Amino acid dipepetide frequency for Bacillus coahuilensis p1.1.43

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.684AlaAla: 4.684 ± 0.109	0.497AlaCys: 0.497 ± 0.028	2.881AlaAsp: 2.881 ± 0.064	4.254AlaGlu: 4.254 ± 0.08	3.139AlaPhe: 3.139 ± 0.064	4.642AlaGly: 4.642 ± 0.091	1.185AlaHis: 1.185 ± 0.038	5.295AlaIle: 5.295 ± 0.09	4.179AlaLys: 4.179 ± 0.081	6.709AlaLeu: 6.709 ± 0.105	1.735AlaMet: 1.735 ± 0.046	2.375AlaAsn: 2.375 ± 0.05	1.915AlaPro: 1.915 ± 0.048	1.772AlaGln: 1.772 ± 0.046	2.608AlaArg: 2.608 ± 0.058	3.971AlaSer: 3.971 ± 0.07	3.384AlaThr: 3.384 ± 0.063	4.749AlaVal: 4.749 ± 0.087	0.519AlaTrp: 0.519 ± 0.029	2.231AlaTyr: 2.231 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.331CysAla: 0.331 ± 0.021	0.088CysCys: 0.088 ± 0.01	0.354CysAsp: 0.354 ± 0.022	0.451CysGlu: 0.451 ± 0.026	0.263CysPhe: 0.263 ± 0.019	0.579CysGly: 0.579 ± 0.029	0.202CysHis: 0.202 ± 0.015	0.483CysIle: 0.483 ± 0.023	0.352CysLys: 0.352 ± 0.021	0.632CysLeu: 0.632 ± 0.03	0.166CysMet: 0.166 ± 0.013	0.272CysAsn: 0.272 ± 0.019	0.313CysPro: 0.313 ± 0.021	0.256CysGln: 0.256 ± 0.018	0.263CysArg: 0.263 ± 0.016	0.467CysSer: 0.467 ± 0.028	0.378CysThr: 0.378 ± 0.023	0.439CysVal: 0.439 ± 0.026	0.07CysTrp: 0.07 ± 0.008	0.235CysTyr: 0.235 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.976AspAla: 2.976 ± 0.065	0.373AspCys: 0.373 ± 0.021	2.188AspAsp: 2.188 ± 0.064	4.527AspGlu: 4.527 ± 0.082	2.281AspPhe: 2.281 ± 0.048	3.307AspGly: 3.307 ± 0.063	1.264AspHis: 1.264 ± 0.038	4.06AspIle: 4.06 ± 0.069	2.848AspLys: 2.848 ± 0.06	4.889AspLeu: 4.889 ± 0.084	1.298AspMet: 1.298 ± 0.042	1.567AspAsn: 1.567 ± 0.044	1.961AspPro: 1.961 ± 0.049	2.174AspGln: 2.174 ± 0.052	2.403AspArg: 2.403 ± 0.05	2.926AspSer: 2.926 ± 0.056	2.549AspThr: 2.549 ± 0.06	3.936AspVal: 3.936 ± 0.068	0.641AspTrp: 0.641 ± 0.027	2.187AspTyr: 2.187 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	5.334GluAla: 5.334 ± 0.091	0.408GluCys: 0.408 ± 0.025	4.228GluAsp: 4.228 ± 0.075	8.483GluGlu: 8.483 ± 0.13	2.808GluPhe: 2.808 ± 0.06	4.92GluGly: 4.92 ± 0.083	1.644GluHis: 1.644 ± 0.044	5.594GluIle: 5.594 ± 0.079	6.439GluLys: 6.439 ± 0.089	8.036GluLeu: 8.036 ± 0.11	2.422GluMet: 2.422 ± 0.057	3.571GluAsn: 3.571 ± 0.062	2.018GluPro: 2.018 ± 0.057	3.377GluGln: 3.377 ± 0.068	3.782GluArg: 3.782 ± 0.073	4.083GluSer: 4.083 ± 0.066	4.019GluThr: 4.019 ± 0.074	5.597GluVal: 5.597 ± 0.089	0.976GluTrp: 0.976 ± 0.034	2.547GluTyr: 2.547 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.749PheAla: 2.749 ± 0.066	0.317PheCys: 0.317 ± 0.021	2.301PheAsp: 2.301 ± 0.053	2.844PheGlu: 2.844 ± 0.056	2.412PhePhe: 2.412 ± 0.065	3.149PheGly: 3.149 ± 0.07	1.194PheHis: 1.194 ± 0.038	3.991PheIle: 3.991 ± 0.088	2.324PheLys: 2.324 ± 0.051	4.863PheLeu: 4.863 ± 0.091	1.117PheMet: 1.117 ± 0.04	1.813PheAsn: 1.813 ± 0.043	1.637PhePro: 1.637 ± 0.044	1.758PheGln: 1.758 ± 0.044	1.405PheArg: 1.405 ± 0.044	3.375PheSer: 3.375 ± 0.067	2.792PheThr: 2.792 ± 0.056	3.219PheVal: 3.219 ± 0.067	0.419PheTrp: 0.419 ± 0.023	1.811PheTyr: 1.811 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.591GlyAla: 4.591 ± 0.089	0.524GlyCys: 0.524 ± 0.026	3.321GlyAsp: 3.321 ± 0.07	4.976GlyGlu: 4.976 ± 0.084	3.298GlyPhe: 3.298 ± 0.061	4.744GlyGly: 4.744 ± 0.101	1.328GlyHis: 1.328 ± 0.042	5.86GlyIle: 5.86 ± 0.104	4.778GlyLys: 4.778 ± 0.082	6.419GlyLeu: 6.419 ± 0.097	2.032GlyMet: 2.032 ± 0.046	2.649GlyAsn: 2.649 ± 0.068	1.689GlyPro: 1.689 ± 0.045	2.163GlyGln: 2.163 ± 0.056	2.706GlyArg: 2.706 ± 0.058	3.945GlySer: 3.945 ± 0.068	4.029GlyThr: 4.029 ± 0.076	5.312GlyVal: 5.312 ± 0.084	0.747GlyTrp: 0.747 ± 0.03	2.82GlyTyr: 2.82 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.19HisAla: 1.19 ± 0.047	0.181HisCys: 0.181 ± 0.015	1.113HisAsp: 1.113 ± 0.038	1.545HisGlu: 1.545 ± 0.05	1.112HisPhe: 1.112 ± 0.04	1.411HisGly: 1.411 ± 0.051	0.763HisHis: 0.763 ± 0.034	1.608HisIle: 1.608 ± 0.044	1.07HisLys: 1.07 ± 0.04	2.228HisLeu: 2.228 ± 0.057	0.516HisMet: 0.516 ± 0.027	0.813HisAsn: 0.813 ± 0.031	1.216HisPro: 1.216 ± 0.047	0.928HisGln: 0.928 ± 0.029	0.961HisArg: 0.961 ± 0.034	1.452HisSer: 1.452 ± 0.045	1.196HisThr: 1.196 ± 0.033	1.494HisVal: 1.494 ± 0.041	0.18HisTrp: 0.18 ± 0.015	0.971HisTyr: 0.971 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.286IleAla: 5.286 ± 0.082	0.579IleCys: 0.579 ± 0.027	4.073IleAsp: 4.073 ± 0.067	6.151IleGlu: 6.151 ± 0.074	3.164IlePhe: 3.164 ± 0.079	5.912IleGly: 5.912 ± 0.099	1.872IleHis: 1.872 ± 0.043	5.804IleIle: 5.804 ± 0.117	4.183IleLys: 4.183 ± 0.06	7.584IleLeu: 7.584 ± 0.107	1.761IleMet: 1.761 ± 0.051	2.86IleAsn: 2.86 ± 0.059	3.257IlePro: 3.257 ± 0.065	3.327IleGln: 3.327 ± 0.061	3.185IleArg: 3.185 ± 0.052	5.104IleSer: 5.104 ± 0.112	4.22IleThr: 4.22 ± 0.076	5.851IleVal: 5.851 ± 0.094	0.666IleTrp: 0.666 ± 0.03	2.38IleTyr: 2.38 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.083LysAla: 4.083 ± 0.065	0.297LysCys: 0.297 ± 0.019	3.852LysAsp: 3.852 ± 0.064	7.238LysGlu: 7.238 ± 0.102	1.78LysPhe: 1.78 ± 0.037	4.668LysGly: 4.668 ± 0.083	1.282LysHis: 1.282 ± 0.038	4.174LysIle: 4.174 ± 0.068	5.364LysLys: 5.364 ± 0.087	5.647LysLeu: 5.647 ± 0.087	2.085LysMet: 2.085 ± 0.049	3.066LysAsn: 3.066 ± 0.071	1.972LysPro: 1.972 ± 0.043	2.772LysGln: 2.772 ± 0.054	3.405LysArg: 3.405 ± 0.067	3.566LysSer: 3.566 ± 0.057	3.256LysThr: 3.256 ± 0.064	4.642LysVal: 4.642 ± 0.078	0.81LysTrp: 0.81 ± 0.03	1.919LysTyr: 1.919 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	6.659LeuAla: 6.659 ± 0.09	0.631LeuCys: 0.631 ± 0.028	4.881LeuAsp: 4.881 ± 0.08	7.238LeuGlu: 7.238 ± 0.106	5.113LeuPhe: 5.113 ± 0.102	6.465LeuGly: 6.465 ± 0.103	2.237LeuHis: 2.237 ± 0.05	6.772LeuIle: 6.772 ± 0.111	6.222LeuLys: 6.222 ± 0.088	11.11LeuLeu: 11.11 ± 0.148	2.421LeuMet: 2.421 ± 0.053	4.099LeuAsn: 4.099 ± 0.072	4.042LeuPro: 4.042 ± 0.078	4.033LeuGln: 4.033 ± 0.079	3.735LeuArg: 3.735 ± 0.07	7.48LeuSer: 7.48 ± 0.102	5.889LeuThr: 5.889 ± 0.082	6.859LeuVal: 6.859 ± 0.1	0.861LeuTrp: 0.861 ± 0.035	3.431LeuTyr: 3.431 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.727MetAla: 1.727 ± 0.046	0.145MetCys: 0.145 ± 0.014	1.475MetAsp: 1.475 ± 0.038	2.036MetGlu: 2.036 ± 0.051	1.009MetPhe: 1.009 ± 0.033	1.683MetGly: 1.683 ± 0.047	0.372MetHis: 0.372 ± 0.02	2.133MetIle: 2.133 ± 0.054	2.58MetLys: 2.58 ± 0.048	2.359MetLeu: 2.359 ± 0.059	0.933MetMet: 0.933 ± 0.036	1.799MetAsn: 1.799 ± 0.043	0.882MetPro: 0.882 ± 0.035	0.71MetGln: 0.71 ± 0.028	1.013MetArg: 1.013 ± 0.038	1.757MetSer: 1.757 ± 0.044	1.609MetThr: 1.609 ± 0.046	1.919MetVal: 1.919 ± 0.044	0.205MetTrp: 0.205 ± 0.014	0.812MetTyr: 0.812 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.348AsnAla: 2.348 ± 0.057	0.25AsnCys: 0.25 ± 0.018	2.108AsnAsp: 2.108 ± 0.049	3.784AsnGlu: 3.784 ± 0.081	1.538AsnPhe: 1.538 ± 0.037	3.19AsnGly: 3.19 ± 0.058	1.01AsnHis: 1.01 ± 0.036	3.11AsnIle: 3.11 ± 0.069	2.602AsnLys: 2.602 ± 0.057	3.647AsnLeu: 3.647 ± 0.072	1.15AsnMet: 1.15 ± 0.035	1.64AsnAsn: 1.64 ± 0.054	2.007AsnPro: 2.007 ± 0.048	1.939AsnGln: 1.939 ± 0.047	2.062AsnArg: 2.062 ± 0.052	2.365AsnSer: 2.365 ± 0.06	2.048AsnThr: 2.048 ± 0.045	3.087AsnVal: 3.087 ± 0.063	0.5AsnTrp: 0.5 ± 0.026	1.471AsnTyr: 1.471 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	1.866ProAla: 1.866 ± 0.045	0.21ProCys: 0.21 ± 0.017	1.73ProAsp: 1.73 ± 0.046	2.787ProGlu: 2.787 ± 0.059	2.124ProPhe: 2.124 ± 0.051	2.137ProGly: 2.137 ± 0.049	0.877ProHis: 0.877 ± 0.033	2.917ProIle: 2.917 ± 0.064	2.077ProLys: 2.077 ± 0.047	3.541ProLeu: 3.541 ± 0.063	0.811ProMet: 0.811 ± 0.03	1.644ProAsn: 1.644 ± 0.042	0.982ProPro: 0.982 ± 0.036	1.019ProGln: 1.019 ± 0.035	1.113ProArg: 1.113 ± 0.036	2.578ProSer: 2.578 ± 0.053	2.228ProThr: 2.228 ± 0.053	2.688ProVal: 2.688 ± 0.054	0.358ProTrp: 0.358 ± 0.021	1.517ProTyr: 1.517 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.443GlnAla: 2.443 ± 0.059	0.213GlnCys: 0.213 ± 0.015	1.933GlnAsp: 1.933 ± 0.048	3.099GlnGlu: 3.099 ± 0.067	1.657GlnPhe: 1.657 ± 0.043	2.189GlnGly: 2.189 ± 0.048	0.897GlnHis: 0.897 ± 0.03	2.314GlnIle: 2.314 ± 0.044	2.593GlnLys: 2.593 ± 0.056	4.042GlnLeu: 4.042 ± 0.082	1.072GlnMet: 1.072 ± 0.039	1.667GlnAsn: 1.667 ± 0.05	1.177GlnPro: 1.177 ± 0.036	1.728GlnGln: 1.728 ± 0.051	1.439GlnArg: 1.439 ± 0.045	2.486GlnSer: 2.486 ± 0.058	2.087GlnThr: 2.087 ± 0.053	2.391GlnVal: 2.391 ± 0.057	0.402GlnTrp: 0.402 ± 0.021	1.467GlnTyr: 1.467 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.312ArgAla: 2.312 ± 0.06	0.255ArgCys: 0.255 ± 0.017	2.2ArgAsp: 2.2 ± 0.057	3.46ArgGlu: 3.46 ± 0.07	1.967ArgPhe: 1.967 ± 0.05	2.47ArgGly: 2.47 ± 0.056	0.793ArgHis: 0.793 ± 0.028	3.168ArgIle: 3.168 ± 0.067	3.185ArgLys: 3.185 ± 0.06	4.11ArgLeu: 4.11 ± 0.08	1.317ArgMet: 1.317 ± 0.037	1.952ArgAsn: 1.952 ± 0.05	1.278ArgPro: 1.278 ± 0.041	1.428ArgGln: 1.428 ± 0.04	1.883ArgArg: 1.883 ± 0.051	2.383ArgSer: 2.383 ± 0.057	2.055ArgThr: 2.055 ± 0.049	2.906ArgVal: 2.906 ± 0.061	0.392ArgTrp: 0.392 ± 0.021	1.619ArgTyr: 1.619 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.512SerAla: 3.512 ± 0.067	0.374SerCys: 0.374 ± 0.022	2.856SerAsp: 2.856 ± 0.061	4.43SerGlu: 4.43 ± 0.086	3.483SerPhe: 3.483 ± 0.066	4.279SerGly: 4.279 ± 0.07	1.335SerHis: 1.335 ± 0.04	5.86SerIle: 5.86 ± 0.104	4.076SerLys: 4.076 ± 0.064	6.997SerLeu: 6.997 ± 0.098	1.841SerMet: 1.841 ± 0.048	2.542SerAsn: 2.542 ± 0.052	2.178SerPro: 2.178 ± 0.053	1.991SerGln: 1.991 ± 0.05	2.422SerArg: 2.422 ± 0.052	4.782SerSer: 4.782 ± 0.093	3.794SerThr: 3.794 ± 0.061	4.47SerVal: 4.47 ± 0.07	0.63SerTrp: 0.63 ± 0.027	2.534SerTyr: 2.534 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.394ThrAla: 3.394 ± 0.066	0.342ThrCys: 0.342 ± 0.021	2.64ThrAsp: 2.64 ± 0.057	3.751ThrGlu: 3.751 ± 0.07	2.749ThrPhe: 2.749 ± 0.061	4.014ThrGly: 4.014 ± 0.076	1.097ThrHis: 1.097 ± 0.043	4.99ThrIle: 4.99 ± 0.079	3.392ThrLys: 3.392 ± 0.065	5.689ThrLeu: 5.689 ± 0.074	1.348ThrMet: 1.348 ± 0.035	2.459ThrAsn: 2.459 ± 0.057	2.344ThrPro: 2.344 ± 0.056	1.449ThrGln: 1.449 ± 0.043	2.002ThrArg: 2.002 ± 0.046	3.685ThrSer: 3.685 ± 0.067	3.127ThrThr: 3.127 ± 0.072	4.352ThrVal: 4.352 ± 0.078	0.52ThrTrp: 0.52 ± 0.023	2.092ThrTyr: 2.092 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.8ValAla: 4.8 ± 0.084	0.513ValCys: 0.513 ± 0.026	3.729ValAsp: 3.729 ± 0.078	5.711ValGlu: 5.711 ± 0.092	3.112ValPhe: 3.112 ± 0.062	5.055ValGly: 5.055 ± 0.075	1.481ValHis: 1.481 ± 0.038	5.586ValIle: 5.586 ± 0.095	4.809ValLys: 4.809 ± 0.086	7.043ValLeu: 7.043 ± 0.09	1.915ValMet: 1.915 ± 0.05	3.005ValAsn: 3.005 ± 0.058	2.689ValPro: 2.689 ± 0.054	2.605ValGln: 2.605 ± 0.049	2.737ValArg: 2.737 ± 0.052	4.853ValSer: 4.853 ± 0.081	4.261ValThr: 4.261 ± 0.074	5.459ValVal: 5.459 ± 0.094	0.626ValTrp: 0.626 ± 0.027	2.401ValTyr: 2.401 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.567TrpAla: 0.567 ± 0.027	0.08TrpCys: 0.08 ± 0.009	0.495TrpAsp: 0.495 ± 0.023	0.733TrpGlu: 0.733 ± 0.029	0.507TrpPhe: 0.507 ± 0.026	0.615TrpGly: 0.615 ± 0.026	0.188TrpHis: 0.188 ± 0.016	0.881TrpIle: 0.881 ± 0.032	0.719TrpLys: 0.719 ± 0.03	1.062TrpLeu: 1.062 ± 0.038	0.363TrpMet: 0.363 ± 0.02	0.578TrpAsn: 0.578 ± 0.028	0.237TrpPro: 0.237 ± 0.016	0.303TrpGln: 0.303 ± 0.019	0.393TrpArg: 0.393 ± 0.022	0.655TrpSer: 0.655 ± 0.025	0.541TrpThr: 0.541 ± 0.023	0.68TrpVal: 0.68 ± 0.029	0.171TrpTrp: 0.171 ± 0.016	0.347TrpTyr: 0.347 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.873TyrAla: 1.873 ± 0.047	0.317TyrCys: 0.317 ± 0.02	1.997TyrAsp: 1.997 ± 0.054	2.79TyrGlu: 2.79 ± 0.068	1.975TyrPhe: 1.975 ± 0.055	2.499TyrGly: 2.499 ± 0.052	0.927TyrHis: 0.927 ± 0.036	2.619TyrIle: 2.619 ± 0.058	2.086TyrLys: 2.086 ± 0.054	3.57TyrLeu: 3.57 ± 0.072	0.851TyrMet: 0.851 ± 0.032	1.487TyrAsn: 1.487 ± 0.044	1.409TyrPro: 1.409 ± 0.04	1.566TyrGln: 1.566 ± 0.042	1.619TyrArg: 1.619 ± 0.05	2.471TyrSer: 2.471 ± 0.055	1.972TyrThr: 1.972 ± 0.058	2.345TyrVal: 2.345 ± 0.053	0.421TyrTrp: 0.421 ± 0.024	1.629TyrTyr: 1.629 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3184 proteins (901207 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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