Amino acid dipepetide frequency for Blochmannia endosymbiont of Camponotus (Colobopsis) obliquus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.894AlaAla: 3.894 ± 0.157
0.943AlaCys: 0.943 ± 0.076
2.154AlaAsp: 2.154 ± 0.09
2.516AlaGlu: 2.516 ± 0.139
2.028AlaPhe: 2.028 ± 0.108
3.365AlaGly: 3.365 ± 0.165
1.169AlaHis: 1.169 ± 0.078
5.734AlaIle: 5.734 ± 0.197
3.538AlaLys: 3.538 ± 0.136
5.807AlaLeu: 5.807 ± 0.174
1.52AlaMet: 1.52 ± 0.088
2.657AlaAsn: 2.657 ± 0.13
1.357AlaPro: 1.357 ± 0.083
1.997AlaGln: 1.997 ± 0.118
2.552AlaArg: 2.552 ± 0.132
3.192AlaSer: 3.192 ± 0.131
2.563AlaThr: 2.563 ± 0.126
3.47AlaVal: 3.47 ± 0.159
0.466AlaTrp: 0.466 ± 0.045
1.756AlaTyr: 1.756 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.755CysAla: 0.755 ± 0.06
0.356CysCys: 0.356 ± 0.044
0.765CysAsp: 0.765 ± 0.065
0.655CysGlu: 0.655 ± 0.057
0.765CysPhe: 0.765 ± 0.063
1.179CysGly: 1.179 ± 0.083
0.414CysHis: 0.414 ± 0.048
1.625CysIle: 1.625 ± 0.096
0.991CysLys: 0.991 ± 0.069
1.467CysLeu: 1.467 ± 0.093
0.383CysMet: 0.383 ± 0.047
1.195CysAsn: 1.195 ± 0.078
0.519CysPro: 0.519 ± 0.055
0.702CysGln: 0.702 ± 0.07
0.681CysArg: 0.681 ± 0.067
1.321CysSer: 1.321 ± 0.084
0.671CysThr: 0.671 ± 0.065
1.017CysVal: 1.017 ± 0.071
0.246CysTrp: 0.246 ± 0.039
0.608CysTyr: 0.608 ± 0.057
0.0CysXaa: 0.0 ± 0.0
Asp
2.353AspAla: 2.353 ± 0.123
0.749AspCys: 0.749 ± 0.061
2.123AspAsp: 2.123 ± 0.111
2.102AspGlu: 2.102 ± 0.107
2.227AspPhe: 2.227 ± 0.117
2.463AspGly: 2.463 ± 0.143
1.095AspHis: 1.095 ± 0.079
5.503AspIle: 5.503 ± 0.193
3.071AspLys: 3.071 ± 0.139
4.628AspLeu: 4.628 ± 0.138
1.106AspMet: 1.106 ± 0.078
2.71AspAsn: 2.71 ± 0.108
1.384AspPro: 1.384 ± 0.082
1.478AspGln: 1.478 ± 0.086
1.992AspArg: 1.992 ± 0.104
2.306AspSer: 2.306 ± 0.105
1.913AspThr: 1.913 ± 0.091
3.475AspVal: 3.475 ± 0.164
0.493AspTrp: 0.493 ± 0.047
1.929AspTyr: 1.929 ± 0.108
0.0AspXaa: 0.0 ± 0.0
Glu
2.448GluAla: 2.448 ± 0.139
0.734GluCys: 0.734 ± 0.055
1.871GluAsp: 1.871 ± 0.123
2.694GluGlu: 2.694 ± 0.129
1.782GluPhe: 1.782 ± 0.095
2.332GluGly: 2.332 ± 0.142
1.143GluHis: 1.143 ± 0.087
5.535GluIle: 5.535 ± 0.177
3.627GluLys: 3.627 ± 0.166
5.183GluLeu: 5.183 ± 0.166
1.394GluMet: 1.394 ± 0.084
2.453GluAsn: 2.453 ± 0.114
1.247GluPro: 1.247 ± 0.082
2.075GluGln: 2.075 ± 0.103
2.526GluArg: 2.526 ± 0.16
2.4GluSer: 2.4 ± 0.117
1.834GluThr: 1.834 ± 0.084
3.202GluVal: 3.202 ± 0.173
0.409GluTrp: 0.409 ± 0.049
1.588GluTyr: 1.588 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
2.107PheAla: 2.107 ± 0.107
1.012PheCys: 1.012 ± 0.078
2.259PheAsp: 2.259 ± 0.117
1.771PheGlu: 1.771 ± 0.104
2.757PhePhe: 2.757 ± 0.158
3.176PheGly: 3.176 ± 0.137
0.943PheHis: 0.943 ± 0.063
4.764PheIle: 4.764 ± 0.189
2.558PheLys: 2.558 ± 0.123
4.607PheLeu: 4.607 ± 0.183
0.949PheMet: 0.949 ± 0.068
3.181PheAsn: 3.181 ± 0.138
1.656PhePro: 1.656 ± 0.094
1.226PheGln: 1.226 ± 0.084
1.677PheArg: 1.677 ± 0.089
3.684PheSer: 3.684 ± 0.155
1.918PheThr: 1.918 ± 0.12
2.72PheVal: 2.72 ± 0.142
0.477PheTrp: 0.477 ± 0.055
2.002PheTyr: 2.002 ± 0.119
0.0PheXaa: 0.0 ± 0.0
Gly
3.339GlyAla: 3.339 ± 0.158
1.08GlyCys: 1.08 ± 0.072
2.731GlyAsp: 2.731 ± 0.119
2.746GlyGlu: 2.746 ± 0.162
2.736GlyPhe: 2.736 ± 0.119
4.156GlyGly: 4.156 ± 0.207
1.536GlyHis: 1.536 ± 0.105
6.902GlyIle: 6.902 ± 0.216
4.151GlyLys: 4.151 ± 0.149
5.597GlyLeu: 5.597 ± 0.218
1.803GlyMet: 1.803 ± 0.113
2.93GlyAsn: 2.93 ± 0.118
1.462GlyPro: 1.462 ± 0.092
1.902GlyGln: 1.902 ± 0.117
2.872GlyArg: 2.872 ± 0.152
3.967GlySer: 3.967 ± 0.179
2.904GlyThr: 2.904 ± 0.148
4.245GlyVal: 4.245 ± 0.157
0.697GlyTrp: 0.697 ± 0.069
2.427GlyTyr: 2.427 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
1.53HisAla: 1.53 ± 0.089
0.425HisCys: 0.425 ± 0.043
1.043HisAsp: 1.043 ± 0.074
1.012HisGlu: 1.012 ± 0.085
1.064HisPhe: 1.064 ± 0.083
1.751HisGly: 1.751 ± 0.096
0.744HisHis: 0.744 ± 0.065
2.306HisIle: 2.306 ± 0.118
1.478HisLys: 1.478 ± 0.098
2.091HisLeu: 2.091 ± 0.102
0.519HisMet: 0.519 ± 0.052
1.735HisAsn: 1.735 ± 0.103
1.247HisPro: 1.247 ± 0.084
1.038HisGln: 1.038 ± 0.068
1.253HisArg: 1.253 ± 0.085
1.525HisSer: 1.525 ± 0.089
1.153HisThr: 1.153 ± 0.084
1.399HisVal: 1.399 ± 0.097
0.293HisTrp: 0.293 ± 0.037
1.127HisTyr: 1.127 ± 0.081
0.0HisXaa: 0.0 ± 0.0
Ile
6.41IleAla: 6.41 ± 0.22
1.667IleCys: 1.667 ± 0.103
5.744IleAsp: 5.744 ± 0.16
5.021IleGlu: 5.021 ± 0.143
4.869IlePhe: 4.869 ± 0.201
7.013IleGly: 7.013 ± 0.237
2.406IleHis: 2.406 ± 0.122
11.593IleIle: 11.593 ± 0.334
8.207IleLys: 8.207 ± 0.258
10.786IleLeu: 10.786 ± 0.283
2.264IleMet: 2.264 ± 0.108
8.202IleAsn: 8.202 ± 0.27
3.532IlePro: 3.532 ± 0.156
3.501IleGln: 3.501 ± 0.126
4.25IleArg: 4.25 ± 0.154
7.6IleSer: 7.6 ± 0.211
5.839IleThr: 5.839 ± 0.226
5.786IleVal: 5.786 ± 0.16
0.917IleTrp: 0.917 ± 0.081
3.27IleTyr: 3.27 ± 0.15
0.0IleXaa: 0.0 ± 0.0
Lys
2.615LysAla: 2.615 ± 0.114
0.802LysCys: 0.802 ± 0.063
2.6LysAsp: 2.6 ± 0.118
3.48LysGlu: 3.48 ± 0.144
2.982LysPhe: 2.982 ± 0.123
2.935LysGly: 2.935 ± 0.13
1.803LysHis: 1.803 ± 0.111
9.119LysIle: 9.119 ± 0.319
7.316LysLys: 7.316 ± 0.277
7.71LysLeu: 7.71 ± 0.259
1.929LysMet: 1.929 ± 0.103
6.085LysAsn: 6.085 ± 0.237
1.672LysPro: 1.672 ± 0.097
3.076LysGln: 3.076 ± 0.154
2.883LysArg: 2.883 ± 0.131
3.742LysSer: 3.742 ± 0.153
3.223LysThr: 3.223 ± 0.155
3.632LysVal: 3.632 ± 0.145
0.597LysTrp: 0.597 ± 0.056
3.223LysTyr: 3.223 ± 0.133
0.0LysXaa: 0.0 ± 0.0
Leu
5.634LeuAla: 5.634 ± 0.184
1.834LeuCys: 1.834 ± 0.096
4.733LeuAsp: 4.733 ± 0.173
4.958LeuGlu: 4.958 ± 0.169
4.832LeuPhe: 4.832 ± 0.164
5.77LeuGly: 5.77 ± 0.179
2.814LeuHis: 2.814 ± 0.125
10.194LeuIle: 10.194 ± 0.309
6.74LeuLys: 6.74 ± 0.188
11.3LeuLeu: 11.3 ± 0.322
2.825LeuMet: 2.825 ± 0.124
6.515LeuAsn: 6.515 ± 0.214
4.203LeuPro: 4.203 ± 0.137
4.109LeuGln: 4.109 ± 0.153
4.848LeuArg: 4.848 ± 0.18
7.573LeuSer: 7.573 ± 0.207
5.22LeuThr: 5.22 ± 0.185
5.718LeuVal: 5.718 ± 0.206
0.943LeuTrp: 0.943 ± 0.067
3.511LeuTyr: 3.511 ± 0.146
0.0LeuXaa: 0.0 ± 0.0
Met
1.352MetAla: 1.352 ± 0.089
0.32MetCys: 0.32 ± 0.043
1.012MetAsp: 1.012 ± 0.091
1.221MetGlu: 1.221 ± 0.086
1.064MetPhe: 1.064 ± 0.077
1.53MetGly: 1.53 ± 0.096
0.776MetHis: 0.776 ± 0.066
2.563MetIle: 2.563 ± 0.114
1.656MetLys: 1.656 ± 0.088
3.092MetLeu: 3.092 ± 0.135
0.739MetMet: 0.739 ± 0.066
1.73MetAsn: 1.73 ± 0.095
0.865MetPro: 0.865 ± 0.055
1.106MetGln: 1.106 ± 0.076
1.174MetArg: 1.174 ± 0.08
1.698MetSer: 1.698 ± 0.1
1.08MetThr: 1.08 ± 0.077
1.447MetVal: 1.447 ± 0.089
0.168MetTrp: 0.168 ± 0.034
0.77MetTyr: 0.77 ± 0.067
0.0MetXaa: 0.0 ± 0.0
Asn
2.704AsnAla: 2.704 ± 0.111
0.86AsnCys: 0.86 ± 0.072
2.752AsnAsp: 2.752 ± 0.126
2.793AsnGlu: 2.793 ± 0.124
3.239AsnPhe: 3.239 ± 0.134
2.93AsnGly: 2.93 ± 0.13
1.452AsnHis: 1.452 ± 0.084
8.407AsnIle: 8.407 ± 0.235
6.405AsnLys: 6.405 ± 0.253
5.618AsnLeu: 5.618 ± 0.207
1.813AsnMet: 1.813 ± 0.099
5.76AsnAsn: 5.76 ± 0.282
1.897AsnPro: 1.897 ± 0.102
2.374AsnGln: 2.374 ± 0.13
2.395AsnArg: 2.395 ± 0.101
3.407AsnSer: 3.407 ± 0.142
3.323AsnThr: 3.323 ± 0.181
3.616AsnVal: 3.616 ± 0.16
0.77AsnTrp: 0.77 ± 0.061
2.694AsnTyr: 2.694 ± 0.107
0.0AsnXaa: 0.0 ± 0.0
Pro
