Amino acid dipepetide frequency for Acetobacter senegalensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.599AlaAla: 14.599 ± 0.182	1.465AlaCys: 1.465 ± 0.038	5.961AlaAsp: 5.961 ± 0.085	6.645AlaGlu: 6.645 ± 0.107	3.983AlaPhe: 3.983 ± 0.064	9.774AlaGly: 9.774 ± 0.113	2.675AlaHis: 2.675 ± 0.054	5.2AlaIle: 5.2 ± 0.093	3.271AlaLys: 3.271 ± 0.062	12.741AlaLeu: 12.741 ± 0.151	2.97AlaMet: 2.97 ± 0.057	2.681AlaAsn: 2.681 ± 0.056	5.873AlaPro: 5.873 ± 0.109	4.698AlaGln: 4.698 ± 0.078	7.758AlaArg: 7.758 ± 0.102	6.71AlaSer: 6.71 ± 0.088	6.113AlaThr: 6.113 ± 0.079	7.769AlaVal: 7.769 ± 0.097	1.577AlaTrp: 1.577 ± 0.044	2.514AlaTyr: 2.514 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.196CysAla: 1.196 ± 0.033	0.184CysCys: 0.184 ± 0.014	0.523CysAsp: 0.523 ± 0.022	0.416CysGlu: 0.416 ± 0.019	0.433CysPhe: 0.433 ± 0.021	1.089CysGly: 1.089 ± 0.033	0.312CysHis: 0.312 ± 0.016	0.484CysIle: 0.484 ± 0.023	0.222CysLys: 0.222 ± 0.015	1.149CysLeu: 1.149 ± 0.032	0.227CysMet: 0.227 ± 0.014	0.252CysAsn: 0.252 ± 0.015	0.574CysPro: 0.574 ± 0.022	0.349CysGln: 0.349 ± 0.019	0.691CysArg: 0.691 ± 0.025	0.647CysSer: 0.647 ± 0.022	0.558CysThr: 0.558 ± 0.022	0.882CysVal: 0.882 ± 0.031	0.157CysTrp: 0.157 ± 0.012	0.22CysTyr: 0.22 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.151AspAla: 6.151 ± 0.074	0.474AspCys: 0.474 ± 0.02	2.678AspAsp: 2.678 ± 0.056	2.736AspGlu: 2.736 ± 0.054	1.984AspPhe: 1.984 ± 0.04	4.481AspGly: 4.481 ± 0.07	1.354AspHis: 1.354 ± 0.034	3.044AspIle: 3.044 ± 0.05	1.657AspLys: 1.657 ± 0.043	5.48AspLeu: 5.48 ± 0.075	1.492AspMet: 1.492 ± 0.04	1.409AspAsn: 1.409 ± 0.034	2.988AspPro: 2.988 ± 0.051	1.753AspGln: 1.753 ± 0.046	3.486AspArg: 3.486 ± 0.061	2.206AspSer: 2.206 ± 0.047	2.864AspThr: 2.864 ± 0.058	4.048AspVal: 4.048 ± 0.056	0.888AspTrp: 0.888 ± 0.029	1.451AspTyr: 1.451 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.514GluAla: 6.514 ± 0.1	0.415GluCys: 0.415 ± 0.022	2.76GluAsp: 2.76 ± 0.054	3.228GluGlu: 3.228 ± 0.075	1.393GluPhe: 1.393 ± 0.039	4.087GluGly: 4.087 ± 0.075	1.256GluHis: 1.256 ± 0.032	2.759GluIle: 2.759 ± 0.055	2.679GluLys: 2.679 ± 0.06	4.113GluLeu: 4.113 ± 0.07	1.225GluMet: 1.225 ± 0.034	1.949GluAsn: 1.949 ± 0.046	2.169GluPro: 2.169 ± 0.053	2.471GluGln: 2.471 ± 0.053	4.004GluArg: 4.004 ± 0.078	2.313GluSer: 2.313 ± 0.045	3.504GluThr: 3.504 ± 0.06	3.068GluVal: 3.068 ± 0.056	0.714GluTrp: 0.714 ± 0.028	0.994GluTyr: 0.994 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.708PheAla: 3.708 ± 0.056	0.52PheCys: 0.52 ± 0.025	2.181PheAsp: 2.181 ± 0.048	1.762PheGlu: 1.762 ± 0.042	1.491PhePhe: 1.491 ± 0.041	3.32PheGly: 3.32 ± 0.05	0.889PheHis: 0.889 ± 0.027	1.596PheIle: 1.596 ± 0.047	0.924PheLys: 0.924 ± 0.032	3.752PheLeu: 3.752 ± 0.06	1.006PheMet: 1.006 ± 0.03	1.164PheAsn: 1.164 ± 0.04	1.72PhePro: 1.72 ± 0.044	1.09PheGln: 1.09 ± 0.032	2.285PheArg: 2.285 ± 0.046	2.829PheSer: 2.829 ± 0.051	2.171PheThr: 2.171 ± 0.048	2.631PheVal: 2.631 ± 0.058	0.536PheTrp: 0.536 ± 0.025	0.977PheTyr: 0.977 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.22GlyAla: 8.22 ± 0.102	0.968GlyCys: 0.968 ± 0.031	3.57GlyAsp: 3.57 ± 0.058	3.797GlyGlu: 3.797 ± 0.064	3.369GlyPhe: 3.369 ± 0.057	6.966GlyGly: 6.966 ± 0.099	2.028GlyHis: 2.028 ± 0.047	4.143GlyIle: 4.143 ± 0.062	3.42GlyLys: 3.42 ± 0.067	8.647GlyLeu: 8.647 ± 0.104	2.4GlyMet: 2.4 ± 0.051	2.336GlyAsn: 2.336 ± 0.05	3.373GlyPro: 3.373 ± 0.063	3.238GlyGln: 3.238 ± 0.063	5.377GlyArg: 5.377 ± 0.075	4.879GlySer: 4.879 ± 0.079	5.023GlyThr: 5.023 ± 0.077	6.1GlyVal: 6.1 ± 0.084	1.534GlyTrp: 1.534 ± 0.038	2.321GlyTyr: 2.321 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.724HisAla: 2.724 ± 0.053	0.267HisCys: 0.267 ± 0.016	1.347HisAsp: 1.347 ± 0.034	1.103HisGlu: 1.103 ± 0.033	0.981HisPhe: 0.981 ± 0.03	2.079HisGly: 2.079 ± 0.046	0.76HisHis: 0.76 ± 0.027	1.241HisIle: 1.241 ± 0.032	0.736HisLys: 0.736 ± 0.027	2.39HisLeu: 2.39 ± 0.048	0.603HisMet: 0.603 ± 0.021	0.718HisAsn: 0.718 ± 0.026	1.562HisPro: 1.562 ± 0.041	0.816HisGln: 0.816 ± 0.031	1.385HisArg: 1.385 ± 0.035	1.287HisSer: 1.287 ± 0.032	1.353HisThr: 1.353 ± 0.036	1.791HisVal: 1.791 ± 0.044	0.375HisTrp: 0.375 ± 0.018	0.698HisTyr: 0.698 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.733IleAla: 5.733 ± 0.076	0.593IleCys: 0.593 ± 0.023	2.765IleAsp: 2.765 ± 0.054	2.707IleGlu: 2.707 ± 0.057	1.579IlePhe: 1.579 ± 0.04	4.352IleGly: 4.352 ± 0.067	0.955IleHis: 0.955 ± 0.032	2.248IleIle: 2.248 ± 0.057	1.437IleLys: 1.437 ± 0.039	4.572IleLeu: 4.572 ± 0.063	1.188IleMet: 1.188 ± 0.038	1.439IleAsn: 1.439 ± 0.042	2.575IlePro: 2.575 ± 0.054	1.478IleGln: 1.478 ± 0.042	3.189IleArg: 3.189 ± 0.053	3.299IleSer: 3.299 ± 0.055	3.178IleThr: 3.178 ± 0.06	3.502IleVal: 3.502 ± 0.071	0.642IleTrp: 0.642 ± 0.024	1.04IleTyr: 1.04 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.303LysAla: 4.303 ± 0.075	0.177LysCys: 0.177 ± 0.011	1.82LysAsp: 1.82 ± 0.043	1.76LysGlu: 1.76 ± 0.046	0.83LysPhe: 0.83 ± 0.025	2.786LysGly: 2.786 ± 0.055	0.709LysHis: 0.709 ± 0.026	1.856LysIle: 1.856 ± 0.05	1.698LysLys: 1.698 ± 0.049	3.208LysLeu: 3.208 ± 0.059	0.8LysMet: 0.8 ± 0.027	1.271LysAsn: 1.271 ± 0.035	2.115LysPro: 2.115 ± 0.043	1.38LysGln: 1.38 ± 0.04	2.217LysArg: 2.217 ± 0.057	1.877LysSer: 1.877 ± 0.041	2.231LysThr: 2.231 ± 0.047	2.158LysVal: 2.158 ± 0.051	0.428LysTrp: 0.428 ± 0.021	0.649LysTyr: 0.649 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.539LeuAla: 12.539 ± 0.149	1.234LeuCys: 1.234 ± 0.037	5.413LeuAsp: 5.413 ± 0.073	4.886LeuGlu: 4.886 ± 0.072	3.866LeuPhe: 3.866 ± 0.071	7.549LeuGly: 7.549 ± 0.101	2.462LeuHis: 2.462 ± 0.05	4.423LeuIle: 4.423 ± 0.066	3.689LeuLys: 3.689 ± 0.056	10.109LeuLeu: 10.109 ± 0.126	2.406LeuMet: 2.406 ± 0.046	2.92LeuAsn: 2.92 ± 0.059	6.637LeuPro: 6.637 ± 0.096	3.322LeuGln: 3.322 ± 0.061	6.897LeuArg: 6.897 ± 0.097	7.183LeuSer: 7.183 ± 0.087	6.123LeuThr: 6.123 ± 0.07	6.871LeuVal: 6.871 ± 0.086	1.32LeuTrp: 1.32 ± 0.035	2.312LeuTyr: 2.312 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.131MetAla: 3.131 ± 0.059	0.161MetCys: 0.161 ± 0.012	1.173MetAsp: 1.173 ± 0.036	1.167MetGlu: 1.167 ± 0.031	0.684MetPhe: 0.684 ± 0.022	1.869MetGly: 1.869 ± 0.042	0.499MetHis: 0.499 ± 0.022	1.264MetIle: 1.264 ± 0.036	0.999MetLys: 0.999 ± 0.031	2.593MetLeu: 2.593 ± 0.051	0.682MetMet: 0.682 ± 0.028	0.784MetAsn: 0.784 ± 0.026	1.659MetPro: 1.659 ± 0.041	1.069MetGln: 1.069 ± 0.031	1.746MetArg: 1.746 ± 0.035	1.569MetSer: 1.569 ± 0.04	1.962MetThr: 1.962 ± 0.04	1.808MetVal: 1.808 ± 0.034	0.214MetTrp: 0.214 ± 0.014	0.317MetTyr: 0.317 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.405AsnAla: 3.405 ± 0.067	0.28AsnCys: 0.28 ± 0.014	1.397AsnAsp: 1.397 ± 0.042	1.168AsnGlu: 1.168 ± 0.034	1.097AsnPhe: 1.097 ± 0.037	2.851AsnGly: 2.851 ± 0.067	0.616AsnHis: 0.616 ± 0.025	1.553AsnIle: 1.553 ± 0.041	0.891AsnLys: 0.891 ± 0.033	2.681AsnLeu: 2.681 ± 0.052	0.699AsnMet: 0.699 ± 0.023	0.95AsnAsn: 0.95 ± 0.041	1.931AsnPro: 1.931 ± 0.044	0.987AsnGln: 0.987 ± 0.038	1.912AsnArg: 1.912 ± 0.045	1.551AsnSer: 1.551 ± 0.042	1.792AsnThr: 1.792 ± 0.045	2.108AsnVal: 2.108 ± 0.056	0.526AsnTrp: 0.526 ± 0.024	0.823AsnTyr: 0.823 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	6.559ProAla: 6.559 ± 0.113	0.476ProCys: 0.476 ± 0.021	3.938ProAsp: 3.938 ± 0.07	3.984ProGlu: 3.984 ± 0.07	2.163ProPhe: 2.163 ± 0.039	4.253ProGly: 4.253 ± 0.075	1.49ProHis: 1.49 ± 0.041	2.043ProIle: 2.043 ± 0.043	1.525ProLys: 1.525 ± 0.035	5.239ProLeu: 5.239 ± 0.073	1.247ProMet: 1.247 ± 0.035	1.421ProAsn: 1.421 ± 0.039	3.116ProPro: 3.116 ± 0.079	2.144ProGln: 2.144 ± 0.05	2.837ProArg: 2.837 ± 0.051	3.422ProSer: 3.422 ± 0.061	2.922ProThr: 2.922 ± 0.047	4.702ProVal: 4.702 ± 0.077	0.778ProTrp: 0.778 ± 0.026	1.32ProTyr: 1.32 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.997GlnAla: 4.997 ± 0.082	0.267GlnCys: 0.267 ± 0.015	2.175GlnAsp: 2.175 ± 0.042	1.928GlnGlu: 1.928 ± 0.039	1.207GlnPhe: 1.207 ± 0.029	2.637GlnGly: 2.637 ± 0.05	0.887GlnHis: 0.887 ± 0.027	2.164GlnIle: 2.164 ± 0.046	1.744GlnLys: 1.744 ± 0.039	2.846GlnLeu: 2.846 ± 0.054	0.995GlnMet: 0.995 ± 0.032	1.396GlnAsn: 1.396 ± 0.044	2.248GlnPro: 2.248 ± 0.048	1.772GlnGln: 1.772 ± 0.056	2.241GlnArg: 2.241 ± 0.049	2.152GlnSer: 2.152 ± 0.044	2.518GlnThr: 2.518 ± 0.06	2.352GlnVal: 2.352 ± 0.045	0.51GlnTrp: 0.51 ± 0.017	0.825GlnTyr: 0.825 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.513ArgAla: 6.513 ± 0.085	0.586ArgCys: 0.586 ± 0.023	3.18ArgAsp: 3.18 ± 0.056	3.377ArgGlu: 3.377 ± 0.071	2.654ArgPhe: 2.654 ± 0.044	4.106ArgGly: 4.106 ± 0.063	1.919ArgHis: 1.919 ± 0.046	3.59ArgIle: 3.59 ± 0.058	2.688ArgLys: 2.688 ± 0.065	7.448ArgLeu: 7.448 ± 0.091	1.78ArgMet: 1.78 ± 0.035	2.111ArgAsn: 2.111 ± 0.041	3.437ArgPro: 3.437 ± 0.059	2.884ArgGln: 2.884 ± 0.056	4.814ArgArg: 4.814 ± 0.092	3.672ArgSer: 3.672 ± 0.054	3.627ArgThr: 3.627 ± 0.055	4.329ArgVal: 4.329 ± 0.067	0.98ArgTrp: 0.98 ± 0.028	1.865ArgTyr: 1.865 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.638SerAla: 6.638 ± 0.079	0.65SerCys: 0.65 ± 0.024	2.967SerAsp: 2.967 ± 0.056	2.644SerGlu: 2.644 ± 0.052	2.539SerPhe: 2.539 ± 0.054	5.696SerGly: 5.696 ± 0.073	1.362SerHis: 1.362 ± 0.037	2.915SerIle: 2.915 ± 0.06	1.592SerLys: 1.592 ± 0.038	6.415SerLeu: 6.415 ± 0.078	1.533SerMet: 1.533 ± 0.038	1.559SerAsn: 1.559 ± 0.045	3.401SerPro: 3.401 ± 0.057	1.856SerGln: 1.856 ± 0.042	3.787SerArg: 3.787 ± 0.066	4.059SerSer: 4.059 ± 0.072	3.337SerThr: 3.337 ± 0.063	4.663SerVal: 4.663 ± 0.074	0.912SerTrp: 0.912 ± 0.03	1.653SerTyr: 1.653 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.442ThrAla: 6.442 ± 0.09	0.528ThrCys: 0.528 ± 0.022	3.096ThrAsp: 3.096 ± 0.063	2.797ThrGlu: 2.797 ± 0.054	2.036ThrPhe: 2.036 ± 0.046	5.437ThrGly: 5.437 ± 0.081	1.475ThrHis: 1.475 ± 0.037	2.796ThrIle: 2.796 ± 0.051	1.533ThrLys: 1.533 ± 0.037	6.986ThrLeu: 6.986 ± 0.091	1.274ThrMet: 1.274 ± 0.035	1.584ThrAsn: 1.584 ± 0.044	4.189ThrPro: 4.189 ± 0.07	2.219ThrGln: 2.219 ± 0.047	3.473ThrArg: 3.473 ± 0.062	3.313ThrSer: 3.313 ± 0.061	3.332ThrThr: 3.332 ± 0.064	4.577ThrVal: 4.577 ± 0.068	0.771ThrTrp: 0.771 ± 0.027	1.47ThrTyr: 1.47 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	7.831ValAla: 7.831 ± 0.112	0.834ValCys: 0.834 ± 0.026	3.479ValAsp: 3.479 ± 0.053	3.776ValGlu: 3.776 ± 0.063	2.763ValPhe: 2.763 ± 0.06	5.087ValGly: 5.087 ± 0.073	1.5ValHis: 1.5 ± 0.038	3.53ValIle: 3.53 ± 0.061	2.251ValLys: 2.251 ± 0.041	7.732ValLeu: 7.732 ± 0.104	1.959ValMet: 1.959 ± 0.041	1.908ValAsn: 1.908 ± 0.048	4.163ValPro: 4.163 ± 0.068	2.563ValGln: 2.563 ± 0.055	4.58ValArg: 4.58 ± 0.065	4.93ValSer: 4.93 ± 0.073	4.558ValThr: 4.558 ± 0.065	5.315ValVal: 5.315 ± 0.079	1.033ValTrp: 1.033 ± 0.033	1.447ValTyr: 1.447 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.2TrpAla: 1.2 ± 0.035	0.203TrpCys: 0.203 ± 0.015	0.705TrpAsp: 0.705 ± 0.027	0.585TrpGlu: 0.585 ± 0.023	0.554TrpPhe: 0.554 ± 0.021	1.01TrpGly: 1.01 ± 0.034	0.479TrpHis: 0.479 ± 0.022	0.669TrpIle: 0.669 ± 0.025	0.604TrpLys: 0.604 ± 0.026	1.804TrpLeu: 1.804 ± 0.043	0.38TrpMet: 0.38 ± 0.019	0.523TrpAsn: 0.523 ± 0.024	0.685TrpPro: 0.685 ± 0.025	0.774TrpGln: 0.774 ± 0.029	1.171TrpArg: 1.171 ± 0.033	0.88TrpSer: 0.88 ± 0.03	0.771TrpThr: 0.771 ± 0.028	0.902TrpVal: 0.902 ± 0.031	0.237TrpTrp: 0.237 ± 0.017	0.344TrpTyr: 0.344 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.573TyrAla: 2.573 ± 0.049	0.284TyrCys: 0.284 ± 0.016	1.495TyrAsp: 1.495 ± 0.037	1.149TyrGlu: 1.149 ± 0.033	0.943TyrPhe: 0.943 ± 0.035	2.279TyrGly: 2.279 ± 0.053	0.588TyrHis: 0.588 ± 0.022	0.952TyrIle: 0.952 ± 0.031	0.715TyrLys: 0.715 ± 0.028	2.255TyrLeu: 2.255 ± 0.048	0.483TyrMet: 0.483 ± 0.02	0.845TyrAsn: 0.845 ± 0.039	1.164TyrPro: 1.164 ± 0.032	1.0TyrGln: 1.0 ± 0.034	1.71TyrArg: 1.71 ± 0.049	1.403TyrSer: 1.403 ± 0.042	1.391TyrThr: 1.391 ± 0.041	1.663TyrVal: 1.663 ± 0.038	0.35TyrTrp: 0.35 ± 0.017	0.796TyrTyr: 0.796 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3497 proteins (1106584 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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