Amino acid dipepetide frequency for Parasitella parasitica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.851AlaAla: 6.851 ± 0.058	0.996AlaCys: 0.996 ± 0.013	3.586AlaAsp: 3.586 ± 0.025	3.955AlaGlu: 3.955 ± 0.032	2.76AlaPhe: 2.76 ± 0.026	3.468AlaGly: 3.468 ± 0.031	1.484AlaHis: 1.484 ± 0.017	4.42AlaIle: 4.42 ± 0.026	4.282AlaLys: 4.282 ± 0.03	6.417AlaLeu: 6.417 ± 0.041	1.751AlaMet: 1.751 ± 0.018	3.362AlaAsn: 3.362 ± 0.026	3.184AlaPro: 3.184 ± 0.029	2.863AlaGln: 2.863 ± 0.036	3.177AlaArg: 3.177 ± 0.026	6.354AlaSer: 6.354 ± 0.045	4.809AlaThr: 4.809 ± 0.036	4.378AlaVal: 4.378 ± 0.034	0.699AlaTrp: 0.699 ± 0.014	2.095AlaTyr: 2.095 ± 0.021	0.003AlaXaa: 0.003 ± 0.001
Cys	0.822CysAla: 0.822 ± 0.014	0.293CysCys: 0.293 ± 0.008	0.706CysAsp: 0.706 ± 0.011	0.658CysGlu: 0.658 ± 0.011	0.651CysPhe: 0.651 ± 0.011	0.843CysGly: 0.843 ± 0.014	0.404CysHis: 0.404 ± 0.009	0.942CysIle: 0.942 ± 0.013	0.8CysLys: 0.8 ± 0.012	1.435CysLeu: 1.435 ± 0.016	0.315CysMet: 0.315 ± 0.008	0.655CysAsn: 0.655 ± 0.01	0.698CysPro: 0.698 ± 0.014	0.61CysGln: 0.61 ± 0.011	0.735CysArg: 0.735 ± 0.011	1.121CysSer: 1.121 ± 0.014	0.744CysThr: 0.744 ± 0.013	0.835CysVal: 0.835 ± 0.013	0.175CysTrp: 0.175 ± 0.006	0.507CysTyr: 0.507 ± 0.01	0.001CysXaa: 0.001 ± 0.0
Asp	3.869AspAla: 3.869 ± 0.025	0.727AspCys: 0.727 ± 0.012	4.705AspAsp: 4.705 ± 0.04	4.656AspGlu: 4.656 ± 0.037	2.432AspPhe: 2.432 ± 0.02	2.892AspGly: 2.892 ± 0.023	1.376AspHis: 1.376 ± 0.017	3.903AspIle: 3.903 ± 0.027	3.245AspLys: 3.245 ± 0.027	5.165AspLeu: 5.165 ± 0.036	1.494AspMet: 1.494 ± 0.017	2.877AspAsn: 2.877 ± 0.021	2.583AspPro: 2.583 ± 0.025	2.456AspGln: 2.456 ± 0.02	2.484AspArg: 2.484 ± 0.023	4.126AspSer: 4.126 ± 0.033	3.251AspThr: 3.251 ± 0.028	3.392AspVal: 3.392 ± 0.028	0.698AspTrp: 0.698 ± 0.012	2.057AspTyr: 2.057 ± 0.019	0.003AspXaa: 0.003 ± 0.001
Glu	4.391GluAla: 4.391 ± 0.033	0.727GluCys: 0.727 ± 0.012	4.202GluAsp: 4.202 ± 0.029	5.629GluGlu: 5.629 ± 0.056	2.246GluPhe: 2.246 ± 0.019	2.568GluGly: 2.568 ± 0.023	1.465GluHis: 1.465 ± 0.016	3.649GluIle: 3.649 ± 0.028	4.681GluLys: 4.681 ± 0.041	5.389GluLeu: 5.389 ± 0.036	1.478GluMet: 1.478 ± 0.015	3.207GluAsn: 3.207 ± 0.026	2.185GluPro: 2.185 ± 0.022	3.126GluGln: 3.126 ± 0.026	3.168GluArg: 3.168 ± 0.025	4.281GluSer: 4.281 ± 0.029	3.376GluThr: 3.376 ± 0.028	2.825GluVal: 2.825 ± 0.025	0.675GluTrp: 0.675 ± 0.01	2.049GluTyr: 2.049 ± 0.022	0.002GluXaa: 0.002 ± 0.001
Phe	2.69PheAla: 2.69 ± 0.021	0.661PheCys: 0.661 ± 0.011	2.641PheAsp: 2.641 ± 0.021	2.461PheGlu: 2.461 ± 0.02	1.695PhePhe: 1.695 ± 0.022	2.528PheGly: 2.528 ± 0.026	0.95PheHis: 0.95 ± 0.013	2.361PheIle: 2.361 ± 0.021	2.252PheLys: 2.252 ± 0.023	3.515PheLeu: 3.515 ± 0.032	0.986PheMet: 0.986 ± 0.014	1.963PheAsn: 1.963 ± 0.018	1.665PhePro: 1.665 ± 0.018	1.597PheGln: 1.597 ± 0.016	1.717PheArg: 1.717 ± 0.015	3.243PheSer: 3.243 ± 0.026	2.241PheThr: 2.241 ± 0.017	2.605PheVal: 2.605 ± 0.024	0.534PheTrp: 0.534 ± 0.01	1.426PheTyr: 1.426 ± 0.019	0.003PheXaa: 0.003 ± 0.001
Gly	3.155GlyAla: 3.155 ± 0.031	0.76GlyCys: 0.76 ± 0.012	2.677GlyAsp: 2.677 ± 0.023	2.503GlyGlu: 2.503 ± 0.022	2.353GlyPhe: 2.353 ± 0.024	3.434GlyGly: 3.434 ± 0.039	1.36GlyHis: 1.36 ± 0.017	3.177GlyIle: 3.177 ± 0.023	3.082GlyLys: 3.082 ± 0.029	4.419GlyLeu: 4.419 ± 0.032	1.115GlyMet: 1.115 ± 0.014	2.428GlyAsn: 2.428 ± 0.023	1.785GlyPro: 1.785 ± 0.018	1.951GlyGln: 1.951 ± 0.02	2.513GlyArg: 2.513 ± 0.025	4.25GlySer: 4.25 ± 0.029	2.802GlyThr: 2.802 ± 0.023	3.08GlyVal: 3.08 ± 0.03	0.681GlyTrp: 0.681 ± 0.013	1.939GlyTyr: 1.939 ± 0.019	0.003GlyXaa: 0.003 ± 0.001
His	1.498HisAla: 1.498 ± 0.017	0.429HisCys: 0.429 ± 0.009	1.3HisAsp: 1.3 ± 0.016	1.277HisGlu: 1.277 ± 0.016	1.091HisPhe: 1.091 ± 0.014	1.274HisGly: 1.274 ± 0.017	1.186HisHis: 1.186 ± 0.022	1.535HisIle: 1.535 ± 0.018	1.314HisLys: 1.314 ± 0.014	2.434HisLeu: 2.434 ± 0.02	0.567HisMet: 0.567 ± 0.01	1.193HisAsn: 1.193 ± 0.015	1.425HisPro: 1.425 ± 0.017	1.555HisGln: 1.555 ± 0.021	1.375HisArg: 1.375 ± 0.017	1.983HisSer: 1.983 ± 0.019	1.363HisThr: 1.363 ± 0.016	1.515HisVal: 1.515 ± 0.016	0.318HisTrp: 0.318 ± 0.007	0.932HisTyr: 0.932 ± 0.014	0.001HisXaa: 0.001 ± 0.0
Ile	4.227IleAla: 4.227 ± 0.03	0.927IleCys: 0.927 ± 0.015	3.757IleAsp: 3.757 ± 0.028	3.724IleGlu: 3.724 ± 0.028	2.241IlePhe: 2.241 ± 0.02	2.819IleGly: 2.819 ± 0.026	1.624IleHis: 1.624 ± 0.019	3.385IleIle: 3.385 ± 0.026	3.771IleLys: 3.771 ± 0.025	5.173IleLeu: 5.173 ± 0.035	1.412IleMet: 1.412 ± 0.018	2.907IleAsn: 2.907 ± 0.025	3.125IlePro: 3.125 ± 0.024	2.749IleGln: 2.749 ± 0.022	2.96IleArg: 2.96 ± 0.024	4.73IleSer: 4.73 ± 0.029	3.486IleThr: 3.486 ± 0.023	3.697IleVal: 3.697 ± 0.029	0.666IleTrp: 0.666 ± 0.012	1.882IleTyr: 1.882 ± 0.019	0.003IleXaa: 0.003 ± 0.001
Lys	4.39LysAla: 4.39 ± 0.033	0.769LysCys: 0.769 ± 0.013	3.512LysAsp: 3.512 ± 0.027	4.369LysGlu: 4.369 ± 0.035	2.089LysPhe: 2.089 ± 0.019	2.625LysGly: 2.625 ± 0.025	1.531LysHis: 1.531 ± 0.017	3.425LysIle: 3.425 ± 0.024	5.674LysLys: 5.674 ± 0.039	5.566LysLeu: 5.566 ± 0.037	1.472LysMet: 1.472 ± 0.019	3.143LysAsn: 3.143 ± 0.025	2.85LysPro: 2.85 ± 0.024	3.114LysGln: 3.114 ± 0.023	4.045LysArg: 4.045 ± 0.029	4.835LysSer: 4.835 ± 0.03	3.67LysThr: 3.67 ± 0.026	3.323LysVal: 3.323 ± 0.027	0.667LysTrp: 0.667 ± 0.01	2.055LysTyr: 2.055 ± 0.021	0.002LysXaa: 0.002 ± 0.001
Leu	6.328LeuAla: 6.328 ± 0.04	1.365LeuCys: 1.365 ± 0.014	5.433LeuAsp: 5.433 ± 0.034	5.579LeuGlu: 5.579 ± 0.037	3.623LeuPhe: 3.623 ± 0.027	4.481LeuGly: 4.481 ± 0.033	2.199LeuHis: 2.199 ± 0.026	4.757LeuIle: 4.757 ± 0.03	5.847LeuLys: 5.847 ± 0.039	8.575LeuLeu: 8.575 ± 0.052	2.113LeuMet: 2.113 ± 0.02	4.345LeuAsn: 4.345 ± 0.032	4.876LeuPro: 4.876 ± 0.036	4.392LeuGln: 4.392 ± 0.033	4.41LeuArg: 4.41 ± 0.028	7.441LeuSer: 7.441 ± 0.041	4.918LeuThr: 4.918 ± 0.033	5.297LeuVal: 5.297 ± 0.03	0.93LeuTrp: 0.93 ± 0.015	2.852LeuTyr: 2.852 ± 0.026	0.005LeuXaa: 0.005 ± 0.001
Met	1.869MetAla: 1.869 ± 0.018	0.279MetCys: 0.279 ± 0.007	1.582MetAsp: 1.582 ± 0.016	1.523MetGlu: 1.523 ± 0.018	0.864MetPhe: 0.864 ± 0.013	1.145MetGly: 1.145 ± 0.015	0.515MetHis: 0.515 ± 0.01	1.343MetIle: 1.343 ± 0.017	1.435MetLys: 1.435 ± 0.019	2.08MetLeu: 2.08 ± 0.019	0.77MetMet: 0.77 ± 0.013	1.25MetAsn: 1.25 ± 0.017	1.139MetPro: 1.139 ± 0.013	1.013MetGln: 1.013 ± 0.013	1.088MetArg: 1.088 ± 0.015	2.108MetSer: 2.108 ± 0.02	1.45MetThr: 1.45 ± 0.014	1.356MetVal: 1.356 ± 0.016	0.223MetTrp: 0.223 ± 0.006	0.694MetTyr: 0.694 ± 0.01	0.001MetXaa: 0.001 ± 0.001
Asn	3.595AsnAla: 3.595 ± 0.027	0.657AsnCys: 0.657 ± 0.011	2.98AsnAsp: 2.98 ± 0.028	3.078AsnGlu: 3.078 ± 0.025	1.758AsnPhe: 1.758 ± 0.02	2.694AsnGly: 2.694 ± 0.027	1.31AsnHis: 1.31 ± 0.017	3.097AsnIle: 3.097 ± 0.024	3.003AsnLys: 3.003 ± 0.025	4.018AsnLeu: 4.018 ± 0.03	1.305AsnMet: 1.305 ± 0.014	3.469AsnAsn: 3.469 ± 0.039	2.344AsnPro: 2.344 ± 0.02	2.291AsnGln: 2.291 ± 0.023	2.273AsnArg: 2.273 ± 0.021	4.153AsnSer: 4.153 ± 0.034	3.235AsnThr: 3.235 ± 0.031	3.018AsnVal: 3.018 ± 0.023	0.584AsnTrp: 0.584 ± 0.008	1.666AsnTyr: 1.666 ± 0.018	0.004AsnXaa: 0.004 ± 0.001
Pro	3.572ProAla: 3.572 ± 0.037	0.513ProCys: 0.513 ± 0.01	2.384ProAsp: 2.384 ± 0.021	2.851ProGlu: 2.851 ± 0.024	1.947ProPhe: 1.947 ± 0.018	2.1ProGly: 2.1 ± 0.023	1.172ProHis: 1.172 ± 0.014	2.804ProIle: 2.804 ± 0.025	2.65ProLys: 2.65 ± 0.027	4.169ProLeu: 4.169 ± 0.022	0.986ProMet: 0.986 ± 0.015	2.33ProAsn: 2.33 ± 0.023	3.674ProPro: 3.674 ± 0.049	2.151ProGln: 2.151 ± 0.023	2.054ProArg: 2.054 ± 0.023	4.918ProSer: 4.918 ± 0.034	3.462ProThr: 3.462 ± 0.029	2.989ProVal: 2.989 ± 0.027	0.441ProTrp: 0.441 ± 0.01	1.5ProTyr: 1.5 ± 0.018	0.003ProXaa: 0.003 ± 0.001
Gln	2.983GlnAla: 2.983 ± 0.031	0.554GlnCys: 0.554 ± 0.011	2.662GlnAsp: 2.662 ± 0.027	3.093GlnGlu: 3.093 ± 0.027	1.678GlnPhe: 1.678 ± 0.016	1.906GlnGly: 1.906 ± 0.019	1.677GlnHis: 1.677 ± 0.024	2.435GlnIle: 2.435 ± 0.024	2.859GlnLys: 2.859 ± 0.026	4.342GlnLeu: 4.342 ± 0.033	1.076GlnMet: 1.076 ± 0.013	2.068GlnAsn: 2.068 ± 0.019	2.296GlnPro: 2.296 ± 0.025	5.979GlnGln: 5.979 ± 0.115	2.461GlnArg: 2.461 ± 0.021	3.312GlnSer: 3.312 ± 0.027	2.346GlnThr: 2.346 ± 0.022	2.556GlnVal: 2.556 ± 0.023	0.503GlnTrp: 0.503 ± 0.01	1.501GlnTyr: 1.501 ± 0.017	0.001GlnXaa: 0.001 ± 0.0
Arg	3.079ArgAla: 3.079 ± 0.023	0.65ArgCys: 0.65 ± 0.01	2.533ArgAsp: 2.533 ± 0.025	2.794ArgGlu: 2.794 ± 0.023	2.099ArgPhe: 2.099 ± 0.023	2.351ArgGly: 2.351 ± 0.027	1.423ArgHis: 1.423 ± 0.018	3.022ArgIle: 3.022 ± 0.024	3.632ArgLys: 3.632 ± 0.027	4.875ArgLeu: 4.875 ± 0.035	1.152ArgMet: 1.152 ± 0.014	2.507ArgAsn: 2.507 ± 0.023	2.297ArgPro: 2.297 ± 0.021	2.472ArgGln: 2.472 ± 0.022	3.51ArgArg: 3.51 ± 0.036	3.92ArgSer: 3.92 ± 0.036	2.527ArgThr: 2.527 ± 0.021	2.636ArgVal: 2.636 ± 0.025	0.604ArgTrp: 0.604 ± 0.011	1.688ArgTyr: 1.688 ± 0.017	0.003ArgXaa: 0.003 ± 0.001
Ser	5.774SerAla: 5.774 ± 0.041	1.076SerCys: 1.076 ± 0.015	4.221SerAsp: 4.221 ± 0.031	3.978SerGlu: 3.978 ± 0.03	3.344SerPhe: 3.344 ± 0.028	3.975SerGly: 3.975 ± 0.03	1.859SerHis: 1.859 ± 0.021	5.19SerIle: 5.19 ± 0.029	4.954SerLys: 4.954 ± 0.03	7.351SerLeu: 7.351 ± 0.041	1.877SerMet: 1.877 ± 0.02	4.711SerAsn: 4.711 ± 0.039	4.457SerPro: 4.457 ± 0.042	3.305SerGln: 3.305 ± 0.026	4.088SerArg: 4.088 ± 0.036	10.467SerSer: 10.467 ± 0.095	6.16SerThr: 6.16 ± 0.05	4.788SerVal: 4.788 ± 0.036	0.832SerTrp: 0.832 ± 0.011	2.327SerTyr: 2.327 ± 0.022	0.006SerXaa: 0.006 ± 0.001
Thr	4.815ThrAla: 4.815 ± 0.037	0.853ThrCys: 0.853 ± 0.014	3.045ThrAsp: 3.045 ± 0.027	3.216ThrGlu: 3.216 ± 0.027	2.399ThrPhe: 2.399 ± 0.019	3.026ThrGly: 3.026 ± 0.025	1.349ThrHis: 1.349 ± 0.015	3.763ThrIle: 3.763 ± 0.028	3.422ThrLys: 3.422 ± 0.024	5.398ThrLeu: 5.398 ± 0.035	1.363ThrMet: 1.363 ± 0.016	2.933ThrAsn: 2.933 ± 0.025	3.393ThrPro: 3.393 ± 0.028	2.217ThrGln: 2.217 ± 0.02	2.682ThrArg: 2.682 ± 0.022	5.606ThrSer: 5.606 ± 0.043	5.138ThrThr: 5.138 ± 0.06	3.674ThrVal: 3.674 ± 0.029	0.629ThrTrp: 0.629 ± 0.011	1.662ThrTyr: 1.662 ± 0.017	0.003ThrXaa: 0.003 ± 0.001
Val	4.331ValAla: 4.331 ± 0.034	0.941ValCys: 0.941 ± 0.014	3.809ValAsp: 3.809 ± 0.029	3.598ValGlu: 3.598 ± 0.03	2.521ValPhe: 2.521 ± 0.022	2.976ValGly: 2.976 ± 0.024	1.419ValHis: 1.419 ± 0.015	3.417ValIle: 3.417 ± 0.027	3.572ValLys: 3.572 ± 0.026	5.315ValLeu: 5.315 ± 0.035	1.378ValMet: 1.378 ± 0.018	2.836ValAsn: 2.836 ± 0.021	2.873ValPro: 2.873 ± 0.027	2.395ValGln: 2.395 ± 0.02	2.701ValArg: 2.701 ± 0.02	4.553ValSer: 4.553 ± 0.031	3.073ValThr: 3.073 ± 0.03	3.942ValVal: 3.942 ± 0.034	0.642ValTrp: 0.642 ± 0.012	1.983ValTyr: 1.983 ± 0.02	0.004ValXaa: 0.004 ± 0.001
Trp	0.65TrpAla: 0.65 ± 0.013	0.186TrpCys: 0.186 ± 0.006	0.675TrpAsp: 0.675 ± 0.012	0.574TrpGlu: 0.574 ± 0.01	0.497TrpPhe: 0.497 ± 0.011	0.532TrpGly: 0.532 ± 0.01	0.291TrpHis: 0.291 ± 0.007	0.724TrpIle: 0.724 ± 0.011	0.794TrpLys: 0.794 ± 0.014	1.009TrpLeu: 1.009 ± 0.014	0.304TrpMet: 0.304 ± 0.007	0.596TrpAsn: 0.596 ± 0.011	0.413TrpPro: 0.413 ± 0.009	0.451TrpGln: 0.451 ± 0.009	0.654TrpArg: 0.654 ± 0.013	0.911TrpSer: 0.911 ± 0.013	0.679TrpThr: 0.679 ± 0.013	0.591TrpVal: 0.591 ± 0.011	0.181TrpTrp: 0.181 ± 0.007	0.368TrpTyr: 0.368 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.0TyrAla: 2.0 ± 0.019	0.587TyrCys: 0.587 ± 0.011	1.978TyrAsp: 1.978 ± 0.02	1.799TyrGlu: 1.799 ± 0.018	1.444TyrPhe: 1.444 ± 0.017	1.827TyrGly: 1.827 ± 0.017	0.968TyrHis: 0.968 ± 0.014	1.915TyrIle: 1.915 ± 0.02	1.854TyrLys: 1.854 ± 0.017	3.115TyrLeu: 3.115 ± 0.026	0.812TyrMet: 0.812 ± 0.011	1.75TyrAsn: 1.75 ± 0.017	1.405TyrPro: 1.405 ± 0.019	1.598TyrGln: 1.598 ± 0.019	1.678TyrArg: 1.678 ± 0.02	2.42TyrSer: 2.42 ± 0.022	1.854TyrThr: 1.854 ± 0.019	1.778TyrVal: 1.778 ± 0.019	0.403TyrTrp: 0.403 ± 0.008	1.364TyrTyr: 1.364 ± 0.02	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.003XaaPhe: 0.003 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.005XaaLys: 0.005 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.004XaaPro: 0.004 ± 0.001	0.002XaaGln: 0.002 ± 0.0	0.003XaaArg: 0.003 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.242XaaXaa: 0.242 ± 0.033

Statistics based on 13357 proteins (5787778 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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