Amino acid dipepetide frequency for Lawsonibacter asaccharolyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.592AlaAla: 11.592 ± 0.164	1.366AlaCys: 1.366 ± 0.041	5.063AlaAsp: 5.063 ± 0.062	6.399AlaGlu: 6.399 ± 0.09	3.169AlaPhe: 3.169 ± 0.055	8.036AlaGly: 8.036 ± 0.098	1.484AlaHis: 1.484 ± 0.035	4.625AlaIle: 4.625 ± 0.072	3.7AlaLys: 3.7 ± 0.067	10.31AlaLeu: 10.31 ± 0.133	2.71AlaMet: 2.71 ± 0.057	2.186AlaAsn: 2.186 ± 0.044	3.698AlaPro: 3.698 ± 0.067	3.829AlaGln: 3.829 ± 0.058	5.263AlaArg: 5.263 ± 0.067	4.559AlaSer: 4.559 ± 0.058	3.46AlaThr: 3.46 ± 0.073	7.836AlaVal: 7.836 ± 0.098	0.995AlaTrp: 0.995 ± 0.031	2.664AlaTyr: 2.664 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.44CysAla: 1.44 ± 0.038	0.371CysCys: 0.371 ± 0.021	0.813CysAsp: 0.813 ± 0.029	0.749CysGlu: 0.749 ± 0.027	0.619CysPhe: 0.619 ± 0.022	1.748CysGly: 1.748 ± 0.041	0.318CysHis: 0.318 ± 0.018	0.794CysIle: 0.794 ± 0.03	0.561CysLys: 0.561 ± 0.022	1.519CysLeu: 1.519 ± 0.042	0.399CysMet: 0.399 ± 0.019	0.446CysAsn: 0.446 ± 0.02	0.862CysPro: 0.862 ± 0.032	0.534CysGln: 0.534 ± 0.022	1.175CysArg: 1.175 ± 0.034	0.918CysSer: 0.918 ± 0.027	0.813CysThr: 0.813 ± 0.026	1.102CysVal: 1.102 ± 0.031	0.214CysTrp: 0.214 ± 0.015	0.531CysTyr: 0.531 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.667AspAla: 4.667 ± 0.072	0.899AspCys: 0.899 ± 0.035	2.749AspAsp: 2.749 ± 0.074	3.788AspGlu: 3.788 ± 0.07	2.392AspPhe: 2.392 ± 0.049	5.231AspGly: 5.231 ± 0.096	1.065AspHis: 1.065 ± 0.033	3.216AspIle: 3.216 ± 0.055	2.357AspLys: 2.357 ± 0.054	5.612AspLeu: 5.612 ± 0.068	1.613AspMet: 1.613 ± 0.037	1.513AspAsn: 1.513 ± 0.036	2.936AspPro: 2.936 ± 0.054	2.083AspGln: 2.083 ± 0.048	3.724AspArg: 3.724 ± 0.063	2.974AspSer: 2.974 ± 0.053	2.915AspThr: 2.915 ± 0.056	3.537AspVal: 3.537 ± 0.063	0.79AspTrp: 0.79 ± 0.028	2.353AspTyr: 2.353 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	6.098GluAla: 6.098 ± 0.082	0.736GluCys: 0.736 ± 0.025	4.149GluAsp: 4.149 ± 0.071	6.437GluGlu: 6.437 ± 0.106	2.188GluPhe: 2.188 ± 0.041	5.053GluGly: 5.053 ± 0.067	1.493GluHis: 1.493 ± 0.039	3.852GluIle: 3.852 ± 0.06	3.956GluLys: 3.956 ± 0.071	7.494GluLeu: 7.494 ± 0.092	2.059GluMet: 2.059 ± 0.043	2.65GluAsn: 2.65 ± 0.054	2.409GluPro: 2.409 ± 0.053	3.322GluGln: 3.322 ± 0.058	4.635GluArg: 4.635 ± 0.084	2.96GluSer: 2.96 ± 0.051	3.529GluThr: 3.529 ± 0.058	4.298GluVal: 4.298 ± 0.065	0.758GluTrp: 0.758 ± 0.029	2.288GluTyr: 2.288 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.08PheAla: 3.08 ± 0.056	0.76PheCys: 0.76 ± 0.026	2.218PheAsp: 2.218 ± 0.048	1.997PheGlu: 1.997 ± 0.042	1.607PhePhe: 1.607 ± 0.043	3.003PheGly: 3.003 ± 0.054	0.826PheHis: 0.826 ± 0.027	1.685PheIle: 1.685 ± 0.039	1.09PheLys: 1.09 ± 0.032	3.956PheLeu: 3.956 ± 0.071	0.856PheMet: 0.856 ± 0.031	1.059PheAsn: 1.059 ± 0.034	1.599PhePro: 1.599 ± 0.038	1.616PheGln: 1.616 ± 0.035	2.137PheArg: 2.137 ± 0.046	2.631PheSer: 2.631 ± 0.048	2.205PheThr: 2.205 ± 0.045	2.489PheVal: 2.489 ± 0.043	0.49PheTrp: 0.49 ± 0.021	1.453PheTyr: 1.453 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.831GlyAla: 6.831 ± 0.092	1.41GlyCys: 1.41 ± 0.04	4.117GlyAsp: 4.117 ± 0.066	5.572GlyGlu: 5.572 ± 0.086	2.871GlyPhe: 2.871 ± 0.048	6.649GlyGly: 6.649 ± 0.107	1.484GlyHis: 1.484 ± 0.035	4.551GlyIle: 4.551 ± 0.074	4.103GlyLys: 4.103 ± 0.066	7.522GlyLeu: 7.522 ± 0.09	2.575GlyMet: 2.575 ± 0.051	2.426GlyAsn: 2.426 ± 0.052	2.433GlyPro: 2.433 ± 0.06	2.906GlyGln: 2.906 ± 0.052	5.041GlyArg: 5.041 ± 0.074	4.609GlySer: 4.609 ± 0.068	4.874GlyThr: 4.874 ± 0.083	5.879GlyVal: 5.879 ± 0.081	1.14GlyTrp: 1.14 ± 0.035	3.099GlyTyr: 3.099 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.246HisAla: 1.246 ± 0.035	0.363HisCys: 0.363 ± 0.019	0.885HisAsp: 0.885 ± 0.031	0.927HisGlu: 0.927 ± 0.032	0.746HisPhe: 0.746 ± 0.024	1.429HisGly: 1.429 ± 0.036	0.373HisHis: 0.373 ± 0.02	1.22HisIle: 1.22 ± 0.029	0.68HisLys: 0.68 ± 0.024	1.861HisLeu: 1.861 ± 0.045	0.485HisMet: 0.485 ± 0.023	0.617HisAsn: 0.617 ± 0.022	1.138HisPro: 1.138 ± 0.034	0.645HisGln: 0.645 ± 0.023	1.161HisArg: 1.161 ± 0.031	1.024HisSer: 1.024 ± 0.031	1.063HisThr: 1.063 ± 0.031	1.093HisVal: 1.093 ± 0.032	0.261HisTrp: 0.261 ± 0.016	0.668HisTyr: 0.668 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.652IleAla: 4.652 ± 0.074	1.021IleCys: 1.021 ± 0.031	2.983IleAsp: 2.983 ± 0.051	2.891IleGlu: 2.891 ± 0.059	2.06IlePhe: 2.06 ± 0.045	3.825IleGly: 3.825 ± 0.074	1.072IleHis: 1.072 ± 0.033	2.863IleIle: 2.863 ± 0.07	2.007IleLys: 2.007 ± 0.045	5.469IleLeu: 5.469 ± 0.092	1.277IleMet: 1.277 ± 0.035	1.735IleAsn: 1.735 ± 0.038	2.876IlePro: 2.876 ± 0.054	2.274IleGln: 2.274 ± 0.051	3.416IleArg: 3.416 ± 0.06	3.687IleSer: 3.687 ± 0.067	3.379IleThr: 3.379 ± 0.062	3.522IleVal: 3.522 ± 0.064	0.562IleTrp: 0.562 ± 0.024	1.887IleTyr: 1.887 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.073LysAla: 4.073 ± 0.064	0.498LysCys: 0.498 ± 0.023	2.459LysAsp: 2.459 ± 0.054	3.429LysGlu: 3.429 ± 0.06	1.275LysPhe: 1.275 ± 0.04	3.192LysGly: 3.192 ± 0.05	0.745LysHis: 0.745 ± 0.027	2.466LysIle: 2.466 ± 0.051	3.014LysLys: 3.014 ± 0.062	4.203LysLeu: 4.203 ± 0.068	1.3LysMet: 1.3 ± 0.033	1.812LysAsn: 1.812 ± 0.04	1.754LysPro: 1.754 ± 0.038	1.657LysGln: 1.657 ± 0.043	2.695LysArg: 2.695 ± 0.06	2.265LysSer: 2.265 ± 0.05	2.63LysThr: 2.63 ± 0.049	2.907LysVal: 2.907 ± 0.058	0.476LysTrp: 0.476 ± 0.02	1.618LysTyr: 1.618 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.762LeuAla: 9.762 ± 0.109	1.904LeuCys: 1.904 ± 0.045	6.092LeuAsp: 6.092 ± 0.078	7.398LeuGlu: 7.398 ± 0.103	3.776LeuPhe: 3.776 ± 0.066	7.232LeuGly: 7.232 ± 0.109	1.685LeuHis: 1.685 ± 0.039	4.844LeuIle: 4.844 ± 0.084	4.284LeuLys: 4.284 ± 0.06	10.64LeuLeu: 10.64 ± 0.157	2.727LeuMet: 2.727 ± 0.053	2.969LeuAsn: 2.969 ± 0.048	4.859LeuPro: 4.859 ± 0.073	2.9LeuGln: 2.9 ± 0.054	6.134LeuArg: 6.134 ± 0.096	7.114LeuSer: 7.114 ± 0.093	5.945LeuThr: 5.945 ± 0.078	6.372LeuVal: 6.372 ± 0.085	1.18LeuTrp: 1.18 ± 0.035	3.326LeuTyr: 3.326 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.955MetAla: 2.955 ± 0.054	0.366MetCys: 0.366 ± 0.02	1.873MetAsp: 1.873 ± 0.044	2.449MetGlu: 2.449 ± 0.045	0.818MetPhe: 0.818 ± 0.027	2.189MetGly: 2.189 ± 0.045	0.359MetHis: 0.359 ± 0.017	1.347MetIle: 1.347 ± 0.034	1.726MetLys: 1.726 ± 0.041	2.664MetLeu: 2.664 ± 0.052	0.774MetMet: 0.774 ± 0.029	1.048MetAsn: 1.048 ± 0.028	1.193MetPro: 1.193 ± 0.036	0.755MetGln: 0.755 ± 0.023	1.41MetArg: 1.41 ± 0.037	1.734MetSer: 1.734 ± 0.037	1.726MetThr: 1.726 ± 0.044	1.858MetVal: 1.858 ± 0.038	0.217MetTrp: 0.217 ± 0.014	0.629MetTyr: 0.629 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.751AsnAla: 2.751 ± 0.049	0.481AsnCys: 0.481 ± 0.022	1.5AsnAsp: 1.5 ± 0.041	1.843AsnGlu: 1.843 ± 0.043	1.128AsnPhe: 1.128 ± 0.03	2.937AsnGly: 2.937 ± 0.064	0.6AsnHis: 0.6 ± 0.022	1.984AsnIle: 1.984 ± 0.047	1.296AsnLys: 1.296 ± 0.035	2.917AsnLeu: 2.917 ± 0.054	0.872AsnMet: 0.872 ± 0.031	0.995AsnAsn: 0.995 ± 0.035	1.63AsnPro: 1.63 ± 0.039	1.172AsnGln: 1.172 ± 0.032	1.802AsnArg: 1.802 ± 0.049	1.756AsnSer: 1.756 ± 0.04	1.74AsnThr: 1.74 ± 0.043	2.002AsnVal: 2.002 ± 0.052	0.39AsnTrp: 0.39 ± 0.019	1.166AsnTyr: 1.166 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.466ProAla: 4.466 ± 0.074	0.598ProCys: 0.598 ± 0.025	2.986ProAsp: 2.986 ± 0.064	4.322ProGlu: 4.322 ± 0.064	1.61ProPhe: 1.61 ± 0.035	3.761ProGly: 3.761 ± 0.067	0.738ProHis: 0.738 ± 0.023	2.078ProIle: 2.078 ± 0.047	1.787ProLys: 1.787 ± 0.041	3.815ProLeu: 3.815 ± 0.065	1.244ProMet: 1.244 ± 0.035	1.273ProAsn: 1.273 ± 0.033	1.798ProPro: 1.798 ± 0.048	1.618ProGln: 1.618 ± 0.041	1.994ProArg: 1.994 ± 0.044	2.41ProSer: 2.41 ± 0.043	1.95ProThr: 1.95 ± 0.048	3.569ProVal: 3.569 ± 0.064	0.517ProTrp: 0.517 ± 0.025	1.462ProTyr: 1.462 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.845GlnAla: 3.845 ± 0.067	0.432GlnCys: 0.432 ± 0.02	1.927GlnAsp: 1.927 ± 0.048	2.991GlnGlu: 2.991 ± 0.057	1.249GlnPhe: 1.249 ± 0.03	2.671GlnGly: 2.671 ± 0.057	0.542GlnHis: 0.542 ± 0.023	2.171GlnIle: 2.171 ± 0.043	1.983GlnLys: 1.983 ± 0.045	3.595GlnLeu: 3.595 ± 0.06	1.192GlnMet: 1.192 ± 0.032	1.334GlnAsn: 1.334 ± 0.034	1.434GlnPro: 1.434 ± 0.035	1.471GlnGln: 1.471 ± 0.04	2.262GlnArg: 2.262 ± 0.049	1.973GlnSer: 1.973 ± 0.045	1.984GlnThr: 1.984 ± 0.042	2.797GlnVal: 2.797 ± 0.05	0.451GlnTrp: 0.451 ± 0.022	1.393GlnTyr: 1.393 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	5.223ArgAla: 5.223 ± 0.081	0.967ArgCys: 0.967 ± 0.028	3.276ArgAsp: 3.276 ± 0.062	5.01ArgGlu: 5.01 ± 0.085	2.231ArgPhe: 2.231 ± 0.045	4.047ArgGly: 4.047 ± 0.064	1.128ArgHis: 1.128 ± 0.031	3.174ArgIle: 3.174 ± 0.057	2.87ArgLys: 2.87 ± 0.058	6.1ArgLeu: 6.1 ± 0.089	1.79ArgMet: 1.79 ± 0.041	1.754ArgAsn: 1.754 ± 0.036	2.598ArgPro: 2.598 ± 0.051	2.619ArgGln: 2.619 ± 0.057	4.686ArgArg: 4.686 ± 0.09	3.179ArgSer: 3.179 ± 0.057	3.155ArgThr: 3.155 ± 0.057	3.803ArgVal: 3.803 ± 0.065	0.79ArgTrp: 0.79 ± 0.028	2.24ArgTyr: 2.24 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.308SerAla: 5.308 ± 0.073	0.881SerCys: 0.881 ± 0.028	3.038SerAsp: 3.038 ± 0.062	3.093SerGlu: 3.093 ± 0.055	2.394SerPhe: 2.394 ± 0.051	5.642SerGly: 5.642 ± 0.079	1.005SerHis: 1.005 ± 0.032	3.158SerIle: 3.158 ± 0.059	2.258SerLys: 2.258 ± 0.047	5.647SerLeu: 5.647 ± 0.079	1.714SerMet: 1.714 ± 0.044	1.713SerAsn: 1.713 ± 0.042	2.533SerPro: 2.533 ± 0.044	2.176SerGln: 2.176 ± 0.049	3.431SerArg: 3.431 ± 0.049	3.522SerSer: 3.522 ± 0.064	2.884SerThr: 2.884 ± 0.049	4.12SerVal: 4.12 ± 0.065	0.796SerTrp: 0.796 ± 0.028	2.046SerTyr: 2.046 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.579ThrAla: 5.579 ± 0.084	0.766ThrCys: 0.766 ± 0.026	3.119ThrAsp: 3.119 ± 0.064	3.195ThrGlu: 3.195 ± 0.062	1.999ThrPhe: 1.999 ± 0.048	4.971ThrGly: 4.971 ± 0.074	0.931ThrHis: 0.931 ± 0.027	3.202ThrIle: 3.202 ± 0.066	1.908ThrLys: 1.908 ± 0.049	5.372ThrLeu: 5.372 ± 0.078	1.408ThrMet: 1.408 ± 0.037	1.583ThrAsn: 1.583 ± 0.039	2.898ThrPro: 2.898 ± 0.059	1.815ThrGln: 1.815 ± 0.039	2.685ThrArg: 2.685 ± 0.046	2.754ThrSer: 2.754 ± 0.061	2.817ThrThr: 2.817 ± 0.074	4.935ThrVal: 4.935 ± 0.081	0.658ThrTrp: 0.658 ± 0.025	1.894ThrTyr: 1.894 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	5.598ValAla: 5.598 ± 0.086	1.279ValCys: 1.279 ± 0.039	4.167ValAsp: 4.167 ± 0.058	4.803ValGlu: 4.803 ± 0.068	2.73ValPhe: 2.73 ± 0.054	4.693ValGly: 4.693 ± 0.075	1.086ValHis: 1.086 ± 0.029	3.839ValIle: 3.839 ± 0.064	3.037ValLys: 3.037 ± 0.055	7.501ValLeu: 7.501 ± 0.092	1.967ValMet: 1.967 ± 0.048	2.233ValAsn: 2.233 ± 0.05	3.427ValPro: 3.427 ± 0.063	2.234ValGln: 2.234 ± 0.05	4.131ValArg: 4.131 ± 0.059	4.623ValSer: 4.623 ± 0.074	4.552ValThr: 4.552 ± 0.09	5.194ValVal: 5.194 ± 0.09	0.836ValTrp: 0.836 ± 0.028	2.339ValTyr: 2.339 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.985TrpAla: 0.985 ± 0.031	0.212TrpCys: 0.212 ± 0.015	0.746TrpAsp: 0.746 ± 0.026	0.864TrpGlu: 0.864 ± 0.028	0.457TrpPhe: 0.457 ± 0.022	0.92TrpGly: 0.92 ± 0.032	0.232TrpHis: 0.232 ± 0.015	0.514TrpIle: 0.514 ± 0.023	0.569TrpLys: 0.569 ± 0.024	1.28TrpLeu: 1.28 ± 0.04	0.399TrpMet: 0.399 ± 0.016	0.457TrpAsn: 0.457 ± 0.023	0.439TrpPro: 0.439 ± 0.021	0.471TrpGln: 0.471 ± 0.021	0.731TrpArg: 0.731 ± 0.028	0.735TrpSer: 0.735 ± 0.023	0.693TrpThr: 0.693 ± 0.026	0.775TrpVal: 0.775 ± 0.026	0.152TrpTrp: 0.152 ± 0.012	0.472TrpTyr: 0.472 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.796TyrAla: 2.796 ± 0.049	0.617TyrCys: 0.617 ± 0.024	2.254TyrAsp: 2.254 ± 0.051	2.205TyrGlu: 2.205 ± 0.046	1.441TyrPhe: 1.441 ± 0.036	2.864TyrGly: 2.864 ± 0.045	0.716TyrHis: 0.716 ± 0.024	1.875TyrIle: 1.875 ± 0.048	1.283TyrLys: 1.283 ± 0.035	3.667TyrLeu: 3.667 ± 0.054	0.729TyrMet: 0.729 ± 0.024	1.162TyrAsn: 1.162 ± 0.036	1.481TyrPro: 1.481 ± 0.037	1.599TyrGln: 1.599 ± 0.038	2.128TyrArg: 2.128 ± 0.049	1.93TyrSer: 1.93 ± 0.043	2.173TyrThr: 2.173 ± 0.06	2.179TyrVal: 2.179 ± 0.051	0.431TyrTrp: 0.431 ± 0.021	1.41TyrTyr: 1.41 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4274 proteins (1174145 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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