Amino acid dipepetide frequency for Pricia antarctica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.028AlaAla: 5.028 ± 0.086	0.579AlaCys: 0.579 ± 0.024	4.048AlaAsp: 4.048 ± 0.065	4.523AlaGlu: 4.523 ± 0.062	3.485AlaPhe: 3.485 ± 0.051	4.69AlaGly: 4.69 ± 0.069	1.3AlaHis: 1.3 ± 0.035	5.282AlaIle: 5.282 ± 0.071	4.669AlaLys: 4.669 ± 0.062	7.052AlaLeu: 7.052 ± 0.085	1.857AlaMet: 1.857 ± 0.044	3.446AlaAsn: 3.446 ± 0.056	2.267AlaPro: 2.267 ± 0.048	2.557AlaGln: 2.557 ± 0.046	2.363AlaArg: 2.363 ± 0.042	4.333AlaSer: 4.333 ± 0.072	3.865AlaThr: 3.865 ± 0.077	4.562AlaVal: 4.562 ± 0.068	0.715AlaTrp: 0.715 ± 0.024	2.622AlaTyr: 2.622 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.515CysAla: 0.515 ± 0.02	0.105CysCys: 0.105 ± 0.01	0.402CysAsp: 0.402 ± 0.018	0.426CysGlu: 0.426 ± 0.018	0.383CysPhe: 0.383 ± 0.018	0.587CysGly: 0.587 ± 0.023	0.213CysHis: 0.213 ± 0.014	0.555CysIle: 0.555 ± 0.019	0.413CysLys: 0.413 ± 0.02	0.644CysLeu: 0.644 ± 0.021	0.159CysMet: 0.159 ± 0.01	0.346CysAsn: 0.346 ± 0.019	0.317CysPro: 0.317 ± 0.018	0.224CysGln: 0.224 ± 0.011	0.256CysArg: 0.256 ± 0.015	0.52CysSer: 0.52 ± 0.021	0.437CysThr: 0.437 ± 0.025	0.414CysVal: 0.414 ± 0.016	0.07CysTrp: 0.07 ± 0.007	0.291CysTyr: 0.291 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.371AspAla: 4.371 ± 0.067	0.415AspCys: 0.415 ± 0.017	3.217AspAsp: 3.217 ± 0.063	3.701AspGlu: 3.701 ± 0.055	3.737AspPhe: 3.737 ± 0.061	4.657AspGly: 4.657 ± 0.102	1.063AspHis: 1.063 ± 0.03	4.502AspIle: 4.502 ± 0.069	3.857AspLys: 3.857 ± 0.067	5.29AspLeu: 5.29 ± 0.069	1.365AspMet: 1.365 ± 0.033	2.998AspAsn: 2.998 ± 0.054	2.064AspPro: 2.064 ± 0.05	1.695AspGln: 1.695 ± 0.034	2.538AspArg: 2.538 ± 0.048	3.534AspSer: 3.534 ± 0.053	3.413AspThr: 3.413 ± 0.052	3.704AspVal: 3.704 ± 0.054	0.88AspTrp: 0.88 ± 0.025	2.722AspTyr: 2.722 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.53GluAla: 4.53 ± 0.058	0.324GluCys: 0.324 ± 0.017	3.62GluAsp: 3.62 ± 0.051	4.607GluGlu: 4.607 ± 0.078	2.784GluPhe: 2.784 ± 0.044	4.246GluGly: 4.246 ± 0.061	1.289GluHis: 1.289 ± 0.034	5.084GluIle: 5.084 ± 0.068	5.774GluLys: 5.774 ± 0.077	5.907GluLeu: 5.907 ± 0.079	1.725GluMet: 1.725 ± 0.035	4.447GluAsn: 4.447 ± 0.062	1.855GluPro: 1.855 ± 0.043	2.31GluGln: 2.31 ± 0.047	2.878GluArg: 2.878 ± 0.048	3.26GluSer: 3.26 ± 0.05	3.633GluThr: 3.633 ± 0.052	4.318GluVal: 4.318 ± 0.059	0.72GluTrp: 0.72 ± 0.024	2.328GluTyr: 2.328 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.175PheAla: 3.175 ± 0.047	0.401PheCys: 0.401 ± 0.019	3.368PheAsp: 3.368 ± 0.051	3.322PheGlu: 3.322 ± 0.049	2.66PhePhe: 2.66 ± 0.054	3.843PheGly: 3.843 ± 0.051	0.862PheHis: 0.862 ± 0.026	3.35PheIle: 3.35 ± 0.058	3.255PheLys: 3.255 ± 0.054	4.878PheLeu: 4.878 ± 0.072	1.17PheMet: 1.17 ± 0.03	2.613PheAsn: 2.613 ± 0.048	1.865PhePro: 1.865 ± 0.034	1.557PheGln: 1.557 ± 0.035	1.934PheArg: 1.934 ± 0.034	3.617PheSer: 3.617 ± 0.059	3.0PheThr: 3.0 ± 0.045	2.913PheVal: 2.913 ± 0.049	0.627PheTrp: 0.627 ± 0.023	2.004PheTyr: 2.004 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.738GlyAla: 4.738 ± 0.088	0.635GlyCys: 0.635 ± 0.031	3.937GlyAsp: 3.937 ± 0.064	4.062GlyGlu: 4.062 ± 0.057	3.737GlyPhe: 3.737 ± 0.063	5.002GlyGly: 5.002 ± 0.101	1.371GlyHis: 1.371 ± 0.03	5.723GlyIle: 5.723 ± 0.082	5.342GlyLys: 5.342 ± 0.072	6.373GlyLeu: 6.373 ± 0.077	1.922GlyMet: 1.922 ± 0.046	3.834GlyAsn: 3.834 ± 0.071	1.815GlyPro: 1.815 ± 0.059	2.216GlyGln: 2.216 ± 0.045	2.667GlyArg: 2.667 ± 0.049	4.469GlySer: 4.469 ± 0.062	4.33GlyThr: 4.33 ± 0.075	4.371GlyVal: 4.371 ± 0.066	0.907GlyTrp: 0.907 ± 0.025	3.038GlyTyr: 3.038 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.116HisAla: 1.116 ± 0.03	0.201HisCys: 0.201 ± 0.012	0.868HisAsp: 0.868 ± 0.026	1.07HisGlu: 1.07 ± 0.031	1.159HisPhe: 1.159 ± 0.032	1.269HisGly: 1.269 ± 0.033	0.512HisHis: 0.512 ± 0.02	1.42HisIle: 1.42 ± 0.034	1.138HisLys: 1.138 ± 0.032	1.9HisLeu: 1.9 ± 0.035	0.424HisMet: 0.424 ± 0.02	0.887HisAsn: 0.887 ± 0.026	1.129HisPro: 1.129 ± 0.034	0.712HisGln: 0.712 ± 0.024	0.877HisArg: 0.877 ± 0.027	1.126HisSer: 1.126 ± 0.028	1.098HisThr: 1.098 ± 0.03	0.989HisVal: 0.989 ± 0.028	0.276HisTrp: 0.276 ± 0.016	0.789HisTyr: 0.789 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.626IleAla: 5.626 ± 0.08	0.603IleCys: 0.603 ± 0.022	4.799IleAsp: 4.799 ± 0.06	4.716IleGlu: 4.716 ± 0.06	3.337IlePhe: 3.337 ± 0.06	5.249IleGly: 5.249 ± 0.067	1.326IleHis: 1.326 ± 0.031	4.833IleIle: 4.833 ± 0.076	4.752IleLys: 4.752 ± 0.071	6.689IleLeu: 6.689 ± 0.09	1.367IleMet: 1.367 ± 0.031	3.489IleAsn: 3.489 ± 0.05	3.237IlePro: 3.237 ± 0.048	2.257IleGln: 2.257 ± 0.04	2.967IleArg: 2.967 ± 0.051	4.992IleSer: 4.992 ± 0.06	4.212IleThr: 4.212 ± 0.063	4.522IleVal: 4.522 ± 0.06	0.724IleTrp: 0.724 ± 0.023	2.462IleTyr: 2.462 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.952LysAla: 4.952 ± 0.062	0.293LysCys: 0.293 ± 0.015	4.251LysAsp: 4.251 ± 0.058	5.397LysGlu: 5.397 ± 0.076	2.66LysPhe: 2.66 ± 0.048	4.685LysGly: 4.685 ± 0.072	1.213LysHis: 1.213 ± 0.036	5.353LysIle: 5.353 ± 0.075	6.37LysLys: 6.37 ± 0.084	5.937LysLeu: 5.937 ± 0.077	2.015LysMet: 2.015 ± 0.043	4.568LysAsn: 4.568 ± 0.059	2.276LysPro: 2.276 ± 0.04	2.288LysGln: 2.288 ± 0.044	3.066LysArg: 3.066 ± 0.053	4.188LysSer: 4.188 ± 0.062	4.243LysThr: 4.243 ± 0.054	4.428LysVal: 4.428 ± 0.065	0.839LysTrp: 0.839 ± 0.026	2.654LysTyr: 2.654 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.551LeuAla: 6.551 ± 0.08	0.699LeuCys: 0.699 ± 0.024	5.458LeuAsp: 5.458 ± 0.068	6.177LeuGlu: 6.177 ± 0.083	4.787LeuPhe: 4.787 ± 0.075	6.477LeuGly: 6.477 ± 0.079	1.635LeuHis: 1.635 ± 0.038	6.22LeuIle: 6.22 ± 0.09	7.192LeuLys: 7.192 ± 0.087	8.929LeuLeu: 8.929 ± 0.129	2.217LeuMet: 2.217 ± 0.041	4.952LeuAsn: 4.952 ± 0.073	3.871LeuPro: 3.871 ± 0.056	3.35LeuGln: 3.35 ± 0.051	3.774LeuArg: 3.774 ± 0.049	6.35LeuSer: 6.35 ± 0.07	5.155LeuThr: 5.155 ± 0.074	5.68LeuVal: 5.68 ± 0.072	0.963LeuTrp: 0.963 ± 0.031	3.133LeuTyr: 3.133 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.133MetAla: 2.133 ± 0.043	0.135MetCys: 0.135 ± 0.01	1.528MetAsp: 1.528 ± 0.031	1.73MetGlu: 1.73 ± 0.041	0.86MetPhe: 0.86 ± 0.029	1.865MetGly: 1.865 ± 0.043	0.488MetHis: 0.488 ± 0.018	1.41MetIle: 1.41 ± 0.037	2.064MetLys: 2.064 ± 0.04	2.053MetLeu: 2.053 ± 0.045	0.643MetMet: 0.643 ± 0.028	1.237MetAsn: 1.237 ± 0.034	0.997MetPro: 0.997 ± 0.025	0.915MetGln: 0.915 ± 0.025	0.977MetArg: 0.977 ± 0.028	1.227MetSer: 1.227 ± 0.032	1.255MetThr: 1.255 ± 0.034	1.637MetVal: 1.637 ± 0.04	0.184MetTrp: 0.184 ± 0.012	0.704MetTyr: 0.704 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.769AsnAla: 3.769 ± 0.052	0.403AsnCys: 0.403 ± 0.019	3.1AsnAsp: 3.1 ± 0.062	3.138AsnGlu: 3.138 ± 0.045	2.734AsnPhe: 2.734 ± 0.052	4.095AsnGly: 4.095 ± 0.071	0.999AsnHis: 0.999 ± 0.029	3.777AsnIle: 3.777 ± 0.053	3.153AsnLys: 3.153 ± 0.057	4.971AsnLeu: 4.971 ± 0.069	1.191AsnMet: 1.191 ± 0.031	2.619AsnAsn: 2.619 ± 0.055	2.771AsnPro: 2.771 ± 0.052	1.778AsnGln: 1.778 ± 0.036	2.374AsnArg: 2.374 ± 0.046	3.308AsnSer: 3.308 ± 0.058	3.324AsnThr: 3.324 ± 0.059	3.168AsnVal: 3.168 ± 0.05	0.684AsnTrp: 0.684 ± 0.025	2.242AsnTyr: 2.242 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.192ProAla: 2.192 ± 0.041	0.217ProCys: 0.217 ± 0.013	2.644ProAsp: 2.644 ± 0.055	3.245ProGlu: 3.245 ± 0.046	2.01ProPhe: 2.01 ± 0.039	2.351ProGly: 2.351 ± 0.05	0.699ProHis: 0.699 ± 0.023	2.769ProIle: 2.769 ± 0.041	2.704ProLys: 2.704 ± 0.052	3.331ProLeu: 3.331 ± 0.048	0.927ProMet: 0.927 ± 0.027	2.12ProAsn: 2.12 ± 0.04	1.084ProPro: 1.084 ± 0.032	1.26ProGln: 1.26 ± 0.04	1.126ProArg: 1.126 ± 0.033	2.357ProSer: 2.357 ± 0.04	2.06ProThr: 2.06 ± 0.048	2.581ProVal: 2.581 ± 0.043	0.458ProTrp: 0.458 ± 0.019	1.47ProTyr: 1.47 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.079GlnAla: 2.079 ± 0.042	0.181GlnCys: 0.181 ± 0.013	1.7GlnAsp: 1.7 ± 0.038	2.26GlnGlu: 2.26 ± 0.041	1.601GlnPhe: 1.601 ± 0.035	2.138GlnGly: 2.138 ± 0.049	0.665GlnHis: 0.665 ± 0.025	2.45GlnIle: 2.45 ± 0.043	2.888GlnLys: 2.888 ± 0.053	3.407GlnLeu: 3.407 ± 0.055	0.889GlnMet: 0.889 ± 0.025	2.026GlnAsn: 2.026 ± 0.035	1.077GlnPro: 1.077 ± 0.027	1.39GlnGln: 1.39 ± 0.036	1.476GlnArg: 1.476 ± 0.036	1.908GlnSer: 1.908 ± 0.041	1.721GlnThr: 1.721 ± 0.038	2.019GlnVal: 2.019 ± 0.037	0.446GlnTrp: 0.446 ± 0.019	1.23GlnTyr: 1.23 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.424ArgAla: 2.424 ± 0.05	0.227ArgCys: 0.227 ± 0.014	2.132ArgAsp: 2.132 ± 0.039	2.562ArgGlu: 2.562 ± 0.045	2.186ArgPhe: 2.186 ± 0.035	2.272ArgGly: 2.272 ± 0.049	0.808ArgHis: 0.808 ± 0.027	3.224ArgIle: 3.224 ± 0.051	3.216ArgLys: 3.216 ± 0.045	3.766ArgLeu: 3.766 ± 0.054	1.12ArgMet: 1.12 ± 0.029	2.402ArgAsn: 2.402 ± 0.044	1.551ArgPro: 1.551 ± 0.03	1.37ArgGln: 1.37 ± 0.032	1.633ArgArg: 1.633 ± 0.042	2.293ArgSer: 2.293 ± 0.046	2.242ArgThr: 2.242 ± 0.044	2.203ArgVal: 2.203 ± 0.04	0.449ArgTrp: 0.449 ± 0.017	1.772ArgTyr: 1.772 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.066SerAla: 4.066 ± 0.061	0.58SerCys: 0.58 ± 0.021	3.788SerAsp: 3.788 ± 0.053	4.209SerGlu: 4.209 ± 0.056	3.393SerPhe: 3.393 ± 0.052	4.795SerGly: 4.795 ± 0.074	1.158SerHis: 1.158 ± 0.031	4.616SerIle: 4.616 ± 0.06	4.256SerLys: 4.256 ± 0.07	5.951SerLeu: 5.951 ± 0.082	1.303SerMet: 1.303 ± 0.032	3.105SerAsn: 3.105 ± 0.055	2.327SerPro: 2.327 ± 0.05	1.917SerGln: 1.917 ± 0.038	2.354SerArg: 2.354 ± 0.044	3.95SerSer: 3.95 ± 0.063	3.411SerThr: 3.411 ± 0.049	4.078SerVal: 4.078 ± 0.056	0.7SerTrp: 0.7 ± 0.023	2.519SerTyr: 2.519 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.135ThrAla: 4.135 ± 0.071	0.372ThrCys: 0.372 ± 0.021	3.842ThrAsp: 3.842 ± 0.064	3.652ThrGlu: 3.652 ± 0.045	2.81ThrPhe: 2.81 ± 0.049	4.482ThrGly: 4.482 ± 0.075	1.019ThrHis: 1.019 ± 0.025	4.236ThrIle: 4.236 ± 0.064	3.383ThrLys: 3.383 ± 0.049	5.462ThrLeu: 5.462 ± 0.064	1.108ThrMet: 1.108 ± 0.032	2.626ThrAsn: 2.626 ± 0.059	2.516ThrPro: 2.516 ± 0.056	1.836ThrGln: 1.836 ± 0.04	1.791ThrArg: 1.791 ± 0.037	3.661ThrSer: 3.661 ± 0.057	3.203ThrThr: 3.203 ± 0.057	3.974ThrVal: 3.974 ± 0.075	0.608ThrTrp: 0.608 ± 0.021	2.248ThrTyr: 2.248 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.528ValAla: 4.528 ± 0.064	0.505ValCys: 0.505 ± 0.022	3.845ValAsp: 3.845 ± 0.063	3.808ValGlu: 3.808 ± 0.053	3.274ValPhe: 3.274 ± 0.047	4.092ValGly: 4.092 ± 0.062	1.212ValHis: 1.212 ± 0.031	4.261ValIle: 4.261 ± 0.058	4.019ValLys: 4.019 ± 0.06	6.322ValLeu: 6.322 ± 0.06	1.491ValMet: 1.491 ± 0.034	3.162ValAsn: 3.162 ± 0.054	2.588ValPro: 2.588 ± 0.045	2.015ValGln: 2.015 ± 0.034	2.411ValArg: 2.411 ± 0.044	4.332ValSer: 4.332 ± 0.061	3.568ValThr: 3.568 ± 0.072	4.277ValVal: 4.277 ± 0.068	0.66ValTrp: 0.66 ± 0.024	2.275ValTyr: 2.275 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.742TrpAla: 0.742 ± 0.021	0.086TrpCys: 0.086 ± 0.008	0.727TrpAsp: 0.727 ± 0.027	0.741TrpGlu: 0.741 ± 0.023	0.584TrpPhe: 0.584 ± 0.023	0.822TrpGly: 0.822 ± 0.023	0.289TrpHis: 0.289 ± 0.015	0.756TrpIle: 0.756 ± 0.025	0.811TrpLys: 0.811 ± 0.028	1.069TrpLeu: 1.069 ± 0.029	0.394TrpMet: 0.394 ± 0.018	0.687TrpAsn: 0.687 ± 0.022	0.387TrpPro: 0.387 ± 0.018	0.489TrpGln: 0.489 ± 0.017	0.507TrpArg: 0.507 ± 0.018	0.673TrpSer: 0.673 ± 0.021	0.57TrpThr: 0.57 ± 0.023	0.657TrpVal: 0.657 ± 0.023	0.194TrpTrp: 0.194 ± 0.012	0.427TrpTyr: 0.427 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.572TyrAla: 2.572 ± 0.044	0.315TyrCys: 0.315 ± 0.016	2.449TyrAsp: 2.449 ± 0.046	2.293TyrGlu: 2.293 ± 0.041	2.234TyrPhe: 2.234 ± 0.044	2.871TyrGly: 2.871 ± 0.049	0.839TyrHis: 0.839 ± 0.028	2.336TyrIle: 2.336 ± 0.041	2.422TyrLys: 2.422 ± 0.043	3.637TyrLeu: 3.637 ± 0.058	0.755TyrMet: 0.755 ± 0.026	2.036TyrAsn: 2.036 ± 0.045	1.613TyrPro: 1.613 ± 0.036	1.416TyrGln: 1.416 ± 0.031	1.885TyrArg: 1.885 ± 0.037	2.377TyrSer: 2.377 ± 0.041	2.223TyrThr: 2.223 ± 0.05	2.147TyrVal: 2.147 ± 0.037	0.508TyrTrp: 0.508 ± 0.021	1.582TyrTyr: 1.582 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4172 proteins (1420157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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