Amino acid dipepetide frequency for Caloramator quimbayensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.049AlaAla: 5.049 ± 0.104	0.743AlaCys: 0.743 ± 0.028	2.969AlaAsp: 2.969 ± 0.06	3.535AlaGlu: 3.535 ± 0.077	2.833AlaPhe: 2.833 ± 0.064	4.135AlaGly: 4.135 ± 0.081	0.834AlaHis: 0.834 ± 0.033	5.416AlaIle: 5.416 ± 0.093	4.835AlaLys: 4.835 ± 0.083	6.088AlaLeu: 6.088 ± 0.095	1.623AlaMet: 1.623 ± 0.04	2.43AlaAsn: 2.43 ± 0.06	1.413AlaPro: 1.413 ± 0.046	1.675AlaGln: 1.675 ± 0.05	1.931AlaArg: 1.931 ± 0.049	3.276AlaSer: 3.276 ± 0.064	2.254AlaThr: 2.254 ± 0.062	4.989AlaVal: 4.989 ± 0.088	0.353AlaTrp: 0.353 ± 0.019	2.162AlaTyr: 2.162 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.718CysAla: 0.718 ± 0.031	0.234CysCys: 0.234 ± 0.019	0.862CysAsp: 0.862 ± 0.032	0.838CysGlu: 0.838 ± 0.031	0.575CysPhe: 0.575 ± 0.029	1.181CysGly: 1.181 ± 0.041	0.227CysHis: 0.227 ± 0.016	1.272CysIle: 1.272 ± 0.046	0.918CysLys: 0.918 ± 0.031	0.96CysLeu: 0.96 ± 0.033	0.291CysMet: 0.291 ± 0.018	0.65CysAsn: 0.65 ± 0.029	0.549CysPro: 0.549 ± 0.029	0.232CysGln: 0.232 ± 0.015	0.486CysArg: 0.486 ± 0.027	0.93CysSer: 0.93 ± 0.032	0.553CysThr: 0.553 ± 0.027	0.661CysVal: 0.661 ± 0.028	0.056CysTrp: 0.056 ± 0.007	0.488CysTyr: 0.488 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.167AspAla: 3.167 ± 0.064	0.654AspCys: 0.654 ± 0.027	3.016AspAsp: 3.016 ± 0.071	5.029AspGlu: 5.029 ± 0.097	3.089AspPhe: 3.089 ± 0.057	3.447AspGly: 3.447 ± 0.064	0.428AspHis: 0.428 ± 0.023	7.112AspIle: 7.112 ± 0.106	5.312AspLys: 5.312 ± 0.084	4.283AspLeu: 4.283 ± 0.068	1.656AspMet: 1.656 ± 0.04	3.091AspAsn: 3.091 ± 0.065	1.226AspPro: 1.226 ± 0.046	0.538AspGln: 0.538 ± 0.023	2.046AspArg: 2.046 ± 0.043	2.921AspSer: 2.921 ± 0.062	2.467AspThr: 2.467 ± 0.057	4.058AspVal: 4.058 ± 0.074	0.367AspTrp: 0.367 ± 0.02	2.783AspTyr: 2.783 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	4.194GluAla: 4.194 ± 0.073	0.752GluCys: 0.752 ± 0.031	4.275GluAsp: 4.275 ± 0.079	5.769GluGlu: 5.769 ± 0.099	3.013GluPhe: 3.013 ± 0.068	4.441GluGly: 4.441 ± 0.078	0.879GluHis: 0.879 ± 0.035	7.466GluIle: 7.466 ± 0.108	7.708GluLys: 7.708 ± 0.114	6.122GluLeu: 6.122 ± 0.092	1.956GluMet: 1.956 ± 0.045	5.109GluAsn: 5.109 ± 0.074	1.432GluPro: 1.432 ± 0.041	1.607GluGln: 1.607 ± 0.051	2.94GluArg: 2.94 ± 0.066	3.381GluSer: 3.381 ± 0.068	2.733GluThr: 2.733 ± 0.056	4.362GluVal: 4.362 ± 0.078	0.429GluTrp: 0.429 ± 0.023	3.244GluTyr: 3.244 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	2.515PheAla: 2.515 ± 0.069	0.566PheCys: 0.566 ± 0.026	2.757PheAsp: 2.757 ± 0.05	3.207PheGlu: 3.207 ± 0.071	2.051PhePhe: 2.051 ± 0.067	2.896PheGly: 2.896 ± 0.068	0.495PheHis: 0.495 ± 0.026	4.985PheIle: 4.985 ± 0.099	4.03PheLys: 4.03 ± 0.075	4.014PheLeu: 4.014 ± 0.092	1.116PheMet: 1.116 ± 0.037	2.874PheAsn: 2.874 ± 0.053	1.233PhePro: 1.233 ± 0.04	0.809PheGln: 0.809 ± 0.035	1.224PheArg: 1.224 ± 0.04	3.034PheSer: 3.034 ± 0.058	2.323PheThr: 2.323 ± 0.059	2.574PheVal: 2.574 ± 0.051	0.306PheTrp: 0.306 ± 0.018	1.958PheTyr: 1.958 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.043GlyAla: 4.043 ± 0.084	1.105GlyCys: 1.105 ± 0.04	3.121GlyAsp: 3.121 ± 0.069	4.0GlyGlu: 4.0 ± 0.08	3.081GlyPhe: 3.081 ± 0.062	4.293GlyGly: 4.293 ± 0.087	0.999GlyHis: 0.999 ± 0.032	7.292GlyIle: 7.292 ± 0.095	5.491GlyLys: 5.491 ± 0.091	5.29GlyLeu: 5.29 ± 0.085	1.787GlyMet: 1.787 ± 0.048	3.006GlyAsn: 3.006 ± 0.061	1.427GlyPro: 1.427 ± 0.049	1.472GlyGln: 1.472 ± 0.04	2.562GlyArg: 2.562 ± 0.058	3.467GlySer: 3.467 ± 0.053	3.219GlyThr: 3.219 ± 0.066	4.318GlyVal: 4.318 ± 0.084	0.515GlyTrp: 0.515 ± 0.024	3.205GlyTyr: 3.205 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.71HisAla: 0.71 ± 0.03	0.157HisCys: 0.157 ± 0.012	0.653HisAsp: 0.653 ± 0.026	0.842HisGlu: 0.842 ± 0.032	0.615HisPhe: 0.615 ± 0.025	0.922HisGly: 0.922 ± 0.033	0.281HisHis: 0.281 ± 0.019	1.335HisIle: 1.335 ± 0.038	0.898HisLys: 0.898 ± 0.032	1.097HisLeu: 1.097 ± 0.038	0.283HisMet: 0.283 ± 0.015	0.672HisAsn: 0.672 ± 0.026	0.658HisPro: 0.658 ± 0.025	0.298HisGln: 0.298 ± 0.018	0.536HisArg: 0.536 ± 0.027	0.808HisSer: 0.808 ± 0.029	0.629HisThr: 0.629 ± 0.022	0.75HisVal: 0.75 ± 0.032	0.085HisTrp: 0.085 ± 0.009	0.585HisTyr: 0.585 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.186IleAla: 6.186 ± 0.096	1.238IleCys: 1.238 ± 0.038	6.601IleAsp: 6.601 ± 0.092	8.017IleGlu: 8.017 ± 0.103	4.255IlePhe: 4.255 ± 0.087	6.201IleGly: 6.201 ± 0.093	1.169IleHis: 1.169 ± 0.034	10.577IleIle: 10.577 ± 0.155	10.27IleLys: 10.27 ± 0.131	9.24IleLeu: 9.24 ± 0.129	2.358IleMet: 2.358 ± 0.053	6.47IleAsn: 6.47 ± 0.113	3.765IlePro: 3.765 ± 0.068	2.06IleGln: 2.06 ± 0.054	3.365IleArg: 3.365 ± 0.071	6.977IleSer: 6.977 ± 0.107	4.802IleThr: 4.802 ± 0.09	6.071IleVal: 6.071 ± 0.085	0.531IleTrp: 0.531 ± 0.026	4.045IleTyr: 4.045 ± 0.08	0.0IleXaa: 0.0 ± 0.0
Lys	4.969LysAla: 4.969 ± 0.085	0.977LysCys: 0.977 ± 0.039	6.136LysAsp: 6.136 ± 0.094	8.164LysGlu: 8.164 ± 0.107	3.058LysPhe: 3.058 ± 0.059	5.444LysGly: 5.444 ± 0.085	1.023LysHis: 1.023 ± 0.031	9.113LysIle: 9.113 ± 0.115	8.639LysLys: 8.639 ± 0.106	7.18LysLeu: 7.18 ± 0.094	2.466LysMet: 2.466 ± 0.051	6.663LysAsn: 6.663 ± 0.097	2.199LysPro: 2.199 ± 0.045	2.179LysGln: 2.179 ± 0.054	3.611LysArg: 3.611 ± 0.074	5.336LysSer: 5.336 ± 0.086	4.104LysThr: 4.104 ± 0.073	5.671LysVal: 5.671 ± 0.097	0.62LysTrp: 0.62 ± 0.028	4.468LysTyr: 4.468 ± 0.071	0.0LysXaa: 0.0 ± 0.0
Leu	4.24LeuAla: 4.24 ± 0.086	1.307LeuCys: 1.307 ± 0.043	4.502LeuAsp: 4.502 ± 0.072	5.755LeuGlu: 5.755 ± 0.094	3.867LeuPhe: 3.867 ± 0.072	5.719LeuGly: 5.719 ± 0.1	1.009LeuHis: 1.009 ± 0.03	8.539LeuIle: 8.539 ± 0.138	9.26LeuLys: 9.26 ± 0.107	7.929LeuLeu: 7.929 ± 0.123	2.241LeuMet: 2.241 ± 0.054	5.852LeuAsn: 5.852 ± 0.083	2.912LeuPro: 2.912 ± 0.048	1.958LeuGln: 1.958 ± 0.052	3.125LeuArg: 3.125 ± 0.064	7.285LeuSer: 7.285 ± 0.107	4.289LeuThr: 4.289 ± 0.076	4.278LeuVal: 4.278 ± 0.076	0.628LeuTrp: 0.628 ± 0.028	3.654LeuTyr: 3.654 ± 0.079	0.0LeuXaa: 0.0 ± 0.0
Met	1.735MetAla: 1.735 ± 0.043	0.269MetCys: 0.269 ± 0.017	1.543MetAsp: 1.543 ± 0.035	1.766MetGlu: 1.766 ± 0.041	1.007MetPhe: 1.007 ± 0.038	1.717MetGly: 1.717 ± 0.039	0.368MetHis: 0.368 ± 0.019	2.388MetIle: 2.388 ± 0.053	2.349MetLys: 2.349 ± 0.048	2.45MetLeu: 2.45 ± 0.055	0.631MetMet: 0.631 ± 0.027	1.478MetAsn: 1.478 ± 0.041	1.098MetPro: 1.098 ± 0.036	0.748MetGln: 0.748 ± 0.03	0.911MetArg: 0.911 ± 0.031	1.558MetSer: 1.558 ± 0.044	1.198MetThr: 1.198 ± 0.04	1.541MetVal: 1.541 ± 0.043	0.17MetTrp: 0.17 ± 0.013	0.881MetTyr: 0.881 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.008AsnAla: 3.008 ± 0.062	0.691AsnCys: 0.691 ± 0.026	2.856AsnAsp: 2.856 ± 0.064	4.044AsnGlu: 4.044 ± 0.066	2.612AsnPhe: 2.612 ± 0.056	3.255AsnGly: 3.255 ± 0.072	0.739AsnHis: 0.739 ± 0.028	7.485AsnIle: 7.485 ± 0.106	5.525AsnLys: 5.525 ± 0.076	5.396AsnLeu: 5.396 ± 0.091	1.663AsnMet: 1.663 ± 0.047	3.823AsnAsn: 3.823 ± 0.078	2.275AsnPro: 2.275 ± 0.053	1.332AsnGln: 1.332 ± 0.032	1.979AsnArg: 1.979 ± 0.045	3.69AsnSer: 3.69 ± 0.076	2.662AsnThr: 2.662 ± 0.055	3.395AsnVal: 3.395 ± 0.061	0.393AsnTrp: 0.393 ± 0.023	2.743AsnTyr: 2.743 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.571ProAla: 1.571 ± 0.051	0.368ProCys: 0.368 ± 0.018	1.811ProAsp: 1.811 ± 0.046	2.251ProGlu: 2.251 ± 0.055	1.615ProPhe: 1.615 ± 0.044	1.588ProGly: 1.588 ± 0.053	0.52ProHis: 0.52 ± 0.023	2.73ProIle: 2.73 ± 0.06	2.351ProLys: 2.351 ± 0.047	2.787ProLeu: 2.787 ± 0.053	0.711ProMet: 0.711 ± 0.031	1.533ProAsn: 1.533 ± 0.048	0.788ProPro: 0.788 ± 0.026	0.914ProGln: 0.914 ± 0.034	0.845ProArg: 0.845 ± 0.028	1.96ProSer: 1.96 ± 0.05	1.355ProThr: 1.355 ± 0.036	2.423ProVal: 2.423 ± 0.057	0.242ProTrp: 0.242 ± 0.016	1.497ProTyr: 1.497 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	1.336GlnAla: 1.336 ± 0.043	0.258GlnCys: 0.258 ± 0.019	1.112GlnAsp: 1.112 ± 0.036	1.511GlnGlu: 1.511 ± 0.043	0.884GlnPhe: 0.884 ± 0.031	1.274GlnGly: 1.274 ± 0.042	0.317GlnHis: 0.317 ± 0.019	2.327GlnIle: 2.327 ± 0.056	2.138GlnLys: 2.138 ± 0.047	1.886GlnLeu: 1.886 ± 0.044	0.642GlnMet: 0.642 ± 0.025	1.585GlnAsn: 1.585 ± 0.042	0.564GlnPro: 0.564 ± 0.025	0.742GlnGln: 0.742 ± 0.034	1.166GlnArg: 1.166 ± 0.034	1.458GlnSer: 1.458 ± 0.04	1.025GlnThr: 1.025 ± 0.037	1.305GlnVal: 1.305 ± 0.036	0.183GlnTrp: 0.183 ± 0.014	1.008GlnTyr: 1.008 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.222ArgAla: 2.222 ± 0.054	0.498ArgCys: 0.498 ± 0.023	2.028ArgAsp: 2.028 ± 0.051	2.949ArgGlu: 2.949 ± 0.068	1.626ArgPhe: 1.626 ± 0.042	2.246ArgGly: 2.246 ± 0.049	0.509ArgHis: 0.509 ± 0.022	3.746ArgIle: 3.746 ± 0.07	3.032ArgLys: 3.032 ± 0.065	3.198ArgLeu: 3.198 ± 0.06	1.032ArgMet: 1.032 ± 0.034	2.0ArgAsn: 2.0 ± 0.049	0.988ArgPro: 0.988 ± 0.036	1.038ArgGln: 1.038 ± 0.034	1.505ArgArg: 1.505 ± 0.042	1.379ArgSer: 1.379 ± 0.04	1.54ArgThr: 1.54 ± 0.046	2.314ArgVal: 2.314 ± 0.05	0.293ArgTrp: 0.293 ± 0.018	1.622ArgTyr: 1.622 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.378SerAla: 3.378 ± 0.064	0.783SerCys: 0.783 ± 0.029	3.233SerAsp: 3.233 ± 0.062	3.734SerGlu: 3.734 ± 0.071	3.207SerPhe: 3.207 ± 0.065	4.265SerGly: 4.265 ± 0.063	0.842SerHis: 0.842 ± 0.03	6.735SerIle: 6.735 ± 0.103	5.65SerLys: 5.65 ± 0.072	5.823SerLeu: 5.823 ± 0.091	1.599SerMet: 1.599 ± 0.047	3.411SerAsn: 3.411 ± 0.073	1.847SerPro: 1.847 ± 0.049	1.634SerGln: 1.634 ± 0.038	2.179SerArg: 2.179 ± 0.051	4.412SerSer: 4.412 ± 0.096	2.847SerThr: 2.847 ± 0.058	3.546SerVal: 3.546 ± 0.059	0.348SerTrp: 0.348 ± 0.021	2.562SerTyr: 2.562 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.24ThrAla: 3.24 ± 0.081	0.505ThrCys: 0.505 ± 0.029	2.419ThrAsp: 2.419 ± 0.051	2.524ThrGlu: 2.524 ± 0.057	2.153ThrPhe: 2.153 ± 0.047	3.596ThrGly: 3.596 ± 0.076	0.648ThrHis: 0.648 ± 0.026	4.463ThrIle: 4.463 ± 0.075	3.41ThrLys: 3.41 ± 0.06	4.374ThrLeu: 4.374 ± 0.075	0.992ThrMet: 0.992 ± 0.032	2.364ThrAsn: 2.364 ± 0.057	1.761ThrPro: 1.761 ± 0.047	1.085ThrGln: 1.085 ± 0.033	1.357ThrArg: 1.357 ± 0.041	2.828ThrSer: 2.828 ± 0.062	2.237ThrThr: 2.237 ± 0.06	3.339ThrVal: 3.339 ± 0.076	0.311ThrTrp: 0.311 ± 0.021	1.787ThrTyr: 1.787 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	3.696ValAla: 3.696 ± 0.076	0.853ValCys: 0.853 ± 0.034	3.719ValAsp: 3.719 ± 0.08	4.401ValGlu: 4.401 ± 0.09	2.915ValPhe: 2.915 ± 0.057	3.775ValGly: 3.775 ± 0.073	0.794ValHis: 0.794 ± 0.031	6.151ValIle: 6.151 ± 0.085	5.742ValLys: 5.742 ± 0.086	5.976ValLeu: 5.976 ± 0.09	1.553ValMet: 1.553 ± 0.044	3.325ValAsn: 3.325 ± 0.064	2.133ValPro: 2.133 ± 0.049	1.314ValGln: 1.314 ± 0.038	2.109ValArg: 2.109 ± 0.061	4.091ValSer: 4.091 ± 0.062	2.959ValThr: 2.959 ± 0.06	4.429ValVal: 4.429 ± 0.093	0.395ValTrp: 0.395 ± 0.022	2.617ValTyr: 2.617 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.408TrpAla: 0.408 ± 0.023	0.093TrpCys: 0.093 ± 0.011	0.43TrpAsp: 0.43 ± 0.023	0.42TrpGlu: 0.42 ± 0.024	0.302TrpPhe: 0.302 ± 0.021	0.498TrpGly: 0.498 ± 0.023	0.119TrpHis: 0.119 ± 0.012	0.572TrpIle: 0.572 ± 0.028	0.462TrpLys: 0.462 ± 0.024	0.54TrpLeu: 0.54 ± 0.029	0.208TrpMet: 0.208 ± 0.016	0.387TrpAsn: 0.387 ± 0.021	0.19TrpPro: 0.19 ± 0.015	0.226TrpGln: 0.226 ± 0.018	0.269TrpArg: 0.269 ± 0.016	0.371TrpSer: 0.371 ± 0.021	0.295TrpThr: 0.295 ± 0.02	0.416TrpVal: 0.416 ± 0.02	0.079TrpTrp: 0.079 ± 0.009	0.265TrpTyr: 0.265 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.16TyrAla: 2.16 ± 0.047	0.628TyrCys: 0.628 ± 0.024	2.65TyrAsp: 2.65 ± 0.053	3.057TyrGlu: 3.057 ± 0.067	2.208TyrPhe: 2.208 ± 0.052	2.802TyrGly: 2.802 ± 0.063	0.615TyrHis: 0.615 ± 0.027	4.494TyrIle: 4.494 ± 0.087	3.999TyrLys: 3.999 ± 0.07	3.718TyrLeu: 3.718 ± 0.072	0.996TyrMet: 0.996 ± 0.033	2.842TyrAsn: 2.842 ± 0.052	1.402TyrPro: 1.402 ± 0.042	0.86TyrGln: 0.86 ± 0.032	1.617TyrArg: 1.617 ± 0.044	2.875TyrSer: 2.875 ± 0.06	1.899TyrThr: 1.899 ± 0.051	2.507TyrVal: 2.507 ± 0.049	0.246TyrTrp: 0.246 ± 0.016	2.012TyrTyr: 2.012 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2996 proteins (921638 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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