.0 ± 0.0
Ile
6.499IleAla: 6.499 ± 0.138
0.634IleCys: 0.634 ± 0.042
3.956IleAsp: 3.956 ± 0.097
5.002IleGlu: 5.002 ± 0.142
2.083IlePhe: 2.083 ± 0.094
5.267IleGly: 5.267 ± 0.139
1.635IleHis: 1.635 ± 0.071
3.977IleIle: 3.977 ± 0.114
2.635IleLys: 2.635 ± 0.093
4.526IleLeu: 4.526 ± 0.128
1.205IleMet: 1.205 ± 0.055
2.107IleAsn: 2.107 ± 0.079
2.937IlePro: 2.937 ± 0.102
2.025IleGln: 2.025 ± 0.079
4.285IleArg: 4.285 ± 0.112
3.352IleSer: 3.352 ± 0.108
3.047IleThr: 3.047 ± 0.097
5.535IleVal: 5.535 ± 0.145
0.579IleTrp: 0.579 ± 0.042
1.976IleTyr: 1.976 ± 0.085
0.0IleXaa: 0.0 ± 0.0
Lys
4.813LysAla: 4.813 ± 0.129
0.314LysCys: 0.314 ± 0.03
2.419LysAsp: 2.419 ± 0.09
5.441LysGlu: 5.441 ± 0.151
1.192LysPhe: 1.192 ± 0.061
3.73LysGly: 3.73 ± 0.095
1.257LysHis: 1.257 ± 0.064
2.9LysIle: 2.9 ± 0.099
3.306LysLys: 3.306 ± 0.132
4.752LysLeu: 4.752 ± 0.125
1.674LysMet: 1.674 ± 0.067
1.894LysAsn: 1.894 ± 0.072
2.361LysPro: 2.361 ± 0.08
3.266LysGln: 3.266 ± 0.112
4.492LysArg: 4.492 ± 0.116
2.129LysSer: 2.129 ± 0.098
3.675LysThr: 3.675 ± 0.103
3.559LysVal: 3.559 ± 0.129
0.784LysTrp: 0.784 ± 0.055
1.54LysTyr: 1.54 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
9.9LeuAla: 9.9 ± 0.193
0.979LeuCys: 0.979 ± 0.054
4.919LeuAsp: 4.919 ± 0.142
6.521LeuGlu: 6.521 ± 0.172
4.743LeuPhe: 4.743 ± 0.148
6.484LeuGly: 6.484 ± 0.174
2.196LeuHis: 2.196 ± 0.081
5.694LeuIle: 5.694 ± 0.14
5.099LeuLys: 5.099 ± 0.134
10.223LeuLeu: 10.223 ± 0.232
2.171LeuMet: 2.171 ± 0.087
2.833LeuAsn: 2.833 ± 0.104
4.535LeuPro: 4.535 ± 0.132
3.086LeuGln: 3.086 ± 0.105
5.697LeuArg: 5.697 ± 0.142
6.054LeuSer: 6.054 ± 0.161
5.023LeuThr: 5.023 ± 0.123
6.813LeuVal: 6.813 ± 0.174
0.985LeuTrp: 0.985 ± 0.056
3.169LeuTyr: 3.169 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
2.906MetAla: 2.906 ± 0.106
0.189MetCys: 0.189 ± 0.026
1.302MetAsp: 1.302 ± 0.072
2.184MetGlu: 2.184 ± 0.088
1.006MetPhe: 1.006 ± 0.059
1.555MetGly: 1.555 ± 0.065
0.537MetHis: 0.537 ± 0.037
1.839MetIle: 1.839 ± 0.072
2.263MetLys: 2.263 ± 0.091
2.327MetLeu: 2.327 ± 0.079
0.906MetMet: 0.906 ± 0.051
1.308MetAsn: 1.308 ± 0.061
1.174MetPro: 1.174 ± 0.063
0.903MetGln: 0.903 ± 0.058
1.58MetArg: 1.58 ± 0.079
1.488MetSer: 1.488 ± 0.07
1.745MetThr: 1.745 ± 0.066
1.741MetVal: 1.741 ± 0.065
0.259MetTrp: 0.259 ± 0.03
0.778MetTyr: 0.778 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
2.595AsnAla: 2.595 ± 0.092
0.235AsnCys: 0.235 ± 0.027
1.748AsnAsp: 1.748 ± 0.071
2.754AsnGlu: 2.754 ± 0.11
1.031AsnPhe: 1.031 ± 0.063
3.147AsnGly: 3.147 ± 0.091
0.717AsnHis: 0.717 ± 0.045
2.239AsnIle: 2.239 ± 0.083
1.61AsnLys: 1.61 ± 0.067
2.226AsnLeu: 2.226 ± 0.084
0.918AsnMet: 0.918 ± 0.063
1.006AsnAsn: 1.006 ± 0.062
1.696AsnPro: 1.696 ± 0.072
1.177AsnGln: 1.177 ± 0.064
2.074AsnArg: 2.074 ± 0.083
1.336AsnSer: 1.336 ± 0.069
1.427AsnThr: 1.427 ± 0.075
2.641AsnVal: 2.641 ± 0.085
0.363AsnTrp: 0.363 ± 0.035
0.927AsnTyr: 0.927 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
3.282ProAla: 3.282 ± 0.109
0.39ProCys: 0.39 ± 0.038
2.461ProAsp: 2.461 ± 0.082
3.068ProGlu: 3.068 ± 0.113
2.29ProPhe: 2.29 ± 0.088
2.602ProGly: 2.602 ± 0.098
1.156ProHis: 1.156 ± 0.055
2.647ProIle: 2.647 ± 0.091
2.324ProLys: 2.324 ± 0.084
4.587ProLeu: 4.587 ± 0.129
1.159ProMet: 1.159 ± 0.066
1.604ProAsn: 1.604 ± 0.072
1.812ProPro: 1.812 ± 0.086
1.269ProGln: 1.269 ± 0.061
1.799ProArg: 1.799 ± 0.087
2.568ProSer: 2.568 ± 0.089
2.062ProThr: 2.062 ± 0.088
3.102ProVal: 3.102 ± 0.094
0.518ProTrp: 0.518 ± 0.039
1.623ProTyr: 1.623 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
3.523GlnAla: 3.523 ± 0.117
0.357GlnCys: 0.357 ± 0.033
1.223GlnAsp: 1.223 ± 0.057
2.48GlnGlu: 2.48 ± 0.095
1.601GlnPhe: 1.601 ± 0.074
2.248GlnGly: 2.248 ± 0.082
0.802GlnHis: 0.802 ± 0.051
2.196GlnIle: 2.196 ± 0.083
2.159GlnLys: 2.159 ± 0.08
4.145GlnLeu: 4.145 ± 0.125
1.238GlnMet: 1.238 ± 0.055
1.189GlnAsn: 1.189 ± 0.062
1.446GlnPro: 1.446 ± 0.066
1.726GlnGln: 1.726 ± 0.088
2.272GlnArg: 2.272 ± 0.089
1.705GlnSer: 1.705 ± 0.073
2.193GlnThr: 2.193 ± 0.085
2.184GlnVal: 2.184 ± 0.088
0.592GlnTrp: 0.592 ± 0.04
1.253GlnTyr: 1.253 ± 0.068
0.0GlnXaa: 0.0 ± 0.0
Arg
4.736ArgAla: 4.736 ± 0.137
0.711ArgCys: 0.711 ± 0.049
2.775ArgAsp: 2.775 ± 0.099
4.608ArgGlu: 4.608 ± 0.128
2.885ArgPhe: 2.885 ± 0.103
3.62ArgGly: 3.62 ± 0.113
1.812ArgHis: 1.812 ± 0.086
3.611ArgIle: 3.611 ± 0.107
3.593ArgLys: 3.593 ± 0.096
7.32ArgLeu: 7.32 ± 0.159
2.144ArgMet: 2.144 ± 0.081
1.891ArgAsn: 1.891 ± 0.096
2.714ArgPro: 2.714 ± 0.101
2.946ArgGln: 2.946 ± 0.091
5.23ArgArg: 5.23 ± 0.133
3.16ArgSer: 3.16 ± 0.099
3.099ArgThr: 3.099 ± 0.089
3.733ArgVal: 3.733 ± 0.125
0.994ArgTrp: 0.994 ± 0.062
2.245ArgTyr: 2.245 ± 0.087
0.0ArgXaa: 0.0 ± 0.0
Ser
4.264SerAla: 4.264 ± 0.128
0.531SerCys: 0.531 ± 0.037
2.306SerAsp: 2.306 ± 0.085
2.897SerGlu: 2.897 ± 0.092
2.888SerPhe: 2.888 ± 0.105
4.072SerGly: 4.072 ± 0.121
1.022SerHis: 1.022 ± 0.057
3.303SerIle: 3.303 ± 0.116
2.226SerLys: 2.226 ± 0.087
5.493SerLeu: 5.493 ± 0.15
1.47SerMet: 1.47 ± 0.06
1.473SerAsn: 1.473 ± 0.073
2.409SerPro: 2.409 ± 0.084
1.446SerGln: 1.446 ± 0.071
2.781SerArg: 2.781 ± 0.092
3.062SerSer: 3.062 ± 0.119
2.15SerThr: 2.15 ± 0.09
3.837SerVal: 3.837 ± 0.104
0.637SerTrp: 0.637 ± 0.047
1.626SerTyr: 1.626 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
4.495ThrAla: 4.495 ± 0.112
0.418ThrCys: 0.418 ± 0.034
2.406ThrAsp: 2.406 ± 0.094
3.013ThrGlu: 3.013 ± 0.088
2.419ThrPhe: 2.419 ± 0.087
3.925ThrGly: 3.925 ± 0.11
1.013ThrHis: 1.013 ± 0.055
4.029ThrIle: 4.029 ± 0.116
3.032ThrLys: 3.032 ± 0.101
4.709ThrLeu: 4.709 ± 0.138
1.372ThrMet: 1.372 ± 0.071
1.873ThrAsn: 1.873 ± 0.087
2.303ThrPro: 2.303 ± 0.073
1.037ThrGln: 1.037 ± 0.054
2.202ThrArg: 2.202 ± 0.083
2.403ThrSer: 2.403 ± 0.096
2.492ThrThr: 2.492 ± 0.097
4.846ThrVal: 4.846 ± 0.132
0.616ThrTrp: 0.616 ± 0.039
1.745ThrTyr: 1.745 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
6.231ValAla: 6.231 ± 0.152
0.83ValCys: 0.83 ± 0.054
3.703ValAsp: 3.703 ± 0.11
5.151ValGlu: 5.151 ± 0.127
3.294ValPhe: 3.294 ± 0.112
5.029ValGly: 5.029 ± 0.132
1.802ValHis: 1.802 ± 0.071
5.203ValIle: 5.203 ± 0.13
4.617ValLys: 4.617 ± 0.132
7.146ValLeu: 7.146 ± 0.156
2.074ValMet: 2.074 ± 0.079
2.672ValAsn: 2.672 ± 0.108
3.205ValPro: 3.205 ± 0.101
2.382ValGln: 2.382 ± 0.081
4.508ValArg: 4.508 ± 0.133
4.154ValSer: 4.154 ± 0.126
4.172ValThr: 4.172 ± 0.116
5.871ValVal: 5.871 ± 0.149
0.9ValTrp: 0.9 ± 0.056
2.507ValTyr: 2.507 ± 0.088
0.0ValXaa: 0.0 ± 0.0
Trp
0.897TrpAla: 0.897 ± 0.061
0.098TrpCys: 0.098 ± 0.017
0.43TrpAsp: 0.43 ± 0.035
0.805TrpGlu: 0.805 ± 0.053
0.512TrpPhe: 0.512 ± 0.04
0.604TrpGly: 0.604 ± 0.043
0.29TrpHis: 0.29 ± 0.028
0.796TrpIle: 0.796 ± 0.053
0.933TrpLys: 0.933 ± 0.056
1.702TrpLeu: 1.702 ± 0.085
0.503TrpMet: 0.503 ± 0.04
0.488TrpAsn: 0.488 ± 0.045
0.476TrpPro: 0.476 ± 0.039
0.561TrpGln: 0.561 ± 0.045
0.881TrpArg: 0.881 ± 0.059
0.515TrpSer: 0.515 ± 0.037
0.744TrpThr: 0.744 ± 0.052
0.796TrpVal: 0.796 ± 0.06
0.217TrpTrp: 0.217 ± 0.031
0.403TrpTyr: 0.403 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.507TyrAla: 2.507 ± 0.099
0.393TyrCys: 0.393 ± 0.037
1.931TyrAsp: 1.931 ± 0.083
2.778TyrGlu: 2.778 ± 0.086
1.44TyrPhe: 1.44 ± 0.062
2.693TyrGly: 2.693 ± 0.095
0.817TyrHis: 0.817 ± 0.052
2.141TyrIle: 2.141 ± 0.073
1.461TyrLys: 1.461 ± 0.075
2.754TyrLeu: 2.754 ± 0.089
0.833TyrMet: 0.833 ± 0.061
1.089TyrAsn: 1.089 ± 0.059
1.44TyrPro: 1.44 ± 0.08
1.092TyrGln: 1.092 ± 0.055
2.205TyrArg: 2.205 ± 0.085
1.51TyrSer: 1.51 ± 0.069
1.702TyrThr: 1.702 ± 0.072
2.492TyrVal: 2.492 ± 0.081
0.482TyrTrp: 0.482 ± 0.041
1.336TyrTyr: 1.336 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1702 proteins (327887 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski