Amino acid dipepetide frequency for Blumeria graminis f. sp. tritici 96224

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.743AlaAla: 5.743 ± 0.079	0.949AlaCys: 0.949 ± 0.024	3.215AlaAsp: 3.215 ± 0.05	4.325AlaGlu: 4.325 ± 0.061	2.526AlaPhe: 2.526 ± 0.038	4.042AlaGly: 4.042 ± 0.059	1.479AlaHis: 1.479 ± 0.032	4.26AlaIle: 4.26 ± 0.058	3.899AlaLys: 3.899 ± 0.05	6.557AlaLeu: 6.557 ± 0.076	1.513AlaMet: 1.513 ± 0.03	2.764AlaAsn: 2.764 ± 0.042	3.439AlaPro: 3.439 ± 0.049	2.848AlaGln: 2.848 ± 0.047	4.077AlaArg: 4.077 ± 0.052	6.221AlaSer: 6.221 ± 0.062	4.325AlaThr: 4.325 ± 0.05	3.871AlaVal: 3.871 ± 0.05	0.888AlaTrp: 0.888 ± 0.021	1.816AlaTyr: 1.816 ± 0.032	0.001AlaXaa: 0.001 ± 0.001
Cys	0.867CysAla: 0.867 ± 0.024	0.206CysCys: 0.206 ± 0.011	0.724CysAsp: 0.724 ± 0.021	0.779CysGlu: 0.779 ± 0.023	0.552CysPhe: 0.552 ± 0.017	0.961CysGly: 0.961 ± 0.023	0.4CysHis: 0.4 ± 0.012	0.808CysIle: 0.808 ± 0.022	0.677CysLys: 0.677 ± 0.02	1.385CysLeu: 1.385 ± 0.026	0.281CysMet: 0.281 ± 0.014	0.563CysAsn: 0.563 ± 0.018	0.66CysPro: 0.66 ± 0.019	0.54CysGln: 0.54 ± 0.016	0.765CysArg: 0.765 ± 0.02	1.215CysSer: 1.215 ± 0.026	0.74CysThr: 0.74 ± 0.021	0.701CysVal: 0.701 ± 0.019	0.158CysTrp: 0.158 ± 0.008	0.361CysTyr: 0.361 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.467AspAla: 3.467 ± 0.047	0.719AspCys: 0.719 ± 0.021	3.64AspAsp: 3.64 ± 0.065	4.516AspGlu: 4.516 ± 0.062	2.185AspPhe: 2.185 ± 0.037	3.197AspGly: 3.197 ± 0.052	1.184AspHis: 1.184 ± 0.026	3.54AspIle: 3.54 ± 0.044	2.725AspLys: 2.725 ± 0.038	5.078AspLeu: 5.078 ± 0.057	1.128AspMet: 1.128 ± 0.026	2.291AspAsn: 2.291 ± 0.035	2.689AspPro: 2.689 ± 0.042	2.007AspGln: 2.007 ± 0.039	2.723AspArg: 2.723 ± 0.043	4.675AspSer: 4.675 ± 0.064	2.84AspThr: 2.84 ± 0.034	3.177AspVal: 3.177 ± 0.038	0.731AspTrp: 0.731 ± 0.022	1.572AspTyr: 1.572 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	4.684GluAla: 4.684 ± 0.065	0.738GluCys: 0.738 ± 0.019	4.098GluAsp: 4.098 ± 0.061	5.339GluGlu: 5.339 ± 0.09	2.234GluPhe: 2.234 ± 0.039	3.157GluGly: 3.157 ± 0.049	1.233GluHis: 1.233 ± 0.027	4.521GluIle: 4.521 ± 0.05	4.745GluLys: 4.745 ± 0.08	5.491GluLeu: 5.491 ± 0.061	1.5GluMet: 1.5 ± 0.03	3.651GluAsn: 3.651 ± 0.064	2.473GluPro: 2.473 ± 0.049	2.258GluGln: 2.258 ± 0.042	3.775GluArg: 3.775 ± 0.058	5.062GluSer: 5.062 ± 0.067	3.719GluThr: 3.719 ± 0.046	3.51GluVal: 3.51 ± 0.043	0.82GluTrp: 0.82 ± 0.022	1.788GluTyr: 1.788 ± 0.029	0.001GluXaa: 0.001 ± 0.001
Phe	2.492PheAla: 2.492 ± 0.038	0.583PheCys: 0.583 ± 0.02	2.217PheAsp: 2.217 ± 0.039	2.354PheGlu: 2.354 ± 0.038	1.517PhePhe: 1.517 ± 0.031	2.551PheGly: 2.551 ± 0.042	0.937PheHis: 0.937 ± 0.023	2.125PheIle: 2.125 ± 0.039	1.871PheLys: 1.871 ± 0.033	3.477PheLeu: 3.477 ± 0.054	0.802PheMet: 0.802 ± 0.023	1.705PheAsn: 1.705 ± 0.03	1.944PhePro: 1.944 ± 0.037	1.557PheGln: 1.557 ± 0.033	2.005PheArg: 2.005 ± 0.037	3.506PheSer: 3.506 ± 0.05	2.169PheThr: 2.169 ± 0.038	2.184PheVal: 2.184 ± 0.037	0.528PheTrp: 0.528 ± 0.02	1.148PheTyr: 1.148 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	3.646GlyAla: 3.646 ± 0.056	0.747GlyCys: 0.747 ± 0.022	2.938GlyAsp: 2.938 ± 0.043	3.245GlyGlu: 3.245 ± 0.044	2.425GlyPhe: 2.425 ± 0.038	4.09GlyGly: 4.09 ± 0.09	1.377GlyHis: 1.377 ± 0.035	3.799GlyIle: 3.799 ± 0.054	3.596GlyLys: 3.596 ± 0.053	5.317GlyLeu: 5.317 ± 0.057	1.402GlyMet: 1.402 ± 0.033	2.673GlyAsn: 2.673 ± 0.034	2.527GlyPro: 2.527 ± 0.048	2.135GlyGln: 2.135 ± 0.034	3.409GlyArg: 3.409 ± 0.051	5.017GlySer: 5.017 ± 0.068	3.367GlyThr: 3.367 ± 0.046	3.425GlyVal: 3.425 ± 0.044	0.95GlyTrp: 0.95 ± 0.023	1.806GlyTyr: 1.806 ± 0.038	0.004GlyXaa: 0.004 ± 0.002
His	1.485HisAla: 1.485 ± 0.03	0.316HisCys: 0.316 ± 0.012	1.261HisAsp: 1.261 ± 0.029	1.501HisGlu: 1.501 ± 0.03	0.945HisPhe: 0.945 ± 0.023	1.46HisGly: 1.46 ± 0.032	0.743HisHis: 0.743 ± 0.024	1.446HisIle: 1.446 ± 0.031	1.115HisLys: 1.115 ± 0.025	2.231HisLeu: 2.231 ± 0.038	0.461HisMet: 0.461 ± 0.018	1.067HisAsn: 1.067 ± 0.022	1.415HisPro: 1.415 ± 0.029	1.124HisGln: 1.124 ± 0.028	1.403HisArg: 1.403 ± 0.031	2.04HisSer: 2.04 ± 0.032	1.299HisThr: 1.299 ± 0.026	1.28HisVal: 1.28 ± 0.032	0.258HisTrp: 0.258 ± 0.014	0.669HisTyr: 0.669 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.164IleAla: 4.164 ± 0.052	0.943IleCys: 0.943 ± 0.024	3.616IleAsp: 3.616 ± 0.042	4.016IleGlu: 4.016 ± 0.056	2.606IlePhe: 2.606 ± 0.041	3.356IleGly: 3.356 ± 0.048	1.411IleHis: 1.411 ± 0.031	3.814IleIle: 3.814 ± 0.061	3.484IleLys: 3.484 ± 0.05	5.727IleLeu: 5.727 ± 0.067	1.242IleMet: 1.242 ± 0.023	2.803IleAsn: 2.803 ± 0.043	3.518IlePro: 3.518 ± 0.039	2.448IleGln: 2.448 ± 0.038	3.283IleArg: 3.283 ± 0.045	6.099IleSer: 6.099 ± 0.06	3.461IleThr: 3.461 ± 0.045	3.382IleVal: 3.382 ± 0.043	0.744IleTrp: 0.744 ± 0.023	1.744IleTyr: 1.744 ± 0.03	0.001IleXaa: 0.001 ± 0.001
Lys	4.108LysAla: 4.108 ± 0.056	0.734LysCys: 0.734 ± 0.021	3.156LysAsp: 3.156 ± 0.044	3.954LysGlu: 3.954 ± 0.06	2.191LysPhe: 2.191 ± 0.035	2.85LysGly: 2.85 ± 0.046	1.216LysHis: 1.216 ± 0.029	4.082LysIle: 4.082 ± 0.055	4.552LysLys: 4.552 ± 0.08	5.264LysLeu: 5.264 ± 0.054	1.264LysMet: 1.264 ± 0.029	3.075LysAsn: 3.075 ± 0.049	2.866LysPro: 2.866 ± 0.042	2.145LysGln: 2.145 ± 0.037	3.762LysArg: 3.762 ± 0.05	5.195LysSer: 5.195 ± 0.065	3.364LysThr: 3.364 ± 0.047	3.3LysVal: 3.3 ± 0.046	0.699LysTrp: 0.699 ± 0.021	1.771LysTyr: 1.771 ± 0.031	0.001LysXaa: 0.001 ± 0.001
Leu	6.828LeuAla: 6.828 ± 0.069	1.268LeuCys: 1.268 ± 0.026	5.069LeuAsp: 5.069 ± 0.058	6.014LeuGlu: 6.014 ± 0.071	3.296LeuPhe: 3.296 ± 0.051	5.384LeuGly: 5.384 ± 0.068	2.257LeuHis: 2.257 ± 0.037	4.965LeuIle: 4.965 ± 0.066	5.336LeuLys: 5.336 ± 0.057	8.319LeuLeu: 8.319 ± 0.099	1.822LeuMet: 1.822 ± 0.031	4.017LeuAsn: 4.017 ± 0.046	5.14LeuPro: 5.14 ± 0.057	4.084LeuGln: 4.084 ± 0.054	5.531LeuArg: 5.531 ± 0.052	8.182LeuSer: 8.182 ± 0.082	5.105LeuThr: 5.105 ± 0.059	4.928LeuVal: 4.928 ± 0.06	1.036LeuTrp: 1.036 ± 0.028	2.367LeuTyr: 2.367 ± 0.039	0.002LeuXaa: 0.002 ± 0.001
Met	1.856MetAla: 1.856 ± 0.032	0.251MetCys: 0.251 ± 0.014	1.122MetAsp: 1.122 ± 0.026	1.343MetGlu: 1.343 ± 0.03	0.678MetPhe: 0.678 ± 0.02	1.333MetGly: 1.333 ± 0.026	0.416MetHis: 0.416 ± 0.016	1.257MetIle: 1.257 ± 0.026	1.339MetLys: 1.339 ± 0.029	1.701MetLeu: 1.701 ± 0.032	0.535MetMet: 0.535 ± 0.018	1.033MetAsn: 1.033 ± 0.024	1.063MetPro: 1.063 ± 0.027	0.864MetGln: 0.864 ± 0.022	1.237MetArg: 1.237 ± 0.028	1.943MetSer: 1.943 ± 0.038	1.264MetThr: 1.264 ± 0.028	1.137MetVal: 1.137 ± 0.026	0.22MetTrp: 0.22 ± 0.011	0.507MetTyr: 0.507 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.769AsnAla: 2.769 ± 0.039	0.638AsnCys: 0.638 ± 0.018	2.36AsnAsp: 2.36 ± 0.04	2.901AsnGlu: 2.901 ± 0.048	2.055AsnPhe: 2.055 ± 0.036	2.687AsnGly: 2.687 ± 0.048	1.178AsnHis: 1.178 ± 0.025	3.197AsnIle: 3.197 ± 0.044	2.475AsnLys: 2.475 ± 0.042	4.573AsnLeu: 4.573 ± 0.059	0.969AsnMet: 0.969 ± 0.021	2.364AsnAsn: 2.364 ± 0.041	2.705AsnPro: 2.705 ± 0.042	1.987AsnGln: 1.987 ± 0.035	2.431AsnArg: 2.431 ± 0.038	4.642AsnSer: 4.642 ± 0.068	2.792AsnThr: 2.792 ± 0.041	2.488AsnVal: 2.488 ± 0.044	0.538AsnTrp: 0.538 ± 0.02	1.467AsnTyr: 1.467 ± 0.033	0.001AsnXaa: 0.001 ± 0.001
Pro	3.459ProAla: 3.459 ± 0.052	0.598ProCys: 0.598 ± 0.018	2.63ProAsp: 2.63 ± 0.04	3.371ProGlu: 3.371 ± 0.051	1.807ProPhe: 1.807 ± 0.031	2.905ProGly: 2.905 ± 0.048	1.286ProHis: 1.286 ± 0.029	3.071ProIle: 3.071 ± 0.047	3.081ProLys: 3.081 ± 0.047	4.585ProLeu: 4.585 ± 0.048	0.972ProMet: 0.972 ± 0.026	2.47ProAsn: 2.47 ± 0.04	3.709ProPro: 3.709 ± 0.069	2.234ProGln: 2.234 ± 0.046	2.851ProArg: 2.851 ± 0.042	5.649ProSer: 5.649 ± 0.074	3.682ProThr: 3.682 ± 0.048	2.86ProVal: 2.86 ± 0.042	0.538ProTrp: 0.538 ± 0.018	1.369ProTyr: 1.369 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.968GlnAla: 2.968 ± 0.056	0.469GlnCys: 0.469 ± 0.016	2.052GlnAsp: 2.052 ± 0.038	2.537GlnGlu: 2.537 ± 0.051	1.318GlnPhe: 1.318 ± 0.029	2.063GlnGly: 2.063 ± 0.038	0.955GlnHis: 0.955 ± 0.025	2.631GlnIle: 2.631 ± 0.04	2.696GlnLys: 2.696 ± 0.049	3.572GlnLeu: 3.572 ± 0.045	0.85GlnMet: 0.85 ± 0.021	2.279GlnAsn: 2.279 ± 0.043	2.124GlnPro: 2.124 ± 0.035	2.102GlnGln: 2.102 ± 0.074	2.48GlnArg: 2.48 ± 0.042	3.547GlnSer: 3.547 ± 0.056	2.45GlnThr: 2.45 ± 0.038	2.174GlnVal: 2.174 ± 0.034	0.462GlnTrp: 0.462 ± 0.019	1.165GlnTyr: 1.165 ± 0.025	0.001GlnXaa: 0.001 ± 0.001
Arg	3.826ArgAla: 3.826 ± 0.051	0.793ArgCys: 0.793 ± 0.022	3.093ArgAsp: 3.093 ± 0.051	3.826ArgGlu: 3.826 ± 0.056	2.093ArgPhe: 2.093 ± 0.036	3.304ArgGly: 3.304 ± 0.062	1.4ArgHis: 1.4 ± 0.03	3.46ArgIle: 3.46 ± 0.042	4.077ArgLys: 4.077 ± 0.051	5.274ArgLeu: 5.274 ± 0.054	1.246ArgMet: 1.246 ± 0.026	2.871ArgAsn: 2.871 ± 0.044	2.877ArgPro: 2.877 ± 0.039	2.494ArgGln: 2.494 ± 0.04	4.38ArgArg: 4.38 ± 0.078	4.89ArgSer: 4.89 ± 0.067	2.992ArgThr: 2.992 ± 0.043	2.91ArgVal: 2.91 ± 0.04	0.747ArgTrp: 0.747 ± 0.019	1.617ArgTyr: 1.617 ± 0.033	0.001ArgXaa: 0.001 ± 0.001
Ser	5.677SerAla: 5.677 ± 0.066	1.207SerCys: 1.207 ± 0.026	4.611SerAsp: 4.611 ± 0.055	5.202SerGlu: 5.202 ± 0.063	3.288SerPhe: 3.288 ± 0.051	5.231SerGly: 5.231 ± 0.07	2.403SerHis: 2.403 ± 0.039	5.582SerIle: 5.582 ± 0.069	5.317SerLys: 5.317 ± 0.073	8.394SerLeu: 8.394 ± 0.073	1.838SerMet: 1.838 ± 0.032	4.635SerAsn: 4.635 ± 0.06	5.296SerPro: 5.296 ± 0.083	3.939SerGln: 3.939 ± 0.054	5.468SerArg: 5.468 ± 0.075	10.321SerSer: 10.321 ± 0.119	6.04SerThr: 6.04 ± 0.066	4.485SerVal: 4.485 ± 0.054	1.062SerTrp: 1.062 ± 0.023	2.432SerTyr: 2.432 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.075ThrAla: 4.075 ± 0.054	0.801ThrCys: 0.801 ± 0.023	2.758ThrAsp: 2.758 ± 0.038	3.382ThrGlu: 3.382 ± 0.045	2.178ThrPhe: 2.178 ± 0.036	3.622ThrGly: 3.622 ± 0.047	1.392ThrHis: 1.392 ± 0.029	3.658ThrIle: 3.658 ± 0.047	3.292ThrLys: 3.292 ± 0.046	5.207ThrLeu: 5.207 ± 0.064	1.157ThrMet: 1.157 ± 0.028	2.679ThrAsn: 2.679 ± 0.045	3.799ThrPro: 3.799 ± 0.051	2.24ThrGln: 2.24 ± 0.036	3.181ThrArg: 3.181 ± 0.041	6.162ThrSer: 6.162 ± 0.075	4.068ThrThr: 4.068 ± 0.056	3.258ThrVal: 3.258 ± 0.04	0.66ThrTrp: 0.66 ± 0.02	1.569ThrTyr: 1.569 ± 0.028	0.002ThrXaa: 0.002 ± 0.001
Val	4.02ValAla: 4.02 ± 0.06	0.748ValCys: 0.748 ± 0.023	3.198ValAsp: 3.198 ± 0.044	3.728ValGlu: 3.728 ± 0.051	2.066ValPhe: 2.066 ± 0.039	3.235ValGly: 3.235 ± 0.047	1.194ValHis: 1.194 ± 0.027	3.268ValIle: 3.268 ± 0.051	3.147ValLys: 3.147 ± 0.045	4.852ValLeu: 4.852 ± 0.055	1.226ValMet: 1.226 ± 0.026	2.364ValAsn: 2.364 ± 0.036	2.916ValPro: 2.916 ± 0.044	2.153ValGln: 2.153 ± 0.034	2.995ValArg: 2.995 ± 0.044	4.706ValSer: 4.706 ± 0.055	3.205ValThr: 3.205 ± 0.047	3.313ValVal: 3.313 ± 0.05	0.69ValTrp: 0.69 ± 0.021	1.507ValTyr: 1.507 ± 0.036	0.001ValXaa: 0.001 ± 0.001
Trp	0.836TrpAla: 0.836 ± 0.021	0.181TrpCys: 0.181 ± 0.009	0.742TrpAsp: 0.742 ± 0.023	0.767TrpGlu: 0.767 ± 0.022	0.438TrpPhe: 0.438 ± 0.015	0.696TrpGly: 0.696 ± 0.023	0.293TrpHis: 0.293 ± 0.015	0.744TrpIle: 0.744 ± 0.02	0.824TrpLys: 0.824 ± 0.022	1.132TrpLeu: 1.132 ± 0.031	0.307TrpMet: 0.307 ± 0.012	0.641TrpAsn: 0.641 ± 0.019	0.509TrpPro: 0.509 ± 0.019	0.48TrpGln: 0.48 ± 0.017	0.79TrpArg: 0.79 ± 0.021	0.939TrpSer: 0.939 ± 0.026	0.709TrpThr: 0.709 ± 0.019	0.673TrpVal: 0.673 ± 0.019	0.235TrpTrp: 0.235 ± 0.013	0.359TrpTyr: 0.359 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.785TyrAla: 1.785 ± 0.034	0.452TyrCys: 0.452 ± 0.014	1.583TyrAsp: 1.583 ± 0.028	1.697TyrGlu: 1.697 ± 0.032	1.272TyrPhe: 1.272 ± 0.028	1.769TyrGly: 1.769 ± 0.037	0.765TyrHis: 0.765 ± 0.023	1.635TyrIle: 1.635 ± 0.033	1.298TyrLys: 1.298 ± 0.026	2.811TyrLeu: 2.811 ± 0.044	0.584TyrMet: 0.584 ± 0.019	1.274TyrAsn: 1.274 ± 0.025	1.459TyrPro: 1.459 ± 0.03	1.256TyrGln: 1.256 ± 0.029	1.625TyrArg: 1.625 ± 0.028	2.417TyrSer: 2.417 ± 0.038	1.549TyrThr: 1.549 ± 0.03	1.475TyrVal: 1.475 ± 0.034	0.33TyrTrp: 0.33 ± 0.013	0.9TyrTyr: 0.9 ± 0.025	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.716XaaXaa: 0.716 ± 0.233

Statistics based on 4024 proteins (1773325 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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