Amino acid dipepetide frequency for Shewanella maritima

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.339AlaAla: 8.339 ± 0.116
1.061AlaCys: 1.061 ± 0.036
5.379AlaAsp: 5.379 ± 0.11
5.792AlaGlu: 5.792 ± 0.091
3.301AlaPhe: 3.301 ± 0.063
6.043AlaGly: 6.043 ± 0.113
1.751AlaHis: 1.751 ± 0.045
6.222AlaIle: 6.222 ± 0.088
5.988AlaLys: 5.988 ± 0.106
9.593AlaLeu: 9.593 ± 0.115
2.694AlaMet: 2.694 ± 0.058
4.482AlaAsn: 4.482 ± 0.08
3.056AlaPro: 3.056 ± 0.06
4.557AlaGln: 4.557 ± 0.078
3.358AlaArg: 3.358 ± 0.064
6.174AlaSer: 6.174 ± 0.08
4.818AlaThr: 4.818 ± 0.092
5.903AlaVal: 5.903 ± 0.088
0.89AlaTrp: 0.89 ± 0.026
2.458AlaTyr: 2.458 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.821CysAla: 0.821 ± 0.03
0.172CysCys: 0.172 ± 0.017
0.607CysAsp: 0.607 ± 0.023
0.607CysGlu: 0.607 ± 0.023
0.432CysPhe: 0.432 ± 0.019
0.821CysGly: 0.821 ± 0.029
0.429CysHis: 0.429 ± 0.029
0.571CysIle: 0.571 ± 0.022
0.43CysLys: 0.43 ± 0.02
0.891CysLeu: 0.891 ± 0.025
0.223CysMet: 0.223 ± 0.013
0.375CysAsn: 0.375 ± 0.018
0.437CysPro: 0.437 ± 0.02
0.547CysGln: 0.547 ± 0.023
0.423CysArg: 0.423 ± 0.019
0.72CysSer: 0.72 ± 0.027
0.452CysThr: 0.452 ± 0.02
0.684CysVal: 0.684 ± 0.025
0.12CysTrp: 0.12 ± 0.01
0.332CysTyr: 0.332 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.136AspAla: 5.136 ± 0.087
0.564AspCys: 0.564 ± 0.027
3.517AspAsp: 3.517 ± 0.089
3.998AspGlu: 3.998 ± 0.067
2.485AspPhe: 2.485 ± 0.048
4.104AspGly: 4.104 ± 0.091
1.015AspHis: 1.015 ± 0.031
4.078AspIle: 4.078 ± 0.062
3.626AspLys: 3.626 ± 0.064
5.003AspLeu: 5.003 ± 0.065
1.523AspMet: 1.523 ± 0.037
3.106AspAsn: 3.106 ± 0.146
2.046AspPro: 2.046 ± 0.066
1.829AspGln: 1.829 ± 0.041
1.995AspArg: 1.995 ± 0.046
3.682AspSer: 3.682 ± 0.079
3.156AspThr: 3.156 ± 0.082
4.062AspVal: 4.062 ± 0.073
0.881AspTrp: 0.881 ± 0.052
2.159AspTyr: 2.159 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.952GluAla: 4.952 ± 0.089
0.45GluCys: 0.45 ± 0.019
2.84GluAsp: 2.84 ± 0.077
2.88GluGlu: 2.88 ± 0.07
2.526GluPhe: 2.526 ± 0.046
3.19GluGly: 3.19 ± 0.056
1.682GluHis: 1.682 ± 0.043
3.385GluIle: 3.385 ± 0.06
2.896GluLys: 2.896 ± 0.068
7.485GluLeu: 7.485 ± 0.099
1.532GluMet: 1.532 ± 0.035
2.235GluAsn: 2.235 ± 0.044
2.114GluPro: 2.114 ± 0.049
5.163GluGln: 5.163 ± 0.09
3.051GluArg: 3.051 ± 0.06
3.638GluSer: 3.638 ± 0.065
2.874GluThr: 2.874 ± 0.055
4.38GluVal: 4.38 ± 0.07
0.624GluTrp: 0.624 ± 0.022
1.672GluTyr: 1.672 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.92PheAla: 3.92 ± 0.064
0.463PheCys: 0.463 ± 0.018
2.978PheAsp: 2.978 ± 0.061
2.658PheGlu: 2.658 ± 0.047
1.575PhePhe: 1.575 ± 0.047
3.06PheGly: 3.06 ± 0.067
0.76PheHis: 0.76 ± 0.025
2.663PheIle: 2.663 ± 0.058
2.064PheLys: 2.064 ± 0.043
2.771PheLeu: 2.771 ± 0.062
1.014PheMet: 1.014 ± 0.028
2.205PheAsn: 2.205 ± 0.045
1.292PhePro: 1.292 ± 0.04
1.037PheGln: 1.037 ± 0.027
1.271PheArg: 1.271 ± 0.031
3.203PheSer: 3.203 ± 0.062
2.403PheThr: 2.403 ± 0.068
2.771PheVal: 2.771 ± 0.054
0.462PheTrp: 0.462 ± 0.022
1.374PheTyr: 1.374 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.409GlyAla: 5.409 ± 0.079
0.832GlyCys: 0.832 ± 0.029
3.949GlyAsp: 3.949 ± 0.103
4.536GlyGlu: 4.536 ± 0.109
3.251GlyPhe: 3.251 ± 0.052
4.534GlyGly: 4.534 ± 0.087
1.569GlyHis: 1.569 ± 0.042
4.366GlyIle: 4.366 ± 0.063
4.03GlyLys: 4.03 ± 0.077
6.753GlyLeu: 6.753 ± 0.093
2.015GlyMet: 2.015 ± 0.051
2.749GlyAsn: 2.749 ± 0.105
1.521GlyPro: 1.521 ± 0.042
2.951GlyGln: 2.951 ± 0.07
2.769GlyArg: 2.769 ± 0.045
4.141GlySer: 4.141 ± 0.087
3.455GlyThr: 3.455 ± 0.156
5.094GlyVal: 5.094 ± 0.083
0.815GlyTrp: 0.815 ± 0.027
2.565GlyTyr: 2.565 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.688HisAla: 1.688 ± 0.041
0.333HisCys: 0.333 ± 0.018
1.12HisAsp: 1.12 ± 0.035
1.1HisGlu: 1.1 ± 0.028
1.057HisPhe: 1.057 ± 0.03
1.623HisGly: 1.623 ± 0.04
0.71HisHis: 0.71 ± 0.026
1.434HisIle: 1.434 ± 0.038
1.137HisLys: 1.137 ± 0.036
2.214HisLeu: 2.214 ± 0.043
0.502HisMet: 0.502 ± 0.022
0.99HisAsn: 0.99 ± 0.029
1.023HisPro: 1.023 ± 0.031
1.41HisGln: 1.41 ± 0.041
0.944HisArg: 0.944 ± 0.027
1.467HisSer: 1.467 ± 0.043
1.06HisThr: 1.06 ± 0.031
1.251HisVal: 1.251 ± 0.032
0.354HisTrp: 0.354 ± 0.024
0.866HisTyr: 0.866 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.671IleAla: 6.671 ± 0.09
0.665IleCys: 0.665 ± 0.027
4.452IleAsp: 4.452 ± 0.063
4.588IleGlu: 4.588 ± 0.073
1.921IlePhe: 1.921 ± 0.046
4.396IleGly: 4.396 ± 0.074
1.164IleHis: 1.164 ± 0.031
3.432IleIle: 3.432 ± 0.063
3.362IleLys: 3.362 ± 0.064
4.518IleLeu: 4.518 ± 0.084
1.259IleMet: 1.259 ± 0.035
3.425IleAsn: 3.425 ± 0.053
2.29IlePro: 2.29 ± 0.051
2.0IleGln: 2.0 ± 0.046
2.369IleArg: 2.369 ± 0.049
4.444IleSer: 4.444 ± 0.067
3.607IleThr: 3.607 ± 0.114
4.005IleVal: 4.005 ± 0.069
0.595IleTrp: 0.595 ± 0.024
1.675IleTyr: 1.675 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
5.303LysAla: 5.303 ± 0.092
0.314LysCys: 0.314 ± 0.023
2.71LysAsp: 2.71 ± 0.057
2.434LysGlu: 2.434 ± 0.061
1.726LysPhe: 1.726 ± 0.043
3.252LysGly: 3.252 ± 0.053
1.432LysHis: 1.432 ± 0.038
2.584LysIle: 2.584 ± 0.051
2.359LysLys: 2.359 ± 0.057
6.099LysLeu: 6.099 ± 0.091
1.36LysMet: 1.36 ± 0.037
1.686LysAsn: 1.686 ± 0.043
2.566LysPro: 2.566 ± 0.056
4.056LysGln: 4.056 ± 0.084
2.683LysArg: 2.683 ± 0.058
3.11LysSer: 3.11 ± 0.066
2.71LysThr: 2.71 ± 0.055
4.115LysVal: 4.115 ± 0.072
0.599LysTrp: 0.599 ± 0.022
1.458LysTyr: 1.458 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
10.438LeuAla: 10.438 ± 0.134
0.998LeuCys: 0.998 ± 0.03
5.85LeuAsp: 5.85 ± 0.08
5.78LeuGlu: 5.78 ± 0.079
3.924LeuPhe: 3.924 ± 0.083
6.721LeuGly: 6.721 ± 0.105
1.888LeuHis: 1.888 ± 0.043
5.79LeuIle: 5.79 ± 0.082
5.249LeuLys: 5.249 ± 0.094
10.056LeuLeu: 10.056 ± 0.164
2.722LeuMet: 2.722 ± 0.059
4.807LeuAsn: 4.807 ± 0.071
4.498LeuPro: 4.498 ± 0.075
3.825LeuGln: 3.825 ± 0.062
3.831LeuArg: 3.831 ± 0.067
7.763LeuSer: 7.763 ± 0.103
6.427LeuThr: 6.427 ± 0.106
7.189LeuVal: 7.189 ± 0.094
1.034LeuTrp: 1.034 ± 0.036
2.573LeuTyr: 2.573 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.605MetAla: 2.605 ± 0.053
0.208MetCys: 0.208 ± 0.012
1.161MetAsp: 1.161 ± 0.032
1.201MetGlu: 1.201 ± 0.032
0.927MetPhe: 0.927 ± 0.026
1.693MetGly: 1.693 ± 0.047
0.522MetHis: 0.522 ± 0.02
1.29MetIle: 1.29 ± 0.034
1.366MetLys: 1.366 ± 0.04
3.023MetLeu: 3.023 ± 0.057
0.775MetMet: 0.775 ± 0.028
1.037MetAsn: 1.037 ± 0.029
1.286MetPro: 1.286 ± 0.034
1.311MetGln: 1.311 ± 0.038
1.184MetArg: 1.184 ± 0.029
1.952MetSer: 1.952 ± 0.047
1.647MetThr: 1.647 ± 0.035
1.831MetVal: 1.831 ± 0.045
0.255MetTrp: 0.255 ± 0.015
0.561MetTyr: 0.561 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.942AsnAla: 3.942 ± 0.096
0.443AsnCys: 0.443 ± 0.024
2.642AsnAsp: 2.642 ± 0.082
2.445AsnGlu: 2.445 ± 0.05
1.55AsnPhe: 1.55 ± 0.038
3.282AsnGly: 3.282 ± 0.125
0.996AsnHis: 0.996 ± 0.028
2.768AsnIle: 2.768 ± 0.05
2.345AsnLys: 2.345 ± 0.048
4.142AsnLeu: 4.142 ± 0.071
1.081AsnMet: 1.081 ± 0.034
2.119AsnAsn: 2.119 ± 0.052
2.082AsnPro: 2.082 ± 0.04
2.568AsnGln: 2.568 ± 0.05
1.925AsnArg: 1.925 ± 0.043
2.789AsnSer: 2.789 ± 0.052
2.595AsnThr: 2.595 ± 0.196
2.741AsnVal: 2.741 ± 0.077
0.645AsnTrp: 0.645 ± 0.02
1.435AsnTyr: 1.435 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
3.113ProAla: 3.113 ± 0.073
0.293ProCys: 0.293 ± 0.017
2.208ProAsp: 2.208 ± 0.056
2.973ProGlu: 2.973 ± 0.055
1.625ProPhe: 1.625 ± 0.035
2.26ProGly: 2.26 ± 0.054
0.813ProHis: 0.813 ± 0.024
2.362ProIle: 2.362 ± 0.049
2.109ProLys: 2.109 ± 0.047
3.875ProLeu: 3.875 ± 0.073
1.018ProMet: 1.018 ± 0.03
1.764ProAsn: 1.764 ± 0.039
1.016ProPro: 1.016 ± 0.03
1.973ProGln: 1.973 ± 0.042
1.22ProArg: 1.22 ± 0.035
2.437ProSer: 2.437 ± 0.052
2.092ProThr: 2.092 ± 0.044
2.987ProVal: 2.987 ± 0.072
0.497ProTrp: 0.497 ± 0.021
1.201ProTyr: 1.201 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.682GlnAla: 5.682 ± 0.085
0.419GlnCys: 0.419 ± 0.024
2.426GlnAsp: 2.426 ± 0.052
2.182GlnGlu: 2.182 ± 0.047
1.981GlnPhe: 1.981 ± 0.056
3.507GlnGly: 3.507 ± 0.078
1.309GlnHis: 1.309 ± 0.034
2.801GlnIle: 2.801 ± 0.049
2.022GlnLys: 2.022 ± 0.052
6.109GlnLeu: 6.109 ± 0.093
1.263GlnMet: 1.263 ± 0.034
1.643GlnAsn: 1.643 ± 0.041
1.736GlnPro: 1.736 ± 0.035
4.162GlnGln: 4.162 ± 0.101
2.279GlnArg: 2.279 ± 0.052
3.298GlnSer: 3.298 ± 0.068
2.725GlnThr: 2.725 ± 0.044
3.932GlnVal: 3.932 ± 0.065
0.674GlnTrp: 0.674 ± 0.025
1.585GlnTyr: 1.585 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.244ArgAla: 3.244 ± 0.052
0.41ArgCys: 0.41 ± 0.019
2.278ArgAsp: 2.278 ± 0.05
2.528ArgGlu: 2.528 ± 0.053
2.039ArgPhe: 2.039 ± 0.048
2.442ArgGly: 2.442 ± 0.054
1.068ArgHis: 1.068 ± 0.028
2.655ArgIle: 2.655 ± 0.055
2.179ArgLys: 2.179 ± 0.049
4.366ArgLeu: 4.366 ± 0.072
1.084ArgMet: 1.084 ± 0.031
1.729ArgAsn: 1.729 ± 0.036
1.406ArgPro: 1.406 ± 0.038
2.178ArgGln: 2.178 ± 0.053
2.067ArgArg: 2.067 ± 0.048
2.459ArgSer: 2.459 ± 0.048
1.913ArgThr: 1.913 ± 0.043
2.983ArgVal: 2.983 ± 0.053
0.515ArgTrp: 0.515 ± 0.023
1.697ArgTyr: 1.697 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.033SerAla: 6.033 ± 0.092
0.705SerCys: 0.705 ± 0.027
3.819SerAsp: 3.819 ± 0.079
3.925SerGlu: 3.925 ± 0.07
2.943SerPhe: 2.943 ± 0.078
4.883SerGly: 4.883 ± 0.087
1.625SerHis: 1.625 ± 0.039
4.116SerIle: 4.116 ± 0.071
3.385SerLys: 3.385 ± 0.061
7.084SerLeu: 7.084 ± 0.088
1.728SerMet: 1.728 ± 0.038
2.865SerAsn: 2.865 ± 0.056
2.483SerPro: 2.483 ± 0.045
3.493SerGln: 3.493 ± 0.071
2.822SerArg: 2.822 ± 0.05
4.575SerSer: 4.575 ± 0.085
3.241SerThr: 3.241 ± 0.059
4.708SerVal: 4.708 ± 0.099
0.863SerTrp: 0.863 ± 0.027
2.202SerTyr: 2.202 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
4.729ThrAla: 4.729 ± 0.111
0.491ThrCys: 0.491 ± 0.026
3.189ThrAsp: 3.189 ± 0.093
3.304ThrGlu: 3.304 ± 0.062
1.996ThrPhe: 1.996 ± 0.062
4.026ThrGly: 4.026 ± 0.087
1.116ThrHis: 1.116 ± 0.034
3.303ThrIle: 3.303 ± 0.125
2.591ThrLys: 2.591 ± 0.055
6.017ThrLeu: 6.017 ± 0.143
1.127ThrMet: 1.127 ± 0.03
2.37ThrAsn: 2.37 ± 0.102
2.765ThrPro: 2.765 ± 0.076
2.91ThrGln: 2.91 ± 0.068
2.138ThrArg: 2.138 ± 0.044
3.637ThrSer: 3.637 ± 0.075
2.965ThrThr: 2.965 ± 0.102
3.875ThrVal: 3.875 ± 0.159
0.572ThrTrp: 0.572 ± 0.021
1.576ThrTyr: 1.576 ± 0.101
0.0ThrXaa: 0.0 ± 0.0
Val
6.725ValAla: 6.725 ± 0.085
0.751ValCys: 0.751 ± 0.025
4.524ValAsp: 4.524 ± 0.065
4.704ValGlu: 4.704 ± 0.08
2.723ValPhe: 2.723 ± 0.056
4.58ValGly: 4.58 ± 0.063
1.27ValHis: 1.27 ± 0.043
4.774ValIle: 4.774 ± 0.083
3.632ValLys: 3.632 ± 0.065
6.476ValLeu: 6.476 ± 0.108
1.924ValMet: 1.924 ± 0.042
3.282ValAsn: 3.282 ± 0.057
2.462ValPro: 2.462 ± 0.048
2.334ValGln: 2.334 ± 0.062
2.632ValArg: 2.632 ± 0.061
5.185ValSer: 5.185 ± 0.078
4.468ValThr: 4.468 ± 0.159
5.25ValVal: 5.25 ± 0.086
0.716ValTrp: 0.716 ± 0.023
1.955ValTyr: 1.955 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.817TrpAla: 0.817 ± 0.029
0.141TrpCys: 0.141 ± 0.01
0.623TrpAsp: 0.623 ± 0.026
0.452TrpGlu: 0.452 ± 0.017
0.541TrpPhe: 0.541 ± 0.025
0.704TrpGly: 0.704 ± 0.028
0.374TrpHis: 0.374 ± 0.019
0.599TrpIle: 0.599 ± 0.025
0.41TrpLys: 0.41 ± 0.017
1.581TrpLeu: 1.581 ± 0.042
0.327TrpMet: 0.327 ± 0.017
0.452TrpAsn: 0.452 ± 0.055
0.432TrpPro: 0.432 ± 0.018
1.126TrpGln: 1.126 ± 0.036
0.623TrpArg: 0.623 ± 0.023
0.686TrpSer: 0.686 ± 0.022
0.477TrpThr: 0.477 ± 0.018
0.797TrpVal: 0.797 ± 0.03
0.169TrpTrp: 0.169 ± 0.013
0.379TrpTyr: 0.379 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.292TyrAla: 2.292 ± 0.044
0.382TyrCys: 0.382 ± 0.017
1.694TyrAsp: 1.694 ± 0.043
1.483TyrGlu: 1.483 ± 0.037
1.418TyrPhe: 1.418 ± 0.034
2.182TyrGly: 2.182 ± 0.05
0.787TyrHis: 0.787 ± 0.031
1.645TyrIle: 1.645 ± 0.04
1.375TyrLys: 1.375 ± 0.035
3.307TyrLeu: 3.307 ± 0.062
0.662TyrMet: 0.662 ± 0.021
1.214TyrAsn: 1.214 ± 0.045
1.325TyrPro: 1.325 ± 0.034
2.302TyrGln: 2.302 ± 0.047
1.656TyrArg: 1.656 ± 0.04
2.14TyrSer: 2.14 ± 0.045
1.613TyrThr: 1.613 ± 0.112
1.808TyrVal: 1.808 ± 0.037
0.433TyrTrp: 0.433 ± 0.022
1.056TyrTyr: 1.056 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3709 proteins (1257756 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski