Amino acid dipepetide frequency for Neisseria bacilliformis ATCC BAA-1200

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.081AlaAla: 22.081 ± 0.337
1.648AlaCys: 1.648 ± 0.045
7.388AlaAsp: 7.388 ± 0.096
7.92AlaGlu: 7.92 ± 0.131
4.587AlaPhe: 4.587 ± 0.104
8.844AlaGly: 8.844 ± 0.146
2.262AlaHis: 2.262 ± 0.057
3.761AlaIle: 3.761 ± 0.092
5.245AlaLys: 5.245 ± 0.107
12.118AlaLeu: 12.118 ± 0.172
2.651AlaMet: 2.651 ± 0.065
3.33AlaAsn: 3.33 ± 0.078
4.989AlaPro: 4.989 ± 0.117
5.819AlaGln: 5.819 ± 0.104
6.731AlaArg: 6.731 ± 0.115
4.672AlaSer: 4.672 ± 0.1
4.101AlaThr: 4.101 ± 0.1
9.628AlaVal: 9.628 ± 0.161
1.53AlaTrp: 1.53 ± 0.053
2.952AlaTyr: 2.952 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
1.569CysAla: 1.569 ± 0.051
0.231CysCys: 0.231 ± 0.02
0.479CysAsp: 0.479 ± 0.026
0.52CysGlu: 0.52 ± 0.025
0.583CysPhe: 0.583 ± 0.032
1.362CysGly: 1.362 ± 0.048
0.297CysHis: 0.297 ± 0.021
0.499CysIle: 0.499 ± 0.027
0.42CysLys: 0.42 ± 0.025
1.13CysLeu: 1.13 ± 0.037
0.19CysMet: 0.19 ± 0.017
0.333CysAsn: 0.333 ± 0.02
0.693CysPro: 0.693 ± 0.035
0.357CysGln: 0.357 ± 0.022
1.084CysArg: 1.084 ± 0.044
0.526CysSer: 0.526 ± 0.03
0.579CysThr: 0.579 ± 0.028
0.755CysVal: 0.755 ± 0.035
0.115CysTrp: 0.115 ± 0.015
0.313CysTyr: 0.313 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
5.598AspAla: 5.598 ± 0.103
0.54AspCys: 0.54 ± 0.03
2.528AspAsp: 2.528 ± 0.064
3.217AspGlu: 3.217 ± 0.073
2.329AspPhe: 2.329 ± 0.061
4.84AspGly: 4.84 ± 0.107
0.825AspHis: 0.825 ± 0.039
3.197AspIle: 3.197 ± 0.065
2.781AspLys: 2.781 ± 0.067
4.6AspLeu: 4.6 ± 0.093
1.172AspMet: 1.172 ± 0.039
1.891AspAsn: 1.891 ± 0.06
2.151AspPro: 2.151 ± 0.055
1.217AspGln: 1.217 ± 0.04
2.247AspArg: 2.247 ± 0.061
2.38AspSer: 2.38 ± 0.064
3.339AspThr: 3.339 ± 0.077
2.848AspVal: 2.848 ± 0.075
0.891AspTrp: 0.891 ± 0.041
1.866AspTyr: 1.866 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
6.562GluAla: 6.562 ± 0.123
0.537GluCys: 0.537 ± 0.032
2.303GluAsp: 2.303 ± 0.071
3.105GluGlu: 3.105 ± 0.089
1.814GluPhe: 1.814 ± 0.055
3.488GluGly: 3.488 ± 0.079
1.513GluHis: 1.513 ± 0.046
3.446GluIle: 3.446 ± 0.084
3.55GluLys: 3.55 ± 0.075
5.252GluLeu: 5.252 ± 0.083
1.504GluMet: 1.504 ± 0.048
3.184GluAsn: 3.184 ± 0.07
2.033GluPro: 2.033 ± 0.061
2.715GluGln: 2.715 ± 0.072
3.749GluArg: 3.749 ± 0.084
2.602GluSer: 2.602 ± 0.059
3.678GluThr: 3.678 ± 0.073
2.844GluVal: 2.844 ± 0.075
0.742GluTrp: 0.742 ± 0.037
1.475GluTyr: 1.475 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
5.263PheAla: 5.263 ± 0.096
0.649PheCys: 0.649 ± 0.031
2.546PheAsp: 2.546 ± 0.062
1.925PheGlu: 1.925 ± 0.048
1.903PhePhe: 1.903 ± 0.064
3.593PheGly: 3.593 ± 0.08
0.741PheHis: 0.741 ± 0.035
1.714PheIle: 1.714 ± 0.06
1.605PheLys: 1.605 ± 0.056
3.505PheLeu: 3.505 ± 0.081
0.888PheMet: 0.888 ± 0.041
1.483PheAsn: 1.483 ± 0.046
1.743PhePro: 1.743 ± 0.051
1.664PheGln: 1.664 ± 0.056
2.089PheArg: 2.089 ± 0.056
2.767PheSer: 2.767 ± 0.066
2.072PheThr: 2.072 ± 0.056
2.682PheVal: 2.682 ± 0.067
0.544PheTrp: 0.544 ± 0.027
1.285PheTyr: 1.285 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
7.085GlyAla: 7.085 ± 0.132
1.127GlyCys: 1.127 ± 0.045
3.335GlyAsp: 3.335 ± 0.075
4.344GlyGlu: 4.344 ± 0.089
3.747GlyPhe: 3.747 ± 0.072
7.317GlyGly: 7.317 ± 0.133
1.487GlyHis: 1.487 ± 0.048
4.582GlyIle: 4.582 ± 0.089
4.822GlyLys: 4.822 ± 0.09
7.971GlyLeu: 7.971 ± 0.121
2.189GlyMet: 2.189 ± 0.062
2.525GlyAsn: 2.525 ± 0.077
1.042GlyPro: 1.042 ± 0.044
2.824GlyGln: 2.824 ± 0.07
6.255GlyArg: 6.255 ± 0.11
4.58GlySer: 4.58 ± 0.111
3.599GlyThr: 3.599 ± 0.085
4.798GlyVal: 4.798 ± 0.083
1.198GlyTrp: 1.198 ± 0.053
2.306GlyTyr: 2.306 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
2.279HisAla: 2.279 ± 0.052
0.298HisCys: 0.298 ± 0.022
1.011HisAsp: 1.011 ± 0.039
1.078HisGlu: 1.078 ± 0.043
0.86HisPhe: 0.86 ± 0.04
1.948HisGly: 1.948 ± 0.055
0.576HisHis: 0.576 ± 0.035
1.437HisIle: 1.437 ± 0.047
0.859HisLys: 0.859 ± 0.035
2.022HisLeu: 2.022 ± 0.06
0.371HisMet: 0.371 ± 0.022
0.78HisAsn: 0.78 ± 0.034
1.538HisPro: 1.538 ± 0.045
0.765HisGln: 0.765 ± 0.035
1.362HisArg: 1.362 ± 0.046
1.139HisSer: 1.139 ± 0.043
1.666HisThr: 1.666 ± 0.047
1.023HisVal: 1.023 ± 0.046
0.315HisTrp: 0.315 ± 0.019
0.786HisTyr: 0.786 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.813IleAla: 5.813 ± 0.101
0.545IleCys: 0.545 ± 0.024
2.837IleAsp: 2.837 ± 0.063
3.02IleGlu: 3.02 ± 0.077
1.676IlePhe: 1.676 ± 0.058
4.189IleGly: 4.189 ± 0.101
0.971IleHis: 0.971 ± 0.04
2.366IleIle: 2.366 ± 0.071
2.086IleLys: 2.086 ± 0.066
4.499IleLeu: 4.499 ± 0.095
1.078IleMet: 1.078 ± 0.041
1.708IleAsn: 1.708 ± 0.058
2.491IlePro: 2.491 ± 0.061
1.524IleGln: 1.524 ± 0.051
3.395IleArg: 3.395 ± 0.076
2.585IleSer: 2.585 ± 0.063
2.829IleThr: 2.829 ± 0.062
3.36IleVal: 3.36 ± 0.079
0.537IleTrp: 0.537 ± 0.029
1.142IleTyr: 1.142 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.919LysAla: 4.919 ± 0.108
0.312LysCys: 0.312 ± 0.023
2.106LysAsp: 2.106 ± 0.057
2.474LysGlu: 2.474 ± 0.062
1.258LysPhe: 1.258 ± 0.045
3.229LysGly: 3.229 ± 0.076
1.195LysHis: 1.195 ± 0.041
2.793LysIle: 2.793 ± 0.069
2.627LysLys: 2.627 ± 0.066
4.274LysLeu: 4.274 ± 0.087
1.327LysMet: 1.327 ± 0.053
2.481LysAsn: 2.481 ± 0.064
2.734LysPro: 2.734 ± 0.064
2.502LysGln: 2.502 ± 0.07
3.128LysArg: 3.128 ± 0.072
2.393LysSer: 2.393 ± 0.068
3.71LysThr: 3.71 ± 0.073
2.45LysVal: 2.45 ± 0.065
0.551LysTrp: 0.551 ± 0.025
1.171LysTyr: 1.171 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
12.904LeuAla: 12.904 ± 0.184
1.278LeuCys: 1.278 ± 0.045
5.147LeuAsp: 5.147 ± 0.089
4.667LeuGlu: 4.667 ± 0.088
4.21LeuPhe: 4.21 ± 0.092
6.717LeuGly: 6.717 ± 0.115
2.301LeuHis: 2.301 ± 0.055
4.635LeuIle: 4.635 ± 0.085
5.269LeuLys: 5.269 ± 0.086
10.712LeuLeu: 10.712 ± 0.179
2.374LeuMet: 2.374 ± 0.067
3.683LeuAsn: 3.683 ± 0.079
6.312LeuPro: 6.312 ± 0.103
3.598LeuGln: 3.598 ± 0.088
6.212LeuArg: 6.212 ± 0.124
5.812LeuSer: 5.812 ± 0.096
5.154LeuThr: 5.154 ± 0.096
5.414LeuVal: 5.414 ± 0.099
1.288LeuTrp: 1.288 ± 0.052
2.654LeuTyr: 2.654 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.494MetAla: 2.494 ± 0.062
0.264MetCys: 0.264 ± 0.018
1.019MetAsp: 1.019 ± 0.039
1.014MetGlu: 1.014 ± 0.039
0.855MetPhe: 0.855 ± 0.04
1.643MetGly: 1.643 ± 0.053
0.499MetHis: 0.499 ± 0.025
1.019MetIle: 1.019 ± 0.04
1.4MetLys: 1.4 ± 0.044
2.418MetLeu: 2.418 ± 0.067
0.709MetMet: 0.709 ± 0.034
1.063MetAsn: 1.063 ± 0.038
1.441MetPro: 1.441 ± 0.045
1.236MetGln: 1.236 ± 0.043
1.598MetArg: 1.598 ± 0.05
1.416MetSer: 1.416 ± 0.044
1.344MetThr: 1.344 ± 0.044
1.369MetVal: 1.369 ± 0.05
0.261MetTrp: 0.261 ± 0.017
0.482MetTyr: 0.482 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.959AsnAla: 3.959 ± 0.095
0.375AsnCys: 0.375 ± 0.027
1.573AsnAsp: 1.573 ± 0.047
1.74AsnGlu: 1.74 ± 0.056
1.126AsnPhe: 1.126 ± 0.043
3.505AsnGly: 3.505 ± 0.092
0.727AsnHis: 0.727 ± 0.031
2.321AsnIle: 2.321 ± 0.056
1.58AsnLys: 1.58 ± 0.049
3.346AsnLeu: 3.346 ± 0.069
0.791AsnMet: 0.791 ± 0.034
1.306AsnAsn: 1.306 ± 0.051
2.512AsnPro: 2.512 ± 0.062
1.232AsnGln: 1.232 ± 0.046
2.667AsnArg: 2.667 ± 0.074
1.684AsnSer: 1.684 ± 0.062
2.075AsnThr: 2.075 ± 0.064
2.097AsnVal: 2.097 ± 0.053
0.475AsnTrp: 0.475 ± 0.026
1.011AsnTyr: 1.011 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
6.62ProAla: 6.62 ± 0.143
0.579ProCys: 0.579 ± 0.031
3.045ProAsp: 3.045 ± 0.073
3.932ProGlu: 3.932 ± 0.082
2.189ProPhe: 2.189 ± 0.058
2.083ProGly: 2.083 ± 0.063
1.324ProHis: 1.324 ± 0.049
1.527ProIle: 1.527 ± 0.051
2.194ProLys: 2.194 ± 0.068
4.577ProLeu: 4.577 ± 0.088
1.07ProMet: 1.07 ± 0.042
1.677ProAsn: 1.677 ± 0.047
2.775ProPro: 2.775 ± 0.095
2.841ProGln: 2.841 ± 0.068
2.417ProArg: 2.417 ± 0.067
2.703ProSer: 2.703 ± 0.066
1.981ProThr: 1.981 ± 0.056
3.602ProVal: 3.602 ± 0.075
0.441ProTrp: 0.441 ± 0.028
1.476ProTyr: 1.476 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
5.173GlnAla: 5.173 ± 0.106
0.329GlnCys: 0.329 ± 0.023
1.752GlnAsp: 1.752 ± 0.053
2.008GlnGlu: 2.008 ± 0.06
1.258GlnPhe: 1.258 ± 0.044
2.809GlnGly: 2.809 ± 0.062
0.987GlnHis: 0.987 ± 0.041
2.455GlnIle: 2.455 ± 0.065
2.135GlnLys: 2.135 ± 0.059
3.017GlnLeu: 3.017 ± 0.065
1.045GlnMet: 1.045 ± 0.039
2.11GlnAsn: 2.11 ± 0.057
2.117GlnPro: 2.117 ± 0.058
2.113GlnGln: 2.113 ± 0.07
2.467GlnArg: 2.467 ± 0.062
2.381GlnSer: 2.381 ± 0.058
3.72GlnThr: 3.72 ± 0.082
2.121GlnVal: 2.121 ± 0.051
0.585GlnTrp: 0.585 ± 0.03
1.237GlnTyr: 1.237 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
6.079ArgAla: 6.079 ± 0.106
0.61ArgCys: 0.61 ± 0.035
2.917ArgAsp: 2.917 ± 0.072
3.786ArgGlu: 3.786 ± 0.095
3.347ArgPhe: 3.347 ± 0.069
4.06ArgGly: 4.06 ± 0.084
1.92ArgHis: 1.92 ± 0.053
3.456ArgIle: 3.456 ± 0.071
2.674ArgLys: 2.674 ± 0.069
7.731ArgLeu: 7.731 ± 0.129
1.476ArgMet: 1.476 ± 0.047
2.204ArgAsn: 2.204 ± 0.065
3.842ArgPro: 3.842 ± 0.09
3.198ArgGln: 3.198 ± 0.069
5.62ArgArg: 5.62 ± 0.12
3.045ArgSer: 3.045 ± 0.078
2.793ArgThr: 2.793 ± 0.065
3.56ArgVal: 3.56 ± 0.085
0.728ArgTrp: 0.728 ± 0.03
2.2ArgTyr: 2.2 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
5.632SerAla: 5.632 ± 0.122
0.596SerCys: 0.596 ± 0.027
3.308SerAsp: 3.308 ± 0.07
3.505SerGlu: 3.505 ± 0.074
2.003SerPhe: 2.003 ± 0.057
5.445SerGly: 5.445 ± 0.105
1.109SerHis: 1.109 ± 0.042
2.234SerIle: 2.234 ± 0.068
2.013SerLys: 2.013 ± 0.065
5.175SerLeu: 5.175 ± 0.083
1.036SerMet: 1.036 ± 0.04
1.544SerAsn: 1.544 ± 0.052
2.462SerPro: 2.462 ± 0.064
1.688SerGln: 1.688 ± 0.052
3.382SerArg: 3.382 ± 0.066
2.504SerSer: 2.504 ± 0.076
2.1SerThr: 2.1 ± 0.067
3.638SerVal: 3.638 ± 0.086
0.596SerTrp: 0.596 ± 0.028
1.486SerTyr: 1.486 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
7.8ThrAla: 7.8 ± 0.125
0.467ThrCys: 0.467 ± 0.024
2.791ThrAsp: 2.791 ± 0.07
2.59ThrGlu: 2.59 ± 0.067
1.819ThrPhe: 1.819 ± 0.053
4.324ThrGly: 4.324 ± 0.085
1.151ThrHis: 1.151 ± 0.046
2.169ThrIle: 2.169 ± 0.051
1.575ThrLys: 1.575 ± 0.053
6.16ThrLeu: 6.16 ± 0.105
0.96ThrMet: 0.96 ± 0.04
1.317ThrAsn: 1.317 ± 0.053
3.415ThrPro: 3.415 ± 0.07
1.909ThrGln: 1.909 ± 0.054
3.155ThrArg: 3.155 ± 0.077
1.982ThrSer: 1.982 ± 0.068
2.173ThrThr: 2.173 ± 0.058
4.3ThrVal: 4.3 ± 0.075
0.468ThrTrp: 0.468 ± 0.027
1.15ThrTyr: 1.15 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
6.27ValAla: 6.27 ± 0.121
1.105ValCys: 1.105 ± 0.047
2.429ValAsp: 2.429 ± 0.068
3.297ValGlu: 3.297 ± 0.079
3.17ValPhe: 3.17 ± 0.071
4.507ValGly: 4.507 ± 0.096
1.22ValHis: 1.22 ± 0.047
3.16ValIle: 3.16 ± 0.067
3.19ValLys: 3.19 ± 0.079
6.869ValLeu: 6.869 ± 0.119
1.933ValMet: 1.933 ± 0.055
2.029ValAsn: 2.029 ± 0.067
2.84ValPro: 2.84 ± 0.071
2.366ValGln: 2.366 ± 0.057
4.359ValArg: 4.359 ± 0.085
4.468ValSer: 4.468 ± 0.085
2.538ValThr: 2.538 ± 0.075
4.067ValVal: 4.067 ± 0.091
0.963ValTrp: 0.963 ± 0.035
1.946ValTyr: 1.946 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
1.097TrpAla: 1.097 ± 0.043
0.156TrpCys: 0.156 ± 0.013
0.52TrpAsp: 0.52 ± 0.027
0.52TrpGlu: 0.52 ± 0.026
0.628TrpPhe: 0.628 ± 0.032
0.78TrpGly: 0.78 ± 0.035
0.418TrpHis: 0.418 ± 0.026
0.568TrpIle: 0.568 ± 0.031
0.512TrpLys: 0.512 ± 0.031
1.995TrpLeu: 1.995 ± 0.058
0.302TrpMet: 0.302 ± 0.023
0.392TrpAsn: 0.392 ± 0.024
0.458TrpPro: 0.458 ± 0.028
1.098TrpGln: 1.098 ± 0.038
1.102TrpArg: 1.102 ± 0.046
0.454TrpSer: 0.454 ± 0.023
0.533TrpThr: 0.533 ± 0.029
0.725TrpVal: 0.725 ± 0.034
0.183TrpTrp: 0.183 ± 0.019
0.374TrpTyr: 0.374 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.06TyrAla: 3.06 ± 0.059
0.389TyrCys: 0.389 ± 0.021
1.424TyrAsp: 1.424 ± 0.05
1.434TyrGlu: 1.434 ± 0.05
1.299TyrPhe: 1.299 ± 0.046
2.446TyrGly: 2.446 ± 0.059
0.589TyrHis: 0.589 ± 0.028
1.314TyrIle: 1.314 ± 0.049
1.098TyrLys: 1.098 ± 0.046
2.972TyrLeu: 2.972 ± 0.066
0.475TyrMet: 0.475 ± 0.027
1.061TyrAsn: 1.061 ± 0.049
1.466TyrPro: 1.466 ± 0.053
1.153TyrGln: 1.153 ± 0.049
2.227TyrArg: 2.227 ± 0.061
1.364TyrSer: 1.364 ± 0.048
1.693TyrThr: 1.693 ± 0.049
1.442TyrVal: 1.442 ± 0.04
0.403TyrTrp: 0.403 ± 0.023
0.865TyrTyr: 0.865 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2966 proteins (711328 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski