Amino acid dipepetide frequency for Rose yellow vein virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.858AlaAla: 1.858 ± 0.456
0.0AlaCys: 0.0 ± 0.0
1.486AlaAsp: 1.486 ± 0.758
1.858AlaGlu: 1.858 ± 0.593
2.23AlaPhe: 2.23 ± 0.622
1.858AlaGly: 1.858 ± 0.779
0.743AlaHis: 0.743 ± 0.63
4.831AlaIle: 4.831 ± 1.917
4.088AlaLys: 4.088 ± 1.428
4.088AlaLeu: 4.088 ± 1.054
0.743AlaMet: 0.743 ± 0.328
3.344AlaAsn: 3.344 ± 0.873
2.23AlaPro: 2.23 ± 0.885
2.601AlaGln: 2.601 ± 0.864
3.344AlaArg: 3.344 ± 0.826
4.459AlaSer: 4.459 ± 1.245
1.858AlaThr: 1.858 ± 0.905
4.088AlaVal: 4.088 ± 0.702
0.743AlaTrp: 0.743 ± 0.665
1.486AlaTyr: 1.486 ± 0.7
0.0AlaXaa: 0.0 ± 0.0
Cys
0.372CysAla: 0.372 ± 0.333
0.0CysCys: 0.0 ± 0.0
1.115CysAsp: 1.115 ± 0.646
1.115CysGlu: 1.115 ± 0.504
1.115CysPhe: 1.115 ± 0.881
0.743CysGly: 0.743 ± 0.665
0.372CysHis: 0.372 ± 0.262
0.0CysIle: 0.0 ± 0.0
1.115CysLys: 1.115 ± 0.621
1.115CysLeu: 1.115 ± 0.647
0.0CysMet: 0.0 ± 0.0
0.372CysAsn: 0.372 ± 0.315
0.743CysPro: 0.743 ± 0.328
1.115CysGln: 1.115 ± 0.492
0.372CysArg: 0.372 ± 0.333
0.372CysSer: 0.372 ± 0.262
0.372CysThr: 0.372 ± 0.477
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.372CysTyr: 0.372 ± 0.315
0.0CysXaa: 0.0 ± 0.0
Asp
1.858AspAla: 1.858 ± 0.593
0.372AspCys: 0.372 ± 0.262
2.23AspAsp: 2.23 ± 0.839
3.716AspGlu: 3.716 ± 1.13
1.115AspPhe: 1.115 ± 0.279
1.115AspGly: 1.115 ± 0.748
0.743AspHis: 0.743 ± 0.318
4.831AspIle: 4.831 ± 1.153
7.061AspLys: 7.061 ± 1.405
6.689AspLeu: 6.689 ± 1.767
1.486AspMet: 1.486 ± 0.286
2.973AspAsn: 2.973 ± 0.981
1.858AspPro: 1.858 ± 0.612
2.23AspGln: 2.23 ± 1.194
1.486AspArg: 1.486 ± 0.56
4.088AspSer: 4.088 ± 1.122
1.858AspThr: 1.858 ± 0.795
1.486AspVal: 1.486 ± 0.564
0.372AspTrp: 0.372 ± 0.424
1.486AspTyr: 1.486 ± 0.845
0.0AspXaa: 0.0 ± 0.0
Glu
3.344GluAla: 3.344 ± 1.624
0.743GluCys: 0.743 ± 0.563
4.459GluAsp: 4.459 ± 0.765
10.405GluGlu: 10.405 ± 1.663
2.973GluPhe: 2.973 ± 1.117
1.115GluGly: 1.115 ± 0.501
1.858GluHis: 1.858 ± 0.729
9.29GluIle: 9.29 ± 1.694
5.574GluLys: 5.574 ± 1.785
5.946GluLeu: 5.946 ± 1.264
1.858GluMet: 1.858 ± 0.717
2.973GluAsn: 2.973 ± 1.158
1.486GluPro: 1.486 ± 0.726
7.804GluGln: 7.804 ± 1.195
1.858GluArg: 1.858 ± 0.47
7.432GluSer: 7.432 ± 0.983
5.574GluThr: 5.574 ± 1.021
4.088GluVal: 4.088 ± 0.649
0.743GluTrp: 0.743 ± 0.489
2.973GluTyr: 2.973 ± 0.882
0.0GluXaa: 0.0 ± 0.0
Phe
0.743PheAla: 0.743 ± 0.512
0.0PheCys: 0.0 ± 0.0
1.486PheAsp: 1.486 ± 0.523
4.459PheGlu: 4.459 ± 0.467
0.372PhePhe: 0.372 ± 0.333
2.23PheGly: 2.23 ± 0.516
0.743PheHis: 0.743 ± 0.525
4.088PheIle: 4.088 ± 1.381
4.088PheLys: 4.088 ± 1.666
5.946PheLeu: 5.946 ± 1.224
1.486PheMet: 1.486 ± 0.567
2.601PheAsn: 2.601 ± 1.059
2.23PhePro: 2.23 ± 0.547
2.601PheGln: 2.601 ± 0.541
0.743PheArg: 0.743 ± 0.421
4.831PheSer: 4.831 ± 0.781
1.486PheThr: 1.486 ± 0.657
1.115PheVal: 1.115 ± 0.576
1.115PheTrp: 1.115 ± 0.491
2.601PheTyr: 2.601 ± 1.174
0.0PheXaa: 0.0 ± 0.0
Gly
1.115GlyAla: 1.115 ± 0.578
1.486GlyCys: 1.486 ± 0.798
1.115GlyAsp: 1.115 ± 0.445
3.344GlyGlu: 3.344 ± 1.293
2.23GlyPhe: 2.23 ± 0.869
0.743GlyGly: 0.743 ± 0.328
1.115GlyHis: 1.115 ± 0.279
4.088GlyIle: 4.088 ± 1.135
2.973GlyLys: 2.973 ± 0.434
4.831GlyLeu: 4.831 ± 0.856
0.372GlyMet: 0.372 ± 0.48
2.23GlyAsn: 2.23 ± 0.738
0.372GlyPro: 0.372 ± 0.358
1.486GlyGln: 1.486 ± 0.525
1.486GlyArg: 1.486 ± 0.562
2.973GlySer: 2.973 ± 0.544
1.486GlyThr: 1.486 ± 0.574
1.115GlyVal: 1.115 ± 0.501
0.743GlyTrp: 0.743 ± 0.43
2.23GlyTyr: 2.23 ± 0.738
0.0GlyXaa: 0.0 ± 0.0
His
0.743HisAla: 0.743 ± 0.525
0.743HisCys: 0.743 ± 0.526
2.601HisAsp: 2.601 ± 1.14
0.372HisGlu: 0.372 ± 0.333
1.115HisPhe: 1.115 ± 0.737
1.115HisGly: 1.115 ± 0.639
0.372HisHis: 0.372 ± 0.262
1.486HisIle: 1.486 ± 0.802
2.601HisLys: 2.601 ± 0.832
1.858HisLeu: 1.858 ± 0.869
0.0HisMet: 0.0 ± 0.0
1.115HisAsn: 1.115 ± 0.504
0.743HisPro: 0.743 ± 0.328
0.743HisGln: 0.743 ± 0.512
0.743HisArg: 0.743 ± 0.563
0.0HisSer: 0.0 ± 0.0
0.372HisThr: 0.372 ± 0.262
1.858HisVal: 1.858 ± 0.343
0.743HisTrp: 0.743 ± 0.525
1.486HisTyr: 1.486 ± 0.928
0.0HisXaa: 0.0 ± 0.0
Ile
2.601IleAla: 2.601 ± 0.921
2.601IleCys: 2.601 ± 1.002
4.088IleAsp: 4.088 ± 0.573
7.432IleGlu: 7.432 ± 1.199
3.716IlePhe: 3.716 ± 1.015
4.459IleGly: 4.459 ± 1.443
1.486IleHis: 1.486 ± 0.685
4.831IleIle: 4.831 ± 1.426
5.203IleLys: 5.203 ± 1.646
5.946IleLeu: 5.946 ± 1.117
0.743IleMet: 0.743 ± 0.403
6.317IleAsn: 6.317 ± 1.138
3.344IlePro: 3.344 ± 1.229
2.973IleGln: 2.973 ± 1.2
4.088IleArg: 4.088 ± 1.328
5.574IleSer: 5.574 ± 2.452
4.088IleThr: 4.088 ± 0.752
5.203IleVal: 5.203 ± 1.805
0.743IleTrp: 0.743 ± 0.328
2.23IleTyr: 2.23 ± 0.57
0.0IleXaa: 0.0 ± 0.0
Lys
6.689LysAla: 6.689 ± 1.713
1.486LysCys: 1.486 ± 0.657
5.574LysAsp: 5.574 ± 0.871
5.203LysGlu: 5.203 ± 1.385
2.973LysPhe: 2.973 ± 0.553
4.088LysGly: 4.088 ± 1.734
2.23LysHis: 2.23 ± 0.985
4.831LysIle: 4.831 ± 0.905
8.919LysLys: 8.919 ± 3.114
11.52LysLeu: 11.52 ± 1.779
2.973LysMet: 2.973 ± 0.948
4.459LysAsn: 4.459 ± 1.456
7.804LysPro: 7.804 ± 2.329
3.344LysGln: 3.344 ± 0.77
4.459LysArg: 4.459 ± 1.459
5.574LysSer: 5.574 ± 1.402
3.716LysThr: 3.716 ± 0.932
3.344LysVal: 3.344 ± 0.997
1.115LysTrp: 1.115 ± 0.41
1.115LysTyr: 1.115 ± 0.562
0.0LysXaa: 0.0 ± 0.0
Leu
8.175LeuAla: 8.175 ± 1.124
0.372LeuCys: 0.372 ± 0.333
5.946LeuAsp: 5.946 ± 1.537
11.52LeuGlu: 11.52 ± 1.691
3.344LeuPhe: 3.344 ± 0.89
4.831LeuGly: 4.831 ± 0.694
0.743LeuHis: 0.743 ± 0.384
4.088LeuIle: 4.088 ± 1.498
9.29LeuLys: 9.29 ± 1.727
6.689LeuLeu: 6.689 ± 1.76
1.486LeuMet: 1.486 ± 0.636
5.203LeuAsn: 5.203 ± 1.05
4.459LeuPro: 4.459 ± 0.858
6.317LeuGln: 6.317 ± 1.623
3.716LeuArg: 3.716 ± 1.528
8.175LeuSer: 8.175 ± 1.91
3.716LeuThr: 3.716 ± 0.864
5.203LeuVal: 5.203 ± 1.247
0.743LeuTrp: 0.743 ± 0.403
3.716LeuTyr: 3.716 ± 0.542
0.0LeuXaa: 0.0 ± 0.0
Met
0.372MetAla: 0.372 ± 0.48
0.0MetCys: 0.0 ± 0.0
2.23MetAsp: 2.23 ± 0.548
1.858MetGlu: 1.858 ± 1.067
1.115MetPhe: 1.115 ± 0.737
0.372MetGly: 0.372 ± 0.358
1.115MetHis: 1.115 ± 0.992
0.743MetIle: 0.743 ± 0.63
0.743MetLys: 0.743 ± 0.959
1.115MetLeu: 1.115 ± 0.279
0.372MetMet: 0.372 ± 0.304
0.743MetAsn: 0.743 ± 0.403
0.743MetPro: 0.743 ± 0.318
0.743MetGln: 0.743 ± 0.328
0.372MetArg: 0.372 ± 0.262
2.601MetSer: 2.601 ± 0.618
1.115MetThr: 1.115 ± 0.445
2.23MetVal: 2.23 ± 0.776
0.0MetTrp: 0.0 ± 0.0
0.372MetTyr: 0.372 ± 0.262
0.0MetXaa: 0.0 ± 0.0
Asn
2.601AsnAla: 2.601 ± 0.87
0.372AsnCys: 0.372 ± 0.424
1.486AsnAsp: 1.486 ± 0.843
5.203AsnGlu: 5.203 ± 0.666
2.973AsnPhe: 2.973 ± 0.55
2.23AsnGly: 2.23 ± 0.982
1.858AsnHis: 1.858 ± 1.048
1.486AsnIle: 1.486 ± 0.837
3.716AsnLys: 3.716 ± 0.978
6.689AsnLeu: 6.689 ± 1.257
0.743AsnMet: 0.743 ± 0.594
2.601AsnAsn: 2.601 ± 0.904
7.804AsnPro: 7.804 ± 1.511
3.344AsnGln: 3.344 ± 1.092
1.858AsnArg: 1.858 ± 0.98
4.459AsnSer: 4.459 ± 0.882
1.486AsnThr: 1.486 ± 0.525
2.601AsnVal: 2.601 ± 0.788
1.486AsnTrp: 1.486 ± 0.582
1.486AsnTyr: 1.486 ± 0.802
0.0AsnXaa: 0.0 ± 0.0
Pro
2.23ProAla: 2.23 ± 0.846
0.0ProCys: 0.0 ± 0.0
1.858ProAsp: 1.858 ± 0.661
2.601ProGlu: 2.601 ± 0.683
3.716ProPhe: 3.716 ± 0.691
1.115ProGly: 1.115 ± 0.574
0.372ProHis: 0.372 ± 0.48
4.459ProIle: 4.459 ± 1.132
5.946ProLys: 5.946 ± 1.559
4.459ProLeu: 4.459 ± 0.89
1.115ProMet: 1.115 ± 0.41
4.088ProAsn: 4.088 ± 1.412
3.716ProPro: 3.716 ± 0.864
2.601ProGln: 2.601 ± 0.429
2.23ProArg: 2.23 ± 0.414
2.973ProSer: 2.973 ± 1.013
1.486ProThr: 1.486 ± 0.614
1.858ProVal: 1.858 ± 0.657
0.743ProTrp: 0.743 ± 0.525
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.344GlnAla: 3.344 ± 0.942
0.0GlnCys: 0.0 ± 0.0
2.601GlnAsp: 2.601 ± 0.815
4.831GlnGlu: 4.831 ± 1.723
1.115GlnPhe: 1.115 ± 0.576
1.115GlnGly: 1.115 ± 0.279
0.372GlnHis: 0.372 ± 0.315
6.689GlnIle: 6.689 ± 1.064
3.344GlnLys: 3.344 ± 1.149
7.061GlnLeu: 7.061 ± 1.939
1.486GlnMet: 1.486 ± 0.719
2.23GlnAsn: 2.23 ± 0.717
1.115GlnPro: 1.115 ± 0.501
2.23GlnGln: 2.23 ± 0.679
1.486GlnArg: 1.486 ± 0.462
5.574GlnSer: 5.574 ± 1.363
3.716GlnThr: 3.716 ± 0.73
2.601GlnVal: 2.601 ± 0.975
1.115GlnTrp: 1.115 ± 0.279
1.115GlnTyr: 1.115 ± 0.474
0.0GlnXaa: 0.0 ± 0.0
Arg
2.601ArgAla: 2.601 ± 0.635
0.372ArgCys: 0.372 ± 0.262
2.601ArgAsp: 2.601 ± 1.145
1.486ArgGlu: 1.486 ± 0.821
1.858ArgPhe: 1.858 ± 0.456
1.858ArgGly: 1.858 ± 0.719
1.858ArgHis: 1.858 ± 0.691
4.088ArgIle: 4.088 ± 1.452
5.574ArgLys: 5.574 ± 1.154
4.088ArgLeu: 4.088 ± 1.249
0.743ArgMet: 0.743 ± 0.498
1.858ArgAsn: 1.858 ± 1.028
0.743ArgPro: 0.743 ± 0.318
1.858ArgGln: 1.858 ± 0.57
2.973ArgArg: 2.973 ± 1.068
2.601ArgSer: 2.601 ± 0.591
1.115ArgThr: 1.115 ± 0.279
2.23ArgVal: 2.23 ± 0.616
0.743ArgTrp: 0.743 ± 0.63
1.115ArgTyr: 1.115 ± 0.787
0.0ArgXaa: 0.0 ± 0.0
Ser
2.23SerAla: 2.23 ± 1.121
0.372SerCys: 0.372 ± 0.315
4.088SerAsp: 4.088 ± 1.213
6.689SerGlu: 6.689 ± 1.247
5.946SerPhe: 5.946 ± 1.574
2.23SerGly: 2.23 ± 0.766
1.486SerHis: 1.486 ± 0.627
7.061SerIle: 7.061 ± 1.741
7.432SerLys: 7.432 ± 1.547
6.689SerLeu: 6.689 ± 1.24
1.115SerMet: 1.115 ± 0.741
5.574SerAsn: 5.574 ± 1.594
3.716SerPro: 3.716 ± 1.255
2.973SerGln: 2.973 ± 1.029
4.088SerArg: 4.088 ± 0.659
11.148SerSer: 11.148 ± 2.648
5.574SerThr: 5.574 ± 0.627
2.601SerVal: 2.601 ± 1.092
1.115SerTrp: 1.115 ± 0.578
3.344SerTyr: 3.344 ± 0.406
0.0SerXaa: 0.0 ± 0.0
Thr
2.973ThrAla: 2.973 ± 0.879
0.0ThrCys: 0.0 ± 0.0
1.486ThrAsp: 1.486 ± 0.419
4.459ThrGlu: 4.459 ± 1.107
1.858ThrPhe: 1.858 ± 0.622
2.601ThrGly: 2.601 ± 1.357
1.115ThrHis: 1.115 ± 0.716
3.716ThrIle: 3.716 ± 0.822
6.317ThrLys: 6.317 ± 1.136
5.946ThrLeu: 5.946 ± 0.94
0.0ThrMet: 0.0 ± 0.0
2.23ThrAsn: 2.23 ± 0.679
1.115ThrPro: 1.115 ± 0.787
0.743ThrGln: 0.743 ± 0.328
1.486ThrArg: 1.486 ± 0.72
3.344ThrSer: 3.344 ± 1.217
1.115ThrThr: 1.115 ± 0.483
2.601ThrVal: 2.601 ± 0.925
0.743ThrTrp: 0.743 ± 0.489
0.743ThrTyr: 0.743 ± 0.318
0.0ThrXaa: 0.0 ± 0.0
Val
1.115ValAla: 1.115 ± 0.742
0.0ValCys: 0.0 ± 0.0
1.486ValAsp: 1.486 ± 1.102
2.973ValGlu: 2.973 ± 1.05
4.459ValPhe: 4.459 ± 0.882
1.486ValGly: 1.486 ± 0.494
1.115ValHis: 1.115 ± 0.483
3.716ValIle: 3.716 ± 0.936
4.459ValLys: 4.459 ± 1.292
4.831ValLeu: 4.831 ± 0.689
0.372ValMet: 0.372 ± 0.262
2.23ValAsn: 2.23 ± 1.244
1.858ValPro: 1.858 ± 0.746
4.459ValGln: 4.459 ± 1.244
2.601ValArg: 2.601 ± 0.88
4.831ValSer: 4.831 ± 0.692
2.601ValThr: 2.601 ± 0.441
0.372ValVal: 0.372 ± 0.315
0.0ValTrp: 0.0 ± 0.0
1.486ValTyr: 1.486 ± 0.845
0.0ValXaa: 0.0 ± 0.0
Trp
0.743TrpAla: 0.743 ± 0.403
0.372TrpCys: 0.372 ± 0.262
0.0TrpAsp: 0.0 ± 0.0
1.115TrpGlu: 1.115 ± 0.562
0.372TrpPhe: 0.372 ± 0.262
0.0TrpGly: 0.0 ± 0.0
0.372TrpHis: 0.372 ± 0.262
1.486TrpIle: 1.486 ± 0.718
0.372TrpLys: 0.372 ± 0.262
0.743TrpLeu: 0.743 ± 0.403
1.486TrpMet: 1.486 ± 0.552
1.486TrpAsn: 1.486 ± 0.496
0.0TrpPro: 0.0 ± 0.0
1.115TrpGln: 1.115 ± 0.374
0.372TrpArg: 0.372 ± 0.315
1.858TrpSer: 1.858 ± 0.764
1.115TrpThr: 1.115 ± 0.374
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.372TrpTyr: 0.372 ± 0.333
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.23TyrAla: 2.23 ± 0.668
1.486TyrCys: 1.486 ± 0.657
1.115TyrAsp: 1.115 ± 0.716
1.858TyrGlu: 1.858 ± 0.586
0.372TyrPhe: 0.372 ± 0.333
2.23TyrGly: 2.23 ± 1.123
0.743TyrHis: 0.743 ± 0.403
1.858TyrIle: 1.858 ± 0.824
2.601TyrLys: 2.601 ± 0.925
1.486TyrLeu: 1.486 ± 0.552
0.0TyrMet: 0.0 ± 0.0
2.23TyrAsn: 2.23 ± 1.455
1.486TyrPro: 1.486 ± 0.847
1.858TyrGln: 1.858 ± 0.785
2.601TyrArg: 2.601 ± 0.685
2.601TyrSer: 2.601 ± 1.189
0.743TyrThr: 0.743 ± 0.716
1.858TyrVal: 1.858 ± 1.032
0.372TyrTrp: 0.372 ± 0.333
1.486TyrTyr: 1.486 ± 0.61
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2692 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski