Amino acid dipepetide frequency for Vibrio phage vB_VhaM_VH-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.193AlaAla: 3.193 ± 0.433
0.448AlaCys: 0.448 ± 0.195
2.969AlaAsp: 2.969 ± 0.416
2.969AlaGlu: 2.969 ± 0.42
2.129AlaPhe: 2.129 ± 0.358
3.081AlaGly: 3.081 ± 0.394
0.84AlaHis: 0.84 ± 0.214
3.922AlaIle: 3.922 ± 0.541
4.874AlaLys: 4.874 ± 0.534
4.314AlaLeu: 4.314 ± 0.459
1.008AlaMet: 1.008 ± 0.249
3.249AlaAsn: 3.249 ± 0.464
1.008AlaPro: 1.008 ± 0.245
1.569AlaGln: 1.569 ± 0.317
2.801AlaArg: 2.801 ± 0.397
4.09AlaSer: 4.09 ± 0.547
3.53AlaThr: 3.53 ± 0.412
3.362AlaVal: 3.362 ± 0.578
0.672AlaTrp: 0.672 ± 0.199
2.857AlaTyr: 2.857 ± 0.348
0.0AlaXaa: 0.0 ± 0.0
Cys
0.56CysAla: 0.56 ± 0.173
0.224CysCys: 0.224 ± 0.122
0.728CysAsp: 0.728 ± 0.215
0.56CysGlu: 0.56 ± 0.178
0.616CysPhe: 0.616 ± 0.191
0.616CysGly: 0.616 ± 0.191
0.336CysHis: 0.336 ± 0.125
0.672CysIle: 0.672 ± 0.228
0.896CysLys: 0.896 ± 0.29
0.896CysLeu: 0.896 ± 0.24
0.224CysMet: 0.224 ± 0.103
0.672CysAsn: 0.672 ± 0.185
0.728CysPro: 0.728 ± 0.269
0.392CysGln: 0.392 ± 0.141
0.448CysArg: 0.448 ± 0.172
1.121CysSer: 1.121 ± 0.27
0.952CysThr: 0.952 ± 0.287
0.84CysVal: 0.84 ± 0.197
0.224CysTrp: 0.224 ± 0.11
0.504CysTyr: 0.504 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
2.857AspAla: 2.857 ± 0.407
0.56AspCys: 0.56 ± 0.178
4.314AspAsp: 4.314 ± 0.546
4.706AspGlu: 4.706 ± 0.608
2.969AspPhe: 2.969 ± 0.377
5.378AspGly: 5.378 ± 0.561
0.56AspHis: 0.56 ± 0.187
5.098AspIle: 5.098 ± 0.642
5.715AspLys: 5.715 ± 0.591
6.443AspLeu: 6.443 ± 0.445
1.905AspMet: 1.905 ± 0.332
4.314AspAsn: 4.314 ± 0.56
1.457AspPro: 1.457 ± 0.269
0.84AspGln: 0.84 ± 0.248
2.633AspArg: 2.633 ± 0.361
4.09AspSer: 4.09 ± 0.354
3.81AspThr: 3.81 ± 0.451
4.594AspVal: 4.594 ± 0.538
1.513AspTrp: 1.513 ± 0.272
3.81AspTyr: 3.81 ± 0.535
0.0AspXaa: 0.0 ± 0.0
Glu
3.754GluAla: 3.754 ± 0.485
0.952GluCys: 0.952 ± 0.2
4.65GluAsp: 4.65 ± 0.565
4.65GluGlu: 4.65 ± 0.593
2.689GluPhe: 2.689 ± 0.356
4.034GluGly: 4.034 ± 0.564
1.401GluHis: 1.401 ± 0.309
3.81GluIle: 3.81 ± 0.478
4.65GluLys: 4.65 ± 0.659
7.395GluLeu: 7.395 ± 0.666
2.241GluMet: 2.241 ± 0.319
3.418GluAsn: 3.418 ± 0.427
1.905GluPro: 1.905 ± 0.305
2.913GluGln: 2.913 ± 0.456
2.913GluArg: 2.913 ± 0.364
4.986GluSer: 4.986 ± 0.516
3.137GluThr: 3.137 ± 0.369
5.042GluVal: 5.042 ± 0.456
1.513GluTrp: 1.513 ± 0.35
3.586GluTyr: 3.586 ± 0.405
0.0GluXaa: 0.0 ± 0.0
Phe
2.073PheAla: 2.073 ± 0.354
0.448PheCys: 0.448 ± 0.147
2.969PheAsp: 2.969 ± 0.4
2.633PheGlu: 2.633 ± 0.374
1.289PhePhe: 1.289 ± 0.268
2.969PheGly: 2.969 ± 0.373
0.504PheHis: 0.504 ± 0.191
2.409PheIle: 2.409 ± 0.362
2.633PheLys: 2.633 ± 0.35
2.633PheLeu: 2.633 ± 0.372
1.064PheMet: 1.064 ± 0.269
3.137PheAsn: 3.137 ± 0.323
1.233PhePro: 1.233 ± 0.238
0.728PheGln: 0.728 ± 0.221
1.793PheArg: 1.793 ± 0.331
3.025PheSer: 3.025 ± 0.399
3.081PheThr: 3.081 ± 0.428
1.849PheVal: 1.849 ± 0.347
0.392PheTrp: 0.392 ± 0.174
1.457PheTyr: 1.457 ± 0.23
0.0PheXaa: 0.0 ± 0.0
Gly
3.249GlyAla: 3.249 ± 0.53
1.233GlyCys: 1.233 ± 0.289
3.866GlyAsp: 3.866 ± 0.555
4.482GlyGlu: 4.482 ± 0.521
2.857GlyPhe: 2.857 ± 0.439
4.762GlyGly: 4.762 ± 0.799
0.728GlyHis: 0.728 ± 0.22
3.642GlyIle: 3.642 ± 0.583
5.547GlyLys: 5.547 ± 0.568
4.818GlyLeu: 4.818 ± 0.508
1.401GlyMet: 1.401 ± 0.237
3.922GlyAsn: 3.922 ± 0.497
0.0GlyPro: 0.0 ± 0.0
2.297GlyGln: 2.297 ± 0.307
3.418GlyArg: 3.418 ± 0.442
4.986GlySer: 4.986 ± 0.502
3.754GlyThr: 3.754 ± 0.469
5.042GlyVal: 5.042 ± 0.551
1.177GlyTrp: 1.177 ± 0.241
3.642GlyTyr: 3.642 ± 0.498
0.0GlyXaa: 0.0 ± 0.0
His
0.504HisAla: 0.504 ± 0.157
0.336HisCys: 0.336 ± 0.12
1.064HisAsp: 1.064 ± 0.23
0.84HisGlu: 0.84 ± 0.216
1.233HisPhe: 1.233 ± 0.292
1.569HisGly: 1.569 ± 0.451
0.504HisHis: 0.504 ± 0.159
0.896HisIle: 0.896 ± 0.248
1.849HisLys: 1.849 ± 0.394
1.737HisLeu: 1.737 ± 0.327
0.56HisMet: 0.56 ± 0.156
1.233HisAsn: 1.233 ± 0.253
0.84HisPro: 0.84 ± 0.207
0.336HisGln: 0.336 ± 0.18
0.84HisArg: 0.84 ± 0.189
1.737HisSer: 1.737 ± 0.304
1.121HisThr: 1.121 ± 0.229
1.233HisVal: 1.233 ± 0.252
0.28HisTrp: 0.28 ± 0.12
0.84HisTyr: 0.84 ± 0.214
0.0HisXaa: 0.0 ± 0.0
Ile
4.258IleAla: 4.258 ± 0.447
0.504IleCys: 0.504 ± 0.155
5.266IleAsp: 5.266 ± 0.598
5.547IleGlu: 5.547 ± 0.6
2.297IlePhe: 2.297 ± 0.313
2.185IleGly: 2.185 ± 0.405
1.345IleHis: 1.345 ± 0.266
2.577IleIle: 2.577 ± 0.37
4.93IleLys: 4.93 ± 0.535
4.146IleLeu: 4.146 ± 0.548
1.289IleMet: 1.289 ± 0.248
4.594IleAsn: 4.594 ± 0.539
2.745IlePro: 2.745 ± 0.356
1.961IleGln: 1.961 ± 0.314
1.793IleArg: 1.793 ± 0.301
4.314IleSer: 4.314 ± 0.502
4.202IleThr: 4.202 ± 0.487
4.146IleVal: 4.146 ± 0.521
0.672IleTrp: 0.672 ± 0.171
2.521IleTyr: 2.521 ± 0.329
0.0IleXaa: 0.0 ± 0.0
Lys
4.594LysAla: 4.594 ± 0.542
0.784LysCys: 0.784 ± 0.28
6.779LysAsp: 6.779 ± 0.6
6.555LysGlu: 6.555 ± 0.668
2.745LysPhe: 2.745 ± 0.384
4.594LysGly: 4.594 ± 0.495
2.241LysHis: 2.241 ± 0.388
4.874LysIle: 4.874 ± 0.536
5.322LysLys: 5.322 ± 0.637
6.387LysLeu: 6.387 ± 0.636
1.905LysMet: 1.905 ± 0.375
4.482LysAsn: 4.482 ± 0.446
2.297LysPro: 2.297 ± 0.352
2.689LysGln: 2.689 ± 0.391
3.698LysArg: 3.698 ± 0.589
5.771LysSer: 5.771 ± 0.588
3.922LysThr: 3.922 ± 0.507
4.482LysVal: 4.482 ± 0.43
1.121LysTrp: 1.121 ± 0.244
4.37LysTyr: 4.37 ± 0.447
0.0LysXaa: 0.0 ± 0.0
Leu
5.378LeuAla: 5.378 ± 0.538
0.896LeuCys: 0.896 ± 0.236
5.21LeuAsp: 5.21 ± 0.514
6.163LeuGlu: 6.163 ± 0.595
2.521LeuPhe: 2.521 ± 0.419
4.258LeuGly: 4.258 ± 0.682
1.569LeuHis: 1.569 ± 0.367
4.762LeuIle: 4.762 ± 0.527
6.891LeuLys: 6.891 ± 0.607
6.387LeuLeu: 6.387 ± 0.646
1.849LeuMet: 1.849 ± 0.289
4.93LeuAsn: 4.93 ± 0.556
3.418LeuPro: 3.418 ± 0.559
2.969LeuGln: 2.969 ± 0.401
3.081LeuArg: 3.081 ± 0.462
7.227LeuSer: 7.227 ± 0.734
4.314LeuThr: 4.314 ± 0.562
4.706LeuVal: 4.706 ± 0.582
0.896LeuTrp: 0.896 ± 0.218
3.306LeuTyr: 3.306 ± 0.43
0.0LeuXaa: 0.0 ± 0.0
Met
1.457MetAla: 1.457 ± 0.299
0.392MetCys: 0.392 ± 0.158
1.177MetAsp: 1.177 ± 0.279
1.401MetGlu: 1.401 ± 0.273
1.008MetPhe: 1.008 ± 0.244
1.345MetGly: 1.345 ± 0.253
0.504MetHis: 0.504 ± 0.149
1.345MetIle: 1.345 ± 0.288
1.737MetLys: 1.737 ± 0.336
1.737MetLeu: 1.737 ± 0.31
0.672MetMet: 0.672 ± 0.311
1.345MetAsn: 1.345 ± 0.259
1.008MetPro: 1.008 ± 0.285
1.233MetGln: 1.233 ± 0.299
0.784MetArg: 0.784 ± 0.218
2.129MetSer: 2.129 ± 0.327
2.689MetThr: 2.689 ± 0.376
1.401MetVal: 1.401 ± 0.343
0.168MetTrp: 0.168 ± 0.107
0.84MetTyr: 0.84 ± 0.186
0.0MetXaa: 0.0 ± 0.0
Asn
3.081AsnAla: 3.081 ± 0.421
0.728AsnCys: 0.728 ± 0.284
3.418AsnAsp: 3.418 ± 0.56
3.866AsnGlu: 3.866 ± 0.456
1.905AsnPhe: 1.905 ± 0.289
4.986AsnGly: 4.986 ± 0.527
1.513AsnHis: 1.513 ± 0.326
4.706AsnIle: 4.706 ± 0.594
5.322AsnLys: 5.322 ± 0.609
4.034AsnLeu: 4.034 ± 0.494
1.064AsnMet: 1.064 ± 0.257
4.314AsnAsn: 4.314 ± 0.615
2.129AsnPro: 2.129 ± 0.388
1.513AsnGln: 1.513 ± 0.313
2.913AsnArg: 2.913 ± 0.351
3.642AsnSer: 3.642 ± 0.549
5.154AsnThr: 5.154 ± 0.614
3.306AsnVal: 3.306 ± 0.336
0.616AsnTrp: 0.616 ± 0.168
3.081AsnTyr: 3.081 ± 0.409
0.0AsnXaa: 0.0 ± 0.0
Pro
1.177ProAla: 1.177 ± 0.276
0.224ProCys: 0.224 ± 0.109
1.849ProAsp: 1.849 ± 0.358
2.689ProGlu: 2.689 ± 0.363
1.064ProPhe: 1.064 ± 0.231
0.0ProGly: 0.0 ± 0.0
0.504ProHis: 0.504 ± 0.143
2.017ProIle: 2.017 ± 0.245
2.969ProLys: 2.969 ± 0.484
2.129ProLeu: 2.129 ± 0.357
1.064ProMet: 1.064 ± 0.218
1.457ProAsn: 1.457 ± 0.32
0.616ProPro: 0.616 ± 0.16
0.84ProGln: 0.84 ± 0.233
1.289ProArg: 1.289 ± 0.298
2.689ProSer: 2.689 ± 0.396
2.185ProThr: 2.185 ± 0.419
2.353ProVal: 2.353 ± 0.326
0.0ProTrp: 0.0 ± 0.0
1.961ProTyr: 1.961 ± 0.315
0.0ProXaa: 0.0 ± 0.0
Gln
1.905GlnAla: 1.905 ± 0.34
0.28GlnCys: 0.28 ± 0.121
2.633GlnAsp: 2.633 ± 0.312
2.801GlnGlu: 2.801 ± 0.47
1.008GlnPhe: 1.008 ± 0.251
2.353GlnGly: 2.353 ± 0.384
0.672GlnHis: 0.672 ± 0.217
1.177GlnIle: 1.177 ± 0.263
2.073GlnLys: 2.073 ± 0.32
3.137GlnLeu: 3.137 ± 0.508
0.784GlnMet: 0.784 ± 0.21
1.569GlnAsn: 1.569 ± 0.319
0.84GlnPro: 0.84 ± 0.232
1.401GlnGln: 1.401 ± 0.305
1.345GlnArg: 1.345 ± 0.257
1.681GlnSer: 1.681 ± 0.292
2.017GlnThr: 2.017 ± 0.307
2.241GlnVal: 2.241 ± 0.296
0.84GlnTrp: 0.84 ± 0.261
1.569GlnTyr: 1.569 ± 0.245
0.0GlnXaa: 0.0 ± 0.0
Arg
2.017ArgAla: 2.017 ± 0.329
0.504ArgCys: 0.504 ± 0.202
2.465ArgAsp: 2.465 ± 0.405
2.633ArgGlu: 2.633 ± 0.344
2.129ArgPhe: 2.129 ± 0.302
4.09ArgGly: 4.09 ± 0.659
1.008ArgHis: 1.008 ± 0.25
2.017ArgIle: 2.017 ± 0.375
3.025ArgLys: 3.025 ± 0.426
4.034ArgLeu: 4.034 ± 0.48
1.121ArgMet: 1.121 ± 0.23
2.297ArgAsn: 2.297 ± 0.337
1.345ArgPro: 1.345 ± 0.268
1.345ArgGln: 1.345 ± 0.366
1.681ArgArg: 1.681 ± 0.313
2.409ArgSer: 2.409 ± 0.323
2.577ArgThr: 2.577 ± 0.391
4.034ArgVal: 4.034 ± 0.494
0.56ArgTrp: 0.56 ± 0.161
1.737ArgTyr: 1.737 ± 0.276
0.0ArgXaa: 0.0 ± 0.0
Ser
3.418SerAla: 3.418 ± 0.452
0.896SerCys: 0.896 ± 0.228
4.706SerAsp: 4.706 ± 0.487
5.154SerGlu: 5.154 ± 0.517
2.969SerPhe: 2.969 ± 0.38
5.378SerGly: 5.378 ± 0.555
1.233SerHis: 1.233 ± 0.307
5.154SerIle: 5.154 ± 0.604
6.107SerLys: 6.107 ± 0.636
4.762SerLeu: 4.762 ± 0.663
2.017SerMet: 2.017 ± 0.333
4.202SerAsn: 4.202 ± 0.496
2.633SerPro: 2.633 ± 0.477
2.521SerGln: 2.521 ± 0.373
3.193SerArg: 3.193 ± 0.389
5.603SerSer: 5.603 ± 0.706
3.081SerThr: 3.081 ± 0.397
4.482SerVal: 4.482 ± 0.596
0.784SerTrp: 0.784 ± 0.208
4.93SerTyr: 4.93 ± 0.598
0.0SerXaa: 0.0 ± 0.0
Thr
3.081ThrAla: 3.081 ± 0.473
0.784ThrCys: 0.784 ± 0.2
3.754ThrAsp: 3.754 ± 0.453
2.913ThrGlu: 2.913 ± 0.467
1.849ThrPhe: 1.849 ± 0.285
4.37ThrGly: 4.37 ± 0.591
1.569ThrHis: 1.569 ± 0.296
4.258ThrIle: 4.258 ± 0.461
4.202ThrLys: 4.202 ± 0.372
4.93ThrLeu: 4.93 ± 0.456
1.064ThrMet: 1.064 ± 0.269
4.034ThrAsn: 4.034 ± 0.554
1.905ThrPro: 1.905 ± 0.345
2.633ThrGln: 2.633 ± 0.319
2.241ThrArg: 2.241 ± 0.375
4.258ThrSer: 4.258 ± 0.471
3.866ThrThr: 3.866 ± 0.486
4.706ThrVal: 4.706 ± 0.603
0.728ThrTrp: 0.728 ± 0.192
2.689ThrTyr: 2.689 ± 0.415
0.0ThrXaa: 0.0 ± 0.0
Val
3.922ValAla: 3.922 ± 0.422
0.896ValCys: 0.896 ± 0.215
4.706ValAsp: 4.706 ± 0.526
4.93ValGlu: 4.93 ± 0.556
2.633ValPhe: 2.633 ± 0.395
4.594ValGly: 4.594 ± 0.636
1.457ValHis: 1.457 ± 0.276
4.426ValIle: 4.426 ± 0.51
5.939ValLys: 5.939 ± 0.468
4.706ValLeu: 4.706 ± 0.532
1.401ValMet: 1.401 ± 0.269
4.146ValAsn: 4.146 ± 0.409
1.513ValPro: 1.513 ± 0.331
1.961ValGln: 1.961 ± 0.356
2.913ValArg: 2.913 ± 0.39
5.322ValSer: 5.322 ± 0.505
2.745ValThr: 2.745 ± 0.557
5.098ValVal: 5.098 ± 0.635
1.233ValTrp: 1.233 ± 0.281
2.521ValTyr: 2.521 ± 0.376
0.0ValXaa: 0.0 ± 0.0
Trp
0.448TrpAla: 0.448 ± 0.143
0.28TrpCys: 0.28 ± 0.144
1.064TrpAsp: 1.064 ± 0.214
0.952TrpGlu: 0.952 ± 0.244
0.616TrpPhe: 0.616 ± 0.192
0.616TrpGly: 0.616 ± 0.201
0.392TrpHis: 0.392 ± 0.146
0.896TrpIle: 0.896 ± 0.202
1.121TrpLys: 1.121 ± 0.248
2.073TrpLeu: 2.073 ± 0.28
0.392TrpMet: 0.392 ± 0.147
0.784TrpAsn: 0.784 ± 0.188
0.0TrpPro: 0.0 ± 0.0
0.504TrpGln: 0.504 ± 0.192
0.56TrpArg: 0.56 ± 0.176
0.784TrpSer: 0.784 ± 0.191
0.784TrpThr: 0.784 ± 0.165
0.896TrpVal: 0.896 ± 0.209
0.28TrpTrp: 0.28 ± 0.127
0.616TrpTyr: 0.616 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.961TyrAla: 1.961 ± 0.324
0.84TyrCys: 0.84 ± 0.253
3.978TyrAsp: 3.978 ± 0.618
3.193TyrGlu: 3.193 ± 0.391
1.793TyrPhe: 1.793 ± 0.427
3.642TyrGly: 3.642 ± 0.337
0.672TyrHis: 0.672 ± 0.213
2.633TyrIle: 2.633 ± 0.317
3.81TyrLys: 3.81 ± 0.475
4.034TyrLeu: 4.034 ± 0.478
1.289TyrMet: 1.289 ± 0.257
3.193TyrAsn: 3.193 ± 0.481
1.457TyrPro: 1.457 ± 0.255
1.681TyrGln: 1.681 ± 0.269
2.689TyrArg: 2.689 ± 0.297
3.362TyrSer: 3.362 ± 0.387
2.913TyrThr: 2.913 ± 0.528
3.249TyrVal: 3.249 ± 0.434
0.392TyrTrp: 0.392 ± 0.142
2.297TyrTyr: 2.297 ± 0.472
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (17850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski