Amino acid dipepetide frequency for [Candida] pseudohaemulonii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.827AlaAla: 5.827 ± 0.073
0.723AlaCys: 0.723 ± 0.019
3.446AlaAsp: 3.446 ± 0.037
4.446AlaGlu: 4.446 ± 0.058
2.934AlaPhe: 2.934 ± 0.034
3.734AlaGly: 3.734 ± 0.056
1.363AlaHis: 1.363 ± 0.024
3.813AlaIle: 3.813 ± 0.046
4.555AlaLys: 4.555 ± 0.051
7.022AlaLeu: 7.022 ± 0.063
1.413AlaMet: 1.413 ± 0.027
3.018AlaAsn: 3.018 ± 0.034
3.409AlaPro: 3.409 ± 0.06
2.74AlaGln: 2.74 ± 0.04
3.114AlaArg: 3.114 ± 0.041
5.82AlaSer: 5.82 ± 0.062
3.825AlaThr: 3.825 ± 0.051
4.301AlaVal: 4.301 ± 0.047
0.641AlaTrp: 0.641 ± 0.016
1.98AlaTyr: 1.98 ± 0.029
0.0AlaXaa: 0.0 ± 0.0
Cys
0.64CysAla: 0.64 ± 0.019
0.214CysCys: 0.214 ± 0.008
0.616CysAsp: 0.616 ± 0.015
0.58CysGlu: 0.58 ± 0.015
0.623CysPhe: 0.623 ± 0.017
0.778CysGly: 0.778 ± 0.019
0.281CysHis: 0.281 ± 0.01
0.699CysIle: 0.699 ± 0.018
0.618CysLys: 0.618 ± 0.017
1.265CysLeu: 1.265 ± 0.023
0.222CysMet: 0.222 ± 0.008
0.464CysAsn: 0.464 ± 0.014
0.474CysPro: 0.474 ± 0.014
0.349CysGln: 0.349 ± 0.011
0.453CysArg: 0.453 ± 0.016
0.757CysSer: 0.757 ± 0.019
0.516CysThr: 0.516 ± 0.016
0.759CysVal: 0.759 ± 0.018
0.134CysTrp: 0.134 ± 0.007
0.398CysTyr: 0.398 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.857AspAla: 3.857 ± 0.047
0.573AspCys: 0.573 ± 0.015
4.77AspAsp: 4.77 ± 0.063
5.337AspGlu: 5.337 ± 0.06
2.908AspPhe: 2.908 ± 0.037
3.189AspGly: 3.189 ± 0.06
1.294AspHis: 1.294 ± 0.025
3.494AspIle: 3.494 ± 0.042
3.531AspLys: 3.531 ± 0.045
6.336AspLeu: 6.336 ± 0.056
1.187AspMet: 1.187 ± 0.022
2.54AspAsn: 2.54 ± 0.036
2.772AspPro: 2.772 ± 0.035
1.961AspGln: 1.961 ± 0.032
2.264AspArg: 2.264 ± 0.032
4.571AspSer: 4.571 ± 0.058
2.878AspThr: 2.878 ± 0.04
3.895AspVal: 3.895 ± 0.039
0.646AspTrp: 0.646 ± 0.016
2.12AspTyr: 2.12 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
4.828GluAla: 4.828 ± 0.057
0.595GluCys: 0.595 ± 0.016
4.736GluAsp: 4.736 ± 0.061
6.905GluGlu: 6.905 ± 0.101
2.698GluPhe: 2.698 ± 0.035
3.207GluGly: 3.207 ± 0.04
1.399GluHis: 1.399 ± 0.026
3.719GluIle: 3.719 ± 0.041
5.581GluLys: 5.581 ± 0.059
7.047GluLeu: 7.047 ± 0.064
1.318GluMet: 1.318 ± 0.022
3.517GluAsn: 3.517 ± 0.041
2.813GluPro: 2.813 ± 0.055
2.715GluGln: 2.715 ± 0.041
3.12GluArg: 3.12 ± 0.041
4.918GluSer: 4.918 ± 0.06
3.835GluThr: 3.835 ± 0.075
4.146GluVal: 4.146 ± 0.048
0.685GluTrp: 0.685 ± 0.018
2.065GluTyr: 2.065 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
2.859PheAla: 2.859 ± 0.032
0.544PheCys: 0.544 ± 0.015
2.941PheAsp: 2.941 ± 0.037
2.837PheGlu: 2.837 ± 0.039
2.198PhePhe: 2.198 ± 0.037
2.983PheGly: 2.983 ± 0.062
1.035PheHis: 1.035 ± 0.021
2.401PheIle: 2.401 ± 0.032
2.717PheLys: 2.717 ± 0.037
4.368PheLeu: 4.368 ± 0.049
0.935PheMet: 0.935 ± 0.02
2.244PheAsn: 2.244 ± 0.03
1.86PhePro: 1.86 ± 0.033
1.666PheGln: 1.666 ± 0.026
1.818PheArg: 1.818 ± 0.026
3.373PheSer: 3.373 ± 0.035
2.436PheThr: 2.436 ± 0.036
3.011PheVal: 3.011 ± 0.036
0.554PheTrp: 0.554 ± 0.019
1.522PheTyr: 1.522 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
3.733GlyAla: 3.733 ± 0.059
0.7GlyCys: 0.7 ± 0.018
3.173GlyAsp: 3.173 ± 0.037
3.34GlyGlu: 3.34 ± 0.041
2.756GlyPhe: 2.756 ± 0.04
3.825GlyGly: 3.825 ± 0.069
1.276GlyHis: 1.276 ± 0.023
3.162GlyIle: 3.162 ± 0.043
3.615GlyLys: 3.615 ± 0.042
5.561GlyLeu: 5.561 ± 0.055
1.137GlyMet: 1.137 ± 0.026
2.626GlyAsn: 2.626 ± 0.044
2.168GlyPro: 2.168 ± 0.035
1.965GlyGln: 1.965 ± 0.039
2.43GlyArg: 2.43 ± 0.038
4.951GlySer: 4.951 ± 0.076
3.058GlyThr: 3.058 ± 0.063
3.688GlyVal: 3.688 ± 0.051
0.688GlyTrp: 0.688 ± 0.018
1.988GlyTyr: 1.988 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
1.238HisAla: 1.238 ± 0.022
0.282HisCys: 0.282 ± 0.011
1.309HisAsp: 1.309 ± 0.022
1.457HisGlu: 1.457 ± 0.024
1.071HisPhe: 1.071 ± 0.02
1.311HisGly: 1.311 ± 0.024
0.723HisHis: 0.723 ± 0.019
1.269HisIle: 1.269 ± 0.023
1.402HisLys: 1.402 ± 0.023
2.452HisLeu: 2.452 ± 0.036
0.444HisMet: 0.444 ± 0.015
1.05HisAsn: 1.05 ± 0.022
1.189HisPro: 1.189 ± 0.021
0.957HisGln: 0.957 ± 0.021
1.064HisArg: 1.064 ± 0.02
1.643HisSer: 1.643 ± 0.026
1.084HisThr: 1.084 ± 0.023
1.306HisVal: 1.306 ± 0.021
0.252HisTrp: 0.252 ± 0.011
0.797HisTyr: 0.797 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
3.704IleAla: 3.704 ± 0.043
0.684IleCys: 0.684 ± 0.018
3.601IleAsp: 3.601 ± 0.041
3.613IleGlu: 3.613 ± 0.042
2.452IlePhe: 2.452 ± 0.035
2.994IleGly: 2.994 ± 0.042
1.22IleHis: 1.22 ± 0.023
3.0IleIle: 3.0 ± 0.038
3.473IleLys: 3.473 ± 0.039
5.355IleLeu: 5.355 ± 0.057
1.094IleMet: 1.094 ± 0.023
2.661IleAsn: 2.661 ± 0.036
2.836IlePro: 2.836 ± 0.036
1.947IleGln: 1.947 ± 0.03
2.45IleArg: 2.45 ± 0.035
4.178IleSer: 4.178 ± 0.04
3.098IleThr: 3.098 ± 0.042
3.731IleVal: 3.731 ± 0.049
0.611IleTrp: 0.611 ± 0.017
1.738IleTyr: 1.738 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
4.701LysAla: 4.701 ± 0.054
0.633LysCys: 0.633 ± 0.017
4.008LysAsp: 4.008 ± 0.049
5.213LysGlu: 5.213 ± 0.057
2.654LysPhe: 2.654 ± 0.032
3.064LysGly: 3.064 ± 0.042
1.584LysHis: 1.584 ± 0.03
3.622LysIle: 3.622 ± 0.041
5.952LysLys: 5.952 ± 0.085
7.158LysLeu: 7.158 ± 0.071
1.268LysMet: 1.268 ± 0.024
3.281LysAsn: 3.281 ± 0.038
3.292LysPro: 3.292 ± 0.047
2.748LysGln: 2.748 ± 0.034
3.663LysArg: 3.663 ± 0.047
4.552LysSer: 4.552 ± 0.057
3.568LysThr: 3.568 ± 0.039
4.083LysVal: 4.083 ± 0.047
0.731LysTrp: 0.731 ± 0.017
2.298LysTyr: 2.298 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
7.381LeuAla: 7.381 ± 0.069
1.224LeuCys: 1.224 ± 0.025
5.994LeuAsp: 5.994 ± 0.051
6.651LeuGlu: 6.651 ± 0.061
4.263LeuPhe: 4.263 ± 0.046
5.599LeuGly: 5.599 ± 0.062
2.334LeuHis: 2.334 ± 0.029
5.292LeuIle: 5.292 ± 0.058
6.948LeuLys: 6.948 ± 0.063
10.625LeuLeu: 10.625 ± 0.102
2.065LeuMet: 2.065 ± 0.031
5.023LeuAsn: 5.023 ± 0.048
5.202LeuPro: 5.202 ± 0.055
4.249LeuGln: 4.249 ± 0.047
5.23LeuArg: 5.23 ± 0.057
8.167LeuSer: 8.167 ± 0.068
5.526LeuThr: 5.526 ± 0.064
6.428LeuVal: 6.428 ± 0.059
1.09LeuTrp: 1.09 ± 0.021
3.05LeuTyr: 3.05 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
1.569MetAla: 1.569 ± 0.026
0.231MetCys: 0.231 ± 0.011
1.185MetAsp: 1.185 ± 0.021
1.23MetGlu: 1.23 ± 0.022
0.859MetPhe: 0.859 ± 0.021
1.202MetGly: 1.202 ± 0.022
0.339MetHis: 0.339 ± 0.011
1.04MetIle: 1.04 ± 0.022
1.348MetLys: 1.348 ± 0.024
1.952MetLeu: 1.952 ± 0.029
0.459MetMet: 0.459 ± 0.016
1.035MetAsn: 1.035 ± 0.023
0.969MetPro: 0.969 ± 0.021
0.607MetGln: 0.607 ± 0.016
0.855MetArg: 0.855 ± 0.019
1.926MetSer: 1.926 ± 0.028
1.052MetThr: 1.052 ± 0.02
1.23MetVal: 1.23 ± 0.023
0.189MetTrp: 0.189 ± 0.007
0.597MetTyr: 0.597 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.116AsnAla: 3.116 ± 0.038
0.514AsnCys: 0.514 ± 0.013
2.981AsnAsp: 2.981 ± 0.039
3.247AsnGlu: 3.247 ± 0.037
2.192AsnPhe: 2.192 ± 0.031
2.987AsnGly: 2.987 ± 0.047
1.09AsnHis: 1.09 ± 0.023
2.61AsnIle: 2.61 ± 0.033
2.904AsnLys: 2.904 ± 0.034
4.75AsnLeu: 4.75 ± 0.049
0.974AsnMet: 0.974 ± 0.023
2.47AsnAsn: 2.47 ± 0.044
2.424AsnPro: 2.424 ± 0.036
1.861AsnGln: 1.861 ± 0.037
1.97AsnArg: 1.97 ± 0.029
3.686AsnSer: 3.686 ± 0.045
2.497AsnThr: 2.497 ± 0.035
3.008AsnVal: 3.008 ± 0.037
0.556AsnTrp: 0.556 ± 0.015
1.816AsnTyr: 1.816 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
3.294ProAla: 3.294 ± 0.068
0.351ProCys: 0.351 ± 0.011
2.564ProAsp: 2.564 ± 0.033
3.928ProGlu: 3.928 ± 0.055
1.913ProPhe: 1.913 ± 0.028
2.528ProGly: 2.528 ± 0.04
1.079ProHis: 1.079 ± 0.022
2.322ProIle: 2.322 ± 0.033
3.318ProLys: 3.318 ± 0.049
4.485ProLeu: 4.485 ± 0.053
0.825ProMet: 0.825 ± 0.02
2.115ProAsn: 2.115 ± 0.03
3.123ProPro: 3.123 ± 0.083
2.516ProGln: 2.516 ± 0.049
2.087ProArg: 2.087 ± 0.033
4.161ProSer: 4.161 ± 0.057
2.972ProThr: 2.972 ± 0.075
3.19ProVal: 3.19 ± 0.056
0.481ProTrp: 0.481 ± 0.021
1.453ProTyr: 1.453 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
2.689GlnAla: 2.689 ± 0.036
0.369GlnCys: 0.369 ± 0.011
1.99GlnAsp: 1.99 ± 0.031
2.693GlnGlu: 2.693 ± 0.044
1.701GlnPhe: 1.701 ± 0.025
2.039GlnGly: 2.039 ± 0.035
0.998GlnHis: 0.998 ± 0.024
2.115GlnIle: 2.115 ± 0.032
2.804GlnLys: 2.804 ± 0.037
4.322GlnLeu: 4.322 ± 0.046
0.851GlnMet: 0.851 ± 0.023
1.996GlnAsn: 1.996 ± 0.03
2.072GlnPro: 2.072 ± 0.045
2.578GlnGln: 2.578 ± 0.08
2.016GlnArg: 2.016 ± 0.028
2.596GlnSer: 2.596 ± 0.038
2.053GlnThr: 2.053 ± 0.035
2.19GlnVal: 2.19 ± 0.028
0.426GlnTrp: 0.426 ± 0.012
1.258GlnTyr: 1.258 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
2.983ArgAla: 2.983 ± 0.039
0.504ArgCys: 0.504 ± 0.015
2.515ArgAsp: 2.515 ± 0.032
2.968ArgGlu: 2.968 ± 0.04
2.126ArgPhe: 2.126 ± 0.03
2.348ArgGly: 2.348 ± 0.035
1.046ArgHis: 1.046 ± 0.016
2.516ArgIle: 2.516 ± 0.031
3.587ArgLys: 3.587 ± 0.039
4.984ArgLeu: 4.984 ± 0.056
0.954ArgMet: 0.954 ± 0.02
2.221ArgAsn: 2.221 ± 0.03
1.985ArgPro: 1.985 ± 0.036
1.961ArgGln: 1.961 ± 0.031
2.995ArgArg: 2.995 ± 0.05
3.504ArgSer: 3.504 ± 0.043
2.273ArgThr: 2.273 ± 0.041
2.667ArgVal: 2.667 ± 0.036
0.51ArgTrp: 0.51 ± 0.014
1.559ArgTyr: 1.559 ± 0.025
0.0ArgXaa: 0.0 ± 0.0
Ser
4.922SerAla: 4.922 ± 0.051
0.737SerCys: 0.737 ± 0.018
4.616SerAsp: 4.616 ± 0.059
4.97SerGlu: 4.97 ± 0.063
3.494SerPhe: 3.494 ± 0.043
4.698SerGly: 4.698 ± 0.078
1.73SerHis: 1.73 ± 0.028
4.446SerIle: 4.446 ± 0.045
5.157SerLys: 5.157 ± 0.058
8.311SerLeu: 8.311 ± 0.064
1.622SerMet: 1.622 ± 0.026
3.654SerAsn: 3.654 ± 0.046
3.716SerPro: 3.716 ± 0.046
3.194SerGln: 3.194 ± 0.036
3.672SerArg: 3.672 ± 0.044
8.034SerSer: 8.034 ± 0.125
4.849SerThr: 4.849 ± 0.102
4.79SerVal: 4.79 ± 0.046
0.803SerTrp: 0.803 ± 0.021
2.365SerTyr: 2.365 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
3.692ThrAla: 3.692 ± 0.046
0.563ThrCys: 0.563 ± 0.017
2.949ThrAsp: 2.949 ± 0.076
3.475ThrGlu: 3.475 ± 0.067
2.442ThrPhe: 2.442 ± 0.036
3.302ThrGly: 3.302 ± 0.073
1.181ThrHis: 1.181 ± 0.022
3.127ThrIle: 3.127 ± 0.052
3.554ThrLys: 3.554 ± 0.039
5.401ThrLeu: 5.401 ± 0.06
0.981ThrMet: 0.981 ± 0.018
2.531ThrAsn: 2.531 ± 0.029
3.281ThrPro: 3.281 ± 0.056
1.945ThrGln: 1.945 ± 0.034
2.349ThrArg: 2.349 ± 0.043
4.76ThrSer: 4.76 ± 0.091
3.954ThrThr: 3.954 ± 0.238
3.55ThrVal: 3.55 ± 0.083
0.694ThrTrp: 0.694 ± 0.058
1.662ThrTyr: 1.662 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
4.456ValAla: 4.456 ± 0.047
0.769ValCys: 0.769 ± 0.016
3.94ValAsp: 3.94 ± 0.042
4.253ValGlu: 4.253 ± 0.058
2.868ValPhe: 2.868 ± 0.041
3.444ValGly: 3.444 ± 0.037
1.289ValHis: 1.289 ± 0.023
3.398ValIle: 3.398 ± 0.043
4.199ValLys: 4.199 ± 0.045
6.356ValLeu: 6.356 ± 0.065
1.239ValMet: 1.239 ± 0.026
2.937ValAsn: 2.937 ± 0.035
3.392ValPro: 3.392 ± 0.076
2.159ValGln: 2.159 ± 0.028
2.675ValArg: 2.675 ± 0.037
5.084ValSer: 5.084 ± 0.054
3.529ValThr: 3.529 ± 0.069
4.546ValVal: 4.546 ± 0.067
0.677ValTrp: 0.677 ± 0.019
1.953ValTyr: 1.953 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
0.699TrpAla: 0.699 ± 0.018
0.2TrpCys: 0.2 ± 0.009
0.678TrpAsp: 0.678 ± 0.018
0.621TrpGlu: 0.621 ± 0.016
0.542TrpPhe: 0.542 ± 0.015
0.613TrpGly: 0.613 ± 0.017
0.234TrpHis: 0.234 ± 0.01
0.613TrpIle: 0.613 ± 0.016
0.778TrpLys: 0.778 ± 0.018
1.189TrpLeu: 1.189 ± 0.024
0.216TrpMet: 0.216 ± 0.009
0.576TrpAsn: 0.576 ± 0.016
0.352TrpPro: 0.352 ± 0.011
0.364TrpGln: 0.364 ± 0.012
0.572TrpArg: 0.572 ± 0.016
0.78TrpSer: 0.78 ± 0.02
0.708TrpThr: 0.708 ± 0.062
0.65TrpVal: 0.65 ± 0.018
0.193TrpTrp: 0.193 ± 0.009
0.389TrpTyr: 0.389 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.938TyrAla: 1.938 ± 0.027
0.429TyrCys: 0.429 ± 0.014
2.113TyrAsp: 2.113 ± 0.03
2.085TyrGlu: 2.085 ± 0.028
1.61TyrPhe: 1.61 ± 0.028
1.994TyrGly: 1.994 ± 0.029
0.806TyrHis: 0.806 ± 0.019
1.782TyrIle: 1.782 ± 0.029
2.032TyrLys: 2.032 ± 0.028
3.402TyrLeu: 3.402 ± 0.04
0.669TyrMet: 0.669 ± 0.017
1.692TyrAsn: 1.692 ± 0.027
1.375TyrPro: 1.375 ± 0.026
1.273TyrGln: 1.273 ± 0.025
1.407TyrArg: 1.407 ± 0.024
2.32TyrSer: 2.32 ± 0.028
1.68TyrThr: 1.68 ± 0.037
1.997TyrVal: 1.997 ± 0.031
0.406TyrTrp: 0.406 ± 0.014
1.263TyrTyr: 1.263 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5132 proteins (2713752 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski