Amino acid dipepetide frequency for Stagnimonas aquatica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.495AlaAla: 18.495 ± 0.214
1.29AlaCys: 1.29 ± 0.037
6.607AlaAsp: 6.607 ± 0.075
8.464AlaGlu: 8.464 ± 0.102
3.508AlaPhe: 3.508 ± 0.061
11.409AlaGly: 11.409 ± 0.118
2.256AlaHis: 2.256 ± 0.048
4.659AlaIle: 4.659 ± 0.069
3.844AlaLys: 3.844 ± 0.076
16.106AlaLeu: 16.106 ± 0.179
2.708AlaMet: 2.708 ± 0.055
2.98AlaAsn: 2.98 ± 0.061
6.748AlaPro: 6.748 ± 0.1
5.33AlaGln: 5.33 ± 0.075
9.356AlaArg: 9.356 ± 0.117
6.961AlaSer: 6.961 ± 0.101
5.537AlaThr: 5.537 ± 0.106
8.826AlaVal: 8.826 ± 0.095
1.74AlaTrp: 1.74 ± 0.049
2.957AlaTyr: 2.957 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
1.166CysAla: 1.166 ± 0.034
0.121CysCys: 0.121 ± 0.011
0.465CysAsp: 0.465 ± 0.021
0.507CysGlu: 0.507 ± 0.024
0.286CysPhe: 0.286 ± 0.016
1.015CysGly: 1.015 ± 0.032
0.244CysHis: 0.244 ± 0.023
0.325CysIle: 0.325 ± 0.017
0.22CysLys: 0.22 ± 0.015
0.908CysLeu: 0.908 ± 0.027
0.122CysMet: 0.122 ± 0.009
0.226CysAsn: 0.226 ± 0.014
0.497CysPro: 0.497 ± 0.028
0.315CysGln: 0.315 ± 0.017
0.626CysArg: 0.626 ± 0.027
0.505CysSer: 0.505 ± 0.024
0.435CysThr: 0.435 ± 0.022
0.578CysVal: 0.578 ± 0.021
0.135CysTrp: 0.135 ± 0.012
0.214CysTyr: 0.214 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.624AspAla: 6.624 ± 0.096
0.541AspCys: 0.541 ± 0.024
2.431AspAsp: 2.431 ± 0.048
2.838AspGlu: 2.838 ± 0.052
2.097AspPhe: 2.097 ± 0.045
4.997AspGly: 4.997 ± 0.095
1.043AspHis: 1.043 ± 0.033
1.913AspIle: 1.913 ± 0.045
1.454AspLys: 1.454 ± 0.04
5.631AspLeu: 5.631 ± 0.083
0.768AspMet: 0.768 ± 0.025
1.279AspAsn: 1.279 ± 0.039
3.152AspPro: 3.152 ± 0.051
1.765AspGln: 1.765 ± 0.04
3.31AspArg: 3.31 ± 0.054
2.819AspSer: 2.819 ± 0.059
2.044AspThr: 2.044 ± 0.044
3.045AspVal: 3.045 ± 0.054
1.091AspTrp: 1.091 ± 0.03
1.942AspTyr: 1.942 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
7.952GluAla: 7.952 ± 0.109
0.364GluCys: 0.364 ± 0.019
2.48GluAsp: 2.48 ± 0.047
2.559GluGlu: 2.559 ± 0.061
1.841GluPhe: 1.841 ± 0.036
4.109GluGly: 4.109 ± 0.067
1.262GluHis: 1.262 ± 0.036
2.602GluIle: 2.602 ± 0.054
1.818GluLys: 1.818 ± 0.047
6.81GluLeu: 6.81 ± 0.091
1.069GluMet: 1.069 ± 0.034
1.227GluAsn: 1.227 ± 0.034
2.992GluPro: 2.992 ± 0.052
3.019GluGln: 3.019 ± 0.06
5.057GluArg: 5.057 ± 0.077
2.653GluSer: 2.653 ± 0.047
2.994GluThr: 2.994 ± 0.049
4.123GluVal: 4.123 ± 0.061
0.749GluTrp: 0.749 ± 0.026
1.113GluTyr: 1.113 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.001PheAla: 4.001 ± 0.052
0.337PheCys: 0.337 ± 0.017
2.136PheAsp: 2.136 ± 0.045
2.041PheGlu: 2.041 ± 0.045
1.224PhePhe: 1.224 ± 0.04
3.336PheGly: 3.336 ± 0.059
0.707PheHis: 0.707 ± 0.025
1.251PheIle: 1.251 ± 0.032
1.041PheLys: 1.041 ± 0.034
3.19PheLeu: 3.19 ± 0.068
0.603PheMet: 0.603 ± 0.025
1.04PheAsn: 1.04 ± 0.034
1.499PhePro: 1.499 ± 0.035
1.094PheGln: 1.094 ± 0.028
2.016PheArg: 2.016 ± 0.041
2.077PheSer: 2.077 ± 0.052
1.706PheThr: 1.706 ± 0.042
2.366PheVal: 2.366 ± 0.047
0.478PheTrp: 0.478 ± 0.021
0.897PheTyr: 0.897 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.475GlyAla: 9.475 ± 0.14
0.912GlyCys: 0.912 ± 0.032
4.152GlyAsp: 4.152 ± 0.075
5.233GlyGlu: 5.233 ± 0.069
3.192GlyPhe: 3.192 ± 0.058
7.735GlyGly: 7.735 ± 0.122
1.846GlyHis: 1.846 ± 0.042
3.68GlyIle: 3.68 ± 0.065
3.143GlyLys: 3.143 ± 0.061
10.634GlyLeu: 10.634 ± 0.123
1.751GlyMet: 1.751 ± 0.041
2.229GlyAsn: 2.229 ± 0.06
3.244GlyPro: 3.244 ± 0.059
3.414GlyGln: 3.414 ± 0.057
5.94GlyArg: 5.94 ± 0.075
5.305GlySer: 5.305 ± 0.108
3.821GlyThr: 3.821 ± 0.072
6.205GlyVal: 6.205 ± 0.075
1.463GlyTrp: 1.463 ± 0.033
2.714GlyTyr: 2.714 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.298HisAla: 2.298 ± 0.05
0.279HisCys: 0.279 ± 0.015
0.999HisAsp: 0.999 ± 0.034
1.025HisGlu: 1.025 ± 0.034
0.843HisPhe: 0.843 ± 0.031
1.942HisGly: 1.942 ± 0.045
0.598HisHis: 0.598 ± 0.032
0.71HisIle: 0.71 ± 0.028
0.48HisLys: 0.48 ± 0.023
2.239HisLeu: 2.239 ± 0.047
0.355HisMet: 0.355 ± 0.016
0.452HisAsn: 0.452 ± 0.019
1.453HisPro: 1.453 ± 0.037
0.716HisGln: 0.716 ± 0.026
1.532HisArg: 1.532 ± 0.043
1.031HisSer: 1.031 ± 0.031
0.776HisThr: 0.776 ± 0.026
1.117HisVal: 1.117 ± 0.034
0.464HisTrp: 0.464 ± 0.02
0.768HisTyr: 0.768 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.647IleAla: 5.647 ± 0.077
0.374IleCys: 0.374 ± 0.019
2.52IleAsp: 2.52 ± 0.049
2.759IleGlu: 2.759 ± 0.059
1.078IlePhe: 1.078 ± 0.035
3.797IleGly: 3.797 ± 0.065
0.856IleHis: 0.856 ± 0.026
1.207IleIle: 1.207 ± 0.04
1.295IleLys: 1.295 ± 0.037
3.137IleLeu: 3.137 ± 0.056
0.466IleMet: 0.466 ± 0.023
1.342IleAsn: 1.342 ± 0.043
2.159IlePro: 2.159 ± 0.043
1.305IleGln: 1.305 ± 0.034
2.611IleArg: 2.611 ± 0.055
2.262IleSer: 2.262 ± 0.051
1.975IleThr: 1.975 ± 0.043
2.741IleVal: 2.741 ± 0.052
0.441IleTrp: 0.441 ± 0.019
1.002IleTyr: 1.002 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.956LysAla: 3.956 ± 0.076
0.177LysCys: 0.177 ± 0.017
1.593LysAsp: 1.593 ± 0.043
1.347LysGlu: 1.347 ± 0.039
0.834LysPhe: 0.834 ± 0.026
2.26LysGly: 2.26 ± 0.054
0.545LysHis: 0.545 ± 0.026
1.322LysIle: 1.322 ± 0.043
1.401LysLys: 1.401 ± 0.054
3.988LysLeu: 3.988 ± 0.066
0.653LysMet: 0.653 ± 0.025
0.865LysAsn: 0.865 ± 0.03
2.254LysPro: 2.254 ± 0.054
1.234LysGln: 1.234 ± 0.032
1.951LysArg: 1.951 ± 0.038
1.702LysSer: 1.702 ± 0.04
1.886LysThr: 1.886 ± 0.048
2.11LysVal: 2.11 ± 0.053
0.275LysTrp: 0.275 ± 0.015
0.617LysTyr: 0.617 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
16.68LeuAla: 16.68 ± 0.175
1.021LeuCys: 1.021 ± 0.032
6.511LeuAsp: 6.511 ± 0.084
5.867LeuGlu: 5.867 ± 0.08
3.765LeuPhe: 3.765 ± 0.073
9.668LeuGly: 9.668 ± 0.114
2.306LeuHis: 2.306 ± 0.045
4.597LeuIle: 4.597 ± 0.064
4.023LeuLys: 4.023 ± 0.071
14.103LeuLeu: 14.103 ± 0.185
2.134LeuMet: 2.134 ± 0.037
2.926LeuAsn: 2.926 ± 0.057
7.419LeuPro: 7.419 ± 0.096
3.995LeuGln: 3.995 ± 0.054
9.552LeuArg: 9.552 ± 0.115
7.612LeuSer: 7.612 ± 0.095
5.141LeuThr: 5.141 ± 0.07
7.785LeuVal: 7.785 ± 0.102
1.456LeuTrp: 1.456 ± 0.04
2.418LeuTyr: 2.418 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.286MetAla: 2.286 ± 0.039
0.114MetCys: 0.114 ± 0.01
0.867MetAsp: 0.867 ± 0.03
0.857MetGlu: 0.857 ± 0.029
0.569MetPhe: 0.569 ± 0.024
1.415MetGly: 1.415 ± 0.04
0.358MetHis: 0.358 ± 0.016
0.729MetIle: 0.729 ± 0.03
0.806MetLys: 0.806 ± 0.03
2.007MetLeu: 2.007 ± 0.046
0.365MetMet: 0.365 ± 0.021
0.663MetAsn: 0.663 ± 0.023
1.214MetPro: 1.214 ± 0.033
0.751MetGln: 0.751 ± 0.022
1.391MetArg: 1.391 ± 0.035
1.511MetSer: 1.511 ± 0.038
1.136MetThr: 1.136 ± 0.031
1.122MetVal: 1.122 ± 0.034
0.183MetTrp: 0.183 ± 0.014
0.29MetTyr: 0.29 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.185AsnAla: 3.185 ± 0.066
0.254AsnCys: 0.254 ± 0.014
1.243AsnAsp: 1.243 ± 0.039
1.173AsnGlu: 1.173 ± 0.031
0.955AsnPhe: 0.955 ± 0.029
2.253AsnGly: 2.253 ± 0.044
0.543AsnHis: 0.543 ± 0.022
1.032AsnIle: 1.032 ± 0.034
0.687AsnLys: 0.687 ± 0.028
3.054AsnLeu: 3.054 ± 0.058
0.401AsnMet: 0.401 ± 0.021
0.73AsnAsn: 0.73 ± 0.03
1.892AsnPro: 1.892 ± 0.046
0.931AsnGln: 0.931 ± 0.031
1.726AsnArg: 1.726 ± 0.048
1.333AsnSer: 1.333 ± 0.044
1.3AsnThr: 1.3 ± 0.041
1.607AsnVal: 1.607 ± 0.04
0.365AsnTrp: 0.365 ± 0.017
0.757AsnTyr: 0.757 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
7.963ProAla: 7.963 ± 0.111
0.368ProCys: 0.368 ± 0.021
3.119ProAsp: 3.119 ± 0.056
4.159ProGlu: 4.159 ± 0.062
1.709ProPhe: 1.709 ± 0.04
5.126ProGly: 5.126 ± 0.08
0.956ProHis: 0.956 ± 0.026
1.753ProIle: 1.753 ± 0.04
1.65ProLys: 1.65 ± 0.044
6.249ProLeu: 6.249 ± 0.08
1.21ProMet: 1.21 ± 0.032
1.277ProAsn: 1.277 ± 0.036
3.4ProPro: 3.4 ± 0.084
2.22ProGln: 2.22 ± 0.046
3.411ProArg: 3.411 ± 0.053
2.917ProSer: 2.917 ± 0.056
2.414ProThr: 2.414 ± 0.043
4.386ProVal: 4.386 ± 0.067
0.777ProTrp: 0.777 ± 0.029
1.316ProTyr: 1.316 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
5.553GlnAla: 5.553 ± 0.085
0.272GlnCys: 0.272 ± 0.017
1.56GlnAsp: 1.56 ± 0.036
1.648GlnGlu: 1.648 ± 0.041
1.331GlnPhe: 1.331 ± 0.032
3.15GlnGly: 3.15 ± 0.052
0.813GlnHis: 0.813 ± 0.028
1.624GlnIle: 1.624 ± 0.041
1.126GlnLys: 1.126 ± 0.036
4.891GlnLeu: 4.891 ± 0.078
0.782GlnMet: 0.782 ± 0.027
0.816GlnAsn: 0.816 ± 0.028
2.445GlnPro: 2.445 ± 0.047
1.943GlnGln: 1.943 ± 0.045
3.414GlnArg: 3.414 ± 0.064
2.035GlnSer: 2.035 ± 0.049
1.927GlnThr: 1.927 ± 0.045
2.806GlnVal: 2.806 ± 0.052
0.591GlnTrp: 0.591 ± 0.024
0.85GlnTyr: 0.85 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
8.386ArgAla: 8.386 ± 0.102
0.602ArgCys: 0.602 ± 0.026
3.633ArgAsp: 3.633 ± 0.063
4.646ArgGlu: 4.646 ± 0.07
2.655ArgPhe: 2.655 ± 0.054
5.164ArgGly: 5.164 ± 0.068
1.674ArgHis: 1.674 ± 0.046
3.421ArgIle: 3.421 ± 0.064
1.965ArgLys: 1.965 ± 0.044
9.992ArgLeu: 9.992 ± 0.118
1.496ArgMet: 1.496 ± 0.035
1.765ArgAsn: 1.765 ± 0.041
3.732ArgPro: 3.732 ± 0.062
3.185ArgGln: 3.185 ± 0.055
6.077ArgArg: 6.077 ± 0.099
3.695ArgSer: 3.695 ± 0.053
2.551ArgThr: 2.551 ± 0.047
4.872ArgVal: 4.872 ± 0.062
1.318ArgTrp: 1.318 ± 0.037
2.504ArgTyr: 2.504 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
7.203SerAla: 7.203 ± 0.087
0.496SerCys: 0.496 ± 0.023
2.634SerAsp: 2.634 ± 0.057
3.139SerGlu: 3.139 ± 0.053
2.127SerPhe: 2.127 ± 0.05
5.738SerGly: 5.738 ± 0.108
1.116SerHis: 1.116 ± 0.028
2.099SerIle: 2.099 ± 0.05
1.554SerLys: 1.554 ± 0.044
6.96SerLeu: 6.96 ± 0.083
0.959SerMet: 0.959 ± 0.031
1.489SerAsn: 1.489 ± 0.043
3.133SerPro: 3.133 ± 0.051
2.159SerGln: 2.159 ± 0.052
4.002SerArg: 4.002 ± 0.063
3.404SerSer: 3.404 ± 0.086
2.682SerThr: 2.682 ± 0.06
3.689SerVal: 3.689 ± 0.061
0.792SerTrp: 0.792 ± 0.025
1.557SerTyr: 1.557 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
6.008ThrAla: 6.008 ± 0.074
0.341ThrCys: 0.341 ± 0.018
2.161ThrAsp: 2.161 ± 0.051
2.415ThrGlu: 2.415 ± 0.044
1.179ThrPhe: 1.179 ± 0.034
4.506ThrGly: 4.506 ± 0.085
0.83ThrHis: 0.83 ± 0.027
1.601ThrIle: 1.601 ± 0.038
1.175ThrLys: 1.175 ± 0.037
5.931ThrLeu: 5.931 ± 0.083
0.712ThrMet: 0.712 ± 0.025
0.993ThrAsn: 0.993 ± 0.032
3.508ThrPro: 3.508 ± 0.058
1.547ThrGln: 1.547 ± 0.037
2.937ThrArg: 2.937 ± 0.044
2.399ThrSer: 2.399 ± 0.065
2.348ThrThr: 2.348 ± 0.064
3.874ThrVal: 3.874 ± 0.071
0.571ThrTrp: 0.571 ± 0.025
0.956ThrTyr: 0.956 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
8.54ValAla: 8.54 ± 0.106
0.634ValCys: 0.634 ± 0.025
3.681ValAsp: 3.681 ± 0.046
4.244ValGlu: 4.244 ± 0.055
2.29ValPhe: 2.29 ± 0.047
5.214ValGly: 5.214 ± 0.074
1.341ValHis: 1.341 ± 0.035
3.061ValIle: 3.061 ± 0.058
2.16ValLys: 2.16 ± 0.053
7.996ValLeu: 7.996 ± 0.091
1.412ValMet: 1.412 ± 0.046
1.975ValAsn: 1.975 ± 0.045
3.515ValPro: 3.515 ± 0.06
2.691ValGln: 2.691 ± 0.05
4.794ValArg: 4.794 ± 0.068
4.307ValSer: 4.307 ± 0.073
3.307ValThr: 3.307 ± 0.059
5.355ValVal: 5.355 ± 0.088
0.955ValTrp: 0.955 ± 0.034
1.672ValTyr: 1.672 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.342TrpAla: 1.342 ± 0.038
0.14TrpCys: 0.14 ± 0.012
0.621TrpAsp: 0.621 ± 0.026
0.571TrpGlu: 0.571 ± 0.02
0.531TrpPhe: 0.531 ± 0.023
0.909TrpGly: 0.909 ± 0.03
0.294TrpHis: 0.294 ± 0.017
0.555TrpIle: 0.555 ± 0.025
0.438TrpLys: 0.438 ± 0.017
2.339TrpLeu: 2.339 ± 0.053
0.335TrpMet: 0.335 ± 0.019
0.409TrpAsn: 0.409 ± 0.021
0.827TrpPro: 0.827 ± 0.032
0.802TrpGln: 0.802 ± 0.027
1.325TrpArg: 1.325 ± 0.041
0.895TrpSer: 0.895 ± 0.03
0.733TrpThr: 0.733 ± 0.026
0.885TrpVal: 0.885 ± 0.03
0.272TrpTrp: 0.272 ± 0.016
0.33TrpTyr: 0.33 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.022TyrAla: 3.022 ± 0.056
0.271TyrCys: 0.271 ± 0.015
1.373TyrAsp: 1.373 ± 0.04
1.3TyrGlu: 1.3 ± 0.033
1.027TyrPhe: 1.027 ± 0.035
2.345TyrGly: 2.345 ± 0.053
0.487TyrHis: 0.487 ± 0.023
0.834TyrIle: 0.834 ± 0.027
0.689TyrLys: 0.689 ± 0.024
2.812TyrLeu: 2.812 ± 0.05
0.332TyrMet: 0.332 ± 0.018
0.741TyrAsn: 0.741 ± 0.027
1.296TyrPro: 1.296 ± 0.034
1.161TyrGln: 1.161 ± 0.033
2.305TyrArg: 2.305 ± 0.047
1.511TyrSer: 1.511 ± 0.043
1.277TyrThr: 1.277 ± 0.039
1.656TyrVal: 1.656 ± 0.038
0.438TyrTrp: 0.438 ± 0.02
0.766TyrTyr: 0.766 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3293 proteins (1144562 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski