Amino acid dipepetide frequency for Altererythrobacter sp. BO-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.134AlaAla: 17.134 ± 0.223	1.113AlaCys: 1.113 ± 0.036	6.937AlaAsp: 6.937 ± 0.094	8.275AlaGlu: 8.275 ± 0.111	4.196AlaPhe: 4.196 ± 0.072	10.724AlaGly: 10.724 ± 0.128	2.272AlaHis: 2.272 ± 0.054	6.868AlaIle: 6.868 ± 0.103	4.399AlaLys: 4.399 ± 0.086	13.307AlaLeu: 13.307 ± 0.169	3.796AlaMet: 3.796 ± 0.082	3.284AlaAsn: 3.284 ± 0.067	5.672AlaPro: 5.672 ± 0.104	4.597AlaGln: 4.597 ± 0.089	8.809AlaArg: 8.809 ± 0.13	6.64AlaSer: 6.64 ± 0.094	5.839AlaThr: 5.839 ± 0.104	7.781AlaVal: 7.781 ± 0.105	1.58AlaTrp: 1.58 ± 0.046	2.559AlaTyr: 2.559 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.018CysAla: 1.018 ± 0.035	0.093CysCys: 0.093 ± 0.01	0.614CysAsp: 0.614 ± 0.028	0.537CysGlu: 0.537 ± 0.027	0.312CysPhe: 0.312 ± 0.02	0.915CysGly: 0.915 ± 0.036	0.232CysHis: 0.232 ± 0.016	0.384CysIle: 0.384 ± 0.023	0.235CysLys: 0.235 ± 0.017	0.772CysLeu: 0.772 ± 0.032	0.147CysMet: 0.147 ± 0.013	0.246CysAsn: 0.246 ± 0.019	0.449CysPro: 0.449 ± 0.028	0.222CysGln: 0.222 ± 0.016	0.544CysArg: 0.544 ± 0.023	0.471CysSer: 0.471 ± 0.028	0.409CysThr: 0.409 ± 0.022	0.577CysVal: 0.577 ± 0.028	0.113CysTrp: 0.113 ± 0.011	0.18CysTyr: 0.18 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.208AspAla: 7.208 ± 0.101	0.537AspCys: 0.537 ± 0.025	3.328AspAsp: 3.328 ± 0.087	3.941AspGlu: 3.941 ± 0.071	2.409AspPhe: 2.409 ± 0.05	5.604AspGly: 5.604 ± 0.113	1.205AspHis: 1.205 ± 0.041	2.968AspIle: 2.968 ± 0.06	1.863AspLys: 1.863 ± 0.047	5.617AspLeu: 5.617 ± 0.081	1.477AspMet: 1.477 ± 0.044	1.464AspAsn: 1.464 ± 0.045	3.959AspPro: 3.959 ± 0.068	1.81AspGln: 1.81 ± 0.051	4.401AspArg: 4.401 ± 0.073	2.31AspSer: 2.31 ± 0.058	2.691AspThr: 2.691 ± 0.066	3.832AspVal: 3.832 ± 0.072	1.208AspTrp: 1.208 ± 0.039	1.678AspTyr: 1.678 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.436GluAla: 8.436 ± 0.121	0.405GluCys: 0.405 ± 0.024	3.376GluAsp: 3.376 ± 0.076	3.929GluGlu: 3.929 ± 0.099	2.152GluPhe: 2.152 ± 0.05	5.053GluGly: 5.053 ± 0.074	1.302GluHis: 1.302 ± 0.036	3.457GluIle: 3.457 ± 0.064	2.24GluLys: 2.24 ± 0.06	6.347GluLeu: 6.347 ± 0.105	1.714GluMet: 1.714 ± 0.048	1.692GluAsn: 1.692 ± 0.043	2.868GluPro: 2.868 ± 0.065	2.583GluGln: 2.583 ± 0.059	5.199GluArg: 5.199 ± 0.083	2.5GluSer: 2.5 ± 0.056	3.149GluThr: 3.149 ± 0.053	4.238GluVal: 4.238 ± 0.084	1.038GluTrp: 1.038 ± 0.035	1.23GluTyr: 1.23 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	4.917PheAla: 4.917 ± 0.08	0.351PheCys: 0.351 ± 0.021	2.753PheAsp: 2.753 ± 0.064	2.414PheGlu: 2.414 ± 0.057	1.4PhePhe: 1.4 ± 0.051	3.942PheGly: 3.942 ± 0.076	0.743PheHis: 0.743 ± 0.025	1.63PheIle: 1.63 ± 0.041	1.042PheLys: 1.042 ± 0.037	3.153PheLeu: 3.153 ± 0.07	0.853PheMet: 0.853 ± 0.034	1.196PheAsn: 1.196 ± 0.052	1.616PhePro: 1.616 ± 0.038	0.991PheGln: 0.991 ± 0.032	2.057PheArg: 2.057 ± 0.044	2.176PheSer: 2.176 ± 0.057	2.123PheThr: 2.123 ± 0.061	2.712PheVal: 2.712 ± 0.064	0.564PheTrp: 0.564 ± 0.03	0.976PheTyr: 0.976 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.603GlyAla: 9.603 ± 0.119	0.856GlyCys: 0.856 ± 0.03	4.91GlyAsp: 4.91 ± 0.095	5.637GlyGlu: 5.637 ± 0.084	3.868GlyPhe: 3.868 ± 0.076	7.902GlyGly: 7.902 ± 0.128	1.803GlyHis: 1.803 ± 0.046	4.676GlyIle: 4.676 ± 0.073	3.706GlyLys: 3.706 ± 0.071	8.547GlyLeu: 8.547 ± 0.113	2.543GlyMet: 2.543 ± 0.057	2.5GlyAsn: 2.5 ± 0.068	3.488GlyPro: 3.488 ± 0.06	3.104GlyGln: 3.104 ± 0.061	5.66GlyArg: 5.66 ± 0.081	4.975GlySer: 4.975 ± 0.087	4.795GlyThr: 4.795 ± 0.103	5.977GlyVal: 5.977 ± 0.093	1.591GlyTrp: 1.591 ± 0.045	2.356GlyTyr: 2.356 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.359HisAla: 2.359 ± 0.053	0.269HisCys: 0.269 ± 0.017	1.234HisAsp: 1.234 ± 0.038	1.097HisGlu: 1.097 ± 0.035	0.906HisPhe: 0.906 ± 0.033	1.95HisGly: 1.95 ± 0.056	0.568HisHis: 0.568 ± 0.031	0.933HisIle: 0.933 ± 0.03	0.54HisLys: 0.54 ± 0.027	1.829HisLeu: 1.829 ± 0.05	0.469HisMet: 0.469 ± 0.024	0.526HisAsn: 0.526 ± 0.028	1.333HisPro: 1.333 ± 0.045	0.598HisGln: 0.598 ± 0.031	1.345HisArg: 1.345 ± 0.041	0.991HisSer: 0.991 ± 0.034	0.841HisThr: 0.841 ± 0.033	1.32HisVal: 1.32 ± 0.041	0.343HisTrp: 0.343 ± 0.02	0.603HisTyr: 0.603 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.714IleAla: 7.714 ± 0.107	0.502IleCys: 0.502 ± 0.025	3.86IleAsp: 3.86 ± 0.06	4.061IleGlu: 4.061 ± 0.074	1.647IlePhe: 1.647 ± 0.041	5.142IleGly: 5.142 ± 0.081	0.933IleHis: 0.933 ± 0.032	2.121IleIle: 2.121 ± 0.06	1.452IleLys: 1.452 ± 0.044	3.876IleLeu: 3.876 ± 0.073	0.986IleMet: 0.986 ± 0.035	1.475IleAsn: 1.475 ± 0.048	2.373IlePro: 2.373 ± 0.056	1.087IleGln: 1.087 ± 0.04	3.084IleArg: 3.084 ± 0.059	2.763IleSer: 2.763 ± 0.057	2.71IleThr: 2.71 ± 0.08	3.913IleVal: 3.913 ± 0.08	0.651IleTrp: 0.651 ± 0.029	1.115IleTyr: 1.115 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.195LysAla: 4.195 ± 0.086	0.215LysCys: 0.215 ± 0.016	1.669LysAsp: 1.669 ± 0.051	1.565LysGlu: 1.565 ± 0.055	1.065LysPhe: 1.065 ± 0.036	2.808LysGly: 2.808 ± 0.07	0.657LysHis: 0.657 ± 0.029	1.594LysIle: 1.594 ± 0.049	1.316LysLys: 1.316 ± 0.066	3.428LysLeu: 3.428 ± 0.071	0.809LysMet: 0.809 ± 0.031	0.763LysAsn: 0.763 ± 0.034	2.124LysPro: 2.124 ± 0.054	1.151LysGln: 1.151 ± 0.035	2.527LysArg: 2.527 ± 0.056	1.737LysSer: 1.737 ± 0.046	1.593LysThr: 1.593 ± 0.046	2.438LysVal: 2.438 ± 0.062	0.441LysTrp: 0.441 ± 0.023	0.698LysTyr: 0.698 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	13.966LeuAla: 13.966 ± 0.171	0.788LeuCys: 0.788 ± 0.036	6.048LeuAsp: 6.048 ± 0.082	5.767LeuGlu: 5.767 ± 0.089	3.577LeuPhe: 3.577 ± 0.073	8.517LeuGly: 8.517 ± 0.117	1.795LeuHis: 1.795 ± 0.049	4.679LeuIle: 4.679 ± 0.09	3.28LeuLys: 3.28 ± 0.075	9.293LeuLeu: 9.293 ± 0.154	2.158LeuMet: 2.158 ± 0.053	2.366LeuAsn: 2.366 ± 0.055	5.42LeuPro: 5.42 ± 0.093	2.631LeuGln: 2.631 ± 0.06	6.366LeuArg: 6.366 ± 0.096	5.731LeuSer: 5.731 ± 0.09	5.17LeuThr: 5.17 ± 0.088	7.37LeuVal: 7.37 ± 0.094	1.169LeuTrp: 1.169 ± 0.05	1.978LeuTyr: 1.978 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.412MetAla: 3.412 ± 0.072	0.173MetCys: 0.173 ± 0.015	1.152MetAsp: 1.152 ± 0.038	1.324MetGlu: 1.324 ± 0.035	0.719MetPhe: 0.719 ± 0.024	2.028MetGly: 2.028 ± 0.05	0.497MetHis: 0.497 ± 0.024	1.338MetIle: 1.338 ± 0.036	1.001MetLys: 1.001 ± 0.037	2.629MetLeu: 2.629 ± 0.063	0.651MetMet: 0.651 ± 0.032	0.762MetAsn: 0.762 ± 0.033	1.539MetPro: 1.539 ± 0.042	0.85MetGln: 0.85 ± 0.034	1.821MetArg: 1.821 ± 0.042	1.541MetSer: 1.541 ± 0.04	1.488MetThr: 1.488 ± 0.044	1.733MetVal: 1.733 ± 0.045	0.262MetTrp: 0.262 ± 0.018	0.275MetTyr: 0.275 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.234AsnAla: 3.234 ± 0.063	0.268AsnCys: 0.268 ± 0.016	1.453AsnAsp: 1.453 ± 0.049	1.311AsnGlu: 1.311 ± 0.039	1.118AsnPhe: 1.118 ± 0.043	2.48AsnGly: 2.48 ± 0.06	0.516AsnHis: 0.516 ± 0.024	1.414AsnIle: 1.414 ± 0.048	0.718AsnLys: 0.718 ± 0.028	2.652AsnLeu: 2.652 ± 0.065	0.624AsnMet: 0.624 ± 0.027	0.773AsnAsn: 0.773 ± 0.035	1.954AsnPro: 1.954 ± 0.054	0.831AsnGln: 0.831 ± 0.033	1.896AsnArg: 1.896 ± 0.048	1.38AsnSer: 1.38 ± 0.042	1.257AsnThr: 1.257 ± 0.053	1.896AsnVal: 1.896 ± 0.049	0.477AsnTrp: 0.477 ± 0.025	0.774AsnTyr: 0.774 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.273ProAla: 6.273 ± 0.104	0.329ProCys: 0.329 ± 0.019	3.876ProAsp: 3.876 ± 0.068	4.014ProGlu: 4.014 ± 0.074	1.959ProPhe: 1.959 ± 0.047	4.592ProGly: 4.592 ± 0.08	1.078ProHis: 1.078 ± 0.037	2.497ProIle: 2.497 ± 0.057	1.627ProLys: 1.627 ± 0.053	4.804ProLeu: 4.804 ± 0.084	1.148ProMet: 1.148 ± 0.035	1.331ProAsn: 1.331 ± 0.038	2.456ProPro: 2.456 ± 0.087	1.884ProGln: 1.884 ± 0.051	2.909ProArg: 2.909 ± 0.065	2.595ProSer: 2.595 ± 0.052	2.375ProThr: 2.375 ± 0.054	3.997ProVal: 3.997 ± 0.065	0.701ProTrp: 0.701 ± 0.028	1.123ProTyr: 1.123 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.189GlnAla: 4.189 ± 0.075	0.267GlnCys: 0.267 ± 0.021	1.607GlnAsp: 1.607 ± 0.048	1.595GlnGlu: 1.595 ± 0.046	1.3GlnPhe: 1.3 ± 0.045	2.567GlnGly: 2.567 ± 0.057	0.726GlnHis: 0.726 ± 0.03	1.825GlnIle: 1.825 ± 0.045	0.903GlnLys: 0.903 ± 0.04	3.527GlnLeu: 3.527 ± 0.057	0.937GlnMet: 0.937 ± 0.032	0.839GlnAsn: 0.839 ± 0.035	1.791GlnPro: 1.791 ± 0.046	1.281GlnGln: 1.281 ± 0.046	2.484GlnArg: 2.484 ± 0.059	1.735GlnSer: 1.735 ± 0.042	1.533GlnThr: 1.533 ± 0.046	2.456GlnVal: 2.456 ± 0.051	0.486GlnTrp: 0.486 ± 0.022	0.727GlnTyr: 0.727 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.74ArgAla: 7.74 ± 0.108	0.455ArgCys: 0.455 ± 0.027	4.155ArgAsp: 4.155 ± 0.074	4.773ArgGlu: 4.773 ± 0.074	2.806ArgPhe: 2.806 ± 0.058	4.745ArgGly: 4.745 ± 0.078	1.534ArgHis: 1.534 ± 0.041	3.9ArgIle: 3.9 ± 0.07	2.364ArgLys: 2.364 ± 0.054	7.336ArgLeu: 7.336 ± 0.106	1.963ArgMet: 1.963 ± 0.053	1.841ArgAsn: 1.841 ± 0.043	3.241ArgPro: 3.241 ± 0.072	2.471ArgGln: 2.471 ± 0.06	4.904ArgArg: 4.904 ± 0.094	3.456ArgSer: 3.456 ± 0.072	3.013ArgThr: 3.013 ± 0.056	4.381ArgVal: 4.381 ± 0.07	1.162ArgTrp: 1.162 ± 0.038	1.812ArgTyr: 1.812 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.135SerAla: 6.135 ± 0.089	0.441SerCys: 0.441 ± 0.028	3.295SerAsp: 3.295 ± 0.061	3.256SerGlu: 3.256 ± 0.056	2.265SerPhe: 2.265 ± 0.052	5.673SerGly: 5.673 ± 0.09	1.064SerHis: 1.064 ± 0.035	2.618SerIle: 2.618 ± 0.05	1.518SerLys: 1.518 ± 0.048	5.007SerLeu: 5.007 ± 0.089	1.259SerMet: 1.259 ± 0.04	1.506SerAsn: 1.506 ± 0.051	2.747SerPro: 2.747 ± 0.056	1.773SerGln: 1.773 ± 0.052	3.307SerArg: 3.307 ± 0.068	2.82SerSer: 2.82 ± 0.075	2.492SerThr: 2.492 ± 0.058	3.475SerVal: 3.475 ± 0.078	0.821SerTrp: 0.821 ± 0.036	1.384SerTyr: 1.384 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.809ThrAla: 5.809 ± 0.113	0.454ThrCys: 0.454 ± 0.025	2.816ThrAsp: 2.816 ± 0.086	2.61ThrGlu: 2.61 ± 0.054	1.878ThrPhe: 1.878 ± 0.054	5.116ThrGly: 5.116 ± 0.095	0.952ThrHis: 0.952 ± 0.035	2.856ThrIle: 2.856 ± 0.07	1.353ThrLys: 1.353 ± 0.045	5.153ThrLeu: 5.153 ± 0.084	1.146ThrMet: 1.146 ± 0.037	1.312ThrAsn: 1.312 ± 0.044	3.096ThrPro: 3.096 ± 0.074	1.425ThrGln: 1.425 ± 0.043	3.206ThrArg: 3.206 ± 0.066	2.79ThrSer: 2.79 ± 0.058	2.489ThrThr: 2.489 ± 0.063	3.864ThrVal: 3.864 ± 0.092	0.597ThrTrp: 0.597 ± 0.027	1.301ThrTyr: 1.301 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	8.538ValAla: 8.538 ± 0.121	0.571ValCys: 0.571 ± 0.024	4.087ValAsp: 4.087 ± 0.074	4.764ValGlu: 4.764 ± 0.082	2.4ValPhe: 2.4 ± 0.057	5.483ValGly: 5.483 ± 0.078	1.244ValHis: 1.244 ± 0.039	4.068ValIle: 4.068 ± 0.069	2.147ValLys: 2.147 ± 0.061	6.717ValLeu: 6.717 ± 0.091	1.703ValMet: 1.703 ± 0.048	2.022ValAsn: 2.022 ± 0.055	3.688ValPro: 3.688 ± 0.067	1.985ValGln: 1.985 ± 0.049	4.313ValArg: 4.313 ± 0.07	4.01ValSer: 4.01 ± 0.075	4.313ValThr: 4.313 ± 0.097	5.028ValVal: 5.028 ± 0.095	0.913ValTrp: 0.913 ± 0.036	1.339ValTyr: 1.339 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.38TrpAla: 1.38 ± 0.043	0.118TrpCys: 0.118 ± 0.01	0.8TrpAsp: 0.8 ± 0.03	0.734TrpGlu: 0.734 ± 0.031	0.636TrpPhe: 0.636 ± 0.03	1.033TrpGly: 1.033 ± 0.034	0.411TrpHis: 0.411 ± 0.02	0.72TrpIle: 0.72 ± 0.032	0.477TrpLys: 0.477 ± 0.022	1.824TrpLeu: 1.824 ± 0.055	0.391TrpMet: 0.391 ± 0.024	0.466TrpAsn: 0.466 ± 0.023	0.689TrpPro: 0.689 ± 0.031	0.742TrpGln: 0.742 ± 0.029	1.285TrpArg: 1.285 ± 0.041	0.878TrpSer: 0.878 ± 0.04	0.755TrpThr: 0.755 ± 0.031	0.856TrpVal: 0.856 ± 0.039	0.272TrpTrp: 0.272 ± 0.019	0.282TrpTyr: 0.282 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.52TyrAla: 2.52 ± 0.06	0.265TyrCys: 0.265 ± 0.02	1.537TyrAsp: 1.537 ± 0.042	1.308TyrGlu: 1.308 ± 0.039	0.998TyrPhe: 0.998 ± 0.034	2.224TyrGly: 2.224 ± 0.048	0.522TyrHis: 0.522 ± 0.022	0.921TyrIle: 0.921 ± 0.032	0.611TyrLys: 0.611 ± 0.031	2.251TyrLeu: 2.251 ± 0.061	0.417TyrMet: 0.417 ± 0.022	0.665TyrAsn: 0.665 ± 0.027	1.064TyrPro: 1.064 ± 0.038	0.758TyrGln: 0.758 ± 0.029	1.937TyrArg: 1.937 ± 0.051	1.357TyrSer: 1.357 ± 0.042	1.189TyrThr: 1.189 ± 0.06	1.486TyrVal: 1.486 ± 0.044	0.361TyrTrp: 0.361 ± 0.02	0.674TyrTyr: 0.674 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2774 proteins (866373 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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