1.541ProAla: 1.541 ± 0.097
0.435ProCys: 0.435 ± 0.048
1.394ProAsp: 1.394 ± 0.081
1.771ProGlu: 1.771 ± 0.097
1.426ProPhe: 1.426 ± 0.086
2.17ProGly: 2.17 ± 0.112
0.781ProHis: 0.781 ± 0.068
3.438ProIle: 3.438 ± 0.146
1.965ProLys: 1.965 ± 0.099
3.36ProLeu: 3.36 ± 0.141
0.734ProMet: 0.734 ± 0.065
1.85ProAsn: 1.85 ± 0.116
0.87ProPro: 0.87 ± 0.069
1.053ProGln: 1.053 ± 0.07
1.027ProArg: 1.027 ± 0.077
2.196ProSer: 2.196 ± 0.104
1.599ProThr: 1.599 ± 0.093
2.395ProVal: 2.395 ± 0.135
0.419ProTrp: 0.419 ± 0.054
1.315ProTyr: 1.315 ± 0.077
0.0ProXaa: 0.0 ± 0.0
Gln
2.17GlnAla: 2.17 ± 0.088
0.556GlnCys: 0.556 ± 0.055
1.504GlnAsp: 1.504 ± 0.089
2.128GlnGlu: 2.128 ± 0.106
1.541GlnPhe: 1.541 ± 0.078
2.296GlnGly: 2.296 ± 0.108
1.038GlnHis: 1.038 ± 0.075
3.967GlnIle: 3.967 ± 0.172
2.809GlnLys: 2.809 ± 0.133
4.057GlnLeu: 4.057 ± 0.151
0.791GlnMet: 0.791 ± 0.059
2.238GlnAsn: 2.238 ± 0.115
1.09GlnPro: 1.09 ± 0.072
2.123GlnGln: 2.123 ± 0.132
1.908GlnArg: 1.908 ± 0.114
1.992GlnSer: 1.992 ± 0.093
1.525GlnThr: 1.525 ± 0.1
2.144GlnVal: 2.144 ± 0.101
0.351GlnTrp: 0.351 ± 0.042
1.41GlnTyr: 1.41 ± 0.086
0.0GlnXaa: 0.0 ± 0.0
Arg
2.311ArgAla: 2.311 ± 0.118
0.687ArgCys: 0.687 ± 0.061
2.123ArgAsp: 2.123 ± 0.121
2.327ArgGlu: 2.327 ± 0.146
2.133ArgPhe: 2.133 ± 0.102
2.51ArgGly: 2.51 ± 0.117
1.132ArgHis: 1.132 ± 0.079
4.476ArgIle: 4.476 ± 0.161
2.919ArgLys: 2.919 ± 0.14
4.617ArgLeu: 4.617 ± 0.181
1.211ArgMet: 1.211 ± 0.077
2.437ArgAsn: 2.437 ± 0.109
1.452ArgPro: 1.452 ± 0.076
1.845ArgGln: 1.845 ± 0.099
2.348ArgArg: 2.348 ± 0.159
2.778ArgSer: 2.778 ± 0.14
1.976ArgThr: 1.976 ± 0.106
2.683ArgVal: 2.683 ± 0.149
0.524ArgTrp: 0.524 ± 0.052
1.944ArgTyr: 1.944 ± 0.094
0.0ArgXaa: 0.0 ± 0.0
Ser
3.339SerAla: 3.339 ± 0.145
1.122SerCys: 1.122 ± 0.078
2.961SerAsp: 2.961 ± 0.141
2.406SerGlu: 2.406 ± 0.112
3.092SerPhe: 3.092 ± 0.149
4.486SerGly: 4.486 ± 0.193
1.426SerHis: 1.426 ± 0.092
6.583SerIle: 6.583 ± 0.203
4.062SerLys: 4.062 ± 0.161
7.023SerLeu: 7.023 ± 0.191
1.677SerMet: 1.677 ± 0.099
4.009SerAsn: 4.009 ± 0.153
1.85SerPro: 1.85 ± 0.099
1.992SerGln: 1.992 ± 0.111
2.846SerArg: 2.846 ± 0.124
4.811SerSer: 4.811 ± 0.197
3.035SerThr: 3.035 ± 0.121
4.015SerVal: 4.015 ± 0.169
0.744SerTrp: 0.744 ± 0.066
2.558SerTyr: 2.558 ± 0.131
0.0SerXaa: 0.0 ± 0.0
Thr
2.563ThrAla: 2.563 ± 0.113
0.802ThrCys: 0.802 ± 0.064
2.054ThrAsp: 2.054 ± 0.094
1.96ThrGlu: 1.96 ± 0.122
1.944ThrPhe: 1.944 ± 0.11
3.459ThrGly: 3.459 ± 0.144
1.247ThrHis: 1.247 ± 0.091
4.864ThrIle: 4.864 ± 0.179
3.129ThrLys: 3.129 ± 0.144
5.367ThrLeu: 5.367 ± 0.18
1.006ThrMet: 1.006 ± 0.071
2.893ThrAsn: 2.893 ± 0.146
1.74ThrPro: 1.74 ± 0.102
1.771ThrGln: 1.771 ± 0.097
1.929ThrArg: 1.929 ± 0.099
3.003ThrSer: 3.003 ± 0.147
2.589ThrThr: 2.589 ± 0.147
2.825ThrVal: 2.825 ± 0.141
0.561ThrTrp: 0.561 ± 0.054
1.635ThrTyr: 1.635 ± 0.105
0.0ThrXaa: 0.0 ± 0.0
Val
3.265ValAla: 3.265 ± 0.165
1.027ValCys: 1.027 ± 0.08
3.008ValAsp: 3.008 ± 0.143
2.935ValGlu: 2.935 ± 0.142
2.6ValPhe: 2.6 ± 0.135
3.674ValGly: 3.674 ± 0.178
1.431ValHis: 1.431 ± 0.092
6.656ValIle: 6.656 ± 0.181
3.873ValLys: 3.873 ± 0.175
6.373ValLeu: 6.373 ± 0.235
1.635ValMet: 1.635 ± 0.102
3.475ValAsn: 3.475 ± 0.123
1.944ValPro: 1.944 ± 0.108
1.908ValGln: 1.908 ± 0.097
2.835ValArg: 2.835 ± 0.123
4.03ValSer: 4.03 ± 0.159
3.066ValThr: 3.066 ± 0.121
4.486ValVal: 4.486 ± 0.216
0.582ValTrp: 0.582 ± 0.058
1.882ValTyr: 1.882 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.404TrpAla: 0.404 ± 0.038
0.168TrpCys: 0.168 ± 0.027
0.356TrpAsp: 0.356 ± 0.042
0.435TrpGlu: 0.435 ± 0.051
0.503TrpPhe: 0.503 ± 0.047
0.508TrpGly: 0.508 ± 0.055
0.346TrpHis: 0.346 ± 0.041
1.111TrpIle: 1.111 ± 0.084
0.702TrpLys: 0.702 ± 0.073
1.483TrpLeu: 1.483 ± 0.115
0.257TrpMet: 0.257 ± 0.039
0.508TrpAsn: 0.508 ± 0.054
0.356TrpPro: 0.356 ± 0.045
0.54TrpGln: 0.54 ± 0.062
0.535TrpArg: 0.535 ± 0.047
0.613TrpSer: 0.613 ± 0.057
0.362TrpThr: 0.362 ± 0.041
0.493TrpVal: 0.493 ± 0.053
0.121TrpTrp: 0.121 ± 0.028
0.482TrpTyr: 0.482 ± 0.052
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.944TyrAla: 1.944 ± 0.098
0.739TyrCys: 0.739 ± 0.064
1.913TyrAsp: 1.913 ± 0.118
1.546TyrGlu: 1.546 ± 0.082
1.861TyrPhe: 1.861 ± 0.101
2.484TyrGly: 2.484 ± 0.118
1.038TyrHis: 1.038 ± 0.065
3.538TyrIle: 3.538 ± 0.15
2.227TyrLys: 2.227 ± 0.117
4.109TyrLeu: 4.109 ± 0.132
0.802TyrMet: 0.802 ± 0.057
2.647TyrAsn: 2.647 ± 0.14
1.394TyrPro: 1.394 ± 0.082
1.819TyrGln: 1.819 ± 0.106
1.902TyrArg: 1.902 ± 0.112
2.196TyrSer: 2.196 ± 0.11
1.551TyrThr: 1.551 ± 0.088
1.918TyrVal: 1.918 ± 0.114
0.503TyrTrp: 0.503 ± 0.05
1.635TyrTyr: 1.635 ± 0.109
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 584 proteins (190803 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski