Amino acid dipepetide frequency for Penicillium italicum (Blue mold)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.385AlaAla: 8.385 ± 0.066	0.995AlaCys: 0.995 ± 0.015	4.25AlaAsp: 4.25 ± 0.039	5.105AlaGlu: 5.105 ± 0.047	3.104AlaPhe: 3.104 ± 0.028	5.593AlaGly: 5.593 ± 0.041	1.773AlaHis: 1.773 ± 0.018	4.317AlaIle: 4.317 ± 0.036	3.927AlaLys: 3.927 ± 0.032	7.665AlaLeu: 7.665 ± 0.052	1.963AlaMet: 1.963 ± 0.022	2.952AlaAsn: 2.952 ± 0.027	4.834AlaPro: 4.834 ± 0.052	3.417AlaGln: 3.417 ± 0.031	4.767AlaArg: 4.767 ± 0.038	7.153AlaSer: 7.153 ± 0.051	5.194AlaThr: 5.194 ± 0.043	5.263AlaVal: 5.263 ± 0.039	1.107AlaTrp: 1.107 ± 0.017	2.085AlaTyr: 2.085 ± 0.022	0.001AlaXaa: 0.001 ± 0.001
Cys	0.897CysAla: 0.897 ± 0.016	0.214CysCys: 0.214 ± 0.009	0.645CysAsp: 0.645 ± 0.012	0.591CysGlu: 0.591 ± 0.011	0.545CysPhe: 0.545 ± 0.012	0.895CysGly: 0.895 ± 0.014	0.325CysHis: 0.325 ± 0.009	0.669CysIle: 0.669 ± 0.014	0.476CysLys: 0.476 ± 0.01	1.238CysLeu: 1.238 ± 0.019	0.258CysMet: 0.258 ± 0.006	0.409CysAsn: 0.409 ± 0.009	0.623CysPro: 0.623 ± 0.015	0.444CysGln: 0.444 ± 0.011	0.698CysArg: 0.698 ± 0.015	0.839CysSer: 0.839 ± 0.015	0.64CysThr: 0.64 ± 0.013	0.781CysVal: 0.781 ± 0.014	0.187CysTrp: 0.187 ± 0.007	0.335CysTyr: 0.335 ± 0.007	0.001CysXaa: 0.001 ± 0.0
Asp	4.494AspAla: 4.494 ± 0.039	0.604AspCys: 0.604 ± 0.013	3.955AspAsp: 3.955 ± 0.04	4.445AspGlu: 4.445 ± 0.042	2.231AspPhe: 2.231 ± 0.024	3.817AspGly: 3.817 ± 0.032	1.345AspHis: 1.345 ± 0.019	3.113AspIle: 3.113 ± 0.029	2.286AspLys: 2.286 ± 0.025	5.311AspLeu: 5.311 ± 0.042	1.285AspMet: 1.285 ± 0.02	1.906AspAsn: 1.906 ± 0.02	3.417AspPro: 3.417 ± 0.034	2.072AspGln: 2.072 ± 0.022	3.084AspArg: 3.084 ± 0.032	4.348AspSer: 4.348 ± 0.037	3.053AspThr: 3.053 ± 0.029	3.6AspVal: 3.6 ± 0.026	0.888AspTrp: 0.888 ± 0.016	1.605AspTyr: 1.605 ± 0.02	0.001AspXaa: 0.001 ± 0.0
Glu	5.222GluAla: 5.222 ± 0.051	0.618GluCys: 0.618 ± 0.013	4.24GluAsp: 4.24 ± 0.043	5.435GluGlu: 5.435 ± 0.062	2.074GluPhe: 2.074 ± 0.021	3.639GluGly: 3.639 ± 0.034	1.442GluHis: 1.442 ± 0.018	3.307GluIle: 3.307 ± 0.028	3.639GluLys: 3.639 ± 0.035	5.279GluLeu: 5.279 ± 0.052	1.548GluMet: 1.548 ± 0.018	2.447GluAsn: 2.447 ± 0.028	2.921GluPro: 2.921 ± 0.06	2.536GluGln: 2.536 ± 0.03	3.8GluArg: 3.8 ± 0.037	4.616GluSer: 4.616 ± 0.045	3.726GluThr: 3.726 ± 0.031	3.526GluVal: 3.526 ± 0.029	0.877GluTrp: 0.877 ± 0.013	1.665GluTyr: 1.665 ± 0.021	0.001GluXaa: 0.001 ± 0.0
Phe	3.037PheAla: 3.037 ± 0.031	0.555PheCys: 0.555 ± 0.011	2.36PheAsp: 2.36 ± 0.023	2.241PheGlu: 2.241 ± 0.024	1.739PhePhe: 1.739 ± 0.064	2.847PheGly: 2.847 ± 0.028	0.953PheHis: 0.953 ± 0.015	1.883PheIle: 1.883 ± 0.023	1.519PheLys: 1.519 ± 0.019	3.559PheLeu: 3.559 ± 0.033	0.839PheMet: 0.839 ± 0.013	1.519PheAsn: 1.519 ± 0.019	2.023PhePro: 2.023 ± 0.022	1.455PheGln: 1.455 ± 0.015	2.002PheArg: 2.002 ± 0.022	3.066PheSer: 3.066 ± 0.027	2.176PheThr: 2.176 ± 0.032	2.427PheVal: 2.427 ± 0.029	0.653PheTrp: 0.653 ± 0.013	1.135PheTyr: 1.135 ± 0.016	0.001PheXaa: 0.001 ± 0.001
Gly	5.13GlyAla: 5.13 ± 0.037	0.849GlyCys: 0.849 ± 0.016	3.528GlyAsp: 3.528 ± 0.031	3.534GlyGlu: 3.534 ± 0.027	2.852GlyPhe: 2.852 ± 0.027	5.344GlyGly: 5.344 ± 0.057	1.67GlyHis: 1.67 ± 0.021	3.587GlyIle: 3.587 ± 0.032	3.29GlyLys: 3.29 ± 0.036	6.061GlyLeu: 6.061 ± 0.042	1.601GlyMet: 1.601 ± 0.021	2.54GlyAsn: 2.54 ± 0.025	3.358GlyPro: 3.358 ± 0.033	2.55GlyGln: 2.55 ± 0.034	3.89GlyArg: 3.89 ± 0.034	5.766GlySer: 5.766 ± 0.053	3.877GlyThr: 3.877 ± 0.031	4.289GlyVal: 4.289 ± 0.034	1.133GlyTrp: 1.133 ± 0.019	2.061GlyTyr: 2.061 ± 0.024	0.001GlyXaa: 0.001 ± 0.0
His	1.828HisAla: 1.828 ± 0.023	0.316HisCys: 0.316 ± 0.008	1.334HisAsp: 1.334 ± 0.018	1.372HisGlu: 1.372 ± 0.019	0.952HisPhe: 0.952 ± 0.014	1.732HisGly: 1.732 ± 0.022	0.812HisHis: 0.812 ± 0.014	1.259HisIle: 1.259 ± 0.015	0.895HisLys: 0.895 ± 0.015	2.301HisLeu: 2.301 ± 0.027	0.508HisMet: 0.508 ± 0.009	0.894HisAsn: 0.894 ± 0.013	1.691HisPro: 1.691 ± 0.02	1.01HisGln: 1.01 ± 0.016	1.598HisArg: 1.598 ± 0.018	1.944HisSer: 1.944 ± 0.021	1.321HisThr: 1.321 ± 0.017	1.453HisVal: 1.453 ± 0.019	0.348HisTrp: 0.348 ± 0.009	0.695HisTyr: 0.695 ± 0.013	0.001HisXaa: 0.001 ± 0.0
Ile	4.256IleAla: 4.256 ± 0.038	0.749IleCys: 0.749 ± 0.013	2.94IleAsp: 2.94 ± 0.025	3.008IleGlu: 3.008 ± 0.028	2.11IlePhe: 2.11 ± 0.034	3.265IleGly: 3.265 ± 0.031	1.255IleHis: 1.255 ± 0.016	2.599IleIle: 2.599 ± 0.032	2.214IleLys: 2.214 ± 0.025	4.668IleLeu: 4.668 ± 0.042	1.088IleMet: 1.088 ± 0.013	1.854IleAsn: 1.854 ± 0.021	3.289IlePro: 3.289 ± 0.028	2.005IleGln: 2.005 ± 0.023	2.788IleArg: 2.788 ± 0.025	4.132IleSer: 4.132 ± 0.031	2.897IleThr: 2.897 ± 0.027	3.204IleVal: 3.204 ± 0.029	0.736IleTrp: 0.736 ± 0.014	1.459IleTyr: 1.459 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.047LysAla: 4.047 ± 0.04	0.477LysCys: 0.477 ± 0.011	2.686LysAsp: 2.686 ± 0.028	3.307LysGlu: 3.307 ± 0.032	1.511LysPhe: 1.511 ± 0.019	2.857LysGly: 2.857 ± 0.029	1.088LysHis: 1.088 ± 0.015	2.327LysIle: 2.327 ± 0.024	3.212LysLys: 3.212 ± 0.044	4.034LysLeu: 4.034 ± 0.033	1.018LysMet: 1.018 ± 0.017	1.792LysAsn: 1.792 ± 0.023	2.719LysPro: 2.719 ± 0.03	1.873LysGln: 1.873 ± 0.025	3.293LysArg: 3.293 ± 0.033	3.637LysSer: 3.637 ± 0.03	2.779LysThr: 2.779 ± 0.029	2.755LysVal: 2.755 ± 0.026	0.672LysTrp: 0.672 ± 0.012	1.336LysTyr: 1.336 ± 0.02	0.001LysXaa: 0.001 ± 0.0
Leu	7.759LeuAla: 7.759 ± 0.047	1.187LeuCys: 1.187 ± 0.019	5.292LeuAsp: 5.292 ± 0.042	5.619LeuGlu: 5.619 ± 0.052	3.412LeuPhe: 3.412 ± 0.032	6.012LeuGly: 6.012 ± 0.044	2.255LeuHis: 2.255 ± 0.023	4.078LeuIle: 4.078 ± 0.037	4.178LeuLys: 4.178 ± 0.034	8.344LeuLeu: 8.344 ± 0.061	1.839LeuMet: 1.839 ± 0.022	3.346LeuAsn: 3.346 ± 0.039	5.487LeuPro: 5.487 ± 0.038	3.878LeuGln: 3.878 ± 0.033	5.706LeuArg: 5.706 ± 0.038	7.521LeuSer: 7.521 ± 0.055	4.814LeuThr: 4.814 ± 0.033	5.515LeuVal: 5.515 ± 0.041	1.189LeuTrp: 1.189 ± 0.018	2.359LeuTyr: 2.359 ± 0.02	0.001LeuXaa: 0.001 ± 0.001
Met	2.196MetAla: 2.196 ± 0.021	0.248MetCys: 0.248 ± 0.007	1.305MetAsp: 1.305 ± 0.014	1.334MetGlu: 1.334 ± 0.018	0.791MetPhe: 0.791 ± 0.013	1.529MetGly: 1.529 ± 0.021	0.497MetHis: 0.497 ± 0.01	1.077MetIle: 1.077 ± 0.016	1.028MetLys: 1.028 ± 0.018	1.872MetLeu: 1.872 ± 0.021	0.595MetMet: 0.595 ± 0.014	0.875MetAsn: 0.875 ± 0.017	1.258MetPro: 1.258 ± 0.017	0.914MetGln: 0.914 ± 0.015	1.254MetArg: 1.254 ± 0.018	1.937MetSer: 1.937 ± 0.021	1.34MetThr: 1.34 ± 0.018	1.333MetVal: 1.333 ± 0.016	0.263MetTrp: 0.263 ± 0.008	0.515MetTyr: 0.515 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	3.143AsnAla: 3.143 ± 0.029	0.442AsnCys: 0.442 ± 0.01	1.996AsnAsp: 1.996 ± 0.022	2.152AsnGlu: 2.152 ± 0.022	1.431AsnPhe: 1.431 ± 0.017	2.845AsnGly: 2.845 ± 0.03	0.899AsnHis: 0.899 ± 0.016	2.081AsnIle: 2.081 ± 0.02	1.558AsnLys: 1.558 ± 0.021	3.421AsnLeu: 3.421 ± 0.037	0.89AsnMet: 0.89 ± 0.015	1.452AsnAsn: 1.452 ± 0.025	2.644AsnPro: 2.644 ± 0.023	1.445AsnGln: 1.445 ± 0.022	2.008AsnArg: 2.008 ± 0.022	2.866AsnSer: 2.866 ± 0.026	2.244AsnThr: 2.244 ± 0.021	2.344AsnVal: 2.344 ± 0.025	0.569AsnTrp: 0.569 ± 0.012	1.074AsnTyr: 1.074 ± 0.016	0.001AsnXaa: 0.001 ± 0.0
Pro	5.238ProAla: 5.238 ± 0.053	0.509ProCys: 0.509 ± 0.013	3.194ProAsp: 3.194 ± 0.033	4.051ProGlu: 4.051 ± 0.053	2.13ProPhe: 2.13 ± 0.025	3.855ProGly: 3.855 ± 0.037	1.377ProHis: 1.377 ± 0.02	2.711ProIle: 2.711 ± 0.027	2.719ProLys: 2.719 ± 0.034	4.754ProLeu: 4.754 ± 0.038	1.152ProMet: 1.152 ± 0.019	2.266ProAsn: 2.266 ± 0.025	4.719ProPro: 4.719 ± 0.065	2.493ProGln: 2.493 ± 0.032	3.485ProArg: 3.485 ± 0.036	6.18ProSer: 6.18 ± 0.051	4.166ProThr: 4.166 ± 0.042	3.724ProVal: 3.724 ± 0.032	0.746ProTrp: 0.746 ± 0.013	1.474ProTyr: 1.474 ± 0.021	0.002ProXaa: 0.002 ± 0.001
Gln	3.388GlnAla: 3.388 ± 0.032	0.433GlnCys: 0.433 ± 0.011	2.086GlnAsp: 2.086 ± 0.02	2.433GlnGlu: 2.433 ± 0.022	1.397GlnPhe: 1.397 ± 0.02	2.383GlnGly: 2.383 ± 0.023	1.056GlnHis: 1.056 ± 0.018	2.038GlnIle: 2.038 ± 0.02	2.061GlnLys: 2.061 ± 0.028	3.506GlnLeu: 3.506 ± 0.031	0.951GlnMet: 0.951 ± 0.016	1.668GlnAsn: 1.668 ± 0.021	2.616GlnPro: 2.616 ± 0.037	2.191GlnGln: 2.191 ± 0.044	2.602GlnArg: 2.602 ± 0.025	3.383GlnSer: 3.383 ± 0.035	2.451GlnThr: 2.451 ± 0.022	2.235GlnVal: 2.235 ± 0.023	0.586GlnTrp: 0.586 ± 0.011	1.178GlnTyr: 1.178 ± 0.016	0.001GlnXaa: 0.001 ± 0.0
Arg	4.597ArgAla: 4.597 ± 0.034	0.653ArgCys: 0.653 ± 0.014	3.346ArgAsp: 3.346 ± 0.034	3.776ArgGlu: 3.776 ± 0.043	2.178ArgPhe: 2.178 ± 0.02	3.666ArgGly: 3.666 ± 0.037	1.525ArgHis: 1.525 ± 0.019	2.895ArgIle: 2.895 ± 0.028	3.335ArgLys: 3.335 ± 0.031	5.424ArgLeu: 5.424 ± 0.041	1.316ArgMet: 1.316 ± 0.017	2.248ArgAsn: 2.248 ± 0.024	3.443ArgPro: 3.443 ± 0.035	2.546ArgGln: 2.546 ± 0.024	4.812ArgArg: 4.812 ± 0.051	4.813ArgSer: 4.813 ± 0.043	3.246ArgThr: 3.246 ± 0.029	3.408ArgVal: 3.408 ± 0.026	0.912ArgTrp: 0.912 ± 0.015	1.605ArgTyr: 1.605 ± 0.018	0.003ArgXaa: 0.003 ± 0.001
Ser	6.734SerAla: 6.734 ± 0.046	0.828SerCys: 0.828 ± 0.012	4.457SerAsp: 4.457 ± 0.04	4.468SerGlu: 4.468 ± 0.041	3.128SerPhe: 3.128 ± 0.026	5.591SerGly: 5.591 ± 0.05	2.092SerHis: 2.092 ± 0.025	4.152SerIle: 4.152 ± 0.032	3.808SerLys: 3.808 ± 0.035	7.47SerLeu: 7.47 ± 0.054	1.781SerMet: 1.781 ± 0.021	3.143SerAsn: 3.143 ± 0.027	5.704SerPro: 5.704 ± 0.062	3.478SerGln: 3.478 ± 0.038	4.998SerArg: 4.998 ± 0.045	8.817SerSer: 8.817 ± 0.09	5.763SerThr: 5.763 ± 0.054	4.786SerVal: 4.786 ± 0.033	1.133SerTrp: 1.133 ± 0.017	2.101SerTyr: 2.101 ± 0.024	0.002SerXaa: 0.002 ± 0.001
Thr	5.117ThrAla: 5.117 ± 0.034	0.686ThrCys: 0.686 ± 0.014	2.954ThrAsp: 2.954 ± 0.031	3.427ThrGlu: 3.427 ± 0.033	2.203ThrPhe: 2.203 ± 0.024	4.166ThrGly: 4.166 ± 0.031	1.331ThrHis: 1.331 ± 0.018	3.143ThrIle: 3.143 ± 0.034	2.65ThrLys: 2.65 ± 0.026	5.292ThrLeu: 5.292 ± 0.038	1.193ThrMet: 1.193 ± 0.017	2.159ThrAsn: 2.159 ± 0.023	4.475ThrPro: 4.475 ± 0.046	2.235ThrGln: 2.235 ± 0.024	3.125ThrArg: 3.125 ± 0.025	5.383ThrSer: 5.383 ± 0.044	4.204ThrThr: 4.204 ± 0.057	3.794ThrVal: 3.794 ± 0.037	0.833ThrTrp: 0.833 ± 0.014	1.564ThrTyr: 1.564 ± 0.021	0.001ThrXaa: 0.001 ± 0.001
Val	5.182ValAla: 5.182 ± 0.038	0.793ValCys: 0.793 ± 0.015	3.789ValAsp: 3.789 ± 0.03	3.865ValGlu: 3.865 ± 0.035	2.52ValPhe: 2.52 ± 0.028	3.94ValGly: 3.94 ± 0.037	1.454ValHis: 1.454 ± 0.019	3.084ValIle: 3.084 ± 0.03	2.758ValLys: 2.758 ± 0.029	5.555ValLeu: 5.555 ± 0.045	1.353ValMet: 1.353 ± 0.018	2.264ValAsn: 2.264 ± 0.022	3.628ValPro: 3.628 ± 0.032	2.408ValGln: 2.408 ± 0.028	3.336ValArg: 3.336 ± 0.027	4.886ValSer: 4.886 ± 0.036	3.554ValThr: 3.554 ± 0.044	4.21ValVal: 4.21 ± 0.037	0.834ValTrp: 0.834 ± 0.015	1.692ValTyr: 1.692 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.111TrpAla: 1.111 ± 0.016	0.181TrpCys: 0.181 ± 0.006	0.89TrpAsp: 0.89 ± 0.015	0.854TrpGlu: 0.854 ± 0.014	0.504TrpPhe: 0.504 ± 0.011	0.919TrpGly: 0.919 ± 0.016	0.351TrpHis: 0.351 ± 0.008	0.787TrpIle: 0.787 ± 0.014	0.801TrpLys: 0.801 ± 0.013	1.351TrpLeu: 1.351 ± 0.018	0.375TrpMet: 0.375 ± 0.01	0.644TrpAsn: 0.644 ± 0.012	0.577TrpPro: 0.577 ± 0.011	0.552TrpGln: 0.552 ± 0.011	0.912TrpArg: 0.912 ± 0.015	1.076TrpSer: 1.076 ± 0.014	0.902TrpThr: 0.902 ± 0.016	0.881TrpVal: 0.881 ± 0.014	0.286TrpTrp: 0.286 ± 0.009	0.42TrpTyr: 0.42 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.088TyrAla: 2.088 ± 0.024	0.372TyrCys: 0.372 ± 0.009	1.61TyrAsp: 1.61 ± 0.02	1.541TyrGlu: 1.541 ± 0.018	1.175TyrPhe: 1.175 ± 0.018	2.016TyrGly: 2.016 ± 0.025	0.762TyrHis: 0.762 ± 0.014	1.407TyrIle: 1.407 ± 0.019	1.066TyrLys: 1.066 ± 0.014	2.685TyrLeu: 2.685 ± 0.027	0.61TyrMet: 0.61 ± 0.012	1.129TyrAsn: 1.129 ± 0.016	1.517TyrPro: 1.517 ± 0.021	1.14TyrGln: 1.14 ± 0.015	1.587TyrArg: 1.587 ± 0.02	2.07TyrSer: 2.07 ± 0.023	1.587TyrThr: 1.587 ± 0.019	1.576TyrVal: 1.576 ± 0.022	0.423TyrTrp: 0.423 ± 0.009	0.898TyrTyr: 0.898 ± 0.015	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.003XaaArg: 0.003 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 9993 proteins (4757581 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